User definition and mission requirements for unmanned airborne platforms, revised

The airborne measurement requirements of the scientific and applications experiment user community were assessed with respect to the suitability of proposed strawman airborne platforms. These platforms provide a spectrum of measurement capabilities supporting associated mission tradeoffs such as payload weight, operating altitude, range, duration, flight profile control, deployment flexibility, quick response, and recoverability. The results of the survey are used to examine whether the development of platforms is warranted and to determine platform system requirements as well as research and technology needs

Infrared Emission from the Radio Supernebula in NGC 5253: A Proto-Globular Cluster?

Hidden from optical view in the starburst region of the dwarf galaxy NGC 5253 lies an intense radio source with an unusual spectrum which could be interpreted variously as nebular gas ionized by a young stellar cluster or nonthermal emission from a radio supernova or an AGN. We have obtained 11.7 and 18.7 micron images of this region at the Keck Telescope and find that it is an extremely strong mid-infrared emitter. The infrared to radio flux ratio rules out a supernova and is consistent with an HII region excited by a dense cluster of young stars. This "super nebula" provides at least 15% of the total bolometric luminosity of the galaxy. Its excitation requires 10^5-10^6 stars, giving it the total mass and size (1-2 pc diameter) of a globular cluster. However, its high obscuration, small size, and high gas density all argue that it is very young, no more than a few hundred thousand years old. This may be the youngest globular cluster yet observed.Comment: 6 pages, 2 color figures, Submitted to the ApJL, Revised 4/6/01 based on referee's comment

Effects of Amphetamine on Striatal Dopamine Release, Open-Field Activity, and Play in Fischer 344 and Sprague–Dawley Rats

Previous work from our laboratories has shown that juvenile Fischer 344 (F344) rats are less playful than other strains and also appear to be compromised in dopamine (DA) functioning. To determine whether the dysfunctional play in this strain is associated with deficits in the handling and delivery of vesicular DA, the following experiments assessed the extent to which F344 rats are differentially sensitive to the effects of amphetamine. When exposed to amphetamine, striatal slices obtained from F344 rats showed a small increase in unstimulated DA release when compared with slices from Sprague–Dawley rats; they also showed a more rapid high K+-mediated release of DA. These data provide tentative support for the hypothesis that F344 rats have a higher concentration of cytoplasmic DA than Sprague–Dawley rats. When rats were tested for activity in an open field, F344 rats presented a pattern of results that was consistent with either an enhanced response to amphetamine (3 mg/kg) or a more rapid release of DA (10 mg/kg). Although there was some indication that amphetamine had a dose-dependent differential effect on play in the two strains, play in F344 rats was not enhanced to any degree by amphetamine. Although these results are not consistent with our working hypothesis that F344 rats are less playful because of a deficit in vesicular release of DA, they still suggest that this strain may be a useful model for better understanding the role of DA in social behavior during the juvenile period

Complexity-based learning and teaching: a case study in higher education

This paper presents a learning and teaching strategy based on complexity science and explores its impacts on a higher education game design course. The strategy aimed at generating conditions fostering individual and collective learning in educational complex adaptive systems, and led the design of the course through an iterative and adaptive process informed by evidence emerging from course dynamics. The data collected indicate that collaboration was initially challenging for students, but collective learning emerged as the course developed, positively affecting individual and team performance. Even though challenged, students felt highly motivated and enjoyed working on course activities. Their perception of progress and expertise were always high, and the academic performance was on average very good. The strategy fostered collaboration and allowed students and tutors to deal with complex situations requiring adaptation

Cosmic Renaissance: The First Sources of Light

I review recent progress in understanding the formation of the first stars and quasars. The initial conditions for their emergence are given by the now firmly established model of cosmological structure formation. Numerical simulations of the collapse and fragmentation of primordial gas indicate that the first stars formed at redshifts z ~ 20 - 30, and that they were predominantly very massive, with M_* > 100 M_sun. Important uncertainties, however, remain. Paramount among them is the accretion process, which builds up the final stellar mass by incorporating part of the diffuse, dust-free envelope into the central protostellar core. The first quasars, on the other hand, are predicted to have formed later on, at z ~ 10, in more massive dark matter halos, with total masses, ~ 10^8 M_sun, characteristic of dwarf galaxies.Comment: 16 pages, 7 figures, invited review, to appear in PASP, Feb. 200

The interobserver reliability of a novel qualitative point of care assay for heart-type fatty acid binding protein.

BACKGROUND: Heart-type fatty acid-binding protein (h-FABP) may help to improve the early diagnosis of acute coronary syndromes in patients presenting to the Emergency Department (ED) with chest pain. A novel qualitative point of care h-FABP lateral flow immunoassay (True Rapid, FABPulous BV) could provide results to clinicians within just 5min. Given the qualitative nature of this test and prior to evaluation in a large diagnostic study, we aimed to determine inter-observer reliability when interpreted contemporaneously by staff in the ED. METHODS: In a nested prospective cohort study including adult patients with suspected cardiac chest pain, venous blood samples were tested for h-FABP (FABPulous BV) on arrival and 3h later. Each test result was independently interpreted by two different investigators after 5min. The investigators were blinded to each other's interpretation and recorded their findings on separate case report forms. We determined interobserver reliability by calculating the Cohen's kappa score and 95% confidence intervals. RESULTS: A total of 43 test results (from 31 patients) were each interpreted by two independent investigators. Absolute agreement between investigators was 93.0%, with a Cohen's kappa of 0.81 (95% CI 0.6-1.0), indicating near perfect agreement. In total there were three (7.0%) disagreements. In each case one investigator reported a 'weak positive' result while the other interpreted the result as 'negative'. CONCLUSIONS: These findings demonstrate the interobserver reliability of a qualitative point of care h-FABP assay. Further work must evaluate diagnostic accuracy and determine the clinical implications of the small rate of disagreement

The effect of medications associated with drug-induced pancreatitis on pancreatic cancer risk : a nested case-control study of routine Scottish data

Funding: This work was supported by Cancer Research UK (reference C37316/A25535). Acknowledgements: We wish to thank PCCIUR, University of Aberdeen, especially Artur Wozniak, for extracting the data and performing case-control matching.Peer reviewedPublisher PD

Soil Aggregate Dynamics, Particulate Organic Matter and Phosphate under Dryland and Irrigated Pasture

Soil aggregate formation and turnover affects the rate of occlusion or release of soil organic matter and therefore the availability for mineralisation or stabilisation of soil carbon (C) and phosphorus (P). Furthermore, differences in soil type, management and the quantity and quality of organic inputs can affect aggregate turnover rates (Six et al., 2000). Under pastoral farming the ratio of coarse particulate organic matter (inter-POM) inside macroaggregates but outside microaggregates to fine POM (intra-POM) within microaggregates may provide an indication of physical processes influencing mineralisation and stabilisation of soil C and organic P (Po). Our aim was to determine the coarse and fine POM and associated C and P contents in water stable macro and microaggregates under long term irrigated and dryland pasture grazed by sheep

How Reasoning Aims at Truth

Many hold that theoretical reasoning aims at truth. In this paper, I ask what it is for reasoning to be thus aim-directed. Standard answers to this question explain reasoning’s aim-directedness in terms of intentions, dispositions, or rule-following. I argue that, while these views contain important insights, they are not satisfactory. As an alternative, I introduce and defend a novel account: reasoning aims at truth in virtue of being the exercise of a distinctive kind of cognitive power, one that, unlike ordinary dispositions, is capable of fully explaining its own exercises. I argue that this account is able to avoid the difficulties plaguing standard accounts of the relevant sort of mental teleology