This is the world's hottest autumn on record - and it's impacting the climate system and human society

We are still getting used to a “new normal” of devastating summer heatwaves. But the effects of a warming climate are being felt throughout the year, and recent autumn months have been further off the charts than ever. In fact, climate change and an El Niño have both contributed to the world in 2023 having its hottest autumn since records began in 1850. September was 0.93°C above the 1991-2020 average, and a whole 1.75°C above the 1850-1900 pre-industrial reference period. October was also the hottest on record, at 0.85°C above the recent average. This hot autumn has already meant stronger storms and more intense rainfall and droughts. And this in turn affects farming, energy, tourism and other sectors that depend on reliable seasons

Water as an economic resource and the impacts of climate change on the hydrosphere, regional economies and Scotland

There is increasing evidence that the global climate is changing and that this will have implications for the future of water resources. The impacts of climate change will be transmitted primarily via the global hydrosphere, whereby changes in rainfall patterns and the frequency and magnitude of extreme weather conditions (e.g., flood and drought) will result in significant challenges, including for the way we access, manage and use freshwater resources. In addition, water demand will continue to rise to support a growing global population and its resultant increases in food and energy needs. There are likely to be variations across the globe in climate change impacts and these will further exacerbate existing spatial disparities in water availability. Water is a critical component for all aspects of life, and is particularly significant in many economic activities (e.g. agriculture, energy etc.). Changes in water availability and hydrological extremes will impact at regional and global scales on economic activity, supply chains, key industries and migration. While all regions of the world will be impacted by climate-induced water stress, regions with robust water policies and water management strategies, or at the leading edge of water-technologies may see opportunities. Here, we discuss the projected impacts of climate change on water resources, and the challenges and opportunities this poses for economic activities in Scotland, including Scotland’s readiness to adapt to changes in water availability

Structure-based discovery of glycomimetic FmlH ligands as inhibitors of bacterial adhesion during urinary tract infection

Significance The emergence of multidrug-resistant bacteria, including uropathogenic Escherichia coli (UPEC), makes the development of targeted antivirulence therapeutics a critical focus of research. During urinary tract infections (UTIs), UPEC uses chaperone–usher pathway pili tipped with an array of adhesins that recognize distinct receptors with sterochemical specificity to facilitate persistence in various tissues and habitats. We used an interdisciplinary approach driven by structural biology and synthetic glycoside chemistry to design and optimize glycomimetic inhibitors of the UPEC adhesin FmlH. These inhibitors competitively blocked FmlH in vitro, in in vivo mouse UTI models, and in ex vivo healthy human kidney tissue. This work demonstrates the utility of structure-driven drug design in the effort to develop antivirulence therapeutic compounds. </jats:p

Engaging stakeholders in research to address water-energy-food (WEF) nexus challenges

The water–energy–food (WEF) nexus has become a popular, and potentially powerful, frame through which to analyse interactions and interdependencies between these three systems. Though the case for transdisciplinary research in this space has been made, the extent of stakeholder engagement in research remains limited with stakeholders most commonly incorporated in research as end-users. Yet, stakeholders interact with nexus issues in a variety of ways, consequently there is much that collaboration might offer to develop nexus research and enhance its application. This paper outlines four aspects of nexus research and considers the value and potential challenges for transdisciplinary research in each. We focus on assessing and visualising nexus systems; understanding governance and capacity building; the importance of scale; and the implications of future change. The paper then proceeds to describe a novel mixed-method study that deeply integrates stakeholder knowledge with insights from multiple disciplines. We argue that mixed-method research designs—in this case orientated around a number of cases studies—are best suited to understanding and addressing real-world nexus challenges, with their inevitable complex, non-linear system characteristics. Moreover, integrating multiple forms of knowledge in the manner described in this paper enables research to assess the potential for, and processes of, scaling-up innovations in the nexus space, to contribute insights to policy and decision making

Scaling the nexus: towards integrated frameworks for analysing water, energy and food

The emergence of the water-energy-food (WEF) nexus concept following the 2011 Bonn Nexus Conference has resulted in a change to the way we perceive our natural resources. Global pressures such as climate change, and population growth have highlighted the fragility of our WEF systems, necessitating integrated solutions across multiple scales and levels. Whilst a number of frameworks and analytical tools have been developed since 2011, a comprehensive WEF nexus tool remains elusive, hindered in part by our limited data and understanding of the interdependencies and connections across the WEF systems. To achieve this, the community of academics, practitioners and policy-makers invested in WEF nexus research are addressing several critical areas that currently remain as barriers. Firstly, the plurality of scales (e.g., spatial, temporal, institutional, jurisdictional) necessitates a more comprehensive effort to assess interdependencies between water, energy and food, from household to institutional and national levels. Secondly, and closely related to scale, a lack of available data often hinders our ability to quantify physical stocks and flows of resources. In this paper, we elucidate many of the challenges that have arisen across nexus research, including the impact of multiple scales in operation across the nexus, and concomitantly, what impact these scales have on data accessibility. We review some of the critical frameworks and tools that are applied by nexus researchers and discuss some of the steps required to develop from nexus thinking to an operationalizable concept, with a consistent focus on scale and data availability

Bitter taste sensitivity in domestic dogs ( Canis familiaris ) and its relevance to bitter deterrents of ingestion

As the most favoured animal companion of humans, dogs occupy a unique place in society. Understanding the senses of the dog can bring benefits to both the dogs themselves and their owners. In the case of bitter taste, research may provide useful information on sensitivity to, and acceptance of, diets containing bitter tasting materials. It may also help to protect dogs from the accidental ingestion of toxic substances, as in some instances bitter tasting additives are used as deterrents to ingestion. In this study we examined the receptive range of dog bitter taste receptors (Tas2rs). We found that orthologous dog and human receptors do not always share the same receptive ranges using in vitro assays. One bitter chemical often used as a deterrent, denatonium benzoate, is only moderately active against dTas2r4, and is almost completely inactive against other dog Tas2rs, including dTas2r10, a highly sensitive receptor in humans. We substituted amino acids to create chimeric dog-human versions of the Tas2r10 receptor and found the ECL2 region partly determined denatonium sensitivity. We further confirmed the reduced sensitivity of dogs to this compound in vivo. A concentration of 100μM (44.7ppm) denatonium benzoate was effective as a deterrent to dog ingestion in a two-bottle choice test indicating higher concentrations may increase efficacy for dogs. These data can inform the choice and concentration of bitter deterrents added to toxic substances to help reduce the occurrence of accidental dog poisonings

Predicting microbial water quality with models: Over-arching questions for managing risk in agricultural catchments

The application of models to predict concentrations of faecal indicator organisms (FIOs) in environmental systems plays an important role for guiding decision-making associated with the management of microbial water quality. In recent years there has been an increasing demand by policy-makers for models to help inform FIO dynamics in order to prioritise efforts for environmental and human-health protection. However, given the limited evidence-base on which FIO models are built relative to other agricultural pollutants (e.g. nutrients) it is imperative that the end-user expectations of FIO models are appropriately managed. In response, this commentary highlights four over-arching questions associated with: (i) model purpose; (ii) modelling approach; (iii) data availability; and (iv) model application, that must be considered as part of good practice prior to the deployment of any modelling approach to predict FIO behaviour in catchment systems. A series of short and longer-term research priorities are proposed in response to these questions in order to promote better model deployment in the field of catchment microbial dynamics

Scaling the nexus: Towards integrated frameworks for analyzing water, energy and food

The emergence of the water-energy-food (WEF) nexus has resulted in changes to the way we perceive our natural resources. Stressors such as climate change and population growth have highlighted the fragility of our WEF systems, necessitating integrated solutions across multiple scales. Whilst a number of frameworks and analytical tools have been developed since 2011, a comprehensive WEF nexus tool remains elusive, hindered in part by our limited data and understanding of the interdependencies and connections across the WEF systems. To achieve this, the community of academics, practitioners and policy-makers invested in WEF nexus research are addressing several critical areas that currently remain as barriers. Firstly, the plurality of scales (e.g., spatial, temporal, institutional, jurisdictional) necessitates a more comprehensive effort to assess interdependencies between water, energy and food, from household to institutional and national levels. Secondly, and closely related to scale, a lack of available data often hinders our ability to quantify physical stocks and flows of resources. Overcoming these barriers necessitates engaging multiple stakeholders, and using experiences and local insights to better understand nexus dynamics in particular locations or scenarios, and we exemplify this with the inclusion of a UK-based case-study on exploring the nexus in a particular geographical area. We elucidate many challenges that have arisen across nexus research, including the impact of multiple scales in operation, and concomitantly, what impact these scales have on data accessibility. We assess some of the critical frameworks and tools that are applied by nexus researchers and articulate some of the steps required to develop from nexus thinking to an operationalizable concept, with a consistent focus on scale and data availability

Impacts of urbanisation on hydrological and water quality dynamics, and urban water management : a review

As urban space continues to expand to accommodate a growing global population, there remains a real need to quantify and qualify the impacts of urban space on natural processes. The expansion of global urban areas has resulted in marked alterations to natural processes, environmental quality and natural resource consumption. The urban landscape influences infiltration and evapotranspiration, complicating our capacity to quantify their dynamics across a heterogeneous landscape at contrasting scales. Impervious surfaces exacerbate runoff processes, whereas runoff from pervious areas remains uncertain owing to variable infiltration dynamics. Increasingly, the link between the natural hydrological cycle and engineered water cycle has been made, realising the contributions from leaky infrastructure to recharge and runoff rates. Urban landscapes are host to a suite of contaminants that impact on water quality, where novel contaminants continue to pose new challenges to monitoring and treatment regimes. This review seeks to assess the major advances and remaining challenges that remain within the growing field of urban hydrology