315 research outputs found
Ultraviolet Completion of Flavour Models
Effective Flavour Models do not address questions related to the nature of
the fundamental renormalisable theory at high energies. We study the
ultraviolet completion of Flavour Models, which in general has the advantage of
improving the predictivity of the effective models. In order to illustrate the
important features we provide minimal completions for two known A4 models. We
discuss the phenomenological implications of the explicit completions, such as
lepton flavour violating contributions that arise through the exchange of
messenger fields.Comment: 18 pages, 8 figure
Reactor mixing angle from hybrid neutrino masses
In terms of its eigenvector decomposition, the neutrino mass matrix (in the
basis where the charged lepton mass matrix is diagonal) can be understood as
originating from a tribimaximal dominant structure with small deviations, as
demanded by data. If neutrino masses originate from at least two different
mechanisms, referred to as "hybrid neutrino masses", the experimentally
observed structure naturally emerges provided one mechanism accounts for the
dominant tribimaximal structure while the other is responsible for the
deviations. We demonstrate the feasibility of this picture in a fairly
model-independent way by using lepton-number-violating effective operators,
whose structure we assume becomes dictated by an underlying flavor
symmetry. We show that if a second mechanism is at work, the requirement of
generating a reactor angle within its experimental range always fixes the solar
and atmospheric angles in agreement with data, in contrast to the case where
the deviations are induced by next-to-leading order effective operators. We
prove this idea is viable by constructing an -based ultraviolet
completion, where the dominant tribimaximal structure arises from the type-I
seesaw while the subleading contribution is determined by either type-II or
type-III seesaw driven by a non-trivial singlet (minimal hybrid model).
After finding general criteria, we identify all the symmetries
capable of producing such -based minimal hybrid models.Comment: 18 pages, 5 figures. v3: section including sum rules added, accepted
by JHE
Novel integrative genomic tool for interrogating lithium response in bipolar disorder
We developed a novel integrative genomic tool called GRANITE (Genetic Regulatory Analysis of Networks Investigational Tool Environment) that can effectively analyze large complex data sets to generate interactive networks. GRANITE is an open-source tool and invaluable resource for a variety of genomic fields. Although our analysis is confined to static expression data, GRANITE has the capability of evaluating time-course data and generating interactive networks that may shed light on acute versus chronic treatment, as well as evaluating dose response and providing insight into mechanisms that underlie therapeutic versus sub-therapeutic doses or toxic doses. As a proof-of-concept study, we investigated lithium (Li) response in bipolar disorder (BD). BD is a severe mood disorder marked by cycles of mania and depression. Li is one of the most commonly prescribed and decidedly effective treatments for many patients (responders), although its mode of action is not yet fully understood, nor is it effective in every patient (non-responders). In an in vitro study, we compared vehicle versus chronic Li treatment in patient-derived lymphoblastoid cells (LCLs) (derived from either responders or non-responders) using both microRNA (miRNA) and messenger RNA gene expression profiling. We present both Li responder and non-responder network visualizations created by our GRANITE analysis in BD. We identified by network visualization that the Let-7 family is consistently downregulated by Li in both groups where this miRNA family has been implicated in neurodegeneration, cell survival and synaptic development. We discuss the potential of this analysis for investigating treatment response and even providing clinicians with a tool for predicting treatment response in their patients, as well as for providing the industry with a tool for identifying network nodes as targets for novel drug discovery
Beyond MFV in family symmetry theories of fermion masses
Minimal Flavour Violation (MFV) postulates that the only source of flavour
changing neutral currents and CP violation, as in the Standard Model, is the
CKM matrix. However it does not address the origin of fermion masses and mixing
and models that do usually have a structure that goes well beyond the MFV
framework. In this paper we compare the MFV predictions with those obtained in
models based on spontaneously broken (horizontal) family symmetries, both
Abelian and non-Abelian. The generic suppression of flavour changing processes
in these models turns out to be weaker than in the MFV hypothesis. Despite
this, in the supersymmetric case, the suppression may still be consistent with
a solution to the hierarchy problem, with masses of superpartners below 1 TeV.
A comparison of FCNC and CP violation in processes involving a variety of
different family quantum numbers should be able to distinguish between various
family symmetry models and models satisfying the MFV hypothesis.Comment: 34 pages, no figure
Exotic particles below the TeV from low scale flavour theories
A flavour gauge theory is observable only if the symmetry is broken at
relatively low energies. The intrinsic parity-violation of the fermion
representations in a flavour theory describing quark, lepton and higgsino
masses and mixings generically requires anomaly cancellation by new fermions.
Benchmark supersymmetric flavour models are built and studied to argue that: i)
the flavour symmetry breaking should be about three orders of magnitude above
the higgsino mass, enough also to efficiently suppress FCNC and CP violations
coming from higher-dimensional operators; ii) new fermions with exotic decays
into lighter particles are typically required at scales of the order of the
higgsino mass.Comment: 19 pages, references added, one comment and one footnote added,
results unchange
Primary omental Gastrointestinal stromal tumor (GIST)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens
Scaling up community-based obesity prevention in Australia: Background and evaluation design of the Health Promoting Communities: Being Active Eating Well initiative
Background : There is only limited evidence available on how best to prevent childhood obesity and community-based interventions hold promise, as several successful interventions have now been published. The Victorian Government has recently funded six disadvantaged communities across Victoria, Australia for three years to promote healthy eating and physical activity for children, families, and adults in a community-based participatory manner. Five of these intervention communities are situated in Primary Care Partnerships and are the subject of this paper. The interventions will comprise a mixture of capacity-building, environmental, and whole-of-community approaches with targeted and population-level interventions. The specific intervention activities will be determined locally within each community through stakeholder and community consultation. Implementation of the interventions will occur through funded positions in primary care and local government. This paper describes the design of the evaluation of the five primary care partnership-based initiatives in the \u27Go for your life\u27 Health Promoting Communities: Being Active Eating Well (HPC:BAEW) initiative.Methods/Design : A mixed method and multi-level evaluation of the HPC:BAEW initiative will capture process, impact and outcome data and involve both local and state-wide evaluators. There will be a combined analysis across the five community intervention projects with outcomes compared to a comparison group using a cross-sectional, quasi-experimental design. The evaluation will capture process, weight status, socio-demographic, obesity-related behavioral and environmental data in intervention and comparison areas. This will be achieved using document analysis, paper-based questionnaires, interviews and direct measures of weight, height and waist circumference from participants (children, adolescents and adults).Discussion : This study will add significant evidence on how to prevent obesity at a population level in disadvantaged and ethnically diverse communities. The outcomes will have direct influence on policy and practice and guide the development and implementation of future obesity prevention efforts in Australia and internationally.<br /
The Interplay Between GUT and Flavour Symmetries in a Pati-Salam x S4 Model
Both Grand Unified symmetries and discrete flavour symmetries are appealing
ways to describe apparent structures in the gauge and flavour sectors of the
Standard Model. Both symmetries put constraints on the high energy behaviour of
the theory. This can give rise to unexpected interplay when building models
that possess both symmetries. We investigate on the possibility to combine a
Pati-Salam model with the discrete flavour symmetry that gives rise to
quark-lepton complementarity. Under appropriate assumptions at the GUT scale,
the model reproduces fermion masses and mixings both in the quark and in the
lepton sectors. We show that in particular the Higgs sector and the running
Yukawa couplings are strongly affected by the combined constraints of the Grand
Unified and family symmetries. This in turn reduces the phenomenologically
viable parameter space, with high energy mass scales confined to a small region
and some parameters in the neutrino sector slightly unnatural. In the allowed
regions, we can reproduce the quark masses and the CKM matrix. In the lepton
sector, we reproduce the charged lepton masses, including bottom-tau
unification and the Georgi-Jarlskog relation as well as the two known angles of
the PMNS matrix. The neutrino mass spectrum can present a normal or an inverse
hierarchy, and only allowing the neutrino parameters to spread into a range of
values between and , with .
Finally, our model suggests that the reactor mixing angle is close to its
current experimental bound.Comment: 62 pages, 4 figures; references added, version accepted for
publication in JHE
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