Exclusion of Sox9 as a candidate for the mouse mutant Tail-short

The Sry-related gene Sox9 has been proposed as the gene responsible for the mouse skeletal mutant Tail-short (Ts), on the basis of its expression in skeletogenic mesenchymal condensations in the mouse embryo and its chromosomal location in the region of Ts on distal Chromosome (Chr) 11. We present here detailed mapping of Ts locus relative to the Sox9, using an intersubspecific cross. Among 521 backcross progeny, 16 recombinants were detected between Sox9 and Ts, suggesting a separation of 3.5 +/- 0.01 cM, and excluding Sox9 as a candidate for Ts. A further nine recombinants were detected between Ts and the polycomb-like gene M33, suggesting that these loci are separated by 1.8 +/- 0.011 cM. Six microsatellite markers were co-localized to the Ts locus, providing reagents for positional cloning of Ts. Mes

Palaeoenvironment of braided fluvial systems in different tectonic realms of the Triassic Sherwood Sandstone Group, UK

Fluvial successions comprising the fills of sedimentary basins occur in a variety of tectonic realms related to extensional, compressional and strike-slip settings, as well as on slowly subsiding, passive basin margins. A major rifting phase affected NW Europe during the Triassic and resulted in the generation of numerous sedimentary basins. In the UK, much of the fill of these basins is represented by fluvial and aeolian successions of the Sherwood Sandstone Group. Additionally, regions that experienced slow rates of Mesozoic subsidence unrelated to Triassic rifting also acted as sites of accumulation of the Sherwood Sandstone Group, one well-exposed example being the eastern England Shelf. The fluvial depositional architecture of deposits of the Sherwood Sandstone Group of the eastern England Shelf (a shelf-edge basin) is compared with similar fluvial deposits of the St Bees Sandstone Formation, eastern Irish Sea Basin (a half-graben). The two studied successions represent the preserved deposits of braided fluvial systems that were influenced by common allogenic factors (climate, sediment source, delivery style); differences in preserved sedimentary style principally reflect their different tectonics settings. Analysis of lithofacies and architectural elements demonstrates that both studied successions are characterized by amalgamated channel-fill elements that are recorded predominantly by downstream-accreting sandy barforms. The different tectonic settings in which the two braided-fluvial systems accumulated exerted a dominant control on preserved sedimentary style and long-term preservation potential. On the eastern England Shelf, the vertical stacking of pebbly units and the general absence of fine-grained units reflect a slow rate of sediment accommodation generation (18–19.4 m/Myr). In this shelf-edge basin, successive fluvial cycles repeatedly reworked the uppermost parts of earlier fluvial deposits such that only the lowermost channel lags tend to be preserved. By contrast, in the eastern Irish Sea Basin of west Cumbria, the rate of sediment accommodation generation was substantially greater (119 m/Myr) such that space was available to preserve complete fluvial cycles, including silty drape units that cap the channelized deposits

Recoil imaging for dark matter, neutrinos, and physics beyond the Standard Model

Recoil imaging entails the detection of spatially resolved ionization tracks generated by particle interactions. This is a highly sought-after capability in many classes of detector, with broad applications across particle and astroparticle physics. However, at low energies, where ionization signatures are small in size, recoil imaging only seems to be a practical goal for micro-pattern gas detectors. This white paper outlines the physics case for recoil imaging, and puts forward a decadal plan to advance towards the directional detection of low-energy recoils with sensitivity and resolution close to fundamental performance limits. The science case covered includes: the discovery of dark matter into the neutrino fog, directional detection of sub-MeV solar neutrinos, the precision study of coherent-elastic neutrino-nucleus scattering, the detection of solar axions, the measurement of the Migdal effect, X-ray polarimetry, and several other applied physics goals. We also outline the R&D programs necessary to test concepts that are crucial to advance detector performance towards their fundamental limit: single primary electron sensitivity with full 3D spatial resolution at the $\sim$100 micron-scale. These advancements include: the use of negative ion drift, electron counting with high-definition electronic readout, time projection chambers with optical readout, and the possibility for nuclear recoil tracking in high-density gases such as argon. We also discuss the readout and electronics systems needed to scale-up such detectors to the ton-scale and beyond