Dynamical Model of Coherent Pion Production in Neutrino-Nucleus Scattering

We study coherent pion production in neutrino-nucleus scattering in the energy region relevant to neutrino oscillation experiments of current interest. Our approach is based on a combined use of the Sato-Lee model of electroweak pion production on a nucleon and the Delta-hole model of pion-nucleus reactions. Thus we develop a model which describes pion-nucleus scattering and electroweak coherent pion production in a unified manner. Numerical calculations are carried out for the case of the 12C target. All the free parameters in our model are fixed by fitting to both total and elastic differential cross sections for pi-12C scattering. Then we demonstrate the reliability of our approach by confronting our prediction for the coherent pion photo-productions with data. Finally, we calculate total and differential cross sections for neutrino-induced coherent pion production, and some of the results are (will be) compared with the recent (forthcoming) data from K2K, SciBooNE and MiniBooNE. We also study effect of the non-locality of the Delta-propagation in the nucleus, and compare the elementary amplitudes used in different microscopic calculations.Comment: 42 pages, 21 figure

A Search for Electron Antineutrino Appearance at the Δm2∼\Delta m^2 \sim 1 eV2\mathrm{eV}^{2} Scale

The MiniBooNE Collaboration reports initial results from a search for $\bar{\nu}_{\mu}\to\bar{\nu}_e$ oscillations. A signal-blind analysis was performed using a data sample corresponding to $3.39 \times 10^{20}$ protons on target. The data are consistent with background prediction across the full range of neutrino energy reconstructed assuming quasielastic scattering, $200 < E_{\nu}^{QE} < 3000$ MeV: 144 electron-like events have been observed in this energy range, compared to an expectation of $139.2 \pm 17.6$ events. No significant excess of events has been observed, both at low energy, 200-475 MeV, and at high energy, 475-1250 MeV. The data are inconclusive with respect to antineutrino oscillations suggested by data from the Liquid Scintillator Neutrino Detector at Los Alamos National Laboratory.Comment: 5 pages, 3 figures, 2 table

The Akt inhibitor KP372-1 suppresses Akt activity and cell proliferation and induces apoptosis in thyroid cancer cells

The phosphatidylinositol 3′ kinase (PI3K)/phosphatase and tensin homologue deleted on chromosome ten/Akt pathway, which is a critical regulator of cell proliferation and survival, is mutated or activated in a wide variety of cancers. Akt appears to be a key central node in this pathway and thus is an attractive target for targeted molecular therapy. We demonstrated that Akt is highly phosphorylated in thyroid cancer cell lines and human thyroid cancer specimens, and hypothesised that KP372-1, an Akt inhibitor, would block signalling through the PI3K pathway and inhibit cell proliferation while inducing apoptosis of thyroid cancer cells. KP372-1 blocked signalling downstream of Akt in thyroid tumour cells, leading to inhibition of cell proliferation and increased apoptosis. As thyroid cancer consistently expresses phosphorylated Akt and KP372-1 effectively blocks Akt signalling, further preclinical evaluation of this compound for treatment of thyroid cancer is warranted

Measurement of inclusive charged current interactions on carbon in a few-GeV neutrino beam

The SciBooNE Collaboration reports a measurement of inclusive charged current interactions of muon neutrinos on carbon with an average energy of 0.8 GeV using the Fermilab Booster Neutrino Beam. We compare our measurement with two neutrino interaction simulations: NEUT and NUANCE. The charged current interaction rates (product of flux and cross section) are extracted by fitting the muon kinematics, with a precision of 6-15% for the energy dependent and 3% for the energy integrated analyses. We also extract CC inclusive interaction cross sections from the observed rates, with a precision of 10-30% for the energy dependent and 8% for the energy integrated analyses. This is the first measurement of the CC inclusive cross section on carbon around 1 GeV. These results can be used to convert previous SciBooNE cross section ratio measurements to absolute cross section values.Comment: 21 pages, 16 figures. Accepted by Phys. Rev. D. Minor revisions to match the accepted versio

Measurement of the \nu_\mu charged current \pi^+ to quasi-elastic cross section ratio on mineral oil in a 0.8 GeV neutrino beam

Using high statistics samples of charged current $\nu_\mu$ interactions, MiniBooNE reports a measurement of the single charged pion production to quasi-elastic cross section ratio on mineral oil (CH$_2$), both with and without corrections for hadron re-interactions in the target nucleus. The result is provided as a function of neutrino energy in the range 0.4 GeV $< E_\nu <$ 2.4 GeV with 11% precision in the region of highest statistics. The results are consistent with previous measurements and the prediction from historical neutrino calculations.Comment: 4 pages, 2 figure

Search for electron antineutrino appearance at the △m2□1eV2 Scale

The MiniBooNE Collaboration reports initial results from a search for v̄μ→v̄e oscillations. A signal-blind analysis was performed using a data sample corresponding to 3.39×1020 protons on target. The data are consistent with background prediction across the full range of neutrino energy reconstructed assuming quasielastic scattering, 20

Measurement of inclusive charged current interactions on carbon in a few-GeV neutrino beam

We report a measurement of inclusive charged current interactions of muon neutrinos on carbon with an average energy of 0.8 GeV using the Fermilab Booster Neutrino Beam. We compare our measurement with two neutrino interaction simulations: NEUT and NUANCE. The charged current interaction rates (product of flux and cross section) are extracted by fitting the muon kinematics, with a precision of 6%-15% for the energy dependent and 3% for the energy integrated analyses. We also extract charged current inclusive interaction cross sections from the observed rates, with a precision of 10%-30% for the energy dependent and 8% for the energy integrated analyses. This is the first measurement of the charged current inclusive cross section on carbon around 1 GeV. These results can be used to convert previous SciBooNE cross-section ratio measurements to absolute cross-section values. © 2011 American Physical Society

Measurement of K\u3csup\u3e+\u3c/sup\u3e production cross section by 8 GeV protons using high-energy neutrino interactions in the SciBooNE detector

The SciBooNE Collaboration reports K+ production cross section and rate measurements using high-energy daughter muon neutrino scattering data off the SciBar polystyrene (C8H8) target in the SciBooNE detector. The K+ mesons are produced by 8 GeV protons striking a beryllium target in Fermilab Booster Neutrino Beam line (BNB). Using observed neutrino and antineutrino events in SciBooNE, we measure d2σdpdΩ=(5. 34±0.76)mb/(GeV/c×sr) for p+Be→K++X at mean K + energy of 3.9 GeV and angle (with respect to the proton beam direction) of 3.7 degrees, corresponding to the selected K+ sample. Compared to Monte Carlo predictions using previous higher energy K+ production measurements, this measurement, which uses the NUANCE neutrino interaction generator, is consistent with a normalization factor of 0.85±0.12. This agreement is evidence that the extrapolation of the higher energy K+ measurements to an 8 GeV beam energy using Feynman scaling is valid. This measurement reduces the error on the K+ production cross section from 40% to 14%. © 2011 American Physical Society

Improved measurement of neutral current coherent π0 production on carbon in a few-GeV neutrino beam

The SciBooNE Collaboration reports a measurement of neutral current coherent π0 production on carbon by a muon neutrino beam with average energy 0.8 GeV. The separation of coherent from inclusive π0 production has been improved by detecting recoil protons from resonant π0 production. We measure the ratio of the neutral current coherent π0 production to total charged current cross sections to be (1.16±0.24)×10-2. The ratio of charged current coherent π+ to neutral current coherent π0 production is calculated to be 0.14-0.28+0.30, using our published charged current coherent pion measurement. © 2010 The American Physical Society

Measurement of inclusive neutral current π0 production on carbon in a few-GeV neutrino beam

The SciBooNE Collaboration reports inclusive neutral current neutral pion production by a muon neutrino beam on a polystyrene target (C8H8). We obtain (7.7±0.5(stat)±0.5(sys))×10-2 as the ratio of the neutral current neutral pion production to total charged current cross section; the mean energy of neutrinos producing detected neutral pions is 1.11/2 GeV. The result agrees with the Rein-Sehgal model implemented in our neutrino interaction simulation program with nuclear effects. The spectrum shape of the π0 momentum and angle agree with the model. We also measure the ratio of the neutral current coherent pion production to total charged current cross section to be (0.7±0.4)×10-2. © 2010 The American Physical Society