Why Do Some Aboriginal Communities Have Lower Crime Rates Than Others? A Pilot Study

Crime data collated by the New South Wales (NSW) Bureau of Crime Statistics and Research (BOCSAR) indicates that there is considerable variation in rates of Indigenous1 offending from one area to another in NSW, including in areas that are comparable in terms of Indigenous population. However, despite research findings that raise the importance of community context in relation to the offending of Indigenous individuals, there has been little investigation of the relationship between the dynamics of Indigenous communities and crime rates. In particular, there is a dearth of research that seeks to better understand the factors that may render Indigenous communities less prone to crime. This article outlines the findings of a pilot study undertaken by a research team from Jumbunna Indigenous House of Learning at the University of Technology Sydney, with support from BOCSAR. The pilot study sought to better understand the factors that contribute to variations in rates of Indigenous offending by conducting qualitative research in two communities with significant Aboriginal populations â Wilcannia and Menindee â that are demographically and geographically comparable but with contrasting crime rates

Evaluating the impact of public housing after prison for a sex offence

This article evaluates the impact of housing assistance on the post-release pathways of people convicted of sex offences, in terms of a range of criminal justice outcomes and associated costs. Using linked administrative data from New South Wales government agencies, it compares outcomes and costs for two groups of formerly incarcerated sex offenders–one group who received public housing tenancies at some stage after their release, the other who only received private rental assistance. We find the public housing group had better criminal justice outcomes (e.g. fewer police incidents, court appearances, proven offences, days in custody and days on community-based orders) than the non-public housing group, achieved mostly at less cost to governments. The evidence, likely applicable in other jurisdictions with similar housing systems, strongly supports the increased provision of social housing to this group of ex-prisoners and, we hope, helps disarm the controversy that affects this area of policy in Australia and internationally

Comparison of Urine Output among Patients Treated with More Intensive Versus Less Intensive RRT: Results from the Acute Renal Failure Trial Network Study

Intensive RRT may have adverse effects that account for the absence of benefit observed in randomized trials of more intensive versus less intensive RRT. We wished to determine the association of more intensive RRT with changes in urine output as a marker of worsening residual renal function in critically ill patients with severe AKI

Tubo-Ovarian Abscess Occurring 16 Years After Supracervical Hysterectomy

Background: Supracervical hysterectomy is seldom performed and there are few reports of tubo-ovarian abscess (TOA) after supracervical hysterectomy. Case: The case of a 49-year-old woman with a right TOA is reported. This patient had received a supracervical hysterectomy 16 years earlier due to rupture of the uterus. At this admission, she presented with complaints of lower abdominal pain and fever. Bimanual and transvaginal ultrasound examinations demonstrated a tender mass in the right adnexal region. Laparotomy, pathologic examination and microbiologic study confirmed the diagnosis of right TOA. Conclusion: After supracervical hysterectomy, patients may develop endocervicitis, parametritis and/or TOA. This series may be a subtype of ascending infections in the female genital tract

An evolutionary catalogue of Galactic post-AGB and related objects

With the ongoing AKARI infrared sky survey, of much greater sensitivity than IRAS, a wealth of post-AGB objects may be discovered. It is thus time to organize our present knowledge of known post-AGB stars in th galaxy with a view to using it to search for new post-AGB objects among AKARI sources. We searched the literature available on the NASA Astrophysics Data System up to 1 October 2006, and defined criteria for classifying sources into three categories: "very likely", "possible" and "disqualified" post-AGB objects. The category of "very likely" post-AGB objects is made up of several classes. We have created an evolutionary, on-line catalogue of Galactic post-AGB objects, to be referred to as "The Torun catalogue of Galactic post-AGB and related objects". The present version of the catalogue contains 326 "very likely", 107 "possible" and 64 "disqualified" objects. For the very likely post-AGB objects, the catalogue gives the available optical and infrared photometry, infrared spectroscopy and spectral types, and links to finding charts and bibliography.Comment: 9 pages, 6 figures, accepted for publication in A&

Challenges of Cardio-Kidney Composite Outcomes in Large-Scale Clinical Trials

Patients with chronic cardiovascular or metabolic diseases, including diabetes, hypertension, obesity, and heart failure, often have comorbid kidney disease. Indeed, long-term outcomes are worse in the setting of both cardiac and kidney disease compared with either disease in isolation. In addition, the clinical presentations of certain acute cardiovascular events (such as heart failure) and worsening kidney function are overlapping and may be challenging to distinguish. Recently, certain novel treatments have demonstrated beneficial effects on both cardiac and kidney outcomes. Sodium-glucose cotransporter-2 inhibitors have exhibited concordant risk reduction and clinically important benefits in chronic kidney disease with and without diabetes, diabetes and established cardiovascular disease or multiple atherosclerotic vascular disease risk factors, and heart failure with reduced ejection fraction with and without diabetes mellitus. In addition, primary trial results have revealed that sacubitril-valsartan therapy improves cardiovascular outcomes in patients with chronic heart failure with reduced ejection fraction and post-hoc analyses suggest favorable kidney effects. A concordant pattern of kidney benefit with sacubitril-valsartan has also been observed in chronic heart failure with preserved ejection fraction. Given the complex interplay between cardiac and kidney disease and the possibility that treatments may show concordant cardio-kidney benefits, there has been recent interest to acknowledge formally, define, and utilize composite cardio-kidney outcomes in future cardiovascular trials. This review describes potential challenges in utilization of such outcomes that should be considered and addressed prior to their incorporation into such trials

Altered Monocyte Phenotype in HIV-1 Infection Tends to Normalize with Integrase-Inhibitor-Based Antiretroviral Therapy

Background: Monocytes are increasingly implicated in the inflammatory consequences of HIV-1 disease, yet their phenotype following antiretroviral therapy (ART) initiation is incompletely defined. Here, we define more completely monocyte phenotype both prior to ART initiation and during 48 weeks of ART. Methods: Cryopreserved peripheral blood mononuclear cells (PBMCs) were obtained at baseline (prior to ART initiation) and at weeks 12, 24, and 48 of treatment from 29 patients participating in ACTG clinical trial A5248, an open label study of raltegravir/emtricitibine/tenofovir administration. For comparison, cryopreserved PBMCs were obtained from 15 HIV-1 uninfected donors, each of whom had at least two cardiovascular risk factors. Thawed samples were stained for monocyte subset markers (CD14 and CD16), HLA-DR, CCR2, CX3CR1, CD86, CD83, CD40, CD38, CD36, CD13, and CD163 and examined using flow cytometry. Results: In untreated HIV-1 infection there were perturbations in monocyte subset phenotypes, chiefly a higher frequency and density (mean fluorescence intensity–MFI) of HLA-DR (%-p = 0.004, MFI-p = .0005) and CD86 (%-p = 0.012, MFI-p = 0.005) expression and lower frequency of CCR2 (p = 0.0002) expression on all monocytes, lower CCR2 density on inflammatory monocytes (p = 0.045) when compared to the expression and density of these markers in controls’ monocytes. We also report lower expression of CX3CR1 (p = 0.014) on patrolling monocytes at baseline, compared to levels seen in controls. After ART, these perturbations tended to improve, with decreasing expression and density of HLA-DR and CD86, increasing CCR2 density on inflammatory monocytes, and increasing expression and density of CX3CR1 on patrolling monocytes. Conclusions: In HIV-1 infected patients, ART appears to attenuate the high levels of activation (HLA-DR, CD86) and to increase expression of the chemokine receptors CCR2 and CX3CR1 on monocyte populations. Circulating monocyte phenotypes are altered in untreated infection and tend to normalize with ART; the role of these cells in the inflammatory environment of HIV-1 infection warrants further study