An Extension of the Jeu de Taquin

The Knuth transformations on words, the jeu de taquin moves on tableaux, and the Robinson–Schensted–Knuth algorithm produce the same equivalence classes for words. By observing the connections between these three methods we find and prove there exists connections between the Assaf–Knuth transformations, our extension of the jeu de taquin, and p-RSK. We know there exists an algebraic way to expand Macdonald polynomials in terms of the Schur functions. The form of the expansion implies there should be a combinatorial way to find the expansion. Loehr found a Robinson–Schensted–Knuth like algorithm that works in some cases. By finding an extension of jeu de taquin, we will try to expand the number of cases covered

In-Home Counseling for Young Children Living in Poverty: An Exploration of Counseling Competencies

Home-based counseling is increasingly an alternative mode of providing counseling services for children and families, reduces barriers to accessing traditional counseling services, and has also been shown to be effective. As such, the purpose of this qualitative study was to explore and describe the competencies needed to provide such counseling services. This study yielded five categories of competencies—necessary knowledge sets, case conceptualization, counseling behaviors, flexibility in session, and professional dispositions and behaviors. We also outline implications for counseling practice, counselor education, and public policy

Comparing the physiological cost of step-powered video gaming, sedentary video gaming and self paced ambulatory activity in university students

Objectives: Methods for converting inactive video gaming to active video gaming have gained popularity in recent years. This study compared the physiological cost of a new peripheral device that used steps to power video gaming in an interactive manner against sedentary video gaming and self-paced ambulatory activity of university students (aged 19-29 years).Methods: Nineteen adults (9 male, 10 female) performed six 10-minute activities, namely self-paced leisurely walking, self-paced brisk walking, self-paced jogging, two forms of sedentary video gaming, and step-powered video gaming. Activities were performed in a random order. Physiological cost during the activities was measured using Actiheart.Results: Energy expenditure during step-powered video gaming (388.8 kcal.h-1) was comparable to the energy expended during brisk walking (373.8 kcal.h-1), and elicited a higher energy cost than sedentary video gaming (124.1 kcal.h-1) but a lower energy cost than jogging (694.5 kcal.h-1).Conclusion: Overall, step-powered video gaming could be used as an entertaining and appealing tool to increase physical activity, though it should not be used as a complete substitute for traditional exercise, such as jogging.<br /

Academic Advising at Western: Some Feedback from Alumni

Executive Summary: Repeated studies in recent years, both at Western and elsewhere, have found students less satisfied with advising services than with instruction or various university services. For example, 77% of recent Western alumni are very or mostly satisfied with the undergraduate courses they took at Western, while 41% are similarly satisfied with the academic advising they received from all sources at Western. Satisfaction with advising received from faculty and major departments was lower than satisfaction with advising from the Academic Advising Center. Because of the concerns these studies raise, Western\u27s Academic Advising Center requested that our 1992 alumni survey of the class of \u2791 include a special set of questions on the Center. The focus of these questions was to provide feedback to the Center on ways to improve services, but the entire issue of advising is of great enough concern that a report was written to be more generally available. A total of 1412 (75.9%) alumni of the class of \u2791 completed our survey about one year after their graduation. Of that total, fewer than half (43%) of the class of \u2791 report that they used the Academic Advising Center at least once, and only ten percent more than once. Most of the 57% who never used the center report that they never felt a need. One in six say they were unaware of the office. Of those who used the Academic Advising Center, half (49.8%) sought advise on at least one occasion regarding class scheduling or selection. Two-fifths (42.9%) sought help choosing a major or making major life decisions. Another 41.7% asked about specific university policies. A similar number, 39.8%, asked for information concerning transfer courses or GURs. Nearly one-third (29.2%) asked about pre-professional courses or programs. Another 9.8% sought other types of advice. The Academic Advising Center is more often used by students who are younger, who study more but who get less good grades, who entered Western as native freshmen, who changed their majors more often, who received financial aid while at Western, who value well-rounded education more than occupational training, and who found departmental advising especially weak

GBM heterogeneity as a function of variable epidermal growth factor receptor variant III activity.

Abnormal activation of the epidermal growth factor receptor (EGFR) due to a deletion of exons 2-7 of EGFR (EGFRvIII) is a common alteration in glioblastoma (GBM). While this alteration can drive gliomagenesis, tumors harboring EGFRvIII are heterogeneous. To investigate the role for EGFRvIII activation in tumor phenotype we used a neural progenitor cell-based murine model of GBM driven by EGFR signaling and generated tumor progenitor cells with high and low EGFRvIII activation, pEGFRHi and pEGFRLo. In vivo, ex vivo, and in vitro studies suggested a direct association between EGFRvIII activity and increased tumor cell proliferation, decreased tumor cell adhesion to the extracellular matrix, and altered progenitor cell phenotype. Time-lapse confocal imaging of tumor cells in brain slice cultures demonstrated blood vessel co-option by tumor cells and highlighted differences in invasive pattern. Inhibition of EGFR signaling in pEGFRHi promoted cell differentiation and increased cell-matrix adhesion. Conversely, increased EGFRvIII activation in pEGFRLo reduced cell-matrix adhesion. Our study using a murine model for GBM driven by a single genetic driver, suggests differences in EGFR activation contribute to tumor heterogeneity and aggressiveness

Academic Advising at Western: Some Feedback from Alumni

Executive Summary: Repeated studies in recent years, both at Western and elsewhere, have found students less satisfied with advising services than with instruction or various university services. For example, 77% of recent Western alumni are very or mostly satisfied with the undergraduate courses they took at Western, while 41% are similarly satisfied with the academic advising they received from all sources at Western. Satisfaction with advising received from faculty and major departments was lower than satisfaction with advising from the Academic Advising Center. Because of the concerns these studies raise, Western\u27s Academic Advising Center requested that our 1992 alumni survey of the class of \u2791 include a special set of questions on the Center. The focus of these questions was to provide feedback to the Center on ways to improve services, but the entire issue of advising is of great enough concern that a report was written to be more generally available. A total of 1412 (75.9%) alumni of the class of \u2791 completed our survey about one year after their graduation. Of that total, fewer than half (43%) of the class of \u2791 report that they used the Academic Advising Center at least once, and only ten percent more than once. Most of the 57% who never used the center report that they never felt a need. One in six say they were unaware of the office. If those who used the Academic Advising Center, half (49.8%) sought advise on at least one occasion regarding class scheduling or selection. Two-fifths (42.9%) sought help choosing a major or making major life decisions. Another 41.7% asked about specific university policies. A similar number, 39.8%, asked for information concerning transfer courses or GURs. Nearly one-third (29.2%) asked about pre-professional courses or programs. Another 9.8% sought other types of advice

The Grizzly, October 7, 1996

The Compassionate Spirit : Berman\u27s Newest Offering • A Sugar-Free Halloween Party for Diabetic Children • Sigma Chi Delta: Making an Impact • Roundtable Discussion: Breakdown of the Oslo Accord and Peace in Israel • Olympian Returns to Collegeville • Opinions: Letters from Ireland; Security is Here to Help; One Nation Under God; The Death of a Man, no More • You Can\u27t Take it With You, But You Can Enjoy it While You\u27re There • Spotlight: Roberto Diaz-Luong • Setting Goals to Stay on Track Towards Physical Fitness • My Hero: Stir Fry Guy • Coach Gros Honored • Field Hockey Drops Three • Foster Honored By Patriot League • Volleyball Falls To 6-13 • Bears Clobber Tide • Men\u27s Soccer Defeats Washingtonhttps://digitalcommons.ursinus.edu/grizzlynews/1387/thumbnail.jp

Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus

AbstractMany individual genetic risk loci have been associated with multiple common human diseases. However, the molecular basis of this pleiotropy often remains unclear. We present an integrative approach to reveal the molecular mechanism underlying the PROCR locus, associated with lower coronary artery disease (CAD) risk but higher venous thromboembolism (VTE) risk. We identify PROCR-p.Ser219Gly as the likely causal variant at the locus and protein C as a causal factor. Using genetic analyses, human recall-by-genotype and in vitro experimentation, we demonstrate that PROCR-219Gly increases plasma levels of (activated) protein C through endothelial protein C receptor (EPCR) ectodomain shedding in endothelial cells, attenuating leukocyte–endothelial cell adhesion and vascular inflammation. We also associate PROCR-219Gly with an increased pro-thrombotic state via coagulation factor VII, a ligand of EPCR. Our study, which links PROCR-219Gly to CAD through anti-inflammatory mechanisms and to VTE through pro-thrombotic mechanisms, provides a framework to reveal the mechanisms underlying similar cross-phenotype associations.</jats:p

Safety of Rwanda Bill: legal commentary

Discussion and analysis of some key legal commentary on the Safety of Rwanda Bill next being debated on 16 January 2024