7 research outputs found
Knowledge mobilisation for policy development: Implementing systems approaches through participatory dynamic simulation modelling
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 23/11/2020
- Field of study
Background
Evidence-based decision-making is an important foundation for health policy and service planning decisions, yet there remain challenges in ensuring that the many forms of available evidence are considered when decisions are being made. Mobilising knowledge for policy and practice is an emergent process, and one that is highly relational, often messy and profoundly context dependent. Systems approaches, such as dynamic simulation modelling can be used to examine both complex health issues and the context in which they are embedded, and to develop decision support tools.
Objective
This paper reports on the novel use of participatory simulation modelling as a knowledge mobilisation tool in Australian real-world policy settings. We describe how this approach combined systems science methodology and some of the core elements of knowledge mobilisation best practice. We describe the strategies adopted in three case studies to address both technical and socio-political issues, and compile the experiential lessons derived. Finally, we consider the implications of these knowledge mobilisation case studies and provide evidence for the feasibility of this approach in policy development settings.
Conclusion
Participatory dynamic simulation modelling builds on contemporary knowledge mobilisation approaches for health stakeholders to collaborate and explore policy and health service scenarios for priority public health topics. The participatory methods place the decision-maker at the centre of the process and embed deliberative methods and co-production of knowledge. The simulation models function as health policy and programme dynamic decision support tools that integrate diverse forms of evidence, including research evidence, expert knowledge and localised contextual information. Further research is underway to determine the impact of these methods on health service decision-making.This research was funded through The Australian Prevention Partnership
Centre, which receives funds from the National Health and Medical Research
Council of Australia (NHMRC) through its partnership centre grant scheme
(Grant ID: GNT9100001) with NSW Health, ACT Health, The Australian
Government Department of Health and the Hospitals Contribution Fund of
Australia Research Foundatio
Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD
- Author
- Ahern Geoffrey L.
- Al-Sarraj Safa
- Arzberger Thomas
- Asmann Yan
- Baker Matt
- Batzler Anthony
- Beach Thomas G.
- Bieniek Kevin F.
- Biernacka Joanna M.
- Bigio Eileen H.
- Boeve Bradley F.
- Cairns Nigel J.
- Caselli Richard J.
- Christopher Elizabeth
- Cruchaga Carlos
- DeJesus-Hernandez Mariely
- Dickson Dennis W.
- Diehl-Schmid Janine
- Edbauer Dieter
- Ertekin-Taner Nilufer
- Evers Bret M.
- Farlow Martin R.
- Finger Elizabeth C.
- Fogarty Zachary
- Gearing Marla
- Geier Ethan G.
- Geula Changiz
- Ghetti Bernardino
- Glass Jonathan
- Graff Caroline
- Graff-Radford Neill R.
- Grafman Jordan
- Grinberg Lea T.
- Grossman Murray
- Halliday Glenda M.
- Herms Jochen
- Heutink Peter
- Hodges John R.
- Honig Lawrence S.
- Hsiung Ging-Yuek Robin
- Huey Edward D.
- Irwin David J.
- Jenkins Gregory D.
- Josephs Keith A.
- Karydas Anna M.
- Keith Julia
- King Andrew
- Knopman David S.
- Kofler Julia
- Kwok John B.
- Lee Edward B.
- Lopez Oscar L.
- Mackenzie Ian R. A.
- Mann David
- Matchett Billie
- Matthis Carlo
- McDonnell Shannon K.
- Mead Simon
- Mesulam M. Marsel
- Miller Bruce L.
- Mol Merel O.
- Murray Melissa E.
- Neumann Manuela
- Parisi Joseph E.
- Perkerson Ralph B.
- Petersen Ronald C.
- Petrucelli Leonard
- Pickering-Brown Stuart
- Piguet Olivier
- Pottier Cyril
- Prudlo Johannes
- Rademakers Rosa
- Reiman Eric M.
- Ren Yingxue
- Rissman Robert A.
- Rizzu Patrizia
- Roeber Sigrun
- Rogaeva Ekaterina
- Rohrer Jonathan D.
- Rollinson Sara
- Seelaar Harro
- Seeley William W.
- Simon-Sanchez Javier
- Snowden Julie
- Spina Salvatore
- Suh EunRan
- Synofzik Matthis
- Tartaglia Maria Carmela
- Tian Shulan
- Troakes Claire
- Trojanowski John Q.
- Uitti Ryan J.
- van Blitterswijk Marka
- Van Deerlin Vivianna
- van Rooij Jeroen G. J.
- van Swieten John C.
- Vicente Cristina T.
- Vonsattel Jean Paul
- Weintraub Sandra
- White Charles L.
- Woodruff Bryan K.
- Wszolek Zbigniew K.
- Yokoyama Jennifer S.
- Zinman Lorne
- Öijerstedt Linn
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
Frontotemporal lobar degeneration with neuronal inclusions of the TAR DNA-binding protein 43 (FTLD-TDP) represents the most common pathological subtype of FTLD. We established the international FTLD-TDP whole genome sequencing consortium to thoroughly characterize the known genetic causes of FTLD-TDP and identify novel genetic risk factors. Through the study of 1,131 unrelated Caucasian patients, we estimated that C9orf72 repeat expansions and GRN loss-of-function mutations account for 25.5% and 13.9% of FTLD-TDP patients, respectively. Mutations in TBK1 (1.5%) and other known FTLD genes (1.4%) were rare, and the disease in 57.7% of FTLD-TDP patients was unexplained by the known FTLD genes. To unravel the contribution of common genetic factors to the FTLD-TDP etiology in these patients, we conducted a two-stage association study comprising the analysis of whole-genome sequencing data from 517 FTLD-TDP patients and 838 controls, followed by targeted genotyping of the most associated genomic loci in 119 additional FTLD-TDP patients and 1653 controls. We identified three genome-wide significant FTLD-TDP risk loci: one new locus at chromosome 7q36 within the DPP6 gene led by rs118113626 (pvalue=4.82e-08, OR=2.12), and two known loci: UNC13A, led by rs1297319 (pvalue=1.27e-08, OR=1.50) and HLA-DQA2 led by rs17219281 (pvalue=3.22e-08, OR=1.98). While HLA represents a locus previously implicated in clinical FTLD and related neurodegenerative disorders, the association signal in our study is independent from previously reported associations. Through inspection of our whole genome sequence data for genes with an excess of rare loss-of-function variants in FTLD-TDP patients (n≥3) as compared to controls (n=0), we further discovered a possible role for genes functioning within the TBK1-related immune pathway (e.g. DHX58, TRIM21, IRF7) in the genetic etiology of FTLD-TDP. Together, our study based on the largest cohort of unrelated FTLD-TDP patients assembled to date provides a comprehensive view of the genetic landscape of FTLD-TDP, nominates novel FTLD-TDP risk loci, and strongly implicates the immune pathway in FTLD-TDP pathogenesis
Automated control of dopamine infusion in shocked patients
- Publication venue
- University of New South Wales. Faculty of Engineering. Electrical Engineering
- Publication date
- 01/01/1981
- Field of study
Teachers’ collective bargaining outcomes and tradeoffs
- Author
- Casey Ichniowski
- Daniel G. Gallagher
- David B. Lipsky
- David Lewin
- G. S. Maddala
- Geoffrey Carliner
- Henry S. Farber
- James Luizer
- John A. Fossum
- John C. Anderson
- John C. Anderson
- John Thomas Delaney
- John Thomas Delaney
- John Thomas Delaney
- John Thomas Delaney
- Joseph D. Reid
- Lorraine McDonnell
- Morris M. Kleiner
- Paul F. Gerhart
- Peter Feuille
- Randall W. Eberts
- Randall W. Eberts
- Richard B. Freeman
- Richard B. Freeman
- Stephen A. Woodbury
- Thomas A. Kochan
- Thomas A. Kochan
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Private Proprietary Standards and Public Law: Invoking WTO's Competition Dimension to Avoid Global Market Distortion
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- A Marasco
- A Robert
- A Taubman
- Alden F Abbott
- Andrea Wechsler
- Andrew C Mace
- Andrew Updegrove
- Ankur Gupta
- Anne Layne-Farrar
- Annette Kur
- Annette Kur
- Anu Bradford
- Aoki Reiko
- Ashwin Rooijen
- Ashwin Van Rooijen
- Baisheng An
- Benjamin Diessel
- Branislav Hazucha
- Brendan Sweeney
- C Shapiro
- Carlos Correa
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- Carrier Micheal
- Chantal Blouin
- Chris Noonan
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- Lawrance Treacy
- Lawrence Busch
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- Us-Ftc
- Ward S Bowman
- Xuan &
- Yogesh Pai
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2012
- Field of study
State of the Art Survey of Reference Sources in Engineering
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- Abler William
- Advani L.T
- al History
- American Petroleum Institute
- American Society for Metals.
- Ann Arbor Mich
- Ann Arbor Science
- Armstrong Ellis L
- Association
- Azad H.
- Baerwald John E
- Blanford Percy W
- Brater Ernest F
- Briefly
- Brittain James E
- Brooks Hugh
- Cagle
- Cheremisinoff Paul N
- Cheremisinoff Paul N
- Chilton's Basic Auto Maintenance
- Choppers
- Clauser
- Company's Permanent Magnet Manual
- Computer
- Computerworld Index Newton
- Concrete
- Control Handbook
- Dam
- Davis Bob J
- Demaw Doug
- Dempsey Paul
- Development
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- Drake George R
- Dubin Fred S. H.L.
- Dummer Geoffrey William
- Ecotechnics
- Eichholz Geoffrey G
- EIS
- Electronics
- Electronics Designers' Handbook
- Electronics Engineer's Reference Book
- Emissions Handbook
- Energy
- Energy
- Energy Demand Studies
- Energy Information Abstracts New York
- Energy Microthesaurus
- Energy Technology Handbook
- Engineering
- Engineering Education Institutions
- Finnegan Patrick S
- from the SSIE Inc.
- Garfield Bennet
- Garland J.D
- Gehm Harry W
- George
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- Hajek Victor G
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- Harris Cyril M
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- Historic Architecture Sourcebook
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- Hutchison J.W.
- International Technical Information Institute
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- Joining
- Kaufman M.
- Kingery Jerry
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- Lieberman Jethro K
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- Maintenance Engineering Handbook
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- 'Emerald'
- Publication date
- Field of study
Analysis of Outcomes in Ischemic vs Nonischemic Cardiomyopathy in Patients With Atrial Fibrillation A Report From the GARFIELD-AF Registry
- Author
- A'Court Christine
- Abdel-Qader Muwafeg
- Abe Masahiko
- Abe Masatake
- Abe Mitsunori
- Abe Sumihisa
- Abe Yukihiko
- Abhayaratna Walter
- Accogli Michele
- Adachi Susumu
- Adachi Toru
- Adak Dhriti
- Adam Matthew
- Adriaansen Henk
- Aegerter Emanuel
- Ageta Masato
- Aggarwala Anil
- Agnelli Giancarlo
- AgnieszkaMetzgier-Gumiela AgnieszkaMetzgier-Gumiela
- Ahlmark Hakan
- Ahmad Kamran
- Ahmad Shahid
- Ahmed Fayzal
- Ahn Jung Joo
- Akers Lori
- Akiyama Masahiro
- Al Mahmeed Wael
- Al-Khalili Faris
- Alberts Mark
- Alborough Elizabeth
- Aldegather Jehad
- Aleksandrova Elena
- Alexandre Almeida Carlos
- Ali Amar
- Ali Gholam
- Alia Pilar Montero
- Allasia Bartolomeo
- Alonso Carmela
- Alonso Concepcion
- Altun Armagan
- Alunni Massimo
- Alvarez Garcia Pere
- Alvarez Douglas
- Alvarez Miguel
- Alzogaray Maria Fernanda
- Amarenco Pierre
- Amaro Marisol
- Ambicka Monika
- Ambrosino Pasquale
- Ambrosio Giuseppe
- Amin Joseph
- Amrhein Diana
- Amstutz Daniela
- An Hae Jung
- Andere Natalia
- Andersson Agneta
- Andersson Lisbeth
- Ando Hiroshi
- Ando Shinichi
- Andrzejewski Dariusz
- Angaran Paul
- Ansoult Nadege
- Antonova Petra
- Antonsen Hege
- Aoki Kenji
- Aoyama Takuma
- Appleby Nigel
- Appleby Nigel
- Aracil Villar Joaquin
- Arai Hidekazu
- Araminowicz Joanna
- Aras Funda
- Arcocha Torres Maria Fe
- Argena Antonio
- Arima Shinichi
- Armangau Pauline
- Arstall Margaret
- Asafu-Adjaye Nana
- Asano Hiroshi
- Asano Taku
- Ashraf M. Javed
- Assagay Maharajh S.
- Assouline Serge
- Astridge Penny
- Atar Dan
- Atar Dan
- Ausen Karin
- Austria Aileen
- Aves Theresa
- Avinc Gamze
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- Avinc Gamze
- Axthelm Christoph
- Ayar Ozge
- Aydinlar Ali
- Ayres Bronte
- Azakami Shiro
- Aziz Michael
- Azuma Junya
- Baba Takao
- Babjakova Zuzana
- Babyesiza Adyeri
- Bae Sang Cheol
- Baek Ae Lee
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- Bai Chunlin
- Baksh Farisha
- Balaraju Swathi
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- Barkowski Timothy
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- Baron Esquivias Gonzalo
- Barraquer Feu Edelmira
- Barreau Angeline
- Barreda Maria
- Barretto Antonio Carlos Pereira
- Barrow Susan
- Barry Lisa
- Bartkowiak Radoslaw
- Bartlett Melialoha
- Bartnik Jerzy
- Basiak Marcin
- Basily Wagdy
- Bassand Jean-Pierre
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- Bassand Jean-Pierre
- Bastani Lisa
- Baszak Jacek
- Batalov Roman
- Batlle Javier
- Batta Claire
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- Baumgartner Philipp
- Baweja Paramdeep
- Bayat Junaid
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- Becerra Munoz Victor
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- Bekieszczuk Ewa
- Belenkova Yulia
- Belenky Dmitry
- Bengtsberg Daniel
- Bennett James
- Berardi Mario
- Berg-Johansen Berg-Johansen
- Berge Eivind
- Berge Trude
- Berit Anne
- Berman Sofia Graciela
- Bernat Lukasz
- Berneau Jean-Baptiste
- Best Peggy
- Beton Osman
- Betsuyaku Tetsuo
- Beveridge Rosemary
- Bezrodna Larysa
- Bhargava Kartikeya
- Biagioli Viviana
- Bianchi Alfredo
- Biedrzycka Malgorzata
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- Biedrzycki Lukasz
- Biernacka Anita
- Bigcanoe Julie
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- Bindig Hans-Walter
- Binnekamp Maurits
- Bird Nigel
- Bireciklioglu Mustafa Fehmi
- Birhan MEHMET BİRHAN
- Bitakova Fatima
- Black Andrew
- Blenkhorn Adam
- Blinkova Marina
- Blombery Peter
- Blumberg Edwin
- Bockova Lucie
- Boda Zoltan
- Boehme Stefanie
- Boen Rigmor
- Boersma Misannia
- Boggian Giulio
- Bonet Jorge
- Bongaerts Maarten
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- Bowen-Simpkins Emma
- Bowers Suzanne
- Boys Janice
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- Bremmelgaard Arne
- Breschi Marco
- Breukel Laura
- Briceno Hinojo Ana
- Brimley Jennifer
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- Carpenedo Monica
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- Cassidy Doran
- Cassimjee Soraya
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- Castro Fernandez Daniel
- Catanchin Andrei
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- Cha James
- Cha Tae-Joon
- Chabanna Olena
- Chaiyapong Thanawan
- Chami Charmaine
- Chandwani Prakash
- Chattranukulchai Pairoj
- Chauhan Kuldeep
- Chauhan Naresh
- Cheewatanakornkul Sirichai
- Chemin Frederic
- Chen Jiyan
- Chen Kangning
- Chen Xiao
- Cheryl Laurie Ferleyko
- Cheung Stephen
- Chi Andwoo Jin
- Chiba Kei
- Chibana Hidetoshi
- Ching Chi Keong
- Chizhov Petr
- Chlumsky Jaromir
- Chmielowski Artur
- Cho Amie
- Cho Jeong-Gwan
- Cho Myeong-Chan
- Choi Dong Ju
- Choi Eun A.
- Choi Eun Hee
- Choi Hee Kyung
- Choi Hee Suk
- Chojnowski Przemyslaw
- Choudhary Fiaz
- Choudhary Ulka
- Chowan Hasan
- Christie Heather
- Christoph Marian
- Chugunnaya Svetlana
- Ciabatta Carlo
- Cichomski Rafal
- Cieslak Karol
- Cieszynska Alina
- Ciliberti Giuseppe
- Cimmino Giovanni
- Citykliniken Capio
- Clark M.
- Clarke Bonnie
- Claussen Hege
- Cleveland Tracy
- Cloak Cloak
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- Coates Steven
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- Cooper Krystine
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- Cordoba Mateo
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- Costa Pinto Joana
- Costello Ben
- Couleru Josette
- Coulshed David
- Coulson DrWarwick
- Coutu Benoit
- Cresp Damien
- Crisby Milita
- Cristina Leone Maria
- Croucher Alexandra
- Curyllo Bartosz
- Cymerman Krzysztof
- Czamara Marcin
- D'Agostini Erika
- D'Avino Maria
- Danielsen Mark
- Danilowicz-Szymanowicz Ludmila
- Daniuk Inna
- Danse Ingrid
- DArienzo Carmela
- Darius Harald
- Darius Harald
- Dastychova Lenka
- Date Haruhiko
- Davids Aziza
- Davies Divin
- Davies Emyr
- Davies Richard
- Davis Kent
- Dawood Dawood
- De Blasio Angelo
- De Cristofaro Raimondo
- De Graaf Judith
- de Meyer Lorinda
- Deacon Melanie
- Debordes Mirjam
- Debrunner Johann
- Debruxelles Sabrina
- Decarsin Nathalie
- Dedek Vratislav
- Dehghani Payam
- Delafontaine Patrice
- Delarche Nicolas
- Demir Mesut
- Denis Isabelle
- DePauw Jill
- Deshpande Bhakti
- Dhakrao Priyanka
- Dhillon Ripple
- Di Ancona Torrette
- Di Minno Giovanni
- Diaz Lopez Carlos Maria
- Dichristin Uta
- Diederichs Roelof
- Diercks Deborah
- Dimitri Hany
- Dixon Sue
- Dobson Simon
- Dohovits Emese
- Doiuchi Junji
- Dolman Marilyn
- Domanska Ewa
- Dominguez Helena
- Dominguez Helena
- Dominguez Ingrid
- Dooldeniya Chaminda
- Dorottya Kanizsai
- Dorsch Wilfried
- Douglas Kevin
- Douglass Shannen
- Drapkina Oksana
- Drasnar Tomas
- Dresser George
- Drexel Heinz
- Drown Jane
- Dshabrailov Janna
- du Preez Miranda
- Duff-Coots Margie
- Dumikyan Anait
- Dwivedi Pratik
- Dwyer Nathan
- Dybala Tomasz
- Dzeletovic Susanna
- Earath Manoj
- Ebert Hans-Holger
- Ebner Karl-Martin
- Eccleston David
- Eden Jane
- Eder Wolfgang
- Edin Anton
- Efe Jana
- Egilsson Arnor
- Egorova Liudmila
- Egyutt Mihaly
- Eikelboom John
- Eikelboom John
- Eisleben Lutherstadt
- Eissing Volker
- Ekstrand Ann-Britt
- El-Aziz Ahmed Abd
- El-Etreby Adel
- Elise Guillermet
- Elkhadem Magdi
- Ellervik Christina
- Ellis Tania
- Elmersson Micael
- Elorriaga Madariaga Ane
- Emelife Samuel
- Emura Yoko
- Endo Masato
- Engdahl Johan
- Engelbrecht Johannes
- Engelthaler Gabriella
- Epelde Gonzalo Francisco
- Erdle Werner
- Erga Knut
- Ericsson Marianne
- Ersanli Murat
- Eskandari Mehdi
- Eslick Renee
- Espallargas Anna
- Estifanos Salah
- Eto Takuma
- Evans Lorlie
- Evans Paul
- Evans Phil
- Ewald Gregory
- Ewert Alayna
- Fairhead Sue
- Fanelli Raffaele
- Faron Andwojciech
- Farquhar Donald
- Fattore Luciano
- Fearon Ann
- Fedele Marta
- Fedorowsky Alain
- Feil Jusztina
- Felekoglu Mehmet Ali
- Felpel Susan
- Femiano Claudio
- Feng Shuai
- Feola Mauro
- Ferdinand Keith
- Ferenczi Judit
- Ferkl Richard
- Fernandez Escobar Esther
- Ferreira-Jardim Antonio
- Ferreira-Jardim Antonio
- Ferrer Ana
- Ferrini Piera Maria
- Fetahovic Taufik
- Fielder Debbie
- Figura-Chmielewska Monika
- Figura-Chmielewska Monika
- Fikry Sameh
- Fikry Sameh
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- Ramesh C.
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- Yawila Suree
- Yildirim Rifat
- Yilmaz Faruk
- Yilmaz Ozcan
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- Yokoyama Yasuhiro
- Yoon Eunji
- Yoon Jung Han
- Yoshida Keiki
- Yoshida Tetsuro
- Yoshida Tomohiro
- Yoshida Tomoki
- Yoshimura Akira
- Yoshizawa Naoto
- Yu HyunJu
- Yu Ting
- Yusuf Huma
- Yuyang Tan
- Zaatout Eman
- Zaitsu Ryuji
- Zak Jan
- Zakutynska-Kowalczyk Karolina
- Zaluska Roman
- Zaman Kashif
- Zateyshchikov Dmitry
- Zauzig Heinz-Dieter
- Zdrowotnej Zespol Opieki
- Zecca Cinzia
- Zemlianskaia Oksana
- Zhai Hong
- Zhan Qiong
- Zhang Guoshan
- Zhang Huaiqin
- Zhang Ran
- Zhang Yi
- Zhao Yusheng
- Zhuravleva Evgeniya
- Zidek Milan
- Zidkova Eva
- Zika Jiri
- Zillo Mariana
- Zimmett Leon
- Zimny Hans-Hermann
- Zincke Stephanie
- Zinka Elzbieta
- Zinka Elzbieta
- Zotova Irina
- Zubeeva Galina
- Zuber Mathieu
- Zutz Stefan
- Zwenkau Schwarz
- Zyczynska Malgorzata
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 01/06/2019
- Field of study
IMPORTANCE Congestive heart failure (CHF) is commonly associated with nonvalvular atrial fibrillation (AF), and their combination may affect treatment strategies and outcomes