Red meat from pasture : sustainable livelihoods for small mixed farmers in China's Yunnan Province : a thesis submitted in partial fulfilment of the requirements for the degree of Master in Applied Science in Agribusiness Management at Massey University, Palmerston North, New Zealand

China's pattern of food consumption is changing. The demand for high quality red meat is rapidly increasing, especially in the more affluent coastal regions. The pastoral livestock farmers in Southwest China have low and declining incomes, and operate in a highly uncertain environment. This environmental uncertainty is derived from the seasonal climate, land tenure policies, and a dealer-dominated supply chain in which information is scarce, ambiguous, and untimely. The researcher spent two years in China's Yunnan Province working on a pastoral development project. During this assignment, the researcher undertook a case study of the small, mixed livestock and cropping farmers involved in the project, together with an evaluation of alternative strategies for pastoral development and enhancing livestock production. The case study also involved an overview of agricultural extension and the red meat supply chain in the study area. The current farm production systems are environmentally, financially and socially unsustainable. Farm output is low and achieved inefficiently at considerable cost to future productive potential. Farmers are not investing in farm improvements because they lack confidence in their ability to generate a return from such investments. Confidence is low because farmers do not trust other supply chain participants, and they perceive a low level of control over the operating environment. This is resulting in a vicious cycle of unsustainability. There are numerous market opportunities emerging due to changes food consumption. Farmers have three broad strategic options for taking advantage of these opportunities: invest in technologies to raise output and quality, further process to add value and increase consumer acceptance of red meat and co-operate within the supply chain. The technologies extended as part of the development project were demonstrated to yield significant benefits in terms of production and profit. However, adoption has been low because many of the technologies did not consider local constraints, extension has not widely occurred and uncertainty in the operating environment did not encourage investment. For farmers to be able to successfully implement these strategies farmers need to be empowered and a more enabling environment created. This empowerment involves changing farmers' perception of locus of control, sharing control and supply chain participants learning about each other. Co-operation between farmers and the rest of the supply chain should provide benefits along the whole chain. A model for co-operative and sustainable development is proposed and limitations of this model are discussed. Title: Red Meat from Pasture: Sustainable Livelihoods for Small Mixed Farmers in China's Yunnan Province. Degree: Master of Applied Science in Agribusiness Management Author: Alan Kent McDermott Year: 2001 Keywords: Southwest China; pastoral livestock systems; supply chain management; sustainable livelihoods; trust; perceptions of control; extension of technology

Profile of Immune Cells in Axillary Lymph Nodes Predicts Disease-Free Survival in Breast Cancer

BACKGROUND: While lymph node metastasis is among the strongest predictors of disease-free and overall survival for patients with breast cancer, the immunological nature of tumor-draining lymph nodes is often ignored, and may provide additional prognostic information on clinical outcome. METHODS AND FINDINGS: We performed immunohistochemical analysis of 47 sentinel and 104 axillary (nonsentinel) nodes from 77 breast cancer patients with 5 y of follow-up to determine if alterations in CD4, CD8, and CD1a cell populations predict nodal metastasis or disease-free survival. Sentinel and axillary node CD4 and CD8 T cells were decreased in breast cancer patients compared to control nodes. CD1a dendritic cells were also diminished in sentinel and tumor-involved axillary nodes, but increased in tumor-free axillary nodes. Axillary node, but not sentinel node, CD4 T cell and dendritic cell populations were highly correlated with disease-free survival, independent of axillary metastasis. Immune profiling of ALN from a test set of 48 patients, applying CD4 T cell and CD1a dendritic cell population thresholds of CD4 ≥ 7.0% and CD1a ≥ 0.6%, determined from analysis of a learning set of 29 patients, provided significant risk stratification into favorable and unfavorable prognostic groups superior to clinicopathologic characteristics including tumor size, extent or size of nodal metastasis (CD4, p < 0.001 and CD1a, p < 0.001). Moreover, axillary node CD4 T cell and CD1a dendritic cell populations allowed more significant stratification of disease-free survival of patients with T1 (primary tumor size 2 cm or less) and T2 (5 cm or larger) tumors than all other patient characteristics. Finally, sentinel node immune profiles correlated primarily with the presence of infiltrating tumor cells, while axillary node immune profiles appeared largely independent of nodal metastases, raising the possibility that, within axillary lymph nodes, immune profile changes and nodal metastases represent independent processes. CONCLUSION: These findings demonstrate that the immune profile of tumor-draining lymph nodes is of novel biologic and clinical importance for patients with early stage breast cancer

Gray Peril or Loyal Support? The Effects of the Elderly on Educational Expenditures-super-

Do large concentrations of elderly represent a "gray peril" to maintaining adequate educational expenditures? The gray peril hypothesis is based on an assumption of instrumental self-interest in political behavior. In contrast, we argue that "loyalty" to community schools competes with economic self-interest and that older citizens are heterogeneous in their preferences. Copyright (c) 2004 by the Southwestern Social Science Association.

Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010

Background Measuring disease and injury burden in populations requires a composite metric that captures both premature mortality and the prevalence and severity of ill-health. The 1990 Global Burden of Disease study proposed disability-adjusted life years (DALYs) to measure disease burden. No comprehensive update of disease burden worldwide incorporating a systematic reassessment of disease and injury-specific epidemiology has been done since the 1990 study. We aimed to calculate disease burden worldwide and for 21 regions for 1990, 2005, and 2010 with methods to enable meaningful comparisons over time. Methods We calculated DALYs as the sum of years of life lost (YLLs) and years lived with disability (YLDs). DALYs were calculated for 291 causes, 20 age groups, both sexes, and for 187 countries, and aggregated to regional and global estimates of disease burden for three points in time with strictly comparable definitions and methods. YLLs were calculated from age-sex-country-time-specific estimates of mortality by cause, with death by standardised lost life expectancy at each age. YLDs were calculated as prevalence of 1160 disabling sequelae, by age, sex, and cause, and weighted by new disability weights for each health state. Neither YLLs nor YLDs were age-weighted or discounted. Uncertainty around cause-specific DALYs was calculated incorporating uncertainty in levels of all-cause mortality, cause-specific mortality, prevalence, and disability weights. Findings Global DALYs remained stable from 1990 (2.503 billion) to 2010 (2.490 billion). Crude DALYs per 1000 decreased by 23% (472 per 1000 to 361 per 1000). An important shift has occurred in DALY composition with the contribution of deaths and disability among children (younger than 5 years of age) declining from 41% of global DALYs in 1990 to 25% in 2010. YLLs typically account for about half of disease burden in more developed regions (high-income Asia Pacific, western Europe, high-income North America, and Australasia), rising to over 80% of DALYs in sub-Saharan Africa. In 1990, 47% of DALYs worldwide were from communicable, maternal, neonatal, and nutritional disorders, 43% from non-communicable diseases, and 10% from injuries. By 2010, this had shifted to 35%, 54%, and 11%, respectively. Ischaemic heart disease was the leading cause of DALYs worldwide in 2010 (up from fourth rank in 1990, increasing by 29%), followed by lower respiratory infections (top rank in 1990; 44% decline in DALYs), stroke (fifth in 1990; 19% increase), diarrhoeal diseases (second in 1990; 51% decrease), and HIV/AIDS (33rd in 1990; 351% increase). Major depressive disorder increased from 15th to 11th rank (37% increase) and road injury from 12th to 10th rank (34% increase). Substantial heterogeneity exists in rankings of leading causes of disease burden among regions. Interpretation Global disease burden has continued to shift away from communicable to non-communicable diseases and from premature death to years lived with disability. In sub-Saharan Africa, however, many communicable, maternal, neonatal, and nutritional disorders remain the dominant causes of disease burden. The rising burden from mental and behavioural disorders, musculoskeletal disorders, and diabetes will impose new challenges on health systems. Regional heterogeneity highlights the importance of understanding local burden of disease and setting goals and targets for the post-2015 agenda taking such patterns into account. Because of improved definitions, methods, and data, these results for 1990 and 2010 supersede all previously published Global Burden of Disease results