484 research outputs found
The effect of farming system on dairy cow cleanliness in the UK and implications to udder health
The cleanliness of dairy cows was assessed using a 20 point hygiene score system at different times in the year on 14 organic and 14 conventional farms in the UK. Overall, cows were dirtier during winter housing compared to summer grazing. Farming system had no effect on cow cleanliness when cows were at grass, but when housed in the winter, organic cows were more likely to be cleaner. There was a link between cow hygiene scores and milk hygiene, with herds having lower bulk tank somatic cell counts (BTSCC) tending to have cleaner cows. This relationship was strongest for the organic herds. There was no significant link between hygiene score and Bactoscan (BS) count or mastitis incidence
Witnessing eigenstates for quantum simulation of Hamiltonian spectra
The efficient calculation of Hamiltonian spectra, a problem often intractable
on classical machines, can find application in many fields, from physics to
chemistry. Here, we introduce the concept of an "eigenstate witness" and
through it provide a new quantum approach which combines variational methods
and phase estimation to approximate eigenvalues for both ground and excited
states. This protocol is experimentally verified on a programmable silicon
quantum photonic chip, a mass-manufacturable platform, which embeds entangled
state generation, arbitrary controlled-unitary operations, and projective
measurements. Both ground and excited states are experimentally found with
fidelities >99%, and their eigenvalues are estimated with 32-bits of precision.
We also investigate and discuss the scalability of the approach and study its
performance through numerical simulations of more complex Hamiltonians. This
result shows promising progress towards quantum chemistry on quantum computers.Comment: 9 pages, 4 figures, plus Supplementary Material [New version with
minor typos corrected.
Single and Multi-trait GWAS Identify Genetic Factors Associated with Production Traits in Common Bean Under Abiotic Stress Environments
The genetic improvement of economically important production traits of dry bean (Phaseolus vulgaris L.), for geographic regions where production is threatened by drought and high temperature stress, is challenging because of the complex genetic nature of these traits. Large scale SNP data sets for the two major gene pools of bean, Andean and Middle American, were developed by mapping multiple pools of genotype-by-sequencing reads and identifying over 200k SNPs for each gene pool against the most recent assembly of the P. vulgaris genome sequence. Moderately sized Bean Abiotic Stress Evaluation (BASE) panels, consisting of genotypes appropriate for production in Central America and Africa, were assembled. Phylogenetic analyses demonstrated the BASE populations represented broad genetic diversity for the appropriate races within the two gene pools. Joint mixed linear model genome-wide association studies with data from multiple locations discovered genetic factors associated with four production traits in both heat and drought stress environments using the BASE panels. Pleiotropic genetic factors were discovered using a multi-trait mixed model analysis. SNPs within or near candidate genes associated with hormone signaling, epigenetic regulation, and ROS detoxification under stress conditions were identified and can be used as genetic markers in dry bean breeding programs.
Includes Corrigendu
Definition of strategies for the reduction of operational inefficiencies in a stroke unit
Stroke disease is the second common cause of death in the world and is then of particular concern to policy-makers. Additionally, it is a meaningful problem leaving a high number of people with severe disabilities, placing a heavy burden on society and incurring prolonged length of stay. In this respect, it is necessary to develop analytic models providing information on care system behavior in order to detect potential operational inefficiencies along the stroke patient journey and subsequently design improvement strategies. However, modeling stroke care is highly complex due to the multiple clinical outcomes and different pathways. Therefore, this paper presents an integrated approach between Discrete-event Simulation (DES) and Markov models so that integrated planning of healthcare services relating to stroke care and the evaluation of potential improvement scenarios can be facilitated, made more logically robust and easy to understand. First, a stroke care system from Colombia was characterized by identifying the exogenous and endogenous variables of the process. Afterward, an input analysis was conducted to define the probability distributions of the aforementioned variables. Then, both DES and Markov models were designed and validated to provide deeper analysis of the entire patient journey. Finally, the possible adoption of thrombolytic treatment on patients with stroke disease was assessed based on the proposed approaches within this paper. The results evidenced that the length of stay (LOS) decreased by 12,89% and the mortality ratio was diminished by 21,52%. Evaluation of treatment cost per patient is also carried out
Native incretins prevent the development of atherosclerotic lesions in apolipoprotein E knockout mice
Influences of tongue biomechanics on speech movements during the production of velar stop consonants: a modeling study
This study explores the following hypothesis: forward looping movements of
the tongue that are observed in VCV sequences are due partly to the anatomical
arrangement of the tongue muscles and how they are used to produce a velar
closure. The study uses an anatomically based 2D biomechanical tongue model.
Tissue elastic properties are accounted for in finite-element modeling, and
movement is controlled by constant-rate control parameter shifts. Tongue
raising and lowering movements are produced by the model with the combined
actions of the genioglossus, styloglossus and hyoglossus. Simulations of V1CV2
movements were made, where C is a velar consonant and V is [a], [i] or [u]. If
V1 is one of the vowels [a] and [u], the resulting trajectories describe
movements that begin to loop forward before consonant closure and continue to
slide along the palate during the closure. This prediction is in agreement with
classical data published in the literature. If V1 is vowel [i], we observe a
small backward movement. This is also in agreement with some measurements on
human speakers, but it is also in contradiction with the original data
published by Houde (1967). These observations support the idea that the
biomechanical properties of the tongue could be the main factor responsible for
the forward loops when V1 is a back vowel. In the left [i] context, it seems
that additional factors have to be taken into considerations, in order to
explain the observations made on some speaker
Tomato: a crop species amenable to improvement by cellular and molecular methods
Tomato is a crop plant with a relatively small DNA content per haploid genome and a well developed genetics. Plant regeneration from explants and protoplasts is feasable which led to the development of efficient transformation procedures.
In view of the current data, the isolation of useful mutants at the cellular level probably will be of limited value in the genetic improvement of tomato. Protoplast fusion may lead to novel combinations of organelle and nuclear DNA (cybrids), whereas this technique also provides a means of introducing genetic information from alien species into tomato. Important developments have come from molecular approaches. Following the construction of an RFLP map, these RFLP markers can be used in tomato to tag quantitative traits bred in from related species. Both RFLP's and transposons are in the process of being used to clone desired genes for which no gene products are known. Cloned genes can be introduced and potentially improve specific properties of tomato especially those controlled by single genes. Recent results suggest that, in principle, phenotypic mutants can be created for cloned and characterized genes and will prove their value in further improving the cultivated tomato.
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