Short-timescale Fluctuations in the Difference Light Curves of QSO 0957+561A,B: Microlensing or Noise?

From optical R band data of the double quasar QSO 0957+561A,B, we made two new difference light curves (about 330 days of overlap between the time-shifted light curve for the A image and the magnitude-shifted light curve for the B image). We observed noisy behaviours around the zero line and no short-timescale events (with a duration of months), where the term event refers to a prominent feature that may be due to microlensing or another source of variability. Only one event lasting two weeks and rising - 33 mmag was found. Measured constraints on the possible microlensing variability can be used to obtain information on the granularity of the dark matter in the main lensing galaxy and the size of the source. In addition, one can also test the ability of the observational noise to cause the rms averages and the local features of the difference signals. We focused on this last issue. The combined photometries were related to a process consisting of an intrinsic signal plus a Gaussian observational noise. The intrinsic signal has been assumed to be either a smooth function (polynomial) or a smooth function plus a stationary noise process or a correlated stationary process. Using these three pictures without microlensing, we derived some models totally consistent with the observations. We finally discussed the sensitivity of our telescope (at Teide Observatory) to several classes of microlensing variability.Comment: MNRAS, in press (LaTeX, 14 pages, 22 eps figures

Scientific Basis for the Potential Use of Melatonin in Bone Diseases: Osteoporosis and Adolescent Idiopathic Scoliosis

The objective of this paper was to analyze the data supporting the possible role of melatonin on bone metabolism and its repercussion in the etiology and treatment of bone pathologies such as the osteoporosis and the adolescent idiopathic scoliosis (AIS). Melatonin may prevent bone degradation and promote bone formation through mechanisms involving both melatonin receptor-mediated and receptor-independent actions. The three principal mechanisms of melatonin effects on bone function could be: (a) the promotion of the osteoblast differentiation and activity; (b) an increase in the osteoprotegerin expression by osteoblasts, thereby preventing the differentiation of osteoclasts; (c) scavenging of free radicals generated by osteoclast activity and responsible for bone resorption. A variety of in vitro and in vivo experimental studies, although with some controversial results, point toward a possible role of melatonin deficits in the etiology of osteoporosis and AIS and open a new field related to the possible therapeutic use of melatonin in these bone diseases

A Large Brightness Enhancement of the QSO 0957+561 A Component

We report an increase of more than 0.2 mag in the optical brightness of the leading image (A) of the gravitational lens Q0957+561, detected during the 09/2000 -- 06/2001 monitoring campaign (2001 observing season). The brightening is similar to or even greater than the largest change ever detected during the 20 years of monitoring of this system. We discuss two different provisional explanations to this event: intrinsic source variability or microlensing (either short timescale microlensing or cessation of the historical microlensing). An exhaustive photometric monitoring of Q0957+561 is needed until summer of 2002 and during 2003 to discriminate between these possibilities.Comment: 13 pages including 3 figures and 1 table. Accepted for publication in ApJ Let

Hidden Trigger for the Giant Starburst Arc in M 83?

The huge star formation events that occur at some galactic centers do not provide enough clues as to their origin, since the morphological signatures of the triggering mechanism are smeared out in the timescale of a few orbital revolutions of the galaxy core. Our high spatial resolution three-dimensional near-infrared spectroscopy for the first time reveals that a previously known hidden mass concentration is located exactly at the youngest end of a giant star-forming arc. This location, the inferred average cluster ages, and the dynamical times clearly indicate that the interloper has left behind a spur of violent star formation in M 83, in a transient event lasting less than one orbital revolution. The study of the origin (bar funneling or cannibalized satellite) and fate (black hole merging or giant stellar cluster) of this system could provide clues to the question of core growing and morphological evolution in grand-design spiral galaxies. In particular, our TreeSPH numerical modeling suggests that the two nuclei could coalesce, forming a single massive core in about 60 million years or less

HST FOC spectroscopy of the NLR of NGC 4151. I. Gas kinematics

We present the results from a detailed kinematic analysis of both ground-based, and Hubble Space Telescope/Faint Object Camera long-slit spectroscopy at sub-arcsec spatial resolution, of the narrow-line region of NGC 4151. In agreement with previous work, the extended emission gas (R > 4") is found to be in normal rotation in the galactic plane, a behaviour that we were able to trace even across the nuclear region, where the gas is strongly disturbed by the interaction with the radio jet, and connects smoothly with the large scale rotation defined by the neutral gas emission. The HST data, at 0.029" spatial resolution, allow us for the first time to truly isolate the kinematic behaviour of the individual clouds in the inner narrow-line region. We find that, underlying the perturbations introduced by the radio ejecta, the general velocity field can still be well represented by planar rotation down to a radius of ~ 0.5" (30 pc), distance at which the rotation curve has its turnover. The most striking result that emerges from our analysis is that the galaxy potential derived fitting the rotation curve changes from a "dark halo" at the ENLR distances to dominated by the central mass concentration in the NLR, with an almost Keplerian fall-off in the 1"< R < 4" interval. The observed velocity of the gas at 0.5" implies a mass of M ~ 10E9 M(sol) within the inner 60 pc. The presence of a turnover in the rotation curve indicates that this central mass concentration is extended. The first measured velocity point (outside the region saturated by the nucleus) would imply an enclosed mass of ~ 5E7 M(sol) within R ~ 0.15" (10 pc) which represents an upper limit to any nuclear point mass.Comment: 30 pages (aaspp4.sty), 14 figures. Fig. 1, 2 and 4 available by anonymous FTP at 143.54.2.51 (cd /pub/winge) as GIF files; or upon request to [email protected]. Accepted for publication in the Astrophysical Journal (part 1

Enhanced expression of the voltage-dependent anion channel 1 (VDAC1) in Alzheimer's disease transgenic mice: an insight into the pathogenic effects of amyloid-β

The mitochondrial voltage-dependent anion channel 1 (VDAC1) is involved in the release of apoptotic proteins with possible relevance in Alzheimer's disease (AD) neuropathology. Through proteomic analysis followed by Western blotting and immunohistochemical techniques, we have found that VDAC1 is overexpressed in the hippocampus from amyloidogenic AD transgenic mice models. VDAC1 was also overexpressed in postmortem brain tissue from AD patients at an advanced stage of the disease. Interestingly, amyloid-β (Aβ) soluble oligomers were able to induce upregulation of VDAC1 in a human neuroblastoma cell line, further supporting a correlation between Aβ levels and VDAC1 expression. In hippocampal extracts from transgenic mice, a significant increase was observed in the levels of VDAC1 phosphorylated at an epitope that is susceptible to phosphorylation by glycogen synthase kinase-3β, whose activity was also increased. The levels of hexokinase I (HXKI), which interacts with VDAC1 and affects its function, were decreased in mitochondrial samples from AD models. Since phospho-VDAC and reduced HXKI levels favors a VDAC1 conformational state more prone to the release proapoptotic factors, regulation of the function of this channel may be a promising therapeutic approach to combat AD

Integral Field Spectroscopy of the Central Regions of 3C 120: Evidence of a Past Merging Event

IFS combined with HST WFPC imaging were used to characterize the central regions of the Seyfert 1 radio galaxy 3C 120. We carried out the analysis of the data, deriving intensity maps of different emission lines and the continua at different wavelengths from the observed spectra. Applying a 2D modeling to the HST images we decoupled the nucleus and the host galaxy, and analyzed the host morphology. The host is a highly distorted bulge dominated galaxy, rich in substructures. We developed a new technique to model the IFS data extending the 2D modeling. Using this technique we separated the Seyfert nucleus and the host galaxy spectra, and derived a residual data cube with spectral and spatial information of the different structures in 3C 120. Three continuum-dominated structures (named A, B, and C) and other three extended emission line regions (EELRs, named E1, E2 and E3) are found in 3C 120 which does not follow the general behavior of a bulge dominated galaxy. We also found shells in the central kpc that may be remnants of a past merging event in this galaxy. The origin of E1 is most probably due to the interaction of the radio-jet of 3C 120 with the intergalactic medium. Structures A, B, and the shell at the southeast of the nucleus seem to correspond to a larger morphological clumpy structure that may be a tidal tail, consequence of the past merging event. We found a bright EELR (E2) in the innermost part of this tidal tail, nearby the nucleus, which shows a high ionization level. The kinematics of the E2 region and its connection to the tidal tail suggest that the tail has channeled gas from the outer regions to the center.Comment: 55 pages, 18 figures and 5 tables Accepted by AP

QSO 2237+0305 VR light curves from Gravitational Lenses International Time Project optical monitoring

We present VR observations of QSO 2237+0305 conducted by the GLITP collaboration from 1999 October 1 to 2000 February 3. The observations were made with the 2.56 m Nordic Optical Telescope at Roque de los Muchachos Observatory, La Palma (Spain). The PSF fitting method and an adapted version of the ISIS subtraction method have been used to derive the VR light curves of the four components (A-D) of the quasar. The mean errors range in the intervals 0.01-0.04 mag (PSF fitting) and 0.01-0.02 mag (ISIS subtraction), with the faintest component (D) having the largest uncertainties. We address the relatively good agreement between the A-D light curves derived using different filters, photometric techniques, and telescopes. The new VR light curves of component A extend the time coverage of a high magnification microlensing peak, which was discovered by the OGLE team.Comment: 15 pages, 3 figures, ApJ accepted (Feb 19