Mktg

A new approach to learning the principles of marketing, MKTG is the Asia–Pacific edition of a proven, innovative solution to enhance the students' learning experience. Concise, yet complete, coverage supported by a suite of online learning aids equips students with the tools required to successfully undertake an introductory marketing course. Paving a new way to both teaching and learning, MKTG is designed to truly connect with today's busy tech-savy student. Students have access to online interactive quizzing, videos, podcasts, flashcards, marketing plans, games and more. An accessible, easy-to-read text along with tear out review cards complete a package which helps students to learn important concepts faster

From Observers to Participants: Joining the Scientific Community

In this essay, we have integrated the voices of our mentors and students to explore 45 years of undergraduate research experiences and their role in shaping our scientific community. In considering our collective experiences, we see undergraduate involvement in research as a rich source of community development, one that has both touched our lives and influenced our teaching

Nano-ADEPT Aeroloads Wind Tunnel Test

A wind tunnel test of the Adaptable Deployable Entry and Placement Technology (ADEPT) was conducted in April 2015 at the US Army's 7 by10 Foot Wind Tunnel located at NASA Ames Research Center. Key geometric features of the fabric test article were a 0.7 meter deployed base diameter, a 70 degree half-angle forebody cone angle, eight ribs, and a nose-to-base radius ratio of 0.7. The primary objective of this wind tunnel test was to obtain static deflected shape and pressure distributions while varying pretension at dynamic pressures and angles of attack relevant to entry conditions at Earth, Mars, and Venus. Other objectives included obtaining aerodynamic force and moment data and determining the presence and magnitude of any dynamic aeroelastic behavior (buzz/flutter) in the fabric trailing edge. All instrumentation systems worked as planned and a rich data set was obtained. This paper describes the test articles, instrumentation systems, data products, and test results. Four notable conclusions are drawn. First, test data support adopting a pre-tension lower bound of 10 foot pounds per inch for Nano-ADEPT mission applications in order to minimize the impact of static deflection. Second, test results indicate that the fabric conditioning process needs to be reevaluated. Third, no flutter/buzz of the fabric was observed for any test condition and should also not occur at hypersonic speeds. Fourth, translating one of the gores caused ADEPT to generate lift without the need for a center of gravity offset. At hypersonic speeds, the lift generated by actuating ADEPT gores could be used for vehicle control

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

MKTG2: 2nd Asia-Pacific edition

A unique approach to learning the principles of marketing, MKTG2 is the second Asia-Pacific edition of a proven, innovative solution to enhance the learning experience. Expanded content, supported by a suite of online learning aids, equips students with the tools required to successfully undertake an introductory marketing course. Continuing to pave a new way to both teach and learn, MKTG2 is designed to truly connect with today's busy, tech-savvy student. Students have access to online interactive quizzing, videos, podcasts, flashcards, marketing plan, games and more. An accessible, easy-to-read text along with tear out review cards complete a package which helps students to learn important concepts faster. MKTG delivers a fresh approach to give students what they need and want in a text

Marketing

Bostonxi, 756 p.: illus.; 25 cm

Durable Communities Emerge from Homes and Landscapes Powered by Sunshine

Individuals have an important role in taking actions that significantly reduce household carbon emissions and increase landscape sequestration of carbon. New and existing houses can run on sunshine thereby becoming energy positive. Sun-powered landscapes that are designed for flooding sequester carbon and manage stormwater thereby increasing resilience to climate change. These individual actions influence builders, town planners, neighbors, and neighborhoods to adopt norms aligned with natural processes, thus engendering more durable communities