Country reviews of social assistance in crises: A compendium of rapid assessments of the nexus between social protection and humanitarian assistance in crisis settings

© 2021 Institute of Development Studies. This is an open access report available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://opendocs.ids.ac.uk/opendocs/handle/20.500.12413/16675This collection brings together brief overviews of the social assistance landscape in eight fragile and conflict-affected settings in sub-Saharan Africa and the Middle East: Iraq, Jordan, Lebanon, Mali, Niger, Nigeria, Somalia and Yemen. These overviews were prepared as part of Better Assistance in Crises (BASIC) Research, a multi-year programme (2020–24) supported by the Foreign, Commonwealth and Development Office (FCDO) of the UK government. BASIC Research aims to inform policy and programming on effective social assistance in situations of crisis, including for those who are experiencing climate-related shocks and stressors, protracted conflict and forced displacement.UKAi

Electropalatography and the Linguagraph system

This paper describes the technique of electropalatography and the development of Linguagraph, which is a user-friendly, clinical instrument, for measurement of tongue/palate contact, during speech. Linguagraph allows objective assessment of tongue function; appropriate targeting of therapy is therefore possible. Visual feedback is also provided, for therapy, and an objective measurement of outcome is easily obtained. Linguagraph was used, for both therapy and assessment, in a clinical trial. Technical aspects of Linguagraph and of the trial results are presented here. These suggest that the instrument will prove useful in the assessment and management of many speech disorders. Full clinical details of the trial are reported elsewhere

An instrument for the non-invasive objective assessment of velar function during speech

This paper describes the development of a non-invasive, computer-based, clinical instrument that infers velar function by way of the measurement of nasal and oral airflow. The design criteria of the instrument were based upon a wide ranging review of current practice and available techniques. The instrument measures and displays both nasal and oral airflow, along with the envelope of the speech sound waveform. This allows the clinician to determine whether airflow is associated with oral or nasal airflow and, hence, to infer the position of the velum. Preliminary clinical trials suggest that the instrument provides valuable objective information about the movement of the soft palate, particularly within the time domain. Hence, It Is believed that the device provides additional information for the assessment of velar function, complementing those techniques currently employed

Filaggrin in the frontline: role in skin barrier function and disease

Recently, loss-of-function mutations in FLG, the human gene encoding profilaggrin and filaggrin, have been identified as the cause of the common skin condition ichthyosis vulgaris (which is characterised by dry, scaly skin). These mutations, which are carried by up to 10% of people, also represent a strong genetic predisposing factor for atopic eczema, asthma and allergies. Profilaggrin is the major component of the keratohyalin granules within epidermal granular cells. During epidermal terminal differentiation, the ∼400 kDa profilaggrin polyprotein is dephosphorylated and rapidly cleaved by serine proteases to form monomeric filaggrin (37 kDa), which binds to and condenses the keratin cytoskeleton and thereby contributes to the cell compaction process that is required for squame biogenesis. Within the squames, filaggrin is citrullinated, which promotes its unfolding and further degradation into hygroscopic amino acids, which constitute one element of natural moisturising factor. Loss of profilaggrin or filaggrin leads to a poorly formed stratum corneum (ichthyosis), which is also prone to water loss (xerosis). Recent human genetic studies strongly suggest that perturbation of skin barrier function as a result of reduction or complete loss of filaggrin expression leads to enhanced percutaneous transfer of allergens. Filaggrin is therefore in the frontline of defence, and protects the body from the entry of foreign environmental substances that can otherwise trigger aberrant immune responses

Describing the structural shape of melanocytic lesions

This paper presents an automatic computer system for analysing the structural shape of cutaneous melanocytic lesion borders. The computer system consists of two steps: pre-preprocessing the skin lesion images and lesion border shape analysis. In the preprocessing step, the lesion border is extracted from the skin images after the dark thick hairs are removed by a program called DullRazor. The second step analyses the structural shape of the lesion border using a new measure called sigma-ratio. The new measure is derived from scale-space filtering technique with an extended scale-space image. When comparing the new measure with other common shape descriptors, such as compactness index and fractal dimensional, sigma-ratio is more sensitive to the structural protrusions and indentations. In addition, the extended scale-space image can be used to pinpoint the locations of the structural indentations and protrusions, the potential problem areas of the lesion

Keratin 9 Is Required for the Structural Integrity and Terminal Differentiation of the Palmoplantar Epidermis

Keratin 9 (K9) is a type I intermediate filament protein whose expression is confined to the suprabasal layers of the palmoplantar epidermis. Although mutations in the K9 gene are known to cause epidermolytic palmoplantar keratoderma, a rare dominant-negative skin disorder, its functional significance is poorly understood. To gain insight into the physical requirement and importance of K9, we generated K9-deficient (Krt9−/−) mice. Here, we report that adult Krt9−/−mice develop calluses marked by hyperpigmentation that are exclusively localized to the stress-bearing footpads. Histological, immunohistochemical, and immunoblot analyses of these regions revealed hyperproliferation, impaired terminal differentiation, and abnormal expression of keratins K5, K14, and K2. Furthermore, the absence of K9 induces the stress-activated keratins K6 and K16. Importantly, mice heterozygous for the K9-null allele (Krt9+/−) show neither an overt nor histological phenotype, demonstrating that one Krt9 allele is sufficient for the developing normal palmoplantar epidermis. Together, our data demonstrate that complete ablation of K9 is not tolerable in vivo and that K9 is required for terminal differentiation and maintaining the mechanical integrity of palmoplantar epidermis

The use of temozolomide in paediatric metastatic phaeochromocytoma/paraganglioma: A case report and literature review

Peer reviewed: TrueThere is increasing evidence to support the use of temozolomide therapy for the treatment of metastatic phaeochromocytoma/paraganglioma (PPGL) in adults, particularly in patients with SDHx mutations. In children however, very little data is available. In this report, we present the case of a 12-year-old female with a SDHB-related metastatic paraganglioma treated with surgery followed by temozolomide therapy. The patient presented with symptoms of palpitations, sweating, flushing and hypertension and was diagnosed with a paraganglioma. The primary mass was surgically resected six weeks later after appropriate alpha- and beta-blockade. During the surgery extensive nodal disease was identified that had been masked by the larger paraganglioma. Histological review confirmed a diagnosis of a metastatic SDHB-deficient paraganglioma with nodal involvement. Post-operatively, these nodal lesions demonstrated tracer uptake on 18F-FDG PET-CT. Due to poor tumour tracer uptake on 68Ga-DOTATATE and 123I-MIBG functional imaging studies radionuclide therapy was not undertaken as a potential therapeutic option for this patient. Due to the low tumour burden and lack of clinical symptoms, the multi-disciplinary team opted for close surveillance for the first year, during which time the patient continued to thrive and progress through puberty. 13 months after surgery, evidence of radiological and biochemical progression prompted the decision to start systemic monotherapy using temozolomide. The patient has now completed ten cycles of therapy with limited adverse effects and has benefited from a partial radiological and biochemical response