Learning Theory Expertise in the Design of Learning Spaces: Who Needs a Seat at the Table?

This study highlights the impact of including stakeholders with expertise in learning theory in a learning space design process. We present the decision-making process during the design of the Krause Innovation Studio on the campus of the Pennsylvania State University to draw a distinction between the architect and faculty member’s decision-making process. Often, the architect relied on guiding principles such as flexibility, while the faculty member drew from learning theory such as the sociocultural theory of learning (Vygotsky, 1978). This study demonstrates the value of learning theory expertise and includes suggestions and possible implications for future designs of learning spaces

Weighted complex projective 2-designs from bases: optimal state determination by orthogonal measurements

We introduce the problem of constructing weighted complex projective 2-designs from the union of a family of orthonormal bases. If the weight remains constant across elements of the same basis, then such designs can be interpreted as generalizations of complete sets of mutually unbiased bases, being equivalent whenever the design is composed of d+1 bases in dimension d. We show that, for the purpose of quantum state determination, these designs specify an optimal collection of orthogonal measurements. Using highly nonlinear functions on abelian groups, we construct explicit examples from d+2 orthonormal bases whenever d+1 is a prime power, covering dimensions d=6, 10, and 12, for example, where no complete sets of mutually unbiased bases have thus far been found.Comment: 28 pages, to appear in J. Math. Phy

Forming and Sustaining a Learning Community and Developing Implicit Collective Goals in an Open Future Learning Space

This study investigates the role of space, material, and affect in undergraduate and graduate students’ lived experiences within an open Future Learning Space (FLS) and speaks to the call for research on learning communities in learning spaces, as described in Hod, Bielaczyc, and Ben-Zvi (2018). The methodological approach consists of semi-structured phenomenological interviews with thirteen users of the FLS and thematic analysis to uncover themes. Findings suggest the FLS was able to: (1) bring together individuals by producing individual and shared affective responses; (2) hold community together and inform perceptions; and (3) move the community together and shape practices. This study indicates that open FLSs are complex systems constructed by users and can meet some of the criteria for a learning community (LC), especially if we broaden the definitions to take into account implicit versions of an LC

Comparison of 2-way versus metered 3-way boom shut-off valves for automatic section control on agricultural sprayers

Modern spray rate controllers along with technologies such as automatic section control (ASC) provide benefits such as overlap reduction on agricultural sprayers. However, product (liquid) dynamics within the boom plumbing affect off-rate errors and application uniformity during rate changes and ASC actuation. Therefore, this study was conducted to compare nozzle flow stability and uniformity across the boom when using two different boom shut-off valves (2-way and metered 3-way) on an 18.3-m sprayer boom. Pressure transducers were mounted at 1) the boom manifold, 2) randomly at 12 nozzle bodies across the spray boom, and 3) upstream and downstream of the flow regulating valve. Effective system flow rate was measured using two flow meter(s), one located upstream of the boom control valves (2-way or metered 3-way) and another mounted to measure the tank return flow for the metered 3-way boom valve. Measured nozzle pressure was converted to nozzle flow using the manufacturer’s pressure-flow data. Results indicated that the 2-way boom versus metered 3-way valve response was significantly different. Significant differences in damping ratios were found when exiting (under-damped) and reentering (over-damped) of spray zones. For the metered 3-way boom valve configuration, nozzle flow settled faster (0.1 to 4.2 s) virtually eliminating off-rate errors whereas the 2-way boom valve configuration took up to 34.3 s to settle with off-rate errors ranging from 3.3% to 11.5%. The delayed nozzle flow settling times were associated with pressure settling (0.7 to 31.4 s) downstream of the regulating valve for the 2-way configuration. Ground speed and point row angle impacted nozzle flow settling times and off-rate errors. The increase in ground speed and point row angle increased nozzle flow settling time for the 2-way valve setup, except that acceleration decreased settling times when exiting spray zones. The delayed response contributed to off-rate time which decreased as the sprayer accelerated and point row angle decreased for both the 2-way (1.7 to 19.3 s) and metered 3-way (2.1 to 4.4 s) boom shut-off valve setups

Structure and Chemical Inhibition of the Ret Tyrosine Kinase Domain.

The RET proto-oncogene encodes a receptor tyrosine kinase for the glial cell line-derived neurotrophic factor family of ligands. Loss-of-function mutations in RET are implicated in Hirschsprung disease, whereas activating mutations in RET are found in human cancers, including familial medullar thyroid carcinoma and multiple endocrine neoplasias 2A and 2B. We report here the biochemical characterization of the human RET tyrosine kinase domain and the structure determination of the non-phosphorylated and phosphorylated forms. Both structures adopt the same active kinase conformation competent to bind ATP and substrate and have a pre-organized activation loop conformation that is independent of phosphorylation status. In agreement with the structural data, enzyme kinetic data show that autophosphorylation produces only a modest increase in activity. Longer forms of RET containing the juxtamembrane domain and C-terminal tail exhibited similar kinetic behavior, implying that there is no cis-inhibitory mechanism within the RET intracellular domain. Our results suggest the existence of alternative inhibitory mechanisms, possibly in trans, for the autoregulation of RET kinase activity. We also present the structures of the RET tyrosine kinase domain bound to two inhibitors, the pyrazolopyrimidine PP1 and the clinically relevant 4-anilinoquinazoline ZD6474. These structures explain why certain multiple endocrine neoplasia 2-associated RET mutants found in patients are resistant to inhibition and form the basis for design of more effective inhibitors

A multicentre trial of voltaren in the treatment of rheumatoid arthritis

Voltaren, a compound with analgesic, anti-inflammatory and antipyretic properties, has been compared at two dose levels-25 mg t.d.s. and 50 mg t.d.s. with indomethacin 25 mg t.d.s. and acetylsalicylic acid 1 500 mg t.d.s. Ninety-one patients with definite or classical rheumatoid arthritis took part in this study. The trial was a doubleblind cross-over study, with each  medication being given for one week. Patients were washed out for one week prior to the first active treatment. Each patient received only two of the four possible treatments. Voltaren in a dose of 25 mg t.d.s. was found to improve the symptoms of rheumatoid arthritis to a greater degree than indomethacin or acetylsalicylic acid. Voltaren 50 mg t.d.s. evoked a greater response than acetylsalicylic acid and was at least as efficacious as indomethacin. Voltaren was better tolerated than either indomethacin or acetylsalicylic acid. The incidence of gastro-intestinal side-effects was similar with Voltaren and indomethacin, and half that produced by acetylsalicylic acid. Some evidence of possible drug interaction was found.S. Afr. Med. J., 48, 2013 (1974)

Projections of the healthcare costs and disease burden due to hepatitis C infection under different treatment policies in Malaysia, 2018-2040

The World Health Organisation (WHO) has set ambitious goals to reduce the global disease burden associated with, and eventually eliminate, viral hepatitis

The Linear Theory Power Spectrum from the Lyman-alpha Forest in the Sloan Digital Sky Survey

We analyze the SDSS Ly-alpha forest P_F(k,z) measurement to determine the linear theory power spectrum. Our analysis is based on fully hydrodynamic simulations, extended using hydro-PM simulations. We account for the effect of absorbers with damping wings, which leads to an increase in the slope of the linear power spectrum. We break the degeneracy between the mean level of absorption and the linear power spectrum without significant use of external constraints. We infer linear theory power spectrum amplitude Delta^2_L(k_p=0.009s/km,z_p=3.0)=0.452_{-0.057-0.116}^{+0.069+0.141} and slope n_eff=-2.321_{-0.047-0.102}^{+0.055+0.131} (possible systematic errors are included through nuisance parameters in the fit - a factor >~5 smaller errors would be obtained on both parameters if we ignored modeling uncertainties). The errors are correlated and not perfectly Gaussian, so we provide a chi^2 table to accurately describe the results. The result corresponds to sigma_8=0.85, n=0.94, for a LCDM model with Omega_m=0.3, Omega_b=0.04, and h=0.7, but is most useful in a combined fit with the CMB. The inferred curvature of the linear power spectrum and the evolution of its amplitude and slope with redshift are consistent with expectations for LCDM models, with the evolution of the slope, in particular, being tightly constrained. We use this information to constrain systematic contamination, e.g., fluctuations in the UV background. This paper should serve as a starting point for more work to refine the analysis, including technical improvements such as increasing the size and number of the hydrodynamic simulations, and improvements in the treatment of the various forms of feedback from galaxies and quasars.Comment: Improved presentation, including fit results for (z). Simple code to produce LyaF chi^2 given linear power spectrum available at: http://www.cita.utoronto.ca/~pmcdonal/code.htm

Bridging the data gaps in the epidemiology of hepatitis C virus infection in Malaysia using multi-parameter evidence synthesis

BACKGROUND: Collecting adequate information on key epidemiological indicators is a prerequisite to informing a public health response to reduce the impact of hepatitis C virus (HCV) infection in Malaysia. Our goal was to overcome the acute data shortage typical of low/middle income countries using statistical modelling to estimate the national HCV prevalence and the distribution over transmission pathways as of the end of 2009. METHODS: Multi-parameter evidence synthesis methods were applied to combine all available relevant data sources - both direct and indirect - that inform the epidemiological parameters of interest. RESULTS: An estimated 454,000 (95% credible interval [CrI]: 392,000 to 535,000) HCV antibody-positive individuals were living in Malaysia in 2009; this represents 2.5% (95% CrI: 2.2-3.0%) of the population aged 15-64 years. Among males of Malay ethnicity, for 77% (95% CrI: 69-85%) the route of probable transmission was active or a previous history of injecting drugs. The corresponding proportions were smaller for male Chinese and Indian/other ethnic groups (40% and 71%, respectively). The estimated prevalence in females of all ethnicities was 1% (95% CrI: 0.6 to 1.4%); 92% (95% CrI: 88 to 95%) of infections were attributable to non-drug injecting routes of transmission. CONCLUSIONS: The prevalent number of persons living with HCV infection in Malaysia is estimated to be very high. Low/middle income countries often lack a comprehensive evidence base; however, evidence synthesis methods can assist in filling the data gaps required for the development of effective policy to address the future public health and economic burden due to HCV. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12879-014-0564-6) contains supplementary material, which is available to authorized users