Phenotypic divergence along lines of genetic variance

Natural populations inhabiting the same environment often independently evolve the same phenotype. Is this replicated evolution a result of genetic constraints imposed by patterns of genetic covariation? We looked for associations between directions of morphological divergence and the orientation of the genetic variance-covariance matrix (G) by using an experimental system of morphological evolution in two allopatric nonsister species of rainbow fish. Replicate populations of both Melanotaenia eachamensis and Melanotaenia duboulayi have independently adapted to lake versus stream hydrodynamic environments. The major axis of divergence (z) among all eight study populations was closely associated with the direction of greatest genetic variance (g(max)), suggesting directional genetic constraint on evolution. However, the direction of hydrodynamic adaptation was strongly associated with vectors of G describing relatively small proportions of the total genetic variance, and was only weakly associated with g(max). In contrast, divergence between replicate populations within each habitat was approximately proportional to the level of genetic variance, a result consistent with theoretical predictions for neutral phenotypic divergence. Divergence between the two species was also primarily along major eigenvectors of G. Our results therefore suggest that hydrodynamic adaptation in rainbow fish was not directionally constrained by the dominant eigenvector of G. Without partitioning divergence as a consequence of the adaptation of interest (here, hydrodynamic adaptation) from divergence due to other processes, empirical studies are likely to overestimate the potential for the major eigenvectors of G to directionally constrain adaptive evolution

Evidence for a non-genomic action of testosterone in skeletal muscle which may improve athletic performance: Implications for the female athlete

This review will focus on the proposed second mode of testosterone action (now termed non-genomic) that appears to occur independently of the traditional transcriptional mechanism in mammalian skeletal muscle cells which may enhance skeletal muscle contractile properties. This mechanism of testosterone action differs from the traditional pathway, originating at the cell membrane, having a rapid onset of action, requiring second messengers to execute its effects and is insensitive to inhibitors of traditional androgen receptor action, transcription and protein synthesis. Importantly, unlike the traditional action of testosterone in skeletal muscle, this non-genomic pathway is shown to have a direct acute effect on calcium-dependent components important for the contractile process. The changes within the contractile apparatus may enhance the ability of the muscle to produce explosive power during athletic performance. Rapid increases in Inositol triphosphate mass and calcium release from the sarcoplasmic reticulum have been reported in rodent skeletal muscle cells, and a rapid androgen (dihydrotestosterone)- induced increase in peak force production has been recorded in intact rodent skeletal muscle fibre bundles while showing increases in the activity of the Ras/MAP/ERK mediated pathway. Because the non-genomic action of testosterone is enhanced during increases in exposure to testosterone and is acute in its action, implications for athletic performance are likely greater in females than males due to natural fluctuations in circulating testosterone levels during the female menstrual cycle, reproductive pathology, and changes induced by hormonal contraceptive methods. Research should be undertaken in humans to confirm a pathway for non-genomic testosterone action in human skeletal muscle. Specifically, relationships between testosterone fluctuations and physiological changes within skeletal muscle cells and whole muscle exercise performance need to be examined

Genetic Analysis of Female Preference Functions as Function-Valued Traits

The genetic analysis of female preferences has been seen as a particularly challenging empirical endeavor because of difficulties in generating suitable preference metrics in experiments large enough to adequately characterize variation. In this article, we take an alternative approach, treating female preference as a function-valued trait and exploiting random-coefficient models to characterize the genetic basis of female preference without measuring preference functions in each individual. Applying this approach to Drosophila bunnanda, in which females assess males through a multivariate contact pheromone system, we gain three valuable insights into the genetic basis of female preference functions. First, most genetic variation was attributable to one eigenfunction, suggesting shared genetic control of preferences for nine male pheromones. Second, genetic variance in female preference functions was not associated with genetic variance in the pheromones, implying that genetic variation in female preference did not maintain genetic variation in male traits. Finally, breeding values for female preference functions were skewed away from the direction of selection on the male traits, suggesting directional selection on female preferences. The genetic analysis of female preference functions as function-valued traits offers a robust statistical framework for investigations of female preference, in addition to alleviating some experimental difficulties associated with estimating variation in preference functions

Promoting Family Literacy: An Opportunity for Suburban University-Inner City Agency Resource Exchange

The Family Literacy Project is a preventive program designed to increase lower income children\u27s language readiness for school. The project\u27s approach to literacy enhancement involves both tutoring the children and training the parents to be more effective first teachers of the types of emergent reading skills that are prerequisites to formal elementary school reading instruction. Forty-five undergraduates were trained as literacy facilitators and met on a weekly basis with ninety preschoolers enrolled in Head start or with participating parents (N=20) . The specific tutoring of the children varied according to the child\u27s specific areas of language strengths and weaknesses. The parent training utilized the Parents as Partners in Reading literacy curriculum (Edwards, 1990)

Effects of two contrast training programs on jump performance in rugby union players during a competition phase

Purpose: There is little literature comparing contrast training programs typically performed by team-sport athletes within a competitive phase. We compared the effects of two contrast training programs on a range of measures in high-level rugby union players during the competition season. Methods: The programs consisted of a higher volume-load (strength-power) or lower volume-load (speed-power) resistance training; each included a tapering of loading (higher force early in the week, higher velocity later in the week) and was performed twice a week for 4 wk. Eighteen players were assessed for peak power during a bodyweight countermovement jump (BWCMJ), bodyweight squat jump (BWSJ), 50 kg countermovement jump (50CMJ), 50 kg squat jump (50SJ), broad jump (BJ), and reactive strength index (RSI; jump height divided by contact time during a depth jump). Players were then randomized to either training group and were reassessed following the intervention. Inferences were based on uncertainty in outcomes relative to thresholds for standardized changes. Results: There were small between-group differences in favor of strength-power training for mean changes in the 50CMJ (8%; 90% confidence limits, ±8%), 50SJ (8%; ±10%), and BJ (2%; ±3%). Differences between groups for BWCMJ, BWSJ, and reactive strength index were unclear. For most measures there were smaller individual differences in changes with strength-power training. Conclusion: Our findings suggest that high-level rugby union athletes should be exposed to higher volume-load contrast training which includes one heavy lifting session each week for larger and more uniform adaptation to occur in explosive power throughout a competitive phase of the season

Evaporation of a two-dimensional charged black hole

We construct a dilatonic two-dimensional model of a charged black hole. The classical solution is a static charged black hole, characterized by two parameters, $m$ and $q$, representing the black hole's mass and charge. Then we study the semiclassical effects, and calculate the evaporation rate of both $m$ and $q$, as a function of these two quantities. Analyzing this dynamical system, we find two qualitatively different regimes, depending on the electromagnetic coupling constant $g_{A}$. If the latter is greater than a certain critical value, the charge-to-mass ratio decays to zero upon evaporation. On the other hand, for $g_{A}$ smaller than the critical value, the charge-to-mass ratio approaches a non-zero constant that depends on $g_{A}$ but not on the initial values of $m$ and $q$.Comment: Latex, 30 pages, accepted for publication in Phys. Rev.