47 research outputs found
Predominant role of active versus facilitative glucose transport for glucagon-like peptide-1 secretion
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Matched triplicate design sets in the optimisation of glucokinase activators – maximising medicinal chemistry information content
No full textProperty based optimisation of glucokinase activators – discovery of the phase IIb clinical candidate AZD1656
No full textOvercoming retinoic acid receptor-α based testicular toxicity in the optimisation of glucokinase activators
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Matrix-based multiparameter optimisation of glucokinase activators: the discovery of AZD1092
No full textDecoration of an α-Resorcylate Nucleus as Part of the Manufacture of a Glucokinase Activator
No full textA chemistry wiki to facilitate and enhance compound design in drug discovery
No full textAt AstraZeneca a focus on hypothesis-driven design and the formation of drug design teams has placed a greater emphasis on collaboration in the drug discovery process. We have created a novel software tool based on the principles of wikis and social networks to facilitate collaborative working, visual planning and incorporation of predictive science to improve design capability. Monitoring the design and make process via the tool enabled the identification of bottlenecks and delays. Solutions to these problems were implemented, reducing the time taken from the initial idea stage to the generation of the synthesised compound by more than 50%
Glucokinase activators: molecular tools for studying the physiology of insulin-secreting cells
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