Lightweight composite reflector panels

The Hexel Corp. has produced additional composite panels, based on JPL designs, that: (1) have increased the panel size from 0.15 to 0.40 meters, (2) have improved the as-manufactured surface precision 3.0 to approx. 1.0 micron RMS, (3) have utilized different numbers of face sheet plys, (4) have improved face sheet fiber orientation, (5) have variations of aluminum honeycomb core cell size, (6) have combined graphite/epoxy (Gr/Ep) face sheets with E-glass honeycomb cores, and (7) have used standard aluminum core with face sheets composed of combinations of glass, Kevlar, and carbon fibers. Additionally, JPL has identified candidate alternate materials for the facesheets and core, modified the baseline polymer panel matrix material, and developed new concepts for panel composite cores. Dornier designed and fabricated three 0.6 meter Gr/Ep panels, that were evaluated by JPL. Results of both the Hexel and Dornier panel work were used to characterize the state-of-the-art for Gr/Ep mirrors

Spaceborne CO2 laser communications systems

Projections of the growth of earth-sensing systems for the latter half of the 1980's show a data transmission requirement of 300 Mbps and above. Mission constraints and objectives lead to the conclusion that the most efficient technique to return the data from the sensing satellite to a ground station is through a geosynchronous data relay satellite. Of the two links that are involved (sensing satellite to relay satellite and relay satellite to ground), a laser system is most attractive for the space-to-space link. The development of CO2 laser systems for space-to-space applications is discussed with the completion of a 300 Mpbs data relay receiver and its modification into a transceiver. The technology and state-of-the-art of such systems are described in detail

A longitudinal examination of the measurement equivalence of mental health assessments in two British birth cohorts

Valid inference from the investigation of mental health relies – among others – on the assumption of no measurement error. However, it is well known that data from self-reported measures are likely to be biased by some process that is driven by the respondent’s personality and/or circumstances. We capitalised on data available in two nationally representative birth cohorts, the National Child Development Study (1958 birth cohort) and the 1970 British Cohort Study to formally test the longitudinal measurement equivalence of the nine-item version of the Malaise Inventory, a measure of psychological distress. The inclusion of identical assessments of mental health in adulthood in both cohorts allowed us to evaluate their measurement properties and investigate whether the passage of time has differentially affected the interpretation of mental health assessments. To do so, we employed methods within the generalised latent variable measurement modelling framework and related extensions for formally testing measurement invariance. We found that the passage of two decades and more in both cohorts have not influenced how participants respond to the short version of the Malaise Inventory. The observed scalar invariance of the short version of the Malaise Inventory implies that potential sources of bias such as age effects, survey design, period effects, or cohort specific effects did not influence the way participants in the two cohorts respond to the symptoms described in the Malaise Inventory. Our results offer some reassurance for the extent to which self-reported mental health survey questions are affected by systematic sources of error

Structure and Connectivity of Depressive Symptom Networks Corresponding to Early Treatment Response.

Background There are suggestions that denser network connectivity (i.e., the strength of associations between individual symptoms) may be a prognostic indicator of poor treatment response in depression. We sought to examine this aspect of depressive symptom networks in the context of early responses to treatment in adolescents. Methods Routine psychiatric data were obtained for child/adolescent service users who underwent at least three treatment sessions in publicly funded services in England between 2011 and 2015 (N = 3017, 78% female; mean age [SD] = 14.43 years [1.75]). Depressive symptoms were assessed using the Revised Children's Anxiety and Depression Scale at presentation, and again after three treatment sessions. Treatment response was determined using the Reliable Change Index. Network analysis was used to compare the depressive symptom structure and connectivity of sub-samples who, after three treatment sessions had: 1) positively responded (n = 566), 2) not reliably changed (n = 2277), and 3) reliably deteriorated (n = 174), using matched samples to control for baseline severity. Findings Overall connectivity (i.e., the summed total of weighted connections) was significantly weaker for the positive treatment response group at baseline (compared with unchanged and deteriorated groups), however, this group saw the largest increase in connectivity over the course of treatment. With regard to the overall importance of specific symptoms within the networks, fatigue was highest in strength for the unchanged and deteriorated groups, whereas low mood was highest in strength for the improved group. Interpretation This study demonstrates that adolescents who respond early to treatment for depression are characterised by symptom networks that are less densely connected initially, yet increase in connectivity over the course of treatment. This may be indicative of ‘positive spirals’ whereby improvement in one symptom triggers improvements in other symptoms, thereby increasing symptom–symptom associations even as severity decreases. Funding The study was supported by the Wellcome Trust grant 204366/Z/16/Z. The funders had no role in the study design, data collection, data analysis, interpretation, or writing of the report

Prevalence of mixed genotype hepatitis C virus infections in the UK as determined by genotype‐specific PCR and deep sequencing

The incidence of mixed genotype hepatitis C virus infections in the UK is largely unknown. As the efficacy of direct acting antivirals is variable across different genotypes, treatment regimens are tailored to the infecting genotype, which may pose issues for the treatment of underlying genotypes within undiagnosed mixed genotype HCV infections. There is therefore a need to accurately diagnose mixed genotype infections prior to treatment. PCR-based diagnostic tools were developed to screen for the occurrence of mixed genotype infections caused by the most common UK genotypes, 1a and 3, in a cohort of 506 individuals diagnosed with either of these genotypes. The overall prevalence rate of mixed infection was 3.8% however this rate was unevenly distributed, with 6.7% of individuals diagnosed with genotype 3 harbouring genotype 1a strains and only 0.8% of samples from genotype 1a patients harbouring genotype 3 (p<0.05). Mixed infection samples consisted of a major and a minor genotype, with the latter constituting less than 21% of the total viral load and, in 67% of cases, less than 1% of the viral load. Analysis of a subset of the cohort by Illumina PCR-next generation sequencing resulted in a much greater incidence rate than obtained by PCR. This may have occurred due to the non-quantitative nature of the technique and despite the designation of false positive thresholds based on negative controls

Anti-phase Modulation of Electron- and Hole-like States in Vortex Core of Bi2Sr2CaCu2Ox Probed by Scanning Tunneling Spectroscopy

In the vortex core of slightly overdoped Bi2Sr2CaCu2Ox, the electron-like and hole-like states have been found to exhibit spatial modulations in anti-phase with each other along the Cu-O bonding direction. Some kind of one-dimensionality has been observed in the vortex core, and it is more clearly seen in differential conductance maps at lower biases below +-9 mV