Integrating Analysis Into a Warehouse Design Workflow

Supply chain analyses, including those related to material handling systems, are typically purpose-built to answer specific questions and therefore have many different implementations depending on the question, the instance data, and the solver. The purpose-built nature of these models makes it difficult to integrate them into an iterative design workflow. Despite the myriad analysis implementations, the fundamental structure of these systems and their problem domain remains unchanged, suggesting that perhaps analyses could be automatically generated on demand, given an appropriate specification of the particular system to be analyzed. We apply model-based systems engineering (MBSE) methodologies to explore this possibility in the context of functional warehouse design

Toward an Engineering Discipline of Warehouse Design

Warehouses today are complex dynamic engineered systems, incorporating automation, mechanization, equipment, fixtures, computers, networks, products and people, and they can support the flow of tens or hundreds of thousands of different items to enable fulfilling thousands or tens of thousands of orders daily. In that sense, they represent a design challenge that is not terribly different from the design of other complex dynamic engineered systems, such as a modern passenger airplane, an automobile, or a unique building. What is different is that the design of these other complex dynamic engineered systems typically follows some engineering design discipline. Here, we argue for the development of a corresponding engineering discipline of warehouse design

Operational Phase Life Cycle Assessment of Select NASA Ground Test Facilities

NASA's Aeronautics Test Program (ATP) is responsible for many large, high-energy ground test facilities that accomplish the nation s most advanced aerospace research. In order to accomplish these national objectives, significant energy and resources are consumed. A select group of facilities was analyzed using life-cycle assessment (LCA) to determine carbon footprint and environmental impacts. Most of these impacts stem from electricity and natural gas consumption, used directly at the facility and to generate support processes such as compressed air and steam. Other activities were analyzed but determined to be smaller in scale and frequency with relatively negligible environmental impacts. More specialized facilities use R-134a, R-14, jet fuels, or nitrogen gas, and these unique inputs can have a considerable effect on a facility s overall environmental impact. The results of this LCA will be useful to ATP and NASA as the nation looks to identify its top energy consumers and NASA looks to maximize research output and minimize environmental impact. Keywords: NASA, Aeronautics, Wind tunnel, Keyword 4, Keyword

Remote tire pressure sensing technique

A remote tire pressure sensing technique is provided which uses vibration frequency to determine tire pressure. A vibration frequency measuring device is attached to the external surface of a tire which is then struck with an object, causing the tire to vibrate. The frequency measuring device measures the vibrations and converts the vibrations into corresponding electrical impulses. The electrical impulses are then fed into the frequency analyzing system which uses the electrical impulses to determine the relative peaks of the vibration frequencies as detected by the frequency measuring device. The measured vibration frequency peaks are then compared to predetermined data describing the location of vibration frequency peaks for a given pressure, thereby determining the air pressure of the tire

Survival Outcomes of Pancreatic Intraepithelial Neoplasm (PanIN) versus Intraductal Papillary Mucinous Neoplasm (IPMN) Associated Pancreatic Adenocarcinoma

A grant from the One-University Open Access Fund at the University of Kansas was used to defray the author's publication fees in this Open Access journal. The Open Access Fund, administered by librarians from the KU, KU Law, and KUMC libraries, is made possible by contributions from the offices of KU Provost, KU Vice Chancellor for Research & Graduate Studies, and KUMC Vice Chancellor for Research. For more information about the Open Access Fund, please see http://library.kumc.edu/authors-fund.xml.Pancreatic intraepithelial neoplasms (PanINs) and intraductal papillary mucinous neoplasms (IPMNs) are common pancreatic adenocarcinoma precursor lesions. However, data regarding their respective associations with survival rate and prognosis are lacking. We retrospectively evaluated 72 pancreatic adenocarcinoma tumor resection patients at the University of Kansas Hospital between August 2009 and March 2019. Patients were divided into one of two groups, PanIN or IPMN, based on the results of the surgical pathology report. We compared baseline characteristics, overall survival (OS), and progression free survival (PFS) between the two groups, as well as OS and PFS based on local or distant tumor recurrence for both groups combined. 52 patients had PanINs and 20 patients had IPMNs. Patients who had an IPMN precursor lesion had better median PFS and OS when compared to patients with PanIN precursor lesions. However, the location of tumor recurrence (local or distant) did not show a statistically significant difference in OS

Longitudinal trends in causes of death among adults with HIV on antiretroviral therapy in Europe and North America from 1996 to 2020: a collaboration of cohort studies

Background Mortality rates among people with HIV have fallen since 1996 following the widespread availability of effective antiretroviral therapy (ART). Patterns of cause-specific mortality are evolving as the population with HIV ages. We aimed to investigate longitudinal trends in cause-specific mortality among people with HIV starting ART in Europe and North America. Methods In this collaborative observational cohort study, we used data from 17 European and North American HIV cohorts contributing data to the Antiretroviral Therapy Cohort Collaboration. We included data for people with HIV who started ART between 1996 and 2020 at the age of 16 years or older. Causes of death were classified into a single cause by both a clinician and an algorithm if International Classification of Diseases, Ninth Revision or Tenth Revision data were available, or independently by two clinicians. Disagreements were resolved through panel discussion. We used Poisson models to compare cause-specific mortality rates during the calendar periods 1996-99, 2000-03, 2004-07, 2008-11, 2012-15, and 2016-20, adjusted for time-updated age, CD4 count, and whether the individual was ART -naive at the start of each period. Findings Among 189 301 people with HIV included in this study, 16 832 (8 center dot 9%) deaths were recorded during 1 519 200 person-years of follow-up. 13 180 (78 center dot 3%) deaths were classified by cause: the most common causes were AIDS (4203 deaths; 25 center dot 0%), non-AIDS non -hepatitis malignancy (2311; 13 center dot 7%), and cardiovascular or heart-related (1403; 8 center dot 3%) mortality. The proportion of deaths due to AIDS declined from 49% during 1996-99 to 16% during 2016-20. Rates of all-cause mortality per 1000 person-years decreased from 16 center dot 8 deaths (95% CI 15 center dot 4-18 center dot 4) during 1996-99 to 7 center dot 9 deaths (7 center dot 6-8 center dot 2) during 2016-20. Rates of all-cause mortality declined with time: the average adjusted mortality rate ratio per calendar period was 0 center dot 85 (95% CI 0 center dot 84-0 center dot 86). Rates of cause-specific mortality also declined: the most pronounced reduction was for AIDS-related mortality (0 center dot 81; 0 center dot 79-0 center dot 83). There were also reductions in rates of cardiovascular-related (0 center dot 83, 0 center dot 79-0 center dot 87), liver-related (0 center dot 88, 0 center dot 84-0 center dot 93), non-AIDS infectionrelated (0 center dot 91, 0 center dot 86-0 center dot 96), non-AIDS-non-hepatocellular carcinoma malignancy-related (0 center dot 94, 0 center dot 90-0 center dot 97), and suicide or accident-related mortality (0 center dot 89, 0 center dot 82-0 center dot 95). Mortality rates among people who acquired HIV through injecting drug use increased in women (1 center dot 07, 1 center dot 00-1 center dot 14) and decreased slightly in men (0 center dot 96, 0 center dot 93-0 center dot 99). Interpretation Reductions of most major causes of death, particularly AIDS-related deaths among people with HIV on ART, were not seen for all subgroups. Interventions targeted at high-risk groups, substance use, and comorbidities might further increase life expectancy in people with HIV towards that in the general population. Funding US National Institute on Alcohol Abuse and Alcoholism. Copyright (c) 2024 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license

Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

The major histocompatibility complex (MHC) on chromosome 6 is associated with susceptibility to more common diseases than any other region of the human genome, including almost all disorders classified as autoimmune. In type 1 diabetes the major genetic susceptibility determinants have been mapped to the MHC class II genes HLA-DQB1 and HLA-DRB1 (refs 1-3), but these genes cannot completely explain the association between type 1 diabetes and the MHC region. Owing to the region's extreme gene density, the multiplicity of disease-associated alleles, strong associations between alleles, limited genotyping capability, and inadequate statistical approaches and sample sizes, which, and how many, loci within the MHC determine susceptibility remains unclear. Here, in several large type 1 diabetes data sets, we analyse a combined total of 1,729 polymorphisms, and apply statistical methods - recursive partitioning and regression - to pinpoint disease susceptibility to the MHC class I genes HLA-B and HLA-A (risk ratios >1.5; Pcombined = 2.01 × 10-19 and 2.35 × 10-13, respectively) in addition to the established associations of the MHC class II genes. Other loci with smaller and/or rarer effects might also be involved, but to find these, future searches must take into account both the HLA class II and class I genes and use even larger samples. Taken together with previous studies, we conclude that MHC-class-I-mediated events, principally involving HLA-B*39, contribute to the aetiology of type 1 diabetes. ©2007 Nature Publishing Group

Panel 3 (rescheduled) - Political Ideologies and Political Identities in Post-Atrocity Transitions

A focus on ideological fanaticism and long-standing hatreds between identity-groups dominates media depictions of genocides, crimes against humanity and other atrocities, yet is widely rejected in academic scholarship. In recent years, however, scholars have increasingly offered more nuanced perspectives on political ideologies and identities, that emphasise the important but multifaceted ways in which they can promote atrocity-perpetration. Considerably less studied, however, is the role that political ideologies and identities developed before and during conflict play in the post-atrocity transition. As such, this panels aims to approach following overarching question: How do political ideologies and political identities affect the trajectories of post-atrocity transitions? As such, this panel seeks to incorporate a temporal dimension to the topic of political ideologies and identities in post-atrocity transitions, taking under scrutiny not just the transitions themselves, but the trajectories they have taken out of the violence itself and how the ideologies and identities transform themselves, remain the same or are replaced within this context and what implications this has. This panel will thus contribute to a number of key current literatures in social scientific research on ideas, identity and conflict. First, the panel will contribute to the rapid recent growth of research on political ideology, especially concerning the still understudied dynamics of ideological change. Second, the panel will make similar contributions to the extensive literature on identity, conflict and post-conflict reconstruction, particularly speaking to recent research on the way in which identities evolve during conflict, as fluid identity categories are activated, mobilised, and radicalised under conditions of crisis and threat. Third, the panel will contribute to the burgeoning literature on post-atrocity transitional justice, augmenting it by this explicit perspective on ideologies and identities. Fourth, and finally, the panel will contribute to the memory turn in political science research, highlighting the contentious nature of post-atrocity memory politics, particularly showing how identities are manipulated for political gain, drawing on various extant and (re-)created political identities