Level of adherence to prescribed exercise in spondyloarthritis and factors affecting this adherence: a systematic review

Adherence is a primary determinant of the effectiveness of any intervention. Exercise is considered essential in the management of spondyloarthritis (SpA); however, the overall adherence to exercise programmes and factors affecting adherence are unknown. The aim of this systematic review was to examine measures of, and factors influencing adherence to, prescribed exercise programmes in people with SpA. A search was performed in August 2018 using five data bases; the Cochrane library, CINAHL, EMBASE, MEDLINE, and Web of Science Collections. Inclusion criteria were: studies with adults (> 18 years) with SpA, with a prescribed exercise intervention or educational programme with the aim of increasing exercise participation. Article quality was independently assessed by two assessors. Extracted descriptive data included: populations, interventions, measures of adherence and factors affecting adherence. Percentage adherence rates to prescribed exercises were calculated if not reported. Nine studies were included with a total of 658 participants, 95% of participants had a diagnosis of ankylosing spondylitis. Interventions and measurement of adherence varied, making comparisons difficult. Rates of adherence ranged from 51.4 to 95%. Single studies identified; adherence improved following educational programmes, and higher disease severity and longer diagnostic delays were associated with higher adherence. Conflicting evidence was found as to whether supervision of exercise improved adherence. Three consecutive studies demonstrated adherence reduced over time. Adherence to prescribed exercise in SpA was poorly reported and predominately for people with AS. The levels of adherence and factors affecting prescribed exercise in SpA remain unclear. Future research should measure adherence across a longer time period and investigate possible factors which may influence adherence

The Role of the 1994-95 Coffee Boom in Uganda's Recovery

This paper reports a CGE analysis that explores the consequences of the 1994-95 rise in the international price of coffee for Uganda´s economy. Evidence is found for a small effect on medium-term growth and poverty reduction. Aid dependence is among the reasons why this effect is not found to be larger. Major beneficiary groups are not only the farmers to which the windfall initially accrued but also urban wage earners and the urban self-employed

Bias, redshift space distortions and primordial nongaussianity of nonlinear transformations: application to Lyman alpha forest

On large scales a nonlinear transformation of matter density field can be viewed as a biased tracer of the density field itself. A nonlinear transformation also modifies the redshift space distortions in the same limit, giving rise to a velocity bias. In models with primordial nongaussianity a nonlinear transformation generates a scale dependent bias on large scales. We derive analytic expressions for these for a general nonlinear transformation. These biases can be expressed entirely in terms of the one point distribution function (PDF) of the final field and the parameters of the transformation. Our analysis allows one to devise nonlinear transformations with nearly arbitrary bias properties, which can be used to increase the signal in the large scale clustering limit. We apply the results to the ionizing equilibrium model of Lyman-alpha forest, in which Lyman-alpha flux F is related to the density perturbation delta via a nonlinear transformation. Velocity bias can be expressed as an average over the Lyman-alpha flux PDF. At z=2.4 we predict the velocity bias of -0.1, compared to the observed value of -0.13 +/- 0.03. Bias and primordial nongaussianity bias depend on the parameters of the transformation. Measurements of bias can thus be used to constrain these parameters, and for reasonable values of the ionizing background intensity we can match the predictions to observations. Matching to the observed values we predict the ratio of primordial nongaussianity bias to bias to have the opposite sign and lower magnitude than the corresponding values for the highly biased galaxies, but this depends on the model parameters and can also vanish or change the sign.Comment: 18 pages, 1 figur

Broken Symmetry as a Stabilizing Remnant

The Goldberger-Wise mechanism enables one to stabilize the length of the warped extra dimension employed in Randall-Sundrum models. In this work we generalize this mechanism to models with multiple warped throats sharing a common ultraviolet brane. For independent throats this generalization is straight forward. If the throats possess a discrete interchange symmetry like Z_n the stabilizing dynamics may respect the symmetry, resulting in equal throat lengths, or they may break it. In the latter case the ground state of an initially symmetric configuration is a stabilized asymmetric configuration in which the throat lengths differ. We focus on two- (three-) throat setups with a Z_2 (Z_3) interchange symmetry and present stabilization dynamics suitable for either breaking or maintaining the symmetry. Though admitting more general application, our results are relevant for existing models in the literature, including the two throat model with Kaluza-Klein parity and the three throat model of flavor based on a broken Z_3 symmetry.Comment: 23 pages; v2 minor cosmetic chang

An Ionization Cone in the Dwarf Starburst Galaxy NGC 5253

There are few observational constraints on how the escape of ionizing photons from starburst galaxies depends on galactic parameters. Here, we report on the first major detection of an ionization cone in NGC 5253, a nearby starburst galaxy. This high-excitation feature is identified by mapping the emission-line ratios in the galaxy using [S III] lambda 9069, [S II] lambda 6716, and H_alpha narrow-band images from the Maryland-Magellan Tunable Filter at Las Campanas Observatory. The ionization cone appears optically thin, which is suggestive of the escape of ionizing photons. The cone morphology is narrow with an estimated solid angle covering just 3% of 4pi steradians, and the young, massive clusters of the nuclear starburst can easily generate the radiation required to ionize the cone. Although less likely, we cannot rule out the possibility of an obscured AGN source. An echelle spectrum along the minor axis shows complex kinematics that are consistent with outflow activity. The narrow morphology of the ionization cone supports the scenario that an orientation bias contributes to the difficulty in detecting Lyman continuum emission from starbursts and Lyman break galaxies.Comment: 5 pages, 4 figures, Accepted to ApJ Letter

The variation of solar proton energy spectra size distribution with heliolongitude

A statistical study of the initial phases of 185 solar particle events was carried out using the data from cosmic ray experiments on IMP 4 and IMP 5. Special emphasis was placed on the identification of the associated solar flare, as the parent flare can be determined for 68% of the events. It appears probable that most of the unidentified increases occur on the non-visible disc of the sun. The existence of a 'preferred-connection' longitude between 20 W and 80 W was established by examining the heliolongitude of all the flare associated events. It is demonstrated that the energy spectra determined at the time of maximum particle in the 20 to 80 MeV or 4 to 20 Mev interval range give results identical to that obtained by the 'distance-travelled' method

Factors affecting mortality in late stage Parkinson’s Disease

To determine the effect of dysphagia and hospital admissions on mortality in late stage Parkinson’s disease

New Q-ball Solutions in Gauge-Mediation, Affleck-Dine Baryogenesis and Gravitino Dark Matter

Affleck-Dine (AD) baryogenesis along a d=6 flat direction in gauge-mediated supersymmetry-breaking (GMSB) models can produce unstable Q-balls which naturally have field strength similar to the messenger scale. In this case a new kind of Q-ball is formed, intermediate between gravity-mediated and gauge-mediated type. We study in detail these new Q-ball solutions, showing how their properties interpolate between standard gravity-mediated and gauge-mediated Q-balls as the AD field becomes larger than the messenger scale. It is shown that E/Q for the Q-balls can be greater than the nucleon mass but less than the MSSM-LSP mass, leading to Q-ball decay directly to Standard Model fermions with no MSSM-LSP production. More significantly, if E/Q is greater than the MSSM-LSP mass, decaying Q-balls can provide a natural source of non-thermal MSSM-LSPs, which can subsequently decay to gravitino dark matter without violating nucleosynthesis constraints. The model therefore provides a minimal scenario for baryogenesis and gravitino dark matter in the gauge-mediated MSSM, requiring no new fields.Comment: 13 pages, 9 figures. Some corrections and additional discussion. Version published in JCA

A very deep Chandra observation of Abell 1795: The Cold Front and Cooling Wake

We present a new analysis of very deep Chandra observations of the galaxy cluster Abell 1795. Utilizing nearly 750 ks of net ACIS imaging, we are able to resolve the thermodynamic structure of the Intracluster Medium (ICM) on length scales of ~ 1 kpc near the cool core. We find several previously unresolved structures, including a high pressure feature to the north of the BCG that appears to arise from the bulk motion of Abell 1795's cool core. To the south of the cool core, we find low temperature (~ 3 keV), diffuse ICM gas extending for distances of ~ 50 kpc spatially coincident with previously identified filaments of H-alpha emission. Gas at similar temperatures is also detected in adjacent regions without any H-alpha emission. The X-ray gas coincident with the H-alpha filament has been measured to be cooling spectroscopically at a rate of ~ 1 Solar Masses/ yr, consistent with measurements of the star formation rate in this region as inferred from UV observations, suggesting that the star formation in this filament as inferred by its H$\alpha$ and UV emission can trace its origin to the rapid cooling of dense, X-ray emitting gas. The H-alpha filament is not a unique site of cooler ICM, however, as ICM at similar temperatures and even higher metallicities not cospatial with H$\alpha$ emission is observed just to the west of the H-alpha filament, suggesting that it may have been uplifted by Abell 1795's central active galaxy. Further simulations of cool core sloshing and AGN feedback operating in concert with one another will be necessary to understand how such a dynamic cool core region may have originated and why the H-alpha emission is so localized with respect to the cool X-ray gas despite the evidence for a catastrophic cooling flow.Comment: 14 Pages, 10 Figures, Resubmitted to ApJ after first referee report, Higher Resolution Figures available upon reques