Nodular lymphocyte predominant Hodgkin lymphoma behaves as a distinct clinical entity with good outcome: evidence from 14-year followup in the West of Scotland Cancer Network

Clinically and biologically, nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) has much more in common with germinal-center derived B-cell non-Hodgkin lymphoma (NHL) than with classical Hodgkin lymphoma (cHL). Management of NLPHL remains controversial. In a 14-year multicenter series, 69 cases were analyzed, and the median follow-up was 53 months (range 11–165.) B-symptoms were present in only 4.3% of patients, and 81.1% of patients had stage I/II disease. Treatment was with radiotherapy (53.6%), chemotherapy (21.7%), combined modality (17.4%), and observation (7.2%). In all, 10.1% of patients relapsed and 2.9% of patients developed high-grade transformation to DLBCL. All relapses and transformations were salvageable. No patient died of their disease. The 5-year relapse-free survival was 92%, transformation-free survival 98.4%, and overall survival 100%. We conclude that NLPHL behaves as a distinct clinical entity, often presenting at an early stage without risk factors. It has an excellent outcome. It may be possible, in early-stage disease, to reduce the intensity of therapy in NLPHL, to single-modality radiotherapy, without affecting OS

The pursuit of organizational impact: hits, misses, and bouncing back

Conducting impactful research is a cornerstone of good academic practice. It increases the likelihood that research outcomes are used to generate positive change, e.g., by improving working lives, and delivering improvements in the management, operation, and performance of organizations. This, in turn, makes research relevant, representative, and credible. However, undertaking impactful research is challenging, especially when considered alongside other competing academic pressures and research goals. The purpose of this paper is to consider different approaches to creating impactful research in organizational psychology, and to propose that each approach can help meet different research goals. In particular, we introduce and reflect on the value of building long-term partnerships with organizations to create research impact, and consider lessons that we have learned from doing so. To do this, we conceptualize impact delivery as a socio-technical challenge, and demonstrate this using examples from our collaborations. We conclude with recommendations for those who seek to deliver research impact while grappling with these competing pressures

Anomalous Action in Gauge Invariant, Nonlocal, Dynamical Quark Model

Anomalous sector of chiral Lagrangian is calculated in a gauge invariant, nonlocal, dynamical quark model. The Wess-Zumino term is proved coming from two kinds of sources, one is independent on and another dependent on dynamical quark self energy $\Sigma(k^2)$. $p^6$ and more higher order anomalous sectors come only from $\Sigma(k^2)$ dependent source. After some cancellation, standard Wess-Zumino action is obtained.Comment: 10 page

Ergonomists as designers: computational modelling and simulation of complex socio-technical systems

Contemporary ergonomics problems are increasing in scale, ambition, and complexity. Understanding and creating solutions for these multi-faceted, dynamic, and systemic problems challenges traditional methods. Computational modelling approaches can help address this methodological shortfall. We illustrate this potential by describing applications of computational modelling to: (1) teamworking within a multi-team engineering environment; (2) crowd behaviour in different transport terminals; and (3) performance of engineering supply chains. Our examples highlight the benefits and challenges for multi-disciplinary approaches to computational modelling, demonstrating the need for socio-technical design principles. Our experience highlights opportunities for ergonomists as designers and users of computational models, and the instrumental role that ergonomics can play in developing and enhancing complex socio-technical systems. Recognising the challenges inherent in designing computational models, we reflect on practical issues and lessons learned so that computational modelling and simulation can become a standard and valuable technique in the ergonomists’ toolkit

Wavelength-Diverse Polarization Modulators for Stokes Polarimetry

Information about the three-dimensional structure of solar magnetic fields is encoded in the polarized spectra of solar radiation by a host of physical processes. To extract this information, solar spectra must be obtained in a variety of magnetically sensitive spectral lines at high spatial, spectral, and temporal resolution with high precision. The need to observe many different spectral lines drives the development of Stokes polarimeters with a high degree of wavelength diversity. We present a new paradigm for the design of polarization modulators that operate over a wide wavelength range with near optimal polarimetric efficiency and are directly applicable to the next generation of multi-line Stokes polarimeters. These modulators are not achromatic in the usual sense because their polarimetric properties vary with wavelength, but they do so in an optimal way. Thus we refer to these modulators as polychromatic. We present here the theory behind polychromatic modulators, illustrate the concept with design examples, and present the performance properties of a prototype polychromatic modulator.Comment: 13 pages, 1 table, 5 figures, accepted for publication in Applied Optic

An introduction to rural and agricultural development in the digital age

This special issue contributes to the development economics literature by highlighting the role of information communication and technologies (ICTs) in supporting rural and agricultural development. It is comprised of nine papers. Key findings from this special issue include: (1) internet use increases rural consumption diversity and agricultural productivity; (2) smartphone use empowers rural women in household decision-making and off-farm work participation; (3) smartphone-based agricultural extension services boost rural income growth; (4) a lack of ICT infrastructure and inadequate skills to use digital technologies are two key factors that lead to digital poverty traps for smallholder rural farmers; (5) ICT adoption increases the probability of rural households' access to credit and empowers rural women and farm households in relatively less developed regions to access credit; (6) digital financial inclusion reduces farmers' vulnerability to poverty; and (7) e-commerce adoption increases both sales prices and marketing costs, but the magnitude of increasing the former is higher than the magnitude of increasing the latter, which finally contributes to a higher gross return. This special issue also proposes practical instruments and implications for advancing the application of ICTs in rural areas to accelerate rural and agricultural development in the digital age

Gauge Coupling Unification in Left-Right Symmetric Models

We explore possibilities of gauge coupling unification in left--right symmetric models with non--minimal particle content. In addition to unification we require the absence of anomalies and sufficient proton lifetime. Numerous previously unknown solutions are presented where unification occurs within the latest experimental errors. Solutions exist where the scale of left--right symmetry breaking can be as low as ${\cal O}(TeV)$ or the scale $M_R$ as high as the Planck scale.Comment: 16 pages, LaTeX and PS figure, tar-ed, gzip-ed and uuencoded. To appear in Phys.Lett.B. Additional references and minor corrections. The complete PS file can be found under URL http://www.physik.tu-muenchen.de/tumphy/d/T30d/PAPERS/TUM-HEP-241-96.ps.g

Hormone-dependent control of developmental timing through regulation of chromatin accessibility

Specification of tissue identity during development requires precise coordination of gene expression in both space and time. Spatially, master regulatory transcription factors are required to control tissue-specific gene expression programs. However, the mechanisms controlling how tissue-specific gene expression changes over time are less well understood. Here, we show that hormone-induced transcription factors control temporal gene expression by regulating the accessibility of DNA regulatory elements. Using the Drosophila wing, we demonstrate that temporal changes in gene expression are accompanied by genome-wide changes in chromatin accessibility at temporal-specific enhancers. We also uncover a temporal cascade of transcription factors following a pulse of the steroid hormone ecdysone such that different times in wing development can be defined by distinct combinations of hormone-induced transcription factors. Finally, we show that the ecdysone-induced transcription factor E93 controls temporal identity by directly regulating chromatin accessibility across the genome. Notably, we found that E93 controls enhancer activity through three different modalities, including promoting accessibility of late-acting enhancers and decreasing accessibility of early-acting enhancers. Together, this work supports a model in which an extrinsic signal triggers an intrinsic transcription factor cascade that drives development forward in time through regulation of chromatin accessibility

Is cannabis use a contributory cause of psychosis?

Objective: To assess whether cannabis use in adolescence and young adulthood is a contributory cause of schizophreniform psychosis in that it may precipitate psychosis in vulnerable individuals. Method: We reviewed longitudinal studies of adolescents and young adults that examined the relations between self-reported cannabis use and the risk of diagnosis with a psychosis or of reporting psychotic symptoms. We also reviewed studies that controlled for potential confounders, such as other forms of drug use and personal characteristics that predict an increased risk of psychosis. We assessed evidence for the biological plausibility of a contributory causal relation. Results: Evidence from 6 longitudinal studies in 5 countries shows that regular cannabis use predicts an increased risk of a schizophrenia diagnosis or of reporting symptoms of psychosis. These relations persisted after controlling for confounding variables, such as personal characteristics and other drug use. The relation did not seem to be a result of cannabis use to self-medicate symptoms of psychosis. A contributory causal relation is biologically plausible because psychotic disorders involve disturbances in the dopamine neurotransmitter systems with which the cannabinoid system interacts, as demonstrated by animal studies and one human provocation study. Conclusion: It is most plausible that cannabis use precipitates schizophrenia in individuals who are vulnerable because of a personal or family history of schizophrenia