Data assimilation insights on selecting the most valuable atmospheric measurements

We discuss how objective guidance on selecting the most valuable atmospheric measurements on future Mars spacecraft missions can be provided through already developed Martian atmospheric data assimilation systems, and in particular through Observing System Simulation Experiments (OSSEs) which are widely used to design instruments for the Earth’s atmosphere

Large Dust Aerosol Sizes Seen During the 2018 Martian Global Dust Event by the Curiosity Rover

Mars’ atmosphere typically supports dust aerosol with an effective radius near 1.5 μm, varying from ~1 μm during low dust times near northern summer solstice to ~2 μm during higher dust times in southern spring and summer. After global dust events, size variations outside this range have not previously been observed. We report on imaging and spectral observations by the Curiosity rover through the 2018 global dust event. These observations show that the dust effective radius was seasonally normal prior to the local onset of increased opacity, increased rapidly above 4 μm with increasing opacity, remained above 3 μm over a period of ~50 Martian solar days, then returned to seasonal values before the opacity did so. This demonstrates lifting and regionalâ scale transport of a dust population ~3 times the size of typical dust aerosol.Plain Language SummaryDuring the global dust storm of 2018, the Curiosity rover measured the variation of atmospheric dust over time. During the onset of the dust storm, typical Martian dust was enhanced by much larger particles that were freshly lifted off the surface in distant storms and then carried to the rover site at Gale crater. The larger dust particles persisted for weeks, but fell out of the atmosphere faster than the typical dust as normal conditions were restored.Key PointsThe Curiosity rover observed dust aerosol size variations through the 2018 global dust eventThe average dust radius increased above 4 μm, more than double the largest sizes previously seen with Curiosity’s instrumentsThe observations demonstrate the lifting and regionalâ scale transport of dust significantly larger than typical dust aerosolPeer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/151856/1/grl59493.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/151856/2/grl59493_am.pd

The Surface Energy Budget at Gale Crater During the First 2500 Sols of the Mars Science Laboratory Mission

We use in situ environmental measurements by the Mars Science Laboratory (MSL) mission to obtain the surface energy budget (SEB) across Curiosity's traverse during the first 2500 sols of the mission. This includes values of the downwelling shortwave solar radiation, the upwelling solar radiation reflected by the surface, the downwelling longwave radiation from the atmosphere, the upwelling longwave radiation emitted by the surface, the sensible heat flux associated with turbulent motions, and the latent heat flux associated with water phase changes. We then analyze their temporal variation on different timescales and relate this to the mechanisms causing these variations. Through its Rover Environmental Monitoring Station, MSL allows for a more accurate determination of the SEB than its predecessors on Mars. Moreover, the unprecedented duration, cadence, and frequency of MSL environmental observations allow for analyses of the SEB from diurnal to interannual timescales. The results presented in this article can be used to evaluate the consistency with predictions from atmospheric numerical models, to validate aerosol radiative properties under a range of dust conditions, to understand the energy available for solar-powered missions, and to enable comparisons with measurements of the SEB by the Perseverance rover at Jezero crater.Peer reviewe

Global Warming on Triton

Triton, Neptune's largest moon, has been predicted to undergo significant seasonal changes that would reveal themselves as changes in its mean frost temperature. But whether this temperature should at the present time be increasing, decreasing or constant depends on a number of parameters (such as the thermal properties of the surface, and frost migration patterns) that are unknown. Here we report observations of a recent stellar occultation by Triton which, when combined with earlier results, show that Triton has undergone a period of global warming since 1989. Our most conservative estimates of the rate of temperature and surface-pressure increase during this period imply that the atmosphere is doubling in bulk every 10 years, significantly faster than predicted by any published frost model for Triton. Our result suggests that permanent polar caps on Triton play a c dominant role in regulating seasonal atmospheric changes. Similar processes should also be active on Pluto

Exposure of neonates to Respiratory Syncytial Virus is critical in determining subsequent airway response in adults

BACKGROUND: Respiratory syncytial virus (RSV) is the most common cause of acute bronchiolitis in infants and the elderly. Furthermore, epidemiological data suggest that RSV infection during infancy is a potent trigger of subsequent wheeze and asthma development. However, the mechanism by which RSV contributes to asthma is complex and remains largely unknown. A recent study indicates that the age of initial RSV infection is a key factor in determining airway response to RSV rechallenge. We hypothesized that severe RSV infection during neonatal development significantly alters lung structure and the pulmonary immune micro-environment; and thus, neonatal RSV infection is crucial in the development of or predisposition to allergic inflammatory diseases such as asthma. METHODS: To investigate this hypothesis the present study was conducted in a neonatal mouse model of RSV-induced pulmonary inflammation and airway dysfunction. Seven-day-old mice were infected with RSV (2 × 10(5 )TCID(50)/g body weight) and allowed to mature to adulthood. To determine if neonatal RSV infection predisposed adult animals to enhanced pathophysiological responses to allergens, these mice were then sensitized and challenged with ovalbumin. Various endpoints including lung function, histopathology, cytokine production, and cellularity in bronchoalveolar lavage were examined. RESULTS: RSV infection in neonates alone led to inflammatory airway disease characterized by airway hyperreactivity, peribronchial and perivascular inflammation, and subepithelial fibrosis in adults. If early RSV infection was followed by allergen exposure, this pulmonary phenotype was exacerbated. The initial response to neonatal RSV infection resulted in increased TNF-α levels in bronchoalveolar lavage. Interestingly, increased levels of IL-13 and mucus hyperproduction were observed almost three months after the initial infection with RSV. CONCLUSION: Neonatal RSV exposure results in long term pulmonary inflammation and exacerbates allergic airways disease. The early increase in TNF-α in the bronchoalveolar lavage implicates this inflammatory cytokine in orchestrating these events. Finally, the data presented emphasize IL-13 and TNF-α as potential therapeutic targets for treating RSV induced-asthma

A telehealth integrated asthma-COPD service for primary care: a proposal for a pilot feasibility study in Crete, Greece

<p>Abstract</p> <p>Background</p> <p>Chronic obstructive pulmonary disease (COPD) and asthma are considered underdiagnosed and misdiagnosed chronic diseases. In The Netherlands, a COPD-asthma telemedicine service has been developed to increase GPs' ability to diagnose and manage COPD and asthma. A telemedicine COPD-asthma service may benefit Greece as it is a country, partly due to its geography, that does not have easy access to pulmonologists.</p> <p>Findings</p> <p>Therefore, a pilot feasibility study has been designed in Greece in order to establish this telemedicine service. Ten rural practices, in the island of Crete, with an average population of 2000 patients per practice will pilot the project supported by three pulmonologists. This paper presents the translated interfaces, the flowcharts and the steps that are considered as necessary for this feasibility study in Crete, Greece.</p

Mars methane detection and variability at Gale crater

Reports of plumes or patches of methane in the martian atmosphere that vary over monthly time scales have defied explanation to date. From in situ measurements made over a 20-month period by the tunable laser spectrometer of the Sample Analysis at Mars instrument suite on Curiosity at Gale crater, we report detection of background levels of atmospheric methane of mean value 0.69 ± 0.25 parts per billion by volume (ppbv) at the 95% confidence interval (CI). This abundance is lower than model estimates of ultraviolet degradation of accreted interplanetary dust particles or carbonaceous chondrite material. Additionally, in four sequential measurements spanning a 60-sol period (where 1 sol is a martian day), we observed elevated levels of methane of 7.2 ± 2.1 ppbv (95% CI), implying that Mars is episodically producing methane from an additional unknown source

Mars Science Laboratory Observations of the 2018/Mars Year 34 Global Dust Storm

Mars Science Laboratory Curiosity rover observations of the 2018/Mars year 34 global/planet-encircling dust storm represent the first in situ measurements of a global dust storm with dedicated meteorological sensors since the Viking Landers. The Mars Science Laboratory team planned and executed a science campaign lasting approximately 100 Martian sols to study the storm involving an enhanced cadence of environmental monitoring using the rover's meteorological sensors, cameras, and spectrometers. Mast Camera 880-nanometer optical depth reached 8.5, and Rover Environmental Monitoring Station measurements indicated a 97 percent reduction in incident total ultraviolet solar radiation at the surface, 30 degrees Kelvin reduction in diurnal range of air temperature, and an increase in the semidiurnal pressure tide amplitude to 40 pascals. No active dust-lifting sites were detected within Gale Crater, and global and local atmospheric dynamics were drastically altered during the storm. This work presents an overview of the mission's storm observations and initial results

Mars Science Laboratory Observations of the 2018/Mars Year 34 Global Dust Storm

Mars Science Laboratory Curiosity rover observations of the 2018/Mars year 34 global/planetâ encircling dust storm represent the first in situ measurements of a global dust storm with dedicated meteorological sensors since the Viking Landers. The Mars Science Laboratory team planned and executed a science campaign lasting approximately 100 Martian sols to study the storm involving an enhanced cadence of environmental monitoring using the rover’s meteorological sensors, cameras, and spectrometers. Mast Camera 880â nm optical depth reached 8.5, and Rover Environmental Monitoring Station measurements indicated a 97% reduction in incident total ultraviolet solar radiation at the surface, 30K reduction in diurnal range of air temperature, and an increase in the semidiurnal pressure tide amplitude to 40 Pa. No active dustâ lifting sites were detected within Gale Crater, and global and local atmospheric dynamics were drastically altered during the storm. This work presents an overview of the mission’s storm observations and initial results.Plain Language SummaryThe 2018 Mars global dust storm was observed by six spacecraft in orbit and two rovers on the surface. This paper provides an overview and description of the Mars Science Laboratory Curiosity rover’s observations during the storm. For approximately 100 Martian days (sols), the rover conducted an enhanced cadence of environmental observations to study the storm. These are the first observations of a Martian global dust storm with meteorological sensors near the equator. Atmospheric opacity reached a peak of 8.5, attenuating ~97% of the total solar ultraviolet radiation at the surface. Most of the dust was sourced from outside Gale Crater, with no indications of dust lifting within the crater during the height of the storm. Meteorological conditions were substantially altered, with changes to the pressure, temperature, and humidity patterns. Dust devil activity ceased for several weeks due to the reduction in temperature contrast between the surface and atmosphere. There was no indication of unusual aeolian transport, suggesting Martian global dust storms are not a major cause of sand dune movement.Key PointsThe Curiosity rover conducted a dedicated science campaign to study the 2018 Mars global dust stormAtmospheric opacity reached a peak of 8.5, and horizontal visibility dropped to 2.7 kmMeteorological conditions in Gale Crater were substantially altered, with changes to the pressure, temperature, and humidity cyclesPeer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/147828/1/grl58365_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/147828/2/grl58365.pd

Racemic epinephrine compared to salbutamol in hospitalized young children with bronchiolitis; a randomized controlled clinical trial [ISRCTN46561076]

BACKGROUND: Bronchiolitis is the most common cause of lower respiratory tract illness in infancy, and hospital admission rates appear to be increasing in Canada and the United States. Inhaled beta agonists offer only modest short-term improvement. Trials of racemic epinephrine have shown conflicting results. We sought to determine if administration of racemic epinephrine during hospital stay for bronchiolitis improved respiratory distress, was safe, and shortened length of stay. METHODS: The study was a randomized, double-blind controlled trial of aerosolized racemic epinephrine compared to salbutamol every one to 4 hours in previously well children aged 6 weeks to ≤ 2 years of age hospitalized with bronchiolitis. The primary outcome was symptom improvement as measured by the Respiratory Distress Assessment Instrument (RDAI); secondary outcomes were length of stay in hospital, adverse events, and report of symptoms by structured parental telephone interview one week after discharge. RESULTS: 62 children with a mean age of 6.4 months were enrolled; 80% of children had Respiratory Syncytial Virus (RSV). Racemic epinephrine resulted in significant improvement in wheezing and the total RDAI score on day 2 and over the entire stay (p < 0.05). The mean LOS in the epinephrine arm was 2.6 days (95% CI 2, 3.2) v. 3.4 days in those in the salbutamol group (95% CI 2.6, 4.2) (p > 0.05). Adverse events were not significantly different in the two arms. At one week post-discharge, over half of parents reported that their child still had a respiratory symptom and 40% had less than normal feeding. CONCLUSION: Racemic epinephrine relieves respiratory distress in hospitalized infants with bronchiolitis and is safe but does not abbreviate hospital stay. Morbidity associated with bronchiolitis as identified by parents persists for at least one week after hospital discharge in most infants