Coriocarcinoma no gestacional primario de ovario. A propósito de un caso y revisión de la literatura

Se presenta el caso clínico de una paciente con diagnóstico de coriocarcinoma primario no gestacional de ovario que corresponde a una neoplasia maligna germinal. Asimismo, se revisa la literatura actualizada del tema haciendo énfasis en la biología molecular, el diagnóstico y el manejo oncológico inicial. Se desarrolló en el Hospital Nacional Dos de Mayo (HNDM) en el servicio de Ginecología Oncológica, Lima, Perú. Se registra el presente caso por su poca casuística en nuestro medio y por el importante valor del criterio oncológico en el manejo de masas anexiales ováricas.

Luzaroan irauteko eraiki. Harritutako aberastasuna eta identitate soziala. XI.-ZIV. mendeak

Con autorización de la editorial para este libro.Petrifying Wealth. The Southern European Shift to Masonry as Collective Investment in identity, c.1050-1300Peer reviewe

Crítica arquitectónica producción residencial en Cuenca 1961-1980

Inicia enfocando la problemática de la crítica arquitectónica y define los principios del desarrollo de la arquitectura. Determina un método de análisis arquitectónico y un sistema de estudio. Analiza los factores condicionantes, circunstancias generales específicas que provocan este crecimiento en la producción residencial en Cuenca. Se analiza además los subsistemas de códigos arquitectónicos y los valores de significado, se estudian diversas tipologías. Finalmente se realiza una síntesis de la críticaArquitectoCuenc

Dorsal striatal dopamine induces fronto-cortical hypoactivity and attenuates anxiety and compulsive behaviors in rats.

Dorsal striatal dopamine transmission engages the cortico-striato-thalamo-cortical (CSTC) circuit, which is implicated in many neuropsychiatric diseases, including obsessive-compulsive disorder (OCD). Yet it is unknown if dorsal striatal dopamine hyperactivity is the cause or consequence of changes elsewhere in the CSTC circuit. Classical pharmacological and neurotoxic manipulations of the CSTC and other brain circuits suffer from various drawbacks related to off-target effects and adaptive changes. Chemogenetics, on the other hand, enables a highly selective targeting of specific neuronal populations within a given circuit. In this study, we developed a chemogenetic method for selective activation of dopamine neurons in the substantia nigra, which innervates the dorsal striatum in the rat. We used this model to investigate effects of targeted dopamine activation on CSTC circuit function, especially in fronto-cortical regions. We found that chemogenetic activation of these neurons increased movement (as expected with increased dopamine release), rearings and time spent in center, while also lower self-grooming. Furthermore, this activation increased prepulse inhibition of the startle response in females. Remarkably, we observed reduced [18F]FDG metabolism in the frontal cortex, following dopamine activation in the dorsal striatum, while total glutamate levels- in this region were increased. This result is in accord with clinical studies of increased [18F]FDG metabolism and lower glutamate levels in similar regions of the brain of people with OCD. Taken together, the present chemogenetic model adds a mechanistic basis with behavioral and translational relevance to prior clinical neuroimaging studies showing deficits in fronto-cortical glucose metabolism across a variety of clinical populations (e.g. addiction, risky decision-making, compulsivity or obesity)