The NW sector of the Sicily Channel: geometry and evolution of inverted structural lineaments

The 3-D trend of anticline axial planes, fault planes and surfaces has been reconstructed in the offshore area between the Egadi Islands and the Sciacca High from the interpretation of multichannel seismic reflection profiles and well data (available from the VIDEPI project database). In particular, isopach maps generated for the five seismic units of age between Cretaceous and Quaternary allowed highlighting the space-time migration of the tectonic processes. The western portion of the studied area covers the submerged prolongation of the inner sector of the Sicilian-Maghrebian chain, limited in the NW and in the SE by two tectonic lineaments running along the western and eastern margins of the Adventure Bank: the Maghrebian Thrust Front and Adventure Thrust Front, respectively (see Argnani et al., 1986). The eastern portion is characterized by transpressive zones orientated NNE-SSW identifying the Separation Belt that partly corresponds to the foreland area which contains the Gela Nappe Thrust. Age constraints indicate that contraction related to the Sicilian-Maghrebian fold and thrust belt migrated progressively towards the southeast. The emplacement of the western front is attributable to the Middle-Upper Miocene while that of the eastern front is Plio-Pleistocene. Within this tectonic framework, two tectonic basins were identified on the basis of the different trend, age and evolution. The Adventure foredeep exhibits the maximum thickness of 500 m in correspondence of the Adventure Plateau. Here, the younger Gela foredeep displays minor depth showing a thickness increase towards the Gela Nappe and the Pantelleria graben. Positive inversion structures form by the Plio-Pleistocene compressional reactivation of preexisting structures limiting the Saccense and Trapanese domains were recognized the offshore sector between Mazara and Sciacca. Moreover, a correlation between the Campobello di Mazara-Castelvetrano alignment as proposed by Barreca et al., 2013, Ferranti et al., this meeting, and the tectonic units recognized in their offshore prolongation has been recognized. Therefore, we propose that in this area contractional tectonics is still active (see also Pepe et al., this meeting), and occurs on high-angle, NW-dipping crustal ramps (Monaco et al., 1996)

Comparison of the TaqMan and LightCycler systems in pharmacogenetic testing: evaluation of the CYP2C9*2/*3 polymorphisms.

Background: Pharmacogenetic testing for drugmetabolizing enzymes is not yet widely used in clinical practice. Methods: In an attempt to facilitate the application of this procedure, we have compared two real-time PCRbased methods, the TaqMan_ and the LightCycler_ for the pharmacogenetic evaluation of CYP2C9*2/*3 polymorphisms. Results and Conclusion: Both procedures are suitable for pharmacogenetic studies. The TaqMan procedure was less expensive in terms of cost per sample, but the TaqMan apparatus is more expensive than the LightCycler apparatus

Architecture and Pliocene to Recent evolution of the offshore prolongation of the Granitola - Castelvetrano Thrust System (Sicily Channel)

High-resolution, seismic profiles were recorded in the offshore of Mazara - Punta Granitola with the purpose of reconstructing the architecture and Pliocene to Recent evolution of the south-west prolongation of the Granitola- Castelvetrano Thrust System, identified as an active structure possibly related to destructive historical earthquakes (Barreca et al., 2014; Ferranti et al., this meeting). A number of seismic units were identified. The oldest one is interpreted as representative of the Lower Pliocene pelagic deposits known in the region as Trubi. Lower-middle Pleistocene calcarenites are widespread along the continental shelf (CS) between Mazara del Vallo while their top rapidly deepens moving southeast-ward Capo Granitola. In this area, lower-middle Pleistocene calcarenites are unconformably overlain by the late Pleistocene- Holocene deposits. These latter are thin or absent NW of Punta Granitola along the CS, at water depth less than ~30 m, suggesting that this sector experienced uplift during the Quaternary. Small scale, NW- and SE-displacing reverse faults are observed along the CS where they cut the lower-middle Pleistocene calcarenites and offset the seafloor. South-eastwards, south-east-verging, reverse faults affect lower-middle Pleistocene calcarenites as well as the late Pleistocene-Holocene layers, suggesting that fault displacement acted during the post-LGM. Growth folding of Upper Pleistocene-Holocene deposits and thrust faults, predominantly dipping to the NW, affecting Pliocene rocks are observed in the immediate offshore Capo Granitola. The integration of the new data with those obtained from multi-channel profiles suggests that the active folds and thrusts are the uppermost expression of steep crustal ramps (Monaco et al., 1996; Lavecchia et al., 2007; Meccariello et al., this meeting) which upthrust the Saccense platform at depth

First bite syndrome as presenting symptom of parapharyngeal adenoid cystic carcinoma.

First bite syndrome refers to the development of pain in the parotid region after the first bite of each meal.A man was referred to our institution with first bite syndrome as his only symptom. Magnetic resonance imaging of the head and neck revealed a deep lobe parotid mass in close contact with the external carotid artery. Computed tomography guided fine needle biopsy indicated adenoid cystic carcinoma. Total parotidectomy was performed, with en bloc resection of the infiltrated external carotid artery and a selective neck dissection of levels Ib to III. High-weight ion radiotherapy was administered post-operatively.First bite syndrome has hitherto only been described following parapharyngeal space surgery. We present the first case of parotid gland adenoid cystic carcinoma presenting with first bite syndrome as the only symptom. The presence of first bite syndrome should prompt the clinician to investigate the parapharyngeal space and deep lobe of the parotid gland, especially in the absence of other signs or symptoms

Dissection with harmonic scalpel versus cold instruments in parotid surgery.

The harmonic scalpel (HS) has been used successfully in several head and neck surgical procedures. Some authors highlighted its advantages in reducing operative time, blood loss, and damages to surrounding tissue. In our study, we compared the results obtained during parotidectomy using the HS with the traditional approach to determine the benefits of the HS.130 patients with benign parotid tumors were enrolled and randomized into two groups for this prospective study. 63 patients underwent HS parotidectomy, and 67 patients received a parotidectomy using cold instruments and bipolar electrocautery hemostatic control (CI). 20 HS and 2 CI patients did not meet the inclusion criteria requirements, and were excluded.The admission time was significantly shorter in the HS group than the CI group (3.9 ± 1.2 days and 4.7 ± 1.4 days, respectively, p < 0.01). In the early post-operative period, 84\% of HS patients and 60\% of CI cases showed no facial nerve impairment (p = 0.01). Significantly more CI patients than HS patients showed the onset of Frey's syndrome (29\% and 9\%, respectively, p = 0.01). Multivariate stepwise regression analysis confirmed the reduction in admission length (Odds Ratio (OR): 0.62; p = 0.02) and the lower risk of Frey's syndrome (OR: 0.29; p = 0.04) in HS compared to CI parotidectomies.In parotid surgery, the HS is useful in preventing Frey's syndrome and reducing early transitory facial nerve dysfunction and admission times, and results in decreased medical costs and increased quality of life

Pleiotropic Outcomes of Glyphosate Exposure: From Organ Damage to Effects on Inflammation, Cancer, Reproduction and Development.

Glyphosate is widely used worldwide as a potent herbicide. Due to its ubiquitous use, it is detectable in air, water and foodstuffs and can accumulate in human biological fluids and tissues representing a severe human health risk. In plants, glyphosate acts as an inhibitor of the shi-kimate pathway, which is absent in vertebrates. Due to this, international scientific authorities have long‐considered glyphosate as a compound that has no or weak toxicity in humans. Howev-er, increasing evidence has highlighted the toxicity of glyphosate and its formulations in animals and human cells and tissues. Thus, despite the extension of the authorization of the use of glypho-sate in Europe until 2022, several countries have begun to take precautionary measures to reduce its diffusion. Glyphosate has been detected in urine, blood and maternal milk and has been found to induce the generation of reactive oxygen species (ROS) and several cytotoxic and genotoxic effects in vitro and in animal models directly or indirectly through its metabolite, ami-nomethylphosphonic acid (AMPA). This review aims to summarize the more relevant findings on the biological effects and underlying molecular mechanisms of glyphosate, with a particular focus on glyphosateʹs potential to induce inflammation, DNA damage and alterations in gene expression profiles as well as adverse effects on reproduction and development

Single use instruments for total knee arthroplasty

Aim Total knee arthroplasty represents a procedure that is successfully performed to relieve functional limitation and pain in advanced stages of osteoarthritis. In the next 20 years the number of these procedures will be increased about four times. Patient specific instrumentation (PSI) has been introduced in the past years. The aim of this study was to evaluate whether SUI are more useful in clinical, organizational and economic terms. Methods A database search about single use instrumentation (SUI) was conducted on PubMed and Google Scholar for the period 2010-2020 using the following key “total knee replacement”, “total knee arthroplasty”, “single use instruments”, and “disposable instruments”. The results of the selected studies were classified according to clinical, economic and organizational criteria. Results The main advantage of SUI has been reported to reduce costs, timely turnover of operating rooms, maximizing the operating room utilization and patient throughput, improving the number of outpatient total joint replacements. No difference has been found other than with regard to conventional instruments in terms of clinical outcome such as hip-knee-ankle angle and other radio-graphic parameters, Oxford Knee Score, while a decreased infection rate has been demonstrated. Regarding the economic aspect, a reduction of direct and indirect reduction of costs has been shown for the cost of instruments reprocessing, tray sterilization, 90-day infection rate. Conclusion The SUI can be an alternative to conventional instruments, but there are still few studies in the literature regarding clinical outcomes

The role of endocannabinoids in gonadal function and fertility along the evolutionary axis.

Endocannabinoids are natural lipids able to bind to cannabinoid and vanilloid receptors. Their biological actions at the central and peripheral level are under the tight control of the proteins responsible for their synthesis, transport and degradation. In the last few years, several reports have pointed out these lipid mediators as critical signals, together with sex hormones and cytokines, in various aspects of animal and human reproduction. The identification of anandamide (AEA) and 2-arachidonoylglycerol (2-AG) in reproductive cells and tissues of invertebrates, vertebrates and mammals highlights the key role played by these endogenous compounds along the evolutionary axis. Here, we review the main actions of endocannabinoids on female and male reproductive events, and discuss the interplay between them, steroid hormones and cytokines in regulating fertility. In addition, we discuss the involvement of endocannabinoid signalling in ensuring a correct chromatin remodeling, and hence a good DNA quality, in sperm cells

Risk factors for obstructive sleep apnea syndrome in children: state of the art

The obstructive sleep apnea syndrome (OSAS) represents only part of a large group of pathologies of variable entity called respiratory sleep disorders (RSD) which include simple snoring and increased upper airway resistance syndrome (UARS). Although the etiopathogenesis of adult OSAS is well known, many aspects of this syndrome in children are still debated. Its prevalence is about 2% in children from 2 to 8 years of age, mostly related to the size of the upper airways adenoid tissue. Several risk factors linked to the development of OSAS are typical of the pediatric age. The object of this paper is to analyze the state of the art on this specific topic, discussing its implications in terms of diagnosis and management

Reconstructive Options after Oncological Rhinectomy: State of the Art

Background: The nose is a central component of the face, and it is fundamental to an individual's recognition and attractiveness. The aim of this study is to present a review of the last twenty years literature on reconstructive techniques after oncological rhinectomy. Methods: Literature searches were conducted in the databases PubMed, Scopus, Medline and Google Scholar. "Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA)" for scoping review was followed. Results: Seventeen articles regarding total rhinectomy reconstruction were finally identified in the English literature, with a total of 447 cases. The prostheses were the reconstructive choice in 213 (47.7%) patients, followed by local flaps in 172 (38.5%) and free flaps in 62 (13.8%). The forehead flap (FF) and the radial forearm free flap (RFFF) are the most frequently used flaps. Conclusions: This study shows that both prosthetic and surgical reconstruction are very suitable solutions in terms of surgical and aesthetic outcomes for the patient