The most efficient and effective ways to address new literacies for the 21st century classroom

The purpose of this study is to provide an extensive review of literature that focuses on the most efficient and effective ways to implement new literacies in the classroom. It focuses on how to maximize the impact of new literacies instruction on student learning through curriculum, and professional development and discusses the impact of new literacies on student motivation. The thesis provides information on how to define new literacies and discusses the impact they are having on the school environment and learning process. It discusses the importance of new literacies and why they should be integrated into today\u27s classroom. The literature focuses on existing curriculum development approaches that can be beneficial to developing a new literacies curriculum. The literature review finishes with the benefits of motivation and engagement of students with new literacies. Finally, the thesis finishes with considerations for practices and professional development that will allow for successful implementation of new literacies in the classroom. Implementation of new literacies is essential to develop skills and strategies students will need to utilize in order to be successful in the 21st Century

Working at the Speed of Innovation: Impedance Mismatch in Rapid and Innovation Projects

In this paper we report on the results of an ethnographic study of a rapid design innovation (RDI) experiment in NASA Aeronautics. This work is based on the study of the Aeronautics Autonomy Testbed Capability (AATC) team in the Convergent Aeronautics Solutions (CAS) project. This paper focuses on and summarizes one of the key over-arching findings from the study: there is a significant mismatch in the organizational culture in the rest of the organization compared with that required for RDI. And, if this organizational cultural mismatch is not addressed, the likelihood of any organization being able to advance a new and different type of work (such as RDI) will be jeopardized. We delineate several aspects of the two different cultures identified in order to enable leaders and practitioners to better understand what contributes to the cultural dissonance and the implications of the differences in the cultures. As well, we identify ways in which those differences can be addressed. Research from organization and other social sciences are incorporated to highlight the differences. The implications of the research suggest that the significant cultural differences trigger a strong and resistive response from the dominant culture that may negate leaderships strategy to build the new capacity for RDI. While the research results noted the pervasive nature of innovation throughout the workplace, the type of innovation envisioned in RDI is a rare type of innovation that requires significantly new methods, work processes, tools, and skills such that approaches used in the dominate culture cannot be adopted by expediting the existing approaches. Examples include: innovation teaming and leadership; the need for adaptive leadership that changes the relationship of a research leader to the other researchers; and, an interdisciplinary teaming approach which shapes team relationships and activities. Each of these aspects requires new teaming, tools, and skills in order to succeed. Thus, when introducing RDI activities where there is a different dominant culture, teams need to be: well trained; protected; recognized and rewarded. And, team leaders must also be trained in the unique types of teaming and innovation tools used in RDI. Both RDI teaming and team leadership must be sanctioned, supported, and rewarded by leadership. Because of the cultural mismatch, in some organizations looking to add RDI to their existing and established organizations, sep to avoid or mitigate the negative impact of the culture mismatch

Maussollos’s Mnema

Undoubtedly the most renowned example of intramural burial in antiquity was the Maussolleion at Halicarnassus. Since its rediscovery within the writing of Vitruvius, Pliny and other ancient authors by Renaissance architects its form has been a frequent subject of speculation. The results of the archaeological campaigns of the 19th and 20th centuries have allowed the discussion to encompass an aesthetic evaluation of the temple-tomb’s actual remains. The Maussolleion’s seemingly disparate assortment of architectural forms, which samples motifs from prominent Mediterranean cultures (Lykian podium, Greek temple, and Egyptian pyramid) has been characterized as the ultimate statement in bad taste by a self-aggrandizing satrap. In order, however, to understand the architect’s and patron’s intentions it is necessary to reach beyond the superficial reading of the Maussolleion as an omnium-gatherum of architectural and sculptural ornament. An analysis of the iconography of the architectural and sculptural elements which (according to Roman sources and corroborated by archaeological evidence) were combined in the Mausolleion’s design reveals that the motifs were chosen to bring to mind, and to improve on previous, well- known building programs. Not only does the temple architecture central to the design justify the building visually as a place of worship, but specific architectural forms and sculptural subjects appear to draw on the religious buildings of the most important city of the Mediterranean in the 5th century BC, Athens. In the case of the Mausolleion it is a question not of Maussollos’s (or his architect’s) lack of understanding of the conventions that govern architectural forms and styles, but rather of a highly informed, positive solution to the unusual problem of how to incorporate a massive burial monument within the walls of the redesigned city of Halikarnassos, promote Maussollos on a divine scale, and signal Halikarnassos as a major urban center of the Mediterranean in the 4th century BC

Incorporating range uncertainty into proton therapy treatment planning

This dissertation addresses the issue of robustness in proton therapy treatment planning for cancer treatment. Proton therapy is considered to be advantageous in treating most childhood cancers and certain adult cancers, including those of the skull base, spine and head and neck. Protons, unlike X-rays, have a finite range highly dependent on the electron density of the material they are traversing, resulting in a steep dose gradient at the distal edge of the Bragg peak. These characteristics, together with advancements in computation and technology have led to the ability to plan and deliver treatments with greater conformality, sparing normal tissue and organs at risk. Radiotherapy treatment plans aim to meet set dosimetric constraints, and meet them at every fraction. Plan robustness is a measure of deviation between the delivered dose distribution and the planned dose distribution. Due to the same characteristics that make protons advantageous, conventional means of using margins to create a Planning Target Volume (PTV) to ensure plan robustness are inadequate. Additional to this, without a PTV, a new method of analysing plan quality is required in proton therapy. My original contribution to the knowledge in this area is the demonstration of how site- and centre- specific robustness constraints can be established. Robustness constraints can be used both for proton plan analysis and to identify patients that require plans of greater individualisation. I have also used the daily volumetric imaging from patients previously treated with conventional radiotherapy to quantify range uncertainty from inter- and intra-fraction motion. These new methods of both quantifying and analysing the change in proton range in the patient can aid in the choice of beam directions, provide input into a multi- criteria optimisation algorithm or can be used as criteria to determine when adaptive planning may be required. This greater understanding in range uncertainty better informs the planner on how best to balance the trade-off between plan conformality and robustness in proton therapy. This research is directly relevant to furthering the knowledge base in light of HM Government pledging £250 million to build two proton centres in England, to treat NHS patients from 2018. Use of methods described in this dissertation will aid in the establishment of clear and pre-defined protocols for treating patients in the future.This work was supported by a Medical Research Council Doctoral Training Grant

Linking Health Information Technology to Patient Safety and Quality Outcomes: A Bibliometric Analysis and Review

Informatics for Health and Social Care is published by Informa Healthcare. Publisher's version can be found at: http://informahealthcare.com/doi/abs/10.3109/17538157.2012.678451OBJECTIVE: To assess the scholarly output of grants funded by the Agency for Healthcare Research and Quality (AHRQ) that published knowledge relevant to the impact of health information technologies on patient safety and quality of care outcomes. STUDY DESIGN: We performed a bibliometric analysis of the identified scholarly articles, their journals, and citations. In addition, we performed a qualitative review of the full-text articles and grant documents. DATA COLLECTION/EXTRACTION METHODS: Papers published by AHRQ-funded investigators were retrieved from MEDLINE, journal impact factors were extracted from the 2010 Thompson Reuters Journal Citation Report, citations were retrieved from ISI's Web of Knowledge and Google Scholar. PRINCIPAL FINDINGS: Seventy-two articles met the criteria for review. Most articles addressed one or more of AHRQ's outcome goals and focus priorities. The average impact factor for the journals was 4.005 (range: 0.654-28.899). The articles, and their respective grants, represented a broad range of health information technologies. CONCLUSIONS: This set of AHRQ-funded research projects addressed the goals and priorities of AHRQ, indicating notable contributions to the scientific knowledge base on the impact of information system use in healthcare.This work was supported, in part, by the National Resource Center of the Agency for Healthcare Research and Quality, contract number 290-04-0016

Mass deworming to improve developmental health and wellbeing of children in low-income and middle-income countries: a systematic review and network meta-analysis

Background: Soil-transmitted helminthiasis and schistosomiasis, considered among the neglected tropical diseases by WHO, affect more than a third of the world’s population, with varying intensity of infection. We aimed to evaluate the eff ects of mass deworming for soil-transmitted helminths (with or without deworming for schistosomiasis or cointerventions) on growth, educational achievement, cognition, school attendance, quality of life, and adverse effects in children in endemic helminth areas. Methods: We searched 11 databases up to Jan 14, 2016, websites and trial registers, contacted authors, and reviewed reference lists. We included studies published in any language of children aged 6 months to 16 years, with mass deworming for soil-transmitted helminths or schistosomiasis (alone or in combination with other interventions) for 4 months or longer, that reported the primary outcomes of interest. We included randomized and quasi-randomized trials, controlled before–after studies, interrupted time series, and quasi-experimental studies. We screened in duplicate, then extracted data and appraised risk of bias in duplicate with a pre-tested form. We conducted random effects meta-analysis and Bayesian network meta-analysis. Findings: We included 52 studies of duration 5 years or less with 1 108 541 children, and four long-term studies 8–10 years after mass deworming programmes with more than 160 000 children. Overall risk of bias was moderate. Mass deworming for soil-transmitted helminths compared with controls led to little to no improvement in weight over a period of about 12 months (0·99 kg, 95% credible interval [CrI] −0·09 to 0·28; moderate certainty evidence) or height (0·07 cm, 95% CrI −0·10 to 0·24; moderate certainty evidence), little to no difference in proportion stunted (eight fewer per 1000 children, 95% CrI −48 to 32; high certainty evidence), cognition measured by short-term attention (−0·23 points on a 100 point scale, 95% CI −0·56 to 0·14; high certainty evidence), school attendance (1% higher, 95% CI −1 to 3; high certainty evidence), or mortality (one fewer per 1000 children, 95% CI −3 to 1; high certainty evidence). We found no data on quality of life and little evidence of adverse effects. Mass deworming for schistosomiasis might slightly increase weight (0·41 kg, 95% CrI −0·20 to 0·91) and has little to no effect on height (low certainty evidence) and cognition (moderate certainty evidence). Our analyses do not suggest indirect benefits for untreated children from being exposed to treated children in the community. We are uncertain about effects on long-term economic productivity (hours worked), cognition, literacy, and school enrolment owing to very low certainty evidence. Results were consistent across sensitivity and subgroup analyses by age, worm prevalence, baseline nutritional status, infection status, impact on worms, infection intensity, types of worms (ascaris, hookworm, or trichuris), risk of bias, cluster versus individual trials, compliance, and attrition. Interpretation: Mass deworming for soil-transmitted helminths with or without deworming for schistosomiasis had little eff ect. For schistosomiasis, mass deworming might be eff ective for weight but is probably ineffective for height, cognition, and attendance. Future research should assess which subset of children do benefit from mass deworming, if any, using individual participant data meta-analysis

Novel penalised likelihood reconstruction of PET in the assessment of histologically verified small pulmonary nodules

OBJECTIVES: Investigate the effect of a novel Bayesian penalised likelihood (BPL) reconstruction algorithm on analysis of pulmonary nodules examined with 18F-FDG PET/CT, and to determine its effect on small, sub-10-mm nodules. METHODS: 18F-FDG PET/CTs performed for nodule evaluation in 104 patients (121 nodules) were retrospectively reconstructed using the new algorithm, and compared to time-of-flight ordered subset expectation maximisation (OSEM) reconstruction. Nodule and background parameters were analysed semi-quantitatively and visually. RESULTS: BPL compared to OSEM resulted in statistically significant increases in nodule SUV(max) (mean 5.3 to 8.1, p < 0.00001), signal-to-background (mean 3.6 to 5.3, p < 0.00001) and signal-to-noise (mean 24 to 41, p < 0.00001). Mean percentage increase in SUV(max) (%ΔSUV(max)) was significantly higher in nodules ≤10 mm (n = 31, mean 73 %) compared to >10 mm (n = 90, mean 42 %) (p = 0.025). Increase in signal-to-noise was higher in nodules ≤10 mm (224 %, mean 12 to 27) compared to >10 mm (165 %, mean 28 to 46). When applying optimum SUV(max) thresholds for detecting malignancy, the sensitivity and accuracy increased using BPL, with the greatest improvements in nodules ≤10 mm. CONCLUSION: BPL results in a significant increase in signal-to-background and signal-to-noise compared to OSEM. When semi-quantitative analyses to diagnose malignancy are applied, higher SUV(max) thresholds may be warranted owing to the SUV(max) increase compared to OSEM. KEY POINTS: • Novel Bayesian penalised likelihood PET reconstruction was applied for lung nodule evaluation. • This was compared to current standard of care OSEM reconstruction. • The novel reconstruction generated significant increases in lung nodule signal-to-background and signal-to-noise. • These increases were highest in small, sub-10-mm pulmonary nodules. • Higher SUV(max)thresholds may be warranted when using semi-quantitative analyses to diagnose malignancy

A Comprehensive Summary of Services and Resources Provided by Librarians in support of CODA Accredited Predoctoral (DDS/DMD) Dental Education Programs in the United States and Canada

Objective The objective of this study is to provide a summary of library services and resources that support dental education and research. This summary will demonstrate trends in dental librarianship as well as services and resources that can be adopted to serve the needs of dental related education programs. To date, there has not been a comprehensive summary of these services. Methods An environmental scan was carried out to take inventory of services that dental librarians (1) provide. The study population consisted of librarians who work in dental libraries or college / university libraries that serve dental programs. The librarians surveyed were from institutions with a CODA accredited DMD/DDS pre-doctoral program (2). Currently, there are 76 such programs within the United States and Canada, of which 71 responded. Conclusion Our data demonstrates that the majority of dental programs have a dedicated librarian or library liaison providing clinical, educational, and research support through a variety of approaches. Increasing awareness and utilization of available services and resources within the dental community can facilitate research and complement dental education. The service models cited here can be adapted in dental related education programs across North America