The Use of Business Methods as a Means of Identifying Needs of the Deaf

Non

Winifred S. Raymond Correspondence

Entries include brief biographical information and a typed biography of the librarian of the Bangor Public Library, a typed letter of presentation and a biographical letter on Bangor Public Library stationery, as well as correspondence with the Maine State Library concerning the new Federal tax law and donations of books from authors

Raymond R. Manson Correspondence

Entries include a biography and a typed letter on Vassalboro Historical Society stationery

Genevieve Fox Correspondence

Entries include brief and conflicting biographical information and a typed letter from Fox

HST Imaging of the Ionizing Radiation from a Star-forming Galaxy at z = 3.794

We report on the HST detection of the Lyman-continuum (LyC) radiation emitted by a galaxy at redshift z=3.794, dubbed Ion1 (Vanzella et al. 2012). The LyC from Ion1 is detected at rest-frame wavelength 820$\sim$890 \AA with HST WFC3/UVIS in the F410M band ($m_{410}=27.60\pm0.36$ magnitude (AB), peak SNR = 4.17 in a circular aperture with radius r = 0.12'') and at 700$\sim$830 \AA with the VLT/VIMOS in the U-band ($m_U = 27.84\pm0.19$ magnitude (AB), peak SNR = 6.7 with a r = 0.6'' aperture). A 20-hr VLT/VIMOS spectrum shows low- and high-ionization interstellar metal absorption lines, the P-Cygni profile of CIV and Ly$\alpha$ in absorption. The latter spectral feature differs from what observed in known LyC emitters, which show strong Ly$\alpha$ emission. An HST far-UV color map reveals that the LyC emission escapes from a region of the galaxy that is bluer than the rest, presumably because of lower dust obscuration. The F410M image shows that the centroid of the LyC emission is offset from the centroid of the non-ionizing UV emission by 0.12''$\pm$0.03'', corresponding to 0.85$\pm$0.21 kpc (physical), and that its morphology is likely moderately resolved. These morphological characteristics favor a scenario where the LyC photons produced by massive stars escape from low HI column-density "cavities" in the ISM, possibly carved by stellar winds and/or supernova. We also collect the VIMOS U-band images of a sample of 107 Lyman-break galaxies with spectroscopic redshifts at $3.40<z<3.95$, i.e. sampling the LyC, and stack them with inverse-variance weights. No LyC emission is detected in the stacked image, resulting in a 32.5 magnitude (AB) flux limit (1$\sigma$) and an upper limit of absolute LyC escape fraction $f_{esc}^{abs} < 0.63\%$. LyC emitters like Ion1 are very likely at the bright-end of the LyC luminosity function.Comment: 24 pages, 13 figures, accepted for publication in Ap

UBVRI Light Curves of 44 Type Ia Supernovae

We present UBVRI photometry of 44 type-Ia supernovae (SN Ia) observed from 1997 to 2001 as part of a continuing monitoring campaign at the Fred Lawrence Whipple Observatory of the Harvard-Smithsonian Center for Astrophysics. The data set comprises 2190 observations and is the largest homogeneously observed and reduced sample of SN Ia to date, nearly doubling the number of well-observed, nearby SN Ia with published multicolor CCD light curves. The large sample of U-band photometry is a unique addition, with important connections to SN Ia observed at high redshift. The decline rate of SN Ia U-band light curves correlates well with the decline rate in other bands, as does the U-B color at maximum light. However, the U-band peak magnitudes show an increased dispersion relative to other bands even after accounting for extinction and decline rate, amounting to an additional ~40% intrinsic scatter compared to B-band.Comment: 84 authors, 71 pages, 51 tables, 10 figures. Accepted for publication in the Astronomical Journal. Version with high-res figures and electronic data at http://astron.berkeley.edu/~saurabh/cfa2snIa

The changing carbon cycle of the coastal ocean

The carbon cycle of the coastal ocean is a dynamic component of the global carbon budget. But the diverse sources and sinks of carbon and their complex interactions in these waters remain poorly understood. Here we discuss the sources, exchanges and fates of carbon in the coastal ocean and how anthropogenic activities have altered the carbon cycle. Recent evidence suggests that the coastal ocean may have become a net sink for atmospheric carbon dioxide during post-industrial times. Continued human pressures in coastal zones will probably have an important impact on the future evolution of the coastal ocean's carbon budget

Pharmacogenetic prediction of clinical outcome in advanced colorectal cancer patients receiving oxaliplatin/5-fluorouracil as first-line chemotherapy

To determine whether molecular parameters could be partly responsible for resistance or sensitivity to oxaliplatin (OX)-based chemotherapy used as first-line treatment in advanced colorectal cancer (CRC). We studied the usefulness of the excision repair cross-complementing 1 (ERCC1), xeroderma pigmentosum group D (XPD), XRCC1 and GSTP1 polymorphisms as predictors of clinical outcome in these patients. We treated 126 CRC patients with a first-line OX/5-fluorouracil chemotherapeutic regimen. Genetic polymorphisms were determined by real-time PCR on an ABI PRISM 7000, using DNA from peripheral blood. Clinical response (CR), progression-free survival (PFS) and overall survival (OS) were evaluated according to each genotype. In the univariate analysis for CR, ERCC1-118 and XPD 751 polymorphisms were significant (P=0.02 and P=0.05, respectively). After adjustment for the most relevant clinical variables, only ERCC1-118 retained significance (P=0.008). In the univariate analysis for PFS, ERCC1-118 and XPD 751 were significant (P=0.003 and P=0.009, respectively). In the multivariant analysis, only the XPD 751 was significant for PFS (P=0.02). Finally, ERCC1-118 and XPD 751 polymorphisms were significant in the univariate analysis for OS (P=0.006 and P=0.015, respectively). Both genetic variables remained significant in the multivariate Cox survival analysis (P=0.022 and P=0.03). Our data support the hypothesis that enhanced DNA repair diminishes the benefit of platinum-based treatments