236 research outputs found
âEste diablo de viejaâ: Revealing the Conversa Voice in Celestina
Due to the extraordinary socio-religious situation of the Inquisitionâs aggressive attempt at unification looming over late Medieval Spain, the existence of a converso influence in Fernando de Rojasâ masterpiece, Celestina, is rarely up for debate. However, the way in which this influence manifests itself in Rojasâ only known work remains open for discussion among scholars of the work. Despite critics who struggle to view Celestina as an expression of converso literature, arguments have been made to establish the likelihood of converso status for Pleberio, Calisto, and Melibea, but have yet to look profoundly to Celestinaâs own origins. Thanks to her perceived magical abilities, the famous go-between operates within the parody of religion and its relation to courtly love. Parody and irony function as instruments that create a space for the traditionally marginalized voices rendered by the Spanish sentimental romance to be heard, notably due to gender and cultural Christian values. Interpreting Celestina as both a conversa who deviates from the proper Christian way of life and as a deviant from established gender roles further expands the realm of ironic possibilities offered by the sentimental romance genre and furthers the humoristic nature of the religious parody throughout the work. Furthermore, the transgressive nature of converso literature challenges Spanish conventional values related to blood purity and serves as social criticism rather than as condemnations of deviant behavior. This reconsideration of Celestina as a conversa voice expands the possibilities of understanding Rojasâ contribution to the sentimental romance genre
The Design and Validation of the Quantum Mechanics Conceptual Survey
The Quantum Mechanics Conceptual Survey (QMCS) is a 12-question survey of
students' conceptual understanding of quantum mechanics. It is intended to be
used to measure the relative effectiveness of different instructional methods
in modern physics courses. In this paper we describe the design and validation
of the survey, a process that included observations of students, a review of
previous literature and textbooks and syllabi, faculty and student interviews,
and statistical analysis. We also discuss issues in the development of specific
questions, which may be useful both for instructors who wish to use the QMCS in
their classes and for researchers who wish to conduct further research of
student understanding of quantum mechanics. The QMCS has been most thoroughly
tested in, and is most appropriate for assessment of (as a posttest only),
sophomore-level modern physics courses. We also describe testing with students
in junior quantum courses and graduate quantum courses, from which we conclude
that the QMCS may be appropriate for assessing junior quantum courses, but is
not appropriate for assessing graduate courses. One surprising result of our
faculty interviews is a lack of faculty consensus on what topics should be
taught in modern physics, which has made designing a test that is valued by a
majority of physics faculty more difficult than expected.Comment: Submitted to Physical Review Special Topics: Physics Education
Researc
Baseline Chromatin Modification Levels May Predict Interindividual Variability in Ozone-Induced Gene Expression
Traditional toxicological paradigms have relied on factors such as age, genotype, and disease status to explain variability in responsiveness to toxicant exposure; however, these are neither sufficient to faithfully identify differentially responsive individuals nor are they modifiable factors that can be leveraged to mitigate the exposure effects. Unlike these factors, the epigenome is dynamic and shaped by an individualâs environment. We sought to determine whether baseline levels of specific chromatin modifications correlated with the interindividual variability in their ozone (O3)-mediated induction in an airâliquid interface model using primary human bronchial epithelial cells from a panel of 11 donors. We characterized the relationship between the baseline abundance of 6 epigenetic markers with established roles as key regulators of gene expressionâhistone H3 lysine 4 trimethylation (H3K4me3), H3K27 acetylation (H3K27ac), pan-acetyl H4 (H4ac), histone H3K27 di/trimethylation (H3K27me2/3), unmodified H3, and 5-hydroxymethylcytosine (5-hmC)âand the variability in the O3-induced expression of IL-8, IL-6, COX2, and HMOX1. Baseline levels of H3K4me3, H3K27me2/3, and 5-hmC, but not H3K27ac, H4ac, and total H3, correlated with the interindividual variability in O3-mediated induction of HMOX1 and COX2. In contrast, none of the chromatin modifications that we examined correlated with the induction of IL-8 and IL-6. From these findings, we propose an âepigenetic seed and soilâ model in which chromatin modification states between individuals differ in the relative abundance of specific modifications (the âsoilâ) that govern how receptive the gene is to toxicant-mediated cellular signals (the âseedâ) and thus regulate the magnitude of exposure-related gene induction
Observation and Spectral Measurements of the Crab Nebula with Milagro
The Crab Nebula was detected with the Milagro experiment at a statistical
significance of 17 standard deviations over the lifetime of the experiment. The
experiment was sensitive to approximately 100 GeV - 100 TeV gamma ray air
showers by observing the particle footprint reaching the ground. The fraction
of detectors recording signals from photons at the ground is a suitable proxy
for the energy of the primary particle and has been used to measure the photon
energy spectrum of the Crab Nebula between ~1 and ~100 TeV. The TeV emission is
believed to be caused by inverse-Compton up-scattering scattering of ambient
photons by an energetic electron population. The location of a TeV steepening
or cutoff in the energy spectrum reveals important details about the underlying
electron population. We describe the experiment and the technique for
distinguishing gamma-ray events from the much more-abundant hadronic events. We
describe the calculation of the significance of the excess from the Crab and
how the energy spectrum is fit. The fit is consistent with values measured by
IACTs between 1 and 20 TeV. Fixing the spectral index to values that have been
measured below 1 TeV by IACT experiments (2.4 to 2.6), the fit to the Milagro
data suggests that Crab exhibits a spectral steepening or cutoff between about
20 to 40 TeV.Comment: Submitted to Astrophysical Journa
Study protocol: Determinants of participation and quality of life of adolescents with cerebral palsy: a longitudinal study (SPARCLE2)
<p>Abstract</p> <p>Background</p> <p>Children and adults with impairments such as cerebral palsy have lower participation in life situations than able-bodied people. Less is known about their subjective perception of their lives, called their quality of life.</p> <p>During adolescence, rapid physical and psychological changes occur; although these may be more difficult for disabled than for able-bodied adolescents, little research has examined the lives of disabled adolescents.</p> <p>In 2003-4 a European Union funded project, SPARCLE, visited 818 children aged 8-12 years with cerebral palsy, sampled from population-based registers in nine European regions. The quality of life reported by these disabled children was similar to that of the general population but their participation was lower; levels of participation varied between countries even for children with similar severity of cerebral palsy.</p> <p>We are currently following up these children, now aged 13-17 years, to identify (i) to what extent contemporaneous factors (pain, impairment, psychological health and parental stress) predict their participation and quality of life, (ii) what factors modify how participation and quality of life at age 8-12 years are associated with participation and quality of life in adolescence, and (iii) whether differences between European countries in participation and quality of life can be explained by variations in environmental factors.</p> <p>Methods/Design</p> <p>Trained researchers will visit families to administer questionnaires to capture the adolescents' type and severity of impairment, socio-demographic characteristics, participation, quality of life, psychological health, pain, environmental access and parental stress. We will use multivariable models (linear, logistic or ordinal) to assess how adolescent participation, quality of life, psychological health, pain, environmental access and parental stress, vary with impairment and socio-demographic characteristics and, where possible, how these outcomes compare with general population data. For participation and quality of life, longitudinal analyses will assess to what extent these are predicted by corresponding levels in childhood and what factors modify this relationship. Structural equation modelling will be used to identify indirect relationships mediated by other factors.</p
Dark Energy Survey Year 3 results: marginalization over redshift distribution uncertainties using ranking of discrete realizations
Cosmological information from weak lensing surveys is maximized by sorting source galaxies into tomographic redshift subsamples. Any uncertainties on these redshift distributions must be correctly propagated into the cosmological results. We present hyperrank, a new method for marginalizing over redshift distribution uncertainties, using discrete samples from the space of all possible redshift distributions, improving over simple parametrized models. In hyperrank, the set of proposed redshift distributions is ranked according to a small (between one and four) number of summary values, which are then sampled, along with other nuisance parameters and cosmological parameters in the Monte Carlo chain used for inference. This approach can be regarded as a general method for marginalizing over discrete realizations of data vector variation with nuisance parameters, which can consequently be sampled separately from the main parameters of interest, allowing for increased computational efficiency. We focus on the case of weak lensing cosmic shear analyses and demonstrate our method using simulations made for the Dark Energy Survey (DES). We show that the method can correctly and efficiently marginalize over a wide range of models for the redshift distribution uncertainty. Finally, we compare hyperrank to the common mean-shifting method of marginalizing over redshift uncertainty, validating that this simpler model is sufficient for use in the DES Year 3 cosmology results presented in companion papers
The mass and galaxy distribution around SZ-selected clusters
We present measurements of the radial profiles of the mass and galaxy number density around SunyaevâZelâdovich (SZ)-selected clusters using both weak lensing and galaxy counts. The clusters are selected from the Atacama Cosmology Telescope Data Release 5 and the galaxies from the Dark Energy Survey Year 3 data set. With signal-to-noise ratio of 62 (45) for galaxy (weak lensing) profiles over scales of about 0.2â20 hâ1 Mpc, these are the highest precision measurements for SZ-selected clusters to date. Because SZ selection closely approximates mass selection, these measurements enable several tests of theoretical models of the mass and light distribution around clusters. Our main findings are: (1) The splashback feature is detected at a consistent location in both the mass and galaxy profiles and its location is consistent with predictions of cold dark matter N-body simulations. (2) The full mass profile is also consistent with the simulations. (3) The shapes of the galaxy and lensing profiles are remarkably similar for our sample over the entire range of scales, from well inside the cluster halo to the quasilinear regime. We measure the dependence of the profile shapes on the galaxy sample, redshift, and cluster mass. We extend the Diemer & Kravtsov model for the cluster profiles to the linear regime using perturbation theory and show that it provides a good match to the measured profiles. We also compare the measured profiles to predictions of the standard halo model and simulations that include hydrodynamics. Applications of these results to cluster mass estimation, cosmology, and astrophysics are discussed
Dark Energy Survey Year 3 results: Curved-sky weak lensing mass map reconstruction
We present reconstructed convergence maps, mass maps, from the Dark Energy Survey (DES) third year (Y3) weak gravitational lensing data set. The mass maps are weighted projections of the density field (primarily dark matter) in the foreground of the observed galaxies. We use four reconstruction methods, each is a maximum a posteriori estimate with a different model for the prior probability of the map: Kaiser-Squires, null B-mode prior, Gaussian prior, and a sparsity prior. All methods are implemented on the celestial sphere to accommodate the large sky coverage of the DES Y3 data. We compare the methods using realistic \u39bCDM simulations with mock data that are closely matched to the DES Y3 data. We quantify the performance of the methods at the map level and then apply the reconstruction methods to the DES Y3 data, performing tests for systematic error effects. The maps are compared with optical foreground cosmic-web structures and are used to evaluate the lensing signal from cosmic-void profiles. The recovered dark matter map covers the largest sky fraction of any galaxy weak lensing map to date
The DES view of the Eridanus supervoid and the CMB cold spot
The Cold Spot is a puzzling large-scale feature in the Cosmic Microwave Background temperature maps and its origin has been subject to active debate. As an important foreground structure at low redshift, the Eridanus supervoid was recently detected, but it was subsequently determined that, assuming the standard ÎCDM model, only about 10â20 per cent of the observed temperature depression can be accounted for via its Integrated SachsâWolfe imprint. However, R âł 100 hâ1Mpc supervoids elsewhere in the sky have shown ISW imprints AISW â 5.2 ± 1.6 times stronger than expected from ÎCDM (AISW = 1), which warrants further inspection. Using the Year-3 redMaGiC catalogue of luminous red galaxies from the Dark Energy Survey, here we confirm the detection of the Eridanus supervoid as a significant underdensity in the Cold Spotâs direction at z < 0.2. We also show, with S/N âł 5 significance, that the Eridanus supervoid appears as the most prominent large-scale underdensity in the dark matter mass maps that we reconstructed from DES Year-3 gravitational lensing data. While we report no significant anomalies, an interesting aspect is that the amplitude of the lensing signal from the Eridanus supervoid at the Cold Spot centre is about 30 per cent lower than expected from similar peaks found in N-body simulations based on the standard ÎCDM model with parameters Ωm = 0.279 and Ï8 = 0.82. Overall, our results confirm the causal relation between these individually rare structures in the cosmic web and in the CMB, motivating more detailed future surveys in the Cold Spot region
Dark Energy Survey Y3 results: Blending shear and redshift biases in image simulations
As the statistical power of galaxy weak lensing reaches per cent level precision, large, realistic, and robust simulations are required to calibrate observational systematics, especially given the increased importance of object blending as survey depths increase. To capture the coupled effects of blending in both shear and photometric redshift calibration, we define the effective redshift distribution for lensing, nÎł(z), and describe how to estimate it using image simulations. We use an extensive suite of tailored image simulations to characterize the performance of the shear estimation pipeline applied to the Dark Energy Survey (DES) Year 3 data set. We describe the multiband, multi-epoch simulations, and demonstrate their high level of realism through comparisons to the real DES data. We isolate the effects that generate shear calibration biases by running variations on our fiducial simulation, and find that blending-related effects are the dominant contribution to the mean multiplicative bias of approximately . By generating simulations with input shear signals that vary with redshift, we calibrate biases in our estimation of the effective redshift distribution, and demonstrate the importance of this approach when blending is present. We provide corrected effective redshift distributions that incorporate statistical and systematic uncertainties, ready for use in DES Year 3 weak lensing analyses
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