Competing risks of cancer mortality and cardiovascular events in individuals with multimorbidity

Background: Cancer patients with cardiovascular and other comorbidities are at concurrent risk of multiple adverse outcomes. However, most treatment decisions are guided by evidence from single-outcome models, which may be misleading for multimorbid patients. Objective: We assessed the interacting effects of cancer, cardiovascular, and other morbidity burdens on the competing outcomes of cancer mortality, serious cardiovascular events, and other-cause mortality. Design: We analyzed a cohort of 6,500 adults with initial cancer diagnosis between 2001 and 2008, SEER 5-year survival ≥26%, and a range of cardiovascular risk factors. We estimated the cumulative incidence of cancer mortality, a serious cardiovascular event (myocardial infarction, coronary revascularization, or cardiovascular mortality), and other-cause mortality over 5 years, and identified factors associated with the competing risks of each outcome using cause-specific Cox proportional hazard models. Results: Following cancer diagnosis, there were 996 (15.3%) cancer deaths, 328 (5.1%) serious cardiovascular events, and 542 (8.3%) deaths from other causes. In all, 4,634 (71.3%) cohort members had none of these outcomes. Although cancer prognosis had the greatest effect, cardiovascular and other morbidity also independently increased the hazard of each outcome. The effect of cancer prognosis on outcome was greatest in year 1, and the effect of other morbidity was greater in individuals with better cancer prognoses. Conclusion: In multimorbid oncology populations, comorbidities interact to affect the competing risk of different outcomes. Quantifying these risks may provide persons with cancer plus cardiovascular and other comorbidities more accurate information for shared decision-making than risks calculated from single-outcome models. Journal of Comorbidity 2014:4(1):29–3

Factors associated with growth in daily smoking among Indigenous adolescents

North American Indigenous adolescents smoke earlier, smoke more, and are more likely to become regular smokers as adults than youth from any other ethnic group, yet we know very little about their early smoking trajectories. We use multilevel growth modeling across five waves of data from Indigenous adolescents (aged 10-13 years at Wave 1) to investigate factors associated with becoming a daily smoker. Several factors, including number of peers who smoked at Wave 1 and meeting diagnostic criteria for major depressive episode and conduct disorder, were associated with early daily smoking. Only age and increases in the number of smoking peers were associated with increased odds of becoming a daily smoker. © 2012 The Authors. Journal of Research on Adolescence © 2012 Society for Research on Adolescence

Time variation of Kepler transits induced by stellar spots - a way to distinguish between prograde and retrograde motion. II. Application to KOIs

Mazeh, Holczer, and Shporer (2015) have presented an approach that can, in principle, use the derived transit timing variation (TTV) of some transiting planets observed by the $Kepler$ mission to distinguish between prograde and retrograde motion of their orbits with respect to their parent stars' rotation. The approach utilizes TTVs induced by spot-crossing events that occur when the planet moves across a spot on the stellar surface, looking for a correlation between the derived TTVs and the stellar brightness derivatives at the corresponding transits. This can work even in data that cannot temporally resolve the spot-crossing events themselves. Here we apply this approach to the $Kepler$ KOIs, identifying nine systems where the photometric spot modulation is large enough and the transit timing accurate enough to allow detection of a TTV-brightness-derivatives correlation. Of those systems five show highly significant prograde motion (Kepler-17b, Kepler-71b, KOI-883.01, KOI-895.01, and KOI-1074.01), while no system displays retrograde motion, consistent with the suggestion that planets orbiting cool stars have prograde motion. All five systems have impact parameter $0.2\lesssim b\lesssim0.5$, and all systems within that impact parameter range show significant correlation, except HAT-P-11b where the lack of a correlation follows its large stellar obliquity. Our search suffers from an observational bias against detection of high impact parameter cases, and the detected sample is extremely small. Nevertheless, our findings may suggest that stellar spots, or at least the larger ones, tend to be located at a low stellar latitude, but not along the stellar equator, similar to the Sun.Comment: V2: accepted to Ap

Factors Associated with Growth in Daily Smoking among Indigenous Adolescents

North American Indigenous adolescents smoke earlier, smoke more, and are more likely to become regular smokers as adults than youth from any other ethnic group yet we know very little about their early smoking trajectories. We use multilevel growth modeling across five waves of data from Indigenous adolescents (aged 10 to 13 years at Wave 1) to investigate factors associated with becoming a daily smoker. Several factors, including number of peers who smoked at Wave 1 and meeting diagnostic criteria for major depressive episode and conduct disorder were associated with early daily smoking. Only age and increases in the number of smoking peers were associated with increased odds of becoming a daily smoker

Factors Associated with Growth in Daily Smoking among Indigenous Adolescents

North American Indigenous adolescents smoke earlier, smoke more, and are more likely to become regular smokers as adults than youth from any other ethnic group yet we know very little about their early smoking trajectories. We use multilevel growth modeling across five waves of data from Indigenous adolescents (aged 10 to 13 years at Wave 1) to investigate factors associated with becoming a daily smoker. Several factors, including number of peers who smoked at Wave 1 and meeting diagnostic criteria for major depressive episode and conduct disorder were associated with early daily smoking. Only age and increases in the number of smoking peers were associated with increased odds of becoming a daily smoker

Notes and Comments: Do Young People in Japan Like to Read? Let's Take a Closer Look

As part of literacy instruction, teachers use reading programs that use rewards to motivate students to read (Kohn 1999). Underlying such programs is the assumption that young people are not interested in reading and need a system of reward and punishment interventions to motivate them to read. This assumption is not supported by us

An Alpine Malaise trap

The Southernmost region of Australia, the island of Tasmania, is also the most mountainous, with large areas of rugged alpine environments. This entomological frontier offers a distinct suite of insects for study including many endemic taxa. However, harsh weather, remote locations and rough terrain represent an environment too extreme for many existing insect trap designs. We report here on the design and efficacy of a new Alpine Malaise Trap (AMT), which can be readily hybridised with several other common insect trapping techniques. Advantages of the design include its light weight and portability, low cost, robustness, rapid deployment and long autonomous sampling period. The AMT was field tested in the Tasmanian highlands (AUST) in 2017. A total of 16 orders were collected. As expected, samples are dominated by Diptera. However, the trap also collected a range of flightless taxa including endemic and apterous species, Apteropanorpa tasmanica – closest relative of the boreal, snow scorpionflies (Boreidae). Combined and compared with other trap types the Alpine Malaise Traps captured less specimens but of a greater diversity than passive sticky traps, while drop traps captured less specimens but a greater diversity than AMT. The statistical potential of the catch is discussed

Testing the recovery of stellar rotation signals from Kepler light curves using a blind hare-and-hounds exercise

We present the results of a blind exercise to test the recoverability of stellar rotation and differential rotation in Kepler light curves. The simulated light curves lasted 1000 days and included activity cycles, Sun-like butterfly patterns, differential rotation and spot evolution. The range of rotation periods, activity levels and spot lifetime were chosen to be representative of the Kepler data of solar like stars. Of the 1000 simulated light curves, 770 were injected into actual quiescent Kepler light curves to simulate Kepler noise. The test also included five 1000-day segments of the Sun's total irradiance variations at different points in the Sun's activity cycle. Five teams took part in the blind exercise, plus two teams who participated after the content of the light curves had been released. The methods used included Lomb-Scargle periodograms and variants thereof, auto-correlation function, and wavelet-based analyses, plus spot modelling to search for differential rotation. The results show that the `overall' period is well recovered for stars exhibiting low and moderate activity levels. Most teams reported values within 10% of the true value in 70% of the cases. There was, however, little correlation between the reported and simulated values of the differential rotation shear, suggesting that differential rotation studies based on full-disk light curves alone need to be treated with caution, at least for solar-type stars. The simulated light curves and associated parameters are available online for the community to test their own methods.Comment: Accepted for publication in MNRAS. Accepted, 13 April 2015. Received, 26 March 2015; in original form, 9 November 201

Evaluation of US demo helium-cooled blanket options

A He-V-Li blanket design was developed as a candidate for the U.S. fusion demonstration power plant. This paper presents an 18 MPa helium-cooled, lithium breeder, V-alloy design that can be coupled to the Brayton cycle with a gross efficiency of 46%. The critical issue of designing to high gas pressure and the compatibility between helium impurities and V-alloy are addressed