Tracking capsule activation and crack healing in a microcapsule-based self-healing polymer

Structural polymeric materials incorporating a microencapsulated liquid healing agent demonstrate the ability to autonomously heal cracks. Understanding how an advancing crack interacts with the microcapsules is critical to optimizing performance through tailoring the size, distribution and density of these capsules. For the first time, time-lapse synchrotron X-ray phase contrast computed tomography (CT) has been used to observe in three-dimensions (3D) the dynamic process of crack growth, microcapsule rupture and progressive release of solvent into a crack as it propagates and widens, providing unique insights into the activation and repair process. In this epoxy self-healing material, 150 µm diameter microcapsules within 400 µm of the crack plane are found to rupture and contribute to the healing process, their discharge quantified as a function of crack propagation and distance from the crack plane. Significantly, continued release of solvent takes place to repair the crack as it grows and progressively widens

The manifest association structure of the single-factor model: insights from partial correlations

The association structure between manifest variables arising from the single-factor model is investigated using partial correlations. The additional insights to the practitioner provided by partial correlations for detecting a single-factor model are discussed. The parameter space for the partial correlations is presented, as are the patterns of signs in a matrix containing the partial correlations that are not compatible with a single-factor model

Control of atypical PKCι membrane dissociation by tyrosine phosphorylation within a PB1-C1 interdomain interface

Atypical PKCs are cell polarity kinases that operate at the plasma membrane where they function within multiple molecular complexes to contribute to the establishment and maintenance of polarity. In contrast to the classical and novel PKCs, atypical PKCs do not respond to diacylglycerol cues to bind the membrane compartment. Until recently it was not clear how aPKCs are recruited; whether aPKCs can directly interact with membranes or whether they are dependent on other protein interactors to do so. Two recent studies identified the pseudo-substrate region and the C1 domain as direct membrane interaction modules, however their relative importance and coupling are unknown. We combined molecular modelling and functional assays to show that the regulatory module of aPKCι, comprising the PB1 pseudo-substrate and C1 domains, forms a cooperative and spatially continuous invariant membrane interaction platform. Furthermore, we show the coordinated orientation of membrane-binding elements within the regulatory module requires a key PB1-C1 interfacial β-strand (BSL). We show this element contains a highly conserved Tyr residue that can be phosphorylated and that negatively regulates the integrity of the regulatory module, leading to membrane release. We thus expose a novel regulatory mechanism of aPKCι membrane binding and release during cell polarization

Into the fold: advances in understanding aPKC membrane dynamics

Atypical protein kinase Cs (aPKCs) are part of the PKC family of protein kinases and are atypical because they don’t respond to the canonical PKC activators diacylglycerol (DAG) and Ca2+. They are central to the organization of polarized cells and are deregulated in several cancers. aPKC recruitment to the plasma membrane compartment is crucial to their encounter with substrates associated with polarizing functions. However, in contrast with other PKCs, the mechanism by which atypical PKCs are recruited there has remained elusive until recently. Here, we bring aPKC into the fold, summarizing recent reports on the direct recruitment of aPKC to membranes, providing insight into seemingly discrepant findings and integrating them with existing literature

Equation of State of Oscillating Brans-Dicke Scalar and Extra Dimensions

We consider a Brans-Dicke scalar field stabilized by a general power law potential with power index $n$ at a finite equilibrium value. Redshifting matter induces oscillations of the scalar field around its equilibrium due to the scalar field coupling to the trace of the energy momentum tensor. If the stabilizing potential is sufficiently steep these high frequency oscillations are consistent with observational and experimental constraints for arbitrary value of the Brans-Dicke parameter $\omega$. We study analytically and numerically the equation of state of these high frequency oscillations in terms of the parameters $\omega$ and $n$ and find the corresponding evolution of the universe scale factor. We find that the equation of state parameter can be negative and less than -1 but it is not related to the evolution of the scale factor in the usual way. Nevertheless, accelerating expansion is found for a certain parameter range. Our analysis applies also to oscillations of the size of extra dimensions (the radion field) around an equilibrium value. This duality between self-coupled Brans-Dicke and radion dynamics is applicable for $\omega= -1 + 1/D$ where D is the number of extra dimensions.Comment: 10 two-column pages, RevTex4, 8 figures. Added clarifying discussions, new references. Accepted in Phys. Rev. D (to appear

A plasticity model for powder compaction processes incorporating particle deformation and rearrangement

This article is available open access through the publisher’s website at the link below. Copyright @ 2008 Elsevier Ltd.This paper develops a mechanistic model of granular materials that can be used with a commercial finite element package (ABAQUS). The model draws on the ideas of critical state soil mechanics and combines them with the theory of envelopes to develop an elasto-plastic model with a non-associated flow rule. The model incorporates both local deformation at the granule contacts, and rearrangement of the granules so that jointly they account for any bulk deformation. The mechanics of the model closely reflect the physicality of the material behaviour and the model parameters are closely linked (although not simplistically identical) to the characteristics of the granules. This not only gives an insight into the material behaviour, but also enables the model to be used to facilitate design of the material, its processing properties and, hence, component development. The model is used to simulate drained triaxial tests, settlement of a powder in a bin, and some examples of die pressing. Simulations are compared with experimental data and with predictions obtained using other models

Cosmological Effects of Radion Oscillations

We show that the redshift of pressureless matter density due to the expansion of the universe generically induces small oscillations in the stabilized radius of extra dimensions (the radion field). The frequency of these oscillations is proportional to the mass of the radion and can have interesting cosmological consequences. For very low radion masses $m_b$ ($m_b\sim10-100 H_0\simeq10^{-32} eV$) these low frequency oscillations lead to oscillations in the expansion rate of the universe. The occurrence of acceleration periods could naturally lead to a resolution of the coincidence problem, without need of dark energy. Even though this scenario for low radion mass is consistent with several observational tests it has difficulty to meet fifth force constraints. If viewed as an effective Brans-Dicke theory it predicts $\omega=-1+\frac{1}{D}$ ($D$ is the number of extra dimensions), while experiments on scales larger than $1mm$ imply $\omega>2500$. By deriving the generalized Newtonian potential corresponding to a massive toroidally compact radion we demonstrate that Newtonian gravity is modified only on scales smaller than $m_b^{-1}$. Thus, these constraints do not apply for $m_b>10^{-3} eV$ (high frequency oscillations) corresponding to scales less than the current experiments ($0.3mm$). Even though these high frequency oscillations can not resolve the coincidence problem they provide a natural mechanism for dark matter generation. This type of dark matter has many similarities with the axion.Comment: Accepted in Phys. Rev. D. Clarifying comments added in the text and some additional references include

Surface tension of the isotropic-nematic interface

We present the first calculations of the pressure tensor profile in the vicinity of the planar interface between isotropic liquid and nematic liquid crystal, using Onsager's density functional theory and computer simulation. When the liquid crystal director is aligned parallel to the interface, the situation of lowest free energy, there is a large tension on the nematic side of the interface and a small compressive region on the isotropic side. By contrast, for perpendicular alignment, the tension is on the isotropic side. There is excellent agreement between theory and simulation both in the forms of the pressure tensor profiles, and the values of the surface tension.Comment: Minor changes; to appear in Phys. Rev.

Universality classes in nonequilibrium lattice systems

This work is designed to overview our present knowledge about universality classes occurring in nonequilibrium systems defined on regular lattices. In the first section I summarize the most important critical exponents, relations and the field theoretical formalism used in the text. In the second section I briefly address the question of scaling behavior at first order phase transitions. In section three I review dynamical extensions of basic static classes, show the effect of mixing dynamics and the percolation behavior. The main body of this work is given in section four where genuine, dynamical universality classes specific to nonequilibrium systems are introduced. In section five I continue overviewing such nonequilibrium classes but in coupled, multi-component systems. Most of the known nonequilibrium transition classes are explored in low dimensions between active and absorbing states of reaction-diffusion type of systems. However by mapping they can be related to universal behavior of interface growth models, which I overview in section six. Finally in section seven I summarize families of absorbing state system classes, mean-field classes and give an outlook for further directions of research.Comment: Updated comprehensive review, 62 pages (two column), 29 figs included. Scheduled for publication in Reviews of Modern Physics in April 200