A polarographic analysis of the tetracyanoaurate (III) and the dicyanoaurate (I) complexes

A polarographic analysis of the two gold complexes, dicyanoaurate (I) and tetracyanoaurate (III), was undertaken. Both complexes were shown to have distinguishable current-voltage curves. Previous work on the dicyanoaurate (I) was confirmed, and new data was added for the low concentrations. The tetracyanoaurate (III) was investigated, and the half-wave potential was found to be -0.32 volts. Maxima problems with the complex were encountered and resolved

Executive information systems, company libraries and the future of information services in business.

The aim of the study was to investigate the development of Executive Information Systems (EIS) in twenty large British companies and to also determine what role, if any, the company library played. Also investigated was the future of the library and other corporate information systems as a provider of information services to business. A multiple-case study methodology was adopted for carrying out the research. Interviews were conducted with nearly 70 respondents; these included librarians, EIS developers and senior manager users of the EIS, and EIS vendors. All three corporate respondent groups have poor perception of Information Management policy, politics and culture. Most EIS are developed using prototyping or CSF method without reference to any frameworks or strategic business plan, and a lack of co-operation from senior managers. EIS are developed because of internal pressures. Their main use is as an operational tool and for monitoring/analysis. EIS has made managers more aware of information as corporate asset but few request improvements to the system. Most EIS are successful and percolate further down the management hierarchy, but they have not lived up to their original expectations. EIS impact on both the library and company is slight. Most librarians know about EIS, mainly by chance. Only four company libraries were involved in the development of EIS because most EIS are internal financial systems, and the library is seen as irrelevant. However, they are more likely to be involved if the library reports to a corporate strategy department, be physically near EIS teams, and personally know the EIS developers. Libraries are consulted because they are seen as extemal data experts; their main role is acting as external information consultants or as a conduit for external sources directly into the EIS. Despite many librarians being proactive many also have a pessimistic view of their future. They believe they are seen by senior management as increasingly irrelevant and targets for cost cutting, and as such few openly promote themselves within the company. However, the study also shows that librarians may have new roles to play as information becomes much more widely accessible in business through knowledge management technology such as Lotus Notes and intranets

Modulation of folic acid bioaccessibility by encapsulation in pH-responsive gated mesoporous silica particles

[EN] A study on the controlled release of folic acid (FA) from pH-responsive gated mesoporous silica particles (MSP) is reported. The MCM-41 support was synthesized using tetraethyl orthosilicate (TEOS) as hydrolytic inorganic precursor and the surfactant hexadecyltrimethylammonium bromide (CTAB) as porogen species. Calcination of the mesostructured phase resulted in the starting solid. This solid was loaded with FA to obtain the initial support S0. Moreover, this FA-loaded material was further functionalized with 3-[2-(2-aminoethylamino)ethylamino]propyltrimethoxysilane (N3) in order to obtain the gated polyamine-functionalised material S1. Solids S0 and S1 were characterized using standard solid state procedures. It was found that the functionalization process and the inclusion of FA on the pores did not modify the mesoporous structure of the starting material. FA delivery studies in water with solids S0 and S1 were carried out in water at pH 2 and 7.5. S0 was not able to completely inhibit FA delivery at acidic pH yet a rapid FA release at neutral pH was observed in few minutes. In contrast, S1 was tightly capped at pH 2 and displayed a sustained delivery of FA when the pH was switched to 7.5. In the second part of the study, FA loading and functionalization of S1-like supports was optimized. In particular, solids loaded with FA in phosphate buffered saline (PBS) and capped with N3 in acetate buffer at pH 2 exhibited a delivery capacity up to 95 μg FA/mg solid. Finally, FA release from the selected optimized supports was studied following an in vitro digestion procedure. The results showed that amine-capped MSP were not only able to hinder the release of the vitamin in gastric fluids (pH 2), but were also capable of deliver progressively the FA in presence of a simulated intestinal juice (pH 7.5) offering a suitable mechanism to control the bioaccessibility of the vitaminAuthors gratefully acknowledge the financial support from the Ministerio de Economia y Competitividad (Projects AGL201239597-C02 and MAT2012-38429-004-01) and the Generalitat Valenciana (project PROMETEO/2009/016). E.P. is grateful to the Ministerio de Ciencia e Innovacion for his Grant (AP2008-00620). C.C. thanks the Generalitat Valenciana for her post-doctoral contract VALi+D.Pérez-Esteve, É.; Fuentes López, A.; Coll Merino, MC.; Acosta, C.; Bernardos Bau, A.; Amoros Del Toro, PJ.; Marcos Martínez, MD.... (2015). Modulation of folic acid bioaccessibility by encapsulation in pH-responsive gated mesoporous silica particles. Microporous and Mesoporous Materials. 202:124-132. https://doi.org/10.1016/j.micromeso.2014.09.049S12413220

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The impact of microcomputers on small businesses in the financial services sector of the City of Sheffield

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