A review of cryogenic testing performed by the thermochemical test branch, Manned Spacecraft Center in support of Apollo 13 and14

The Apollo 13 anomaly provided considerable impetus for a variety of types of cryogenic and ignition tests. The logic of the various test program designs, the test techniques, and their final impact upon the investigation findings are described. In addition, several test programs initiated to determine the thermal performance and general performance characteristics of the redesigned Apollo 14 cryogenic storage system are presented

A system for synthetic vision and augmented reality in future flight decks

Rockwell Science Center is investigating novel human-computer interaction techniques for enhancing the situational awareness in future flight decks. One aspect is to provide intuitive displays that provide the vital information and the spatial awareness by augmenting the real world with an overlay of relevant information registered to the real world. Such Augmented Reality (AR) techniques can be employed during bad weather scenarios to permit flying in Visual Flight Rules (VFR) in conditions which would normally require Instrumental Flight Rules (IFR). These systems could easily be implemented on heads-up displays (HUD). The advantage of AR systems vs. purely synthetic vision (SV) systems is that the pilot can relate the information overlay to real objects in the world, whereas SV systems provide a constant virtual view, where inconsistencies can hardly be detected. The development of components for such a system led to a demonstrator implemented on a PC. A camera grabs video images which are overlaid with registered information. Orientation of the camera is obtained from an inclinometer and a magnetometer; position is acquired from GPS. In a possible implementation in an airplane, the on-board attitude information can be used for obtaining correct registration. If visibility is sufficient, computer vision modules can be used to fine-tune the registration by matching visual cues with database features. This technology would be especially useful for landing approaches. The current demonstrator provides a frame-rate of 15 fps, using a live video feed as background with an overlay of avionics symbology in the foreground. In addition, terrain rendering from a 1 arc sec. digital elevation model database can be overlaid to provide synthetic vision in case of limited visibility. For true outdoor testing (on ground level), the system has been implemented on a wearable computer

SmokeFree Sports Project Report

Children and young people are amongst the most vulnerable groups in society and are highly susceptible to smoking experimentation and addiction. In Liverpool, smoking prevalence is significantly higher than the UK average. Therefore early intervention strategies are required for smoking prevention and cessation. Research has found a negative association between smoking and physical activity. SmokeFree Sports aims to explore whether physical activity and sport can be used to promote the smoke free message to children and young people. SmokeFree Sports is an innovative multi-dimensional campaign that incorporates social-marketing strategies alongside the provision of sports and physical activities to: a) de-normalise smoking among youth b) empower youth to stay smoke free, and c) increase awareness of the dangers of smoking using positive messaging through the medium of sport and physical activity. This project is delivered across Liverpool and aims to reduce the prevalence of smoking and prevent the uptake of smoking in children and young people. The initiative, which is managed by Liverpool John Moores University in partnership with Liverpool PCT, employs a variety of strategies to promote and deliver the smoke free message to children and young people including a) training sports coaches and teachers to deliver the smoke free message, b) delivering SFS messages in schools and youth clubs through sport and physical activity, c) asking children to sign a pledge to be smoke free, d) support voluntary sports clubs to adopt a smoke free policy on their playing fields, e) encouraging organizations and individuals interested in health and sport to sign up to the SmokeFree Sports Charter and f) signposting children to smoking cessation services

New postnatal urinary incontinence: obstetric and other risk factors in primparae.

Objective To identify obstetric and other risk factors for urinary incontinence which occurs during pregnancy or after childbirth. Design Questionnaire survey of women. Setting Maternity units in Aberdeen (Scotland), Birmingham (England) and Dunedin (New Zealand). Population 3405 primiparous women with singleton births delivered during one year. Methods Questionnaire responses and obstetric casenote data were analysed using multivariate analysis to identify associations with urinary incontinence. Main outcome measures Urinary incontinence at three months after delivery first starting in pregnancy or after birth. Results The prevalence of urinary incontinence was 29%. New incontinence first beginning after delivery was associated with higher maternal age (oldest versus youngest group, odds ratio, OR 2.02, 95% CI 1.35 to 3.02); and method of delivery (caesarean section versus spontaneous vaginal delivery, OR 0.28, 95% CI 0.19 to 0.41). There were no significant associations with forceps delivery (OR 1.18, 95% CI 0.92 to 1.51) or vacuum delivery (OR 1.16, 95% CI 0.83 to 1.63). Incontinence first occurring during pregnancy and still present at three months was associated with higher maternal body mass index (BMI > 25, OR 1.68, 95% CI 1.16 to 2.43), and heavier babies (birthweight in top quartile, OR 1.56, 95% CI 1.12 to 2.19). In these women, caesarean section was associated with less incontinence (OR 0.39, 95% CI 0.27 to 0.58) but incontinence was not associated with age. Conclusions Women have less urinary incontinence after a first delivery by caesarean section whether or not that first starts during pregnancy. Older maternal age was associated with new postnatal incontinence, and higher body mass index and heavier babies with incontinence first starting during pregnancy. The effect of further deliveries may modify these findings

Auxiliary Subunit GSG1L Acts to Suppress Calcium-Permeable AMPA Receptor Function

UNLABELLED: AMPA-type glutamate receptors are ligand-gated cation channels responsible for a majority of the fast excitatory synaptic transmission in the brain. Their behavior and calcium permeability depends critically on their subunit composition and the identity of associated auxiliary proteins. Calcium-permeable AMPA receptors (CP-AMPARs) contribute to various forms of synaptic plasticity, and their dysfunction underlies a number of serious neurological conditions. For CP-AMPARs, the prototypical transmembrane AMPAR regulatory protein stargazin, which acts as an auxiliary subunit, enhances receptor function by increasing single-channel conductance, slowing channel gating, increasing calcium permeability, and relieving the voltage-dependent block by endogenous intracellular polyamines. We find that, in contrast, GSG1L, a transmembrane auxiliary protein identified recently as being part of the AMPAR proteome, acts to reduce the weighted mean single-channel conductance and calcium permeability of recombinant CP-AMPARs, while increasing polyamine-dependent rectification. To examine the effects of GSG1L on native AMPARs, we manipulated its expression in cerebellar and hippocampal neurons. Transfection of GSG1L into mouse cultured cerebellar stellate cells that lack this protein increased the inward rectification of mEPSCs. Conversely, shRNA-mediated knockdown of endogenous GSG1L in rat cultured hippocampal pyramidal neurons led to an increase in mEPSC amplitude and in the underlying weighted mean single-channel conductance, revealing that GSG1L acts to suppress current flow through native CP-AMPARs. Thus, our data suggest that GSG1L extends the functional repertoire of AMPAR auxiliary subunits, which can act not only to enhance but also diminish current flow through their associated AMPARs. SIGNIFICANCE STATEMENT: Calcium-permeable AMPA receptors (CP-AMPARs) are an important group of receptors for the neurotransmitter glutamate. These receptors contribute to various forms of synaptic plasticity, and alterations in their expression or regulation are also seen in a number of serious neurological conditions, including stroke, motor neuron disease, and cocaine addiction. Several groups of auxiliary transmembrane proteins have been described that enhance the function and cell-surface expression of AMPARs. We now report that the recently identified auxiliary protein GSG1L decreases weighted mean channel conductance and calcium permeability of CP-AMPARs while increasing polyamine-dependent rectification by diminishing outward current. Our experiments reveal that GSG1L is an auxiliary subunit that can markedly suppress CP-AMPAR function, in both recombinant systems and central neurons

Waste Corn as a Source of Inoculum of Aspergillus Flavus, the Cause of Aflatoxin

Aspergillus Flavus occurs worldwide in diverse habitats on a variety of plant and animal substrates. In the United States, contamination of susceptible crops particularly maize, peanuts, cottonseed, and tree nuts has become a major health concern because of the development of the carcinogen, aflatoxin. Extensive research into all aspects of the biology of A. flavus over the past twenty years still has left many unanswered but very basic questions about the ecology of this important organism

Application of the Empirical Mode Decomposition and Hilbert-Huang Transform to Seismic Reflection Data

Advancements in signal processing may allow for improved imaging and analysis of complex geologic targets found in seismic reflection data. A recent contribution to signal processing is the empirical mode decomposition (EMD) which combines with the Hilbert transform as the Hilbert- Huang transform (HHT). The EMD empirically reduces a time series to several subsignals, each of which is input to the same time-frequency environment via the Hilbert transform. The HHT allows for signals describing stochastic or astochastic processes to be analyzed using instantaneous attributes in the time-frequency domain. The HHT is applied herein to seismic reflection data to: (1) assess the ability of the EMD and HHT to quantify meaningful geologic information in the time and time-frequency domains, and (2) use instantaneous attributes to develop superior filters for improving the signal-to-noise ratio. The objective of this work is to determine whether the HHT allows for empirically-derived characteristics to be used in filter design and application, resulting in better filter performance and enhanced signal-to-noise ratio. Two data sets are used to show successful application of the EMD and HHT to seismic reflection data processing. Nonlinear cable strum is removed from one data set while the other is used to show how the HHT compares to and outperforms Fourier-based processing under certain conditions