Ramp Up for Research Days : On-Campus + Online = Success

During fall 2015, Himmelfarb Library and The George Washington University Office of the Vice President for Research (OVPR) collaborated to increase health sciences student participation in GW’s annual Research Days event. The library launched two new initiatives designed to target both on-campus students and Distance Education (DE) students: six “Ramp Up to Research Days” workshops with both in-class and WebEx components, and a customized Research Days portal within the Health Sciences Research Commons (HSRC) digital repository

Saffron (Crocus sativus) extract has anticancer activity through inhibition of migration and invasion potential of breast cancer cells

Introduction: Saffron is a spice which has been used throughout history for various therapeutic properties. Recently, it has also been documented to have significant anticancer effect on primary tumors. However, limited studies are found studying its effect on metastatic potential of cancers. The goal of our study was to explore the effect of saffron on migration and metastatic potential of breast cancer cells. Methods: MDA468 breast carcinoma cells were treated with varying concentrations of Saffron and examined using Q-phase holographic time-lapse microscopy to measure the movement of cells over time. The anticancer activity of Saffron was confirmed using cell viability assays. Invasion and metastatic potential was studied using boyden-chamber and scratch wound assays. Finally, tumorigenicity of the cell line was examined through colony formation assays in the presence and absence of Saffron. Results: Q-phase microscopy revealed reduction in projections and significantly reduced movements in cells after Saffron treatment. The inhibition of migration, cell mobility and invasion by Saffron was confirmed in scratch wound and boyden chamber assays (p Conclusions: Our results found saffron to be effective in decreasing breast cancer carcinoma cells MDA468’s viability, migration, and tumorigenicity. Future studies will examine its mechanism of action and will focus on delineating the pathways involved in its anticancer effects

The COS Legacy Archive Spectroscopy SurveY (CLASSY) Treasury Atlas

Far-ultraviolet (FUV; ~1200-2000 angstroms) spectra are fundamental to our understanding of star-forming galaxies, providing a unique window on massive stellar populations, chemical evolution, feedback processes, and reionization. The launch of JWST will soon usher in a new era, pushing the UV spectroscopic frontier to higher redshifts than ever before, however, its success hinges on a comprehensive understanding of the massive star populations and gas conditions that power the observed UV spectral features. This requires a level of detail that is only possible with a combination of ample wavelength coverage, signal-to-noise, spectral-resolution, and sample diversity that has not yet been achieved by any FUV spectral database. We present the COS Legacy Spectroscopic SurveY (CLASSY) treasury and its first high level science product, the CLASSY atlas. CLASSY builds on the HST archive to construct the first high-quality (S/N_1500 >~ 5/resel), high-resolution (R~15,000) FUV spectral database of 45 nearby (0.002 < z < 0.182) star-forming galaxies. The CLASSY atlas, available to the public via the CLASSY website, is the result of optimally extracting and coadding 170 archival+new spectra from 312 orbits of HST observations. The CLASSY sample covers a broad range of properties including stellar mass (6.2 < logM_star(M_sol) < 10.1), star formation rate (-2.0 < log SFR (M_sol/yr) < +1.6), direct gas-phase metallicity (7.0 < 12+log(O/H) < 8.8), ionization (0.5 < O_32 < 38.0), reddening (0.02 < E(B-V < 0.67), and nebular density (10 < n_e (cm^-3) < 1120). CLASSY is biased to UV-bright star-forming galaxies, resulting in a sample that is consistent with z~0 mass-metallicity relationship, but is offset to higher SFRs by roughly 2 dex, similar to z >~2 galaxies. This unique set of properties makes the CLASSY atlas the benchmark training set for star-forming galaxies across cosmic time.Comment: Accepted for publication in Ap

Forensics analysis of the contents of Nokia mobile phones

Acquiring information from a mobile phone is now an important issue in many criminal investigations. Mobile phones can contain large amounts of information which can be of use in an investigation. These include typical mobile device data including SMS, phone records and calendar and diary entries. As the difference between a PDA and a mobile phone is now blurred, the data that can reside on a mobile phone is somewhat endless. This report focuses on the performance of different mobile phone forensic software devices, and reports the findings. All aspects of the different software pieces will be reported, as well as what the investigators extract from the phones. The ability of different software tools to produce certain hash algorithm sums will be analysed, as well as the forensic methods used to extract the information. This area is one which will gain momentum in the future, hence any advances made in the field is an advantage to upcoming studies

Effects of tonal duration on neuromagnetic brain activity revisited

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USF Reentry Project

This study draws upon a risk-needs-responsivity (RNR) model in the context of reentry in an underserved county jail to implement and evaluate pre-release services and/or post-release services customized to address the individual risks and needs of each inmate. This study involves a randomized control trial with four groups: 1) Evaluation (control) group: participants will receive an evaluation of their risks and needs, recommendations, and continue to access “treatment as usual” jail programming (e.g., bible study, AA groups); 2) Pre-release services group: participants receive the evaluation/recommendations and take part in a twice-weekly Dialectical Behavior Therapy (DBT) skills group for 4-6 weeks while in custody; 3) Post-release services group: participants receive receive the evaluation/recommendations and reentry planning and post-release case-management services; 4) Combined in-custody and post-release services group: participants receive receive the evaluation/recommendations and receive both in-custody DBT as well as reentry planning/post-release case management services. This study will evaluate the following outcomes: a) in-custody outcomes prior to release (e.g., improvement in coping skills prior to reentry, more positive perceptions of post-release success, disciplinary infractions), b) intermediate post-release outcomes (e.g., 12-month needs/risk improvement and rearrests), c) long term post-release outcomes (e.g., 36-month recidivism) and cost-benefit analysis. It is expected that 1) the pre-release services and combined services groups will show improved self-reported coping skills, lower in-custody infractions or aggression, and more positive perceptions of reentry success (e.g., more likely to feel optimistic about navigating employment and support) than those in the two other groups; 2) those in the treatment groups, particularly the combined group, will have reduced recidivism and greater improvement in coping skills and strengths/vulnerability scores relative to those in the evaluation group; 3) the treatment groups, particularly the combined group, will result in the largest reductions in costs (as a function of reduced recidivism), even when accounting for the costs associated with implementing the treatments

International quotidian dialysis registry: Annual report 2010

The International Quotidian Dialysis Registry (IQDR) is a global initiative designed to study practices and outcomes associated with the use of hemodialysis (HD) regimens of increased frequency and/or duration. The IQDR grew out of the initiative that lead to the randomized prospective studies of nocturnal HD and short hours daily dialysis vs. conventional thrice weekly HD that are conducted by the Frequent Hemodialysis Network sponsored by the National Institutes of Health. These 2 separate studies are drawing to a close and the first results are expected to be reported later this year. These studies use surrogate outcomes for their primary endpoints as they are not powered to look at outcomes of mortality and hospitalization. The IQDR attempts to aggregate long-term follow-up data from centers utilizing alternative HD regimens worldwide and will have adequate statistical power to examine those important outcomes. To date, the IQDR has enrolled patients from Canada, the United States, Australia, New Zealand, and France and has linked with commercial databases and national registries. This sixth annual report of the IQDR describes: (1) An update on the governance structure; (2) The recommendations made at the first general meetings of the IQDR Scientific Committee and Advisory Board; (3) The status of those recommendations; (4) A summary of current data sources and participating registries; (5) The status of recruitment to date; (6) The creation of a specific Canadian IQDR data set and; (7) The current research agenda

The COS Legacy Archive Spectroscopy Survey (CLASSY) Treasury Atlas*

Far-ultraviolet (FUV; ~1200-2000 Å) spectra are fundamental to our understanding of star-forming galaxies, providing a unique window on massive stellar populations, chemical evolution, feedback processes, and reionization. The launch of the James Webb Space Telescope will soon usher in a new era, pushing the UV spectroscopic frontier to higher redshifts than ever before; however, its success hinges on a comprehensive understanding of the massive star populations and gas conditions that power the observed UV spectral features. This requires a level of detail that is only possible with a combination of ample wavelength coverage, signal-to-noise, spectral-resolution, and sample diversity that has not yet been achieved by any FUV spectral database. We present the Cosmic Origins Spectrograph Legacy Spectroscopic Survey (CLASSY) treasury and its first high-level science product, the CLASSY atlas. CLASSY builds on the Hubble Space Telescope (HST) archive to construct the first high-quality (S/N1500 Å ? 5/resel), high-resolution (R ~ 15,000) FUV spectral database of 45 nearby (0.002 < z < 0.182) star-forming galaxies. The CLASSY atlas, available to the public via the CLASSY website, is the result of optimally extracting and coadding 170 archival+new spectra from 312 orbits of HST observations. The CLASSY sample covers a broad range of properties including stellar mass (6.2 < log M ?(M ?) < 10.1), star formation rate (-2.0 < log SFR (M ? yr-1) < +1.6), direct gas-phase metallicity (7.0 < 12+log(O/H) < 8.8), ionization (0.5 < O32 < 38.0), reddening (0.02 < E(B - V) < 0.67), and nebular density (10 < n e (cm-3) < 1120). CLASSY is biased to UV-bright star-forming galaxies, resulting in a sample that is consistent with the z ~ 0 mass-metallicity relationship, but is offset to higher star formation rates by roughly 2 dex, similar to z ? 2 galaxies. This unique set of properties makes the CLASSY atlas the benchmark training set for star-forming galaxies across cosmic time