2,162 research outputs found
Comorbidity and polypharmacy in chronic heart failure:a large cross-sectional study in primary care
Background: Comorbidity is common in heart failure, but previous prevalence estimates have been based on a limited number of conditions using mainly non-primary care data sources.
Aim: To compare prevalence rates of comorbidity and polypharmacy in those with and without chronic heart failure due to left ventricular systolic dysfunction (LVSD).
Design and setting: A cross-sectional study of 1.4 million patients in primary care in Scotland.
Method: Data on the presence of LVSD, 31 other physical, and seven mental health comorbidities, and prescriptions were extracted from a database of 1 424 378 adults. Comorbidity prevalence was compared in patients with and without LVSD, standardised by age, sex, and deprivation. Pharmacology data were also compared between the two groups.
Results: There were 17 285 patients (1.2%) who had a diagnosis of LVSD. Compared with standardised controls, the LVSD group had greater comorbidity, with the biggest difference found for seven or more conditions (odds ratio [OR] 4.10; 95% confidence interval (CI] = 3.90 to 4.32). Twenty-five physical conditions and six mental health conditions were significantly more prevalent in those with LVSD relative to standardised controls. Polypharmacy was higher in the LVSD group compared with controls, with the biggest difference found for ≥11 repeat prescriptions (OR 4.81; 95% CI = 4.60 to 5.04). However, these differences in polypharmacy were attenuated after controlling for the number of morbidities, indicating that much of the additional prescribing was accounted for by multimorbidity rather than LVSD per se.
Conclusion: Extreme comorbidity and polypharmacy is significantly more common in patients with chronic heart failure due to LVSD. The efficient management of such complexity requires the integration of general and specialist expertise
INTACT PROTEIN ABSORPTION BY THE FISH GUT I. MECHANISM OF UPTAKE AND POTENTIAL PHYSIOLOGICAL SIGNIFICANCE
Chapter 2 ‘A CLOSE AND FRIENDLY ALLIANCE’: BIOLOGY, GEOLOGY AND THE GREAT BARRIER REEF EXPEDITION OF 1928–1929
oceanography, climate change, reefs, marine science, marine conservation, marine researc
Patterns in Deep Time
In this paper, we explore how textile pattern-making can be a useful activity
for live coders used to manipulating software. We ran an algorithmic patterns
workshop in July 2022 -- with a node at "on the fly" festival in Barcelona, a
node in Sheffield and the workshop leader in Penryn -- where we created an
activity recreating ancient patterns by weaving on tablet looms that we
constructed from card and yarn, and sent to the participants for this remote,
multi location workshop. One of the aims of the Algorithmic Pattern project is
to highlight the relationship people have had with patterns over history, and
how we can use this to uncover certain misconceptions we have about algorithmic
patterns in contemporary society. We collected responses from those who
participated in the workshop and collated the responses. We found that tablet
weaving allows us to connect the physical patterns with their algorithmic
descriptions. Also, errors relate with the trade-off among expectations and
surprise and exploring new unexpected possibilities. Finally, sharing the
experiences among the participants allows us to observe how we interpret
patterns when comparing it with other experiences
Utilisation de la couleur pour l'appariement et l'indexation d'images.
De nombreux travaux récents ont montré que l'utilisation directe du signal des images en niveaux de gris permet de développer des systèmes puissants d'appariement, d'indexation et de reconnaissance d'images. Le présent document explore l'utilisation d'images en couleur pour ces mêmes objectifs. Les principaux points en sont le choix du modèle de variation de la couleur, l'utilisation d'invariants colorimétriques, et la normalisation des images
A T8.5 Brown Dwarf Member of the Xi Ursae Majoris System
The Wide-field Infrared Survey Explorer has revealed a T8.5 brown dwarf (WISE
J111838.70+312537.9) that exhibits common proper motion with a
solar-neighborhood (8 pc) quadruple star system - Xi Ursae Majoris. The angular
separation is 8.5 arc-min, and the projected physical separation is about 4000
AU. The sub-solar metallicity and low chromospheric activity of Xi UMa A argue
that the system has an age of at least 2 Gyr. The infrared luminosity and color
of the brown dwarf suggests the mass of this companion ranges between 14 and 38
Jupiter masses for system ages of 2 and 8 Gyr respectively.Comment: AJ in press, 12 pages LaTeX with 6 figures. More astrometric data and
a laser guide star adaptive optics image adde
A Study of the Diverse T Dwarf Population Revealed by WISE
We report the discovery of 87 new T dwarfs uncovered with the Wide-field
Infrared Survey Explorer (WISE) and three brown dwarfs with extremely red
near-infrared colors that exhibit characteristics of both L and T dwarfs. Two
of the new T dwarfs are likely binaries with L7+/-1 primaries and mid-type T
secondaries. In addition, our follow-up program has confirmed 10 previously
identified T dwarfs and four photometrically-selected L and T dwarf candidates
in the literature. This sample, along with the previous WISE discoveries,
triples the number of known brown dwarfs with spectral types later than T5.
Using the WISE All-Sky Source Catalog we present updated color-color and
color-type diagrams for all the WISE-discovered T and Y dwarfs. Near-infrared
spectra of the new discoveries are presented, along with spectral
classifications. To accommodate later T dwarfs we have modified the integrated
flux method of determining spectral indices to instead use the median flux.
Furthermore, a newly defined J-narrow index differentiates the early-type Y
dwarfs from late-type T dwarfs based on the J-band continuum slope. The K/J
indices for this expanded sample show that 32% of late-type T dwarfs have
suppressed K-band flux and are blue relative to the spectral standards, while
only 11% are redder than the standards. Comparison of the Y/J and K/J index to
models suggests diverse atmospheric conditions and supports the possible
re-emergence of clouds after the L/T transition. We also discuss peculiar brown
dwarfs and candidates that were found not to be substellar, including two Young
Stellar Objects and two Active Galactic Nuclei. The coolest WISE-discovered
brown dwarfs are the closest of their type and will remain the only sample of
their kind for many years to come.Comment: Accepted to ApJS on 15 January 2013; 99 pages in preprint format, 30
figures, 12 table
- …