Classification of peacock feather reflectance using principal component analysis similarity factors from multispectral imaging data

This is the author accepted manuscript. The final version is available from the publisher via the DOI in this record.Iridescent structural colors in biology exhibit sophisticated spatially-varying reflectance properties that depend on both the illumination and viewing angles. The classification of such spectral and spatial information in iridescent structurally colored surfaces is important to elucidate the functional role of irregularity and to improve understanding of color pattern formation at different length scales. In this study, we propose a non-invasive method for the spectral classification of spatial reflectance patterns at the micron scale based on the multispectral imaging technique and the principal component analysis similarity factor (PCASF). We demonstrate the effectiveness of this approach and its component methods by detailing its use in the study of the angle-dependent reflectance properties of Pavo cristatus (the common peacock) feathers, a species of peafowl very well known to exhibit bright and saturated iridescent colors. We show that multispectral reflectance imaging and PCASF approaches can be used as effective tools for spectral recognition of iridescent patterns in the visible spectrum and provide meaningful information for spectral classification of the irregularity of the microstructure in iridescent plumage.This research was developed during a visiting research stay of Dr. José M. Medina in the Departamento de Óptica, Universidad de Granada, Spain. We thank to José Medina and Rosalía Ruiz who provided the peacock samples, to David Porcel and Juan de Dios Bueno from the Servicio de Microscopía, (Centro de Instrumentación Científica, Universidad de Granada) for technical assessment, and to the Color Imaging Group (Universidad de Granada) for their hardware partial support. JMM and JAD acknowledge the Departmento de Óptica, Universidad de Granada, Spain. PV acknowledges USAF funding (FA9550-10-1-0020)

Candidate‐Gene Study of Functional Polymorphisms in SLCO1B1 and CYP3A4/5 and the Cholesterol‐Lowering Response to Simvastatin

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/137517/1/cts12432.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/137517/2/cts12432_am.pd

Genetic variation in early fitness traits across European populations of silver birch (Betula pendula)

Given that the ecological niche of tree species is typically narrower for earlier life stages, intraspecific genetic variation at early fitness traits may greatly influence the adaptive response of tree populations to changing environmental conditions. In this study, we evaluated genetic variation in early fitness traits among 12 populations of Betula pendula from a wide latitudinal range in Europe (41-55 degrees N). We first conducted a chamber experiment to test for population differences in germination and the effect of pre-chilling treatment on seed dormancy release. We then established three common gardens spread across the species latitudinal range in order to evaluate levels of quantitative genetic variation and genotype-by-environment interaction at different early life traits. Our results showed significant variation in chamber germination rates among populations (0-60 %), with southern populations exhibiting lower germination. Pre-chilling treatments did not generally improve germination success. Population seedling emergence rates in the field were correlated with chamber germination rates, though being an order of magnitude lower, with an average ranging from 0 to 1.3 % across gardens. Highly significant variation was found in field emergence rates among populations, and between seed-crop years within populations, but not among families within populations. Populations differed in seedling height, diameter, slenderness and budburst date, with significant among-family variation. Population latitude was positively associated with chamber germination rate and with seedling emergence rate in one of the central field sites. Overall, genetic, environmental and demographic factors seem to influence the observed high levels of variation in early fitness traits among B. pendula populations. Our results suggest limited regeneration capacity for the study species under drier conditions, but further field trials with sufficient replication over environments and seed crops will improve our understanding of its vulnerability to climate change

Flavour Physics in the Soft Wall Model

We extend the description of flavour that exists in the Randall-Sundrum (RS) model to the soft wall (SW) model in which the IR brane is removed and the Higgs is free to propagate in the bulk. It is demonstrated that, like the RS model, one can generate the hierarchy of fermion masses by localising the fermions at different locations throughout the space. However, there are two significant differences. Firstly the possible fermion masses scale down, from the electroweak scale, less steeply than in the RS model and secondly there now exists a minimum fermion mass for fermions sitting towards the UV brane. With a quadratic Higgs VEV, this minimum mass is about fifteen orders of magnitude lower than the electroweak scale. We derive the gauge propagator and despite the KK masses scaling as $m_n^2\sim n$, it is demonstrated that the coefficients of four fermion operators are not divergent at tree level. FCNC's amongst kaons and leptons are considered and compared to calculations in the RS model, with a brane localised Higgs and equivalent levels of tuning. It is found that since the gauge fermion couplings are slightly more universal and the SM fermions typically sit slightly further towards the UV brane, the contributions to observables such as $\epsilon_K$ and $\Delta m_K$, from the exchange of KK gauge fields, are significantly reduced.Comment: 33 pages, 15 figures, 5 tables; v2: references added; v3: modifications to figures 4,5 and 6. version to appear in JHE

The Effective Lagrangian for Bulk Fermions in Models with Extra Dimensions

We compute the dimension 6 effective Lagrangian arising from the tree level integration of an arbitrary number of bulk fermions in models with warped extra dimensions. The coefficients of the effective operators are written in terms of simple integrals of the metric and are valid for arbitrary warp factors, with or without an infrared brane, and for a general Higgs profile. All relevant tree level fermion effects in electroweak and flavor observables can be computed using this effective Lagrangian.Comment: 22 pages. V2: typos corrected, matches published versio

Efecto del ejercicio y la actividad física sobre las funciones ejecutivas en niños y en jóvenes. Una revisión sistemática

This qualitative systematic review tries to advance knowledge about the effect of physical activity on executive functions, paying special attention to healthy children, teenagers and youngsters.  Several articles have been identified, categorized and analyzed in electronic databases such as ISI Web of Knowledge, SCOPUS, PubMed, SPORTDiscus, PsyINFO, ERIC, Google Scholar and Dialnet. According to the inclusion/exclusion criteria, following the PRISMA statement to record and categorize the results and throughout the quality assessment tool "The Effective Public Health Practice Project”, 44 pieces of research, structured in acute and chronic episodes of physical activity under two approaches: qualitative and quantitative, were chosen. The results show a higher number of experiments with quantitative acute episodes (45,45%) against qualitative ones (18,18%), chronic quantitative (20,45%) and chronic qualitative episodes (15,92%). The analysis of these investigations has allowed identifying the benefits of different types of physical activity studied on executive components.En la presente revisión sistemática cualitativa se intenta avanzar en el conocimiento sobre la incidencia de la actividad física sobre las funciones ejecutivas, focalizada en poblaciones sanas infantiles, adolescentes y jóvenes. Se identificaron, categorizaron y analizaron artículos de bases de datos electrónicas como ISI Web of Knowledge, SCOPUS, PubMed, SPORTDiscus, PsyINFO, ERIC, Google Scholar y Dialnet. Atendiendo a los criterios de inclusión/exclusión, siguiendo la declaración PRISMA para registrar y categorizar los resultados, y mediante la herramienta de evaluación de calidad “The Effective Public Health Practice Project”, se seleccionaron finalmente 44 investigaciones experimentales, estructuradas en episodios agudos y crónicos de actividad física bajo dos enfoques: cuantitativos y cualitativos. Los resultados muestran una superior cantidad de experimentos con episodios agudos cuantitativos (45,45%), frente a los agudos cualitativos (18,18%), crónicos cuantitativos (20,45%) y crónicos cualitativos (15,92%). Los análisis de estas investigaciones han permitido identificar los beneficios de los diferentes tipos de actividad física estudiados sobre los componentes ejecutivos

A Cross-Sectional Study of People with Epilepsy and Neurocysticercosis in Tanzania: Clinical Characteristics and Diagnostic Approaches.

Neurocysticercosis (NCC) is a major cause of epilepsy in regions where pigs are free-ranging and hygiene is poor. Pork production is expected to increase in the next decade in sub-Saharan Africa, hence NCC will likely become more prevalent. In this study, people with epilepsy (PWE, n=212) were followed up 28.6 months after diagnosis of epilepsy. CT scans were performed, and serum and cerebrospinal fluid (CSF) of selected PWE were analysed. We compared the demographic data, clinical characteristics, and associated risk factors of PWE with and without NCC. PWE with NCC (n=35) were more likely to be older at first seizure (24.3 vs. 16.3 years, p=0.097), consumed more pork (97.1% vs. 73.6%, p=0.001), and were more often a member of the Iraqw tribe (94.3% vs. 67.8%, p=0.005) than PWE without NCC (n=177). PWE and NCC who were compliant with anti-epileptic medications had a significantly higher reduction of seizures (98.6% vs. 89.2%, p=0.046). Other characteristics such as gender, seizure frequency, compliance, past medical history, close contact with pigs, use of latrines and family history of seizures did not differ significantly between the two groups. The number of NCC lesions and active NCC lesions were significantly associated with a positive antibody result. The electroimmunotransfer blot, developed by the Centers for Disease Control and Prevention, was more sensitive than a commercial western blot, especially in PWE and cerebral calcifications. This is the first study to systematically compare the clinical characteristics of PWE due to NCC or other causes and to explore the utility of two different antibody tests for diagnosis of NCC in sub-Saharan Africa

Risk score for first-screening of prevalent undiagnosed chronic kidney disease in Peru: the CRONICAS-CKD risk score.

BACKGROUND: Chronic Kidney Disease (CKD) represents a great burden for the patient and the health system, particularly if diagnosed at late stages. Consequently, tools to identify patients at high risk of having CKD are needed, particularly in limited-resources settings where laboratory facilities are scarce. This study aimed to develop a risk score for prevalent undiagnosed CKD using data from four settings in Peru: a complete risk score including all associated risk factors and another excluding laboratory-based variables. METHODS: Cross-sectional study. We used two population-based studies: one for developing and internal validation (CRONICAS), and another (PREVENCION) for external validation. Risk factors included clinical- and laboratory-based variables, among others: sex, age, hypertension and obesity; and lipid profile, anemia and glucose metabolism. The outcome was undiagnosed CKD: eGFR < 60 ml/min/1.73m2. We tested the performance of the risk scores using the area under the receiver operating characteristic (ROC) curve, sensitivity, specificity, positive/negative predictive values and positive/negative likelihood ratios. RESULTS: Participants in both studies averaged 57.7 years old, and over 50% were females. Age, hypertension and anemia were strongly associated with undiagnosed CKD. In the external validation, at a cut-off point of 2, the complete and laboratory-free risk scores performed similarly well with a ROC area of 76.2% and 76.0%, respectively (P = 0.784). The best assessment parameter of these risk scores was their negative predictive value: 99.1% and 99.0% for the complete and laboratory-free, respectively. CONCLUSIONS: The developed risk scores showed a moderate performance as a screening test. People with a score of ≥ 2 points should undergo further testing to rule out CKD. Using the laboratory-free risk score is a practical approach in developing countries where laboratories are not readily available and undiagnosed CKD has significant morbidity and mortality

Increased ventral striatal volume in college-aged binge drinkers

BACKGROUND Binge drinking is a serious public health issue associated with cognitive, physiological, and anatomical differences from healthy individuals. No studies, however, have reported subcortical grey matter differences in this population. To address this, we compared the grey matter volumes of college-age binge drinkers and healthy controls, focusing on the ventral striatum, hippocampus and amygdala. METHOD T1-weighted images of 19 binge drinkers and 19 healthy volunteers were analyzed using voxel-based morphometry. Structural data were also covaried with Alcohol Use Disorders Identification Test (AUDIT) scores. Cluster-extent threshold and small volume corrections were both used to analyze imaging data. RESULTS Binge drinkers had significantly larger ventral striatal grey matter volumes compared to controls. There were no between group differences in hippocampal or amygdalar volume. Ventral striatal, amygdalar, and hippocampal volumes were also negatively related to AUDIT scores across groups. CONCLUSIONS Our findings stand in contrast to the lower ventral striatal volume previously observed in more severe forms of alcohol use disorders, suggesting that college-age binge drinkers may represent a distinct population from those groups. These findings may instead represent early sequelae, compensatory effects of repeated binge and withdrawal, or an endophenotypic risk factor

Warped Radion Dark Matter

Warped scenarios offer an appealing solution to the hierarchy problem. We consider a non-trivial deformation of the basic Randall-Sundrum framework that has a KK-parity symmetry. This leads to a stable particle beyond the Standard Model, that is generically expected to be the first KK-parity odd excitation of the radion field. We consider the viability of the KK-radion as a DM candidate in the context of thermal and non-thermal production in the early universe. In the thermal case, the KK-radion can account for the observed DM density when the radion decay constant is in the natural multi-TeV range. We also explore the effects of coannihilations with the first KK excitation of the RH top, as well as the effects of radion-Higgs mixing, which imply mixing between the KK-radion and a KK-Higgs (both being KK-parity odd). The non-thermal scenario, with a high radion decay constant, can also lead to a viable scenario provided the reheat temperature and the radion decay constant take appropriate values, although the reheat temperature should not be much higher than the TeV scale. Direct detection is found to be feasible if the DM has a small (KK-parity odd) Higgs admixture. Indirect detection via a photon signal from the galactic center is an interesting possibility, while the positron and neutrino fluxes from KK-radion annihilations are expected to be rather small. Colliders can probe characteristic aspects of the DM sector of warped scenarios with KK-parity, such as the degeneracy between the radion and the KK-radion (DM) modes.Comment: 43 pages, 16 figures; added reference