Re-identifying residential mixing: emergent identity dynamics between incomers and existing residents in a mixed neighbourhood in Northern Ireland

Research on residential diversification has neglected its impact on neighbourhood identity and overlooked the very different identity‐related experiences of new and existing residents. The present research examines how incoming and established group members relate to their changing neighbourhood in the increasingly desegregated city of Belfast, Northern Ireland. Thematic analysis of interviews with 24 residents (12 Protestant long‐term residents, 12 Catholic incomers) from an increasingly mixed neighbourhood identified asymmetrical concerns and experiences: Incomers reported undergoing an ‘identity transition’ between local communities, while long‐term residents faced an ‘identity merger’ within their neighbourhood. Where their identity concerns diverged, emergent intergroup perceptions of the residents were negative and divisive; where they accorded, positive intergroup perceptions and a shared neighbourhood identity evolved. From this, we propose a Social Identity Model of Residential Diversification (SIMRD) to encourage future research into how different identity concerns shape emergent intergroup dynamics between long‐term residents and incomers within diversifying neighbourhoods

Real-Time Probe Data Dashboards for Interstate Performance Monitoring During Winter Weather and Incidents

The Indiana Department of Transportation (INDOT) manages over 1800 centerline miles of interstate that can be profoundly impacted by weather, crashes, and construction. Real-time performance measurement of interstate speeds is critical for successful traffic operations management. Agency managers and Traffic Management Center decision makers need situational awareness of the network and the ability to identify irregularities at a glance in order to manage resources and respond to media queries. One way to access this level of detail is crowdsourced probe vehicle data. Crowdsourced probe vehicle data can be obtained by collecting speed data from cell phones and global positioning system (GPS) devices. In Indiana, approximately 2673 predefined interstate segments are used to generate over 3.8 million speed records per day. These data can be overwhelming without efficient procedures to reduce and aggregate both spatially and temporally. This paper introduces a spatial and temporal aggregation model and an accompanying real-time dashboard to characterize the current and past congestion history of interstate roadways. The primary high level view of the aggregated data resembles a stock ticker and is called the “Congestion Ticker.” The data archive allows for after-action review of major events such as ice storms, major crashes, and construction work zones. The utility of this application is demonstrated with two case studies: a snowstorm that covered northern and central Indiana in February 2015 and an I-70 back of queue crash in April 2015

Real-Time Probe Data Dashboard for Monitoring Detour Route during I-65 N Road Closure

On August 7, 2015, a 37 mile stretch of I-65 N from MM 141 to 178 was closed due to a structural evaluation of a bridge. Traffic was detoured onto US-52, SR-26, and US-231 before returning to the highway. In order to monitor delay and congestion on the detour route, a real-time dashboard was implemented in the style of the interstate Traffic Ticker. Throughout the detour, this website was used to monitor congestion in real time and measure the impact of mitigation actions. The improvement in travel can be seen from the addition of temporary signals, retiming of the US-231 corridor, and conversion of US-231 and SR-18 to a two-way stop

2013–2014 Indiana Mobility Report: Full Version

The 2013–2014 Indiana Mobility Report: Full Version examines the mobility performance of Indiana’s state highway system. Minute-by-minute crowdsourced probe vehicle speed data and vehicle volume data were used to develop performance measures that identify, quantify, and visualize the location and duration of congestion on Indiana Interstates. The report presents overall system performance, including a monthly overview covering January 2011 through June 2014 as well as selected highlights of significant projects. In addition to the Interstate system, the report characterizes selected high-priority arterial corridors to rank their mobility performance in terms of travel time and travel time reliability. The full version includes the following appendices: Appendix A: Interstate Speed Profiles Appendix B: Interstate Speed Profiles with Linear Distance Scale Appendix C: Interstate Congestion Hour Summaries Appendix D: Interstate Summary Statistics Appendix E: Interstate Segment Congestion Ranking

2013–2014 Indiana Mobility Report: Summary Version

The 2013–2014 Indiana Mobility Report: Summary Version examines the mobility performance of Indiana’s state highway system. Minute-by-minute crowdsourced probe vehicle speed data and vehicle volume data were used to develop performance measures that identify, quantify, and visualize the location and duration of congestion on Indiana Interstates. The summary report presents overall system performance, including a monthly overview covering January 2011 through June 2014 as well as selected highlights of significant projects. In addition to the Interstate system, the report characterizes selected high-priority arterial corridors to rank their mobility performance in terms of travel time and travel time reliability

Calnexin, an ER-induced protein, is a prognostic marker and potential therapeutic target in colorectal cancer.

BACKGROUND: Colorectal cancer (CRC) is a leading cause of cancer mortality in the Western world and commonly treated with genotoxic chemotherapy. Stress in the endoplasmic reticulum (ER) was implicated to contribute to chemotherapeutic resistance. Hence, ER stress related protein may be of prognostic or therapeutic significance. METHODS: The expression levels of ER stress proteins calnexin, calreticulin, GRP78 and GRP94 were determined in n = 23 Stage II and III colon cancer fresh frozen tumour and matched normal tissue samples. Data were validated in a cohort of n = 11 rectal cancer patients treated with radiochemotherapy in the neoadjuvant setting. The calnexin gene was silenced using siRNA in HCT116 cells. RESULTS: There were no increased levels of ER stress proteins in tumour compared to matched normal tissue samples in Stage II or III CRC. However, increased calnexin protein levels were predictive of poor clinical outcome in the patient cohort. Data were validated in the rectal cancer cohort treated in the neoadjuvant setting. Calnexin gene-silencing significantly reduced cell survival and increased cancer cell susceptibility to 5FU chemotherapy. CONCLUSION: Increased tumour protein levels of calnexin may be of prognostic significance in CRC, and calnexin may represent a potential target for future therapies

Targeting the 19S proteasomal subunit, Rpt4, for the treatment of colon cancer.

Deregulation of the ubiquitin-proteasome pathway has been frequently observed in a number of malignancies. Using quantitative Western blotting of normal and matched tumour tissue, we here identified a significant increase in the 19S proteasome subunit Rpt4 in response to chemoradiation in locally advanced rectal cancer patients with unfavourable outcome. We therefore explored the potential of Rpt4 reduction as a therapeutic strategy in colorectal cancer (CRC). Utilizing siRNA to down regulate Rpt4 expression, we show that silencing of Rpt4 reduced proteasomal activity and induced endoplasmic reticulum stress. Gene silencing of Rpt4 also inhibited cell proliferation, reduced clonogenic survival and induced apoptosis in HCT-116 colon cancer cells. We next developed a cell penetrating peptide-based nanoparticle delivery system to achieve in vivo gene silencing of Rpt4. Administration of Rpt4 siRNA nanoparticles reduced tumour growth and improved survival in a HCT-116 colon cancer xenograft tumour model in vivo. Collectively, our data suggest that inhibition of Rpt4 represents a novel strategy for the treatment of CRC

Respiratory Syncytial Virus Binds and Undergoes Transcription in Neutrophils From the Blood and Airways of Infants With Severe Bronchiolitis

Background. Neutrophils are the predominant cell in the lung inflammatory infiltrate of infants with respiratory syncytial virus (RSV) bronchiolitis. Although it has previously been shown that neutrophils from both blood and bronchoalveolar lavage (BAL) are activated, little is understood about their role in response to RSV infection. This study investigated whether RSV proteins and mRNA are present in neutrophils from blood and BAL of infected infants