482 research outputs found
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Young's moduli and Poisson's ratios of Sitka spruce and their relations to moisture content
This report is one of a series issued in cooperation with Air Force-Navy-Civil Subcommittee on Aircraft Design Criteria under the supervision of the Aircraft Committee of the Munitions Board. Information reviewed and reaffirmed November 1954 and June 1959. Date of original report October 21, 1946
Recommended from our members
Young's moduli and Poisson's ratios of Douglas-fir and their relations to moisture content
Information reviewed and reaffirmed March 1956 and 1962
Recommended from our members
Young's moduli, moduli of rigidity, and poisson's ratios of yellow birch
This report is one of a series issued in cooperation with the Army-Navy-Civil Committee on aircraft design criteria under the supervision of the Aeronautical Board. Information reviewed and reaffirmed March 1946. Original report issued November 1946
Recommended from our members
The moduli of rigidity of Sitka Spruce and their relations to moisture content
Information reviewed and reaffirmed August 1962. Original report dated September 1946
Recommended from our members
Elastic properties of wood : the Young's moduli, moduli of rigidity, and Poisson's ratios of balsa and quipo
Information reviewed and reaffirmed March 1956 and 1962
Food anticipatory activity on a calorie-restricted diet is independent of Sirt1
A number of studies have demonstrated that the Sirtuin family member, Sirt1, is a key integrator of growth, metabolism, and lifespan. Sirt1 directly interacts with and deacetylates key regulators of the circadian clock, positioning it to be an important link between feeding and circadian rhythms. In fact, one study suggests that Sirt1 is necessary for behavioral anticipation of limited daily food availability, a circadian process termed food anticipatory activity (FAA). In their study, mice overexpressing Sirt1 had enhanced FAA, while mice lacking Sirt1 had little to no FAA. Based on the supposition that Sirt1 was indeed required for FAA, we sought to use Sirt1 deletion to map the neural circuitry responsible for FAA. We began by inactivating Sirt1 using the cell-type specific Cre-driver lines proopiomelanocortin, but after observing no effect on body weight loss or FAA we then moved on to more broadly neuronal Cre drivers Ca2+/calmodulin-dependent protein kinase II and nestin. As neither of these neuronal deletions of Sirt1 had impaired FAA, we then tested 1) a broad postnatal tamoxifen-inducible deletion, 2) a complete, developmental knockout of Sirt1, and 3) a gene replacement, catalytically inactive, form of Sirt1; but all of these mice had FAA similar to controls. Therefore, our findings suggest that FAA is completely independent of Sirt1
Research opportunities for argumentation in social networks
Nowadays, many websites allow social networking between their users in an
explicit or implicit way. In this work, we show how argumentation schemes theory can
provide a valuable help to formalize and structure on-line discussions and user opinions in
decision support and business oriented websites that held social networks between their users.
Two real case studies are studied and analysed. Then, guidelines to enhance social decision
support and recommendations with argumentation are provided.This work summarises results of the authors joint research, funded by an STMS of the Agreement Technologies COST Action 0801, by the Spanish government grants [CONSOLIDER-INGENIO 2010 CSD2007-00022, and TIN2012-36586-C03-01] and by the GVA project [PROMETEO 2008/051].Heras Barberá, SM.; Atkinson, KM.; Botti Navarro, VJ.; Grasso, F.; Julian Inglada, VJ.; Mcburney, PJ. (2013). Research opportunities for argumentation in social networks. Artificial Intelligence Review. 39(1):39-62. doi:10.1007/s10462-012-9389-0S3962391Amgoud L (2009) Argumentation for decision making. Argumentation in artificial intelligence. Springer, BerlinAnderson P (2007) What is Web 2.0? Ideas, technologies and implications for education. JISC Iechnology and Standards Watch reportBentahar J, Meyer CJJ, Moulin B (2007) Securing agent-oriented systems: an argumentation and reputation-based approach. In: Proceedings of the 4th international conference on information technology: new generations (ITNG 2007), IEEE Computer Society, pp 507–515Buckingham Shum S (2008) Cohere: towards Web 2.0 argumentation. In: Proceedings of the 2nd international conference on computational models of argument, COMMA, pp 28–30Burke R (2002) Hybrid recommender systems: survey and experiments. User Model User-Adapt Interact 12:331–370Cartwright D, Atkinson K (2008) Political engagement through tools for argumentation. In: Proceedings of the second international conference on computational models of argument (COMMA 2008), pp 116–127Chesñevar C, McGinnis J, Modgil S, Rahwan I, Reed C, Simari G, South M, Vreeswijk G, Willmott S (2006) Towards an argument interchange format. Knowl Eng Rev 21(4):293–316Chesñevar CI, Maguitman AG, Gonzà lez MP (2009) Empowering recommendation technologies through argumentation. Argumentation in artificial intelligence. Springer, Berlin, pp 403–422GarcÃa AJ, Dix J, Simari GR (2009) Argument-based logic programming. Argumentation in artificial intelligence. Springer, BerlinGolbeck J (2006) Generating predictive movie recommendations from trust in social networks. In: Proceedings of the fourth international conference on trust management, LNCS, vol 3986, 93–104Gordon T, Prakken H, Walton D (2007) The Carneades model of argument and burden of proof. Artif Intell 171(10–15):875–896Guha R, Kumar R, Raghavan P, Tomkins A (2004) Propagating trust and distrust. In: Proceedings of the 13th international conference on, World Wide Web, pp 403–412Heras S, Navarro M, Botti V, Julián V (2009) Applying dialogue games to manage recommendation in social networks. In: Proceedings of the 6th international workshop on argumentation in multi-agent aystems, ArgMASHeras S, Atkinson K, Botti V, Grasso F, Julián V, McBurney P (2010a) How argumentation can enhance dialogues in social networks. In: Proceedings of the 3rd international conference on computational models of argument, COMMA, vol 216, pp 267–274Heras S, Atkinson K, Botti V, Grasso F, Julián V, McBurney P (2010b) Applying argumentation to enhance dialogues in social networks. In: ECAI 2010 workshop on computational models of natural argument, CMNA, pp 10–17Karacapilidis N, Tzagarakis M (2007) Web-based collaboration and decision making support: a multi-disciplinary approach. Web-Based Learn Teach Technol 2(4):12–23Kim D, Benbasat I (2003) Trust-related arguments in internet stores: a framework for evaluation. J Electron Commer Res 4(2):49–64Kim D, Benbasat I (2006) The effects of trust-assuring arguments on consumer trust in internet stores: application of Toulmin’s model of argumentation. Inf Syst Rese 17(3):286–300Laera L, Tamma V, Euzenat J, Bench-Capon T, Payne T (2006) Reaching agreement over ontology alignments. In: Proceedings of the 5th international semantic web conference (ISWC 2006)Lange C, Bojãrs U, Groza T, Breslin J, Handschuh S (2008) Expressing argumentative discussions in social media sites. In: Social data on the web (SDoW2008) workshop at the 7th international semantic web conferenceLinden G, Smith B, York J (2003) Amazon.com recommendations: item-to-item collaborative filtering. IEEE Internet Comput 7(1):76–80Linden G, Hong J, Stonebraker M, Guzdial M (2009) Recommendation algorithms, online privacy and more. Commun ACM, 52(5)Mika P (2007) Ontologies are us: a unified model of social networks and semantics. J Web Semant 5(1):5–15Montaner M, López B, de la Rosa JL (2002) Opinion-based filtering through trust. In: Cooperative information agents VI, LNCS, vol 2446, pp 127–144Ontañón S, Plaza E (2008) Argumentation-based information exchange in prediction markets. In: Proceedings of the 5th international workshop on argumentation in multi-agent systems, ArgMASPazzani MJ, Billsus D (2007) Content-based recommendation systems. In: The adaptive web, LNCS, vol 4321, pp 325–341Rahwan I, Zablith F, Reed C (2007) Laying the foundations for a world wide argument web. Artif Intell 171(10–15):897–921Rahwan I, Banihashemi B (2008) Arguments in OWL: a progress report. In: Proceedings of the 2nd international conference on computational models of argument (COMMA), pp 297–310Reed C, Walton D (2007) Argumentation schemes in dialogue. In: Dissensus and the search for common ground, OSSA-07, volume CD-ROM, pp 1–11Sabater J, Sierra C (2002) Reputation and social network analysis in multi-agent systems. In: Proceedings of the 1st international joint conference on autonomous agents and multiagent systems, vol 1, pp 475–482Schafer JB, Konstan JA, Riedl J (2001) E-commerce recommendation applications. Data Min Knowl Discov 5:115–153Schafer JB, Frankowski D, Herlocker J, Sen S (2007) Collaborative filtering recommender systems. In: The adaptive web, LNCS, vol 4321, pp 291–324Schneider J, Groza T, Passant A (2012) A review of argumentation for the aocial semantic web. Semantic web-interoperability, usability, applicability. IOS Press, Washington, DCTempich C, Pinto HS, Sure Y, Staab S (2005) An argumentation ontology for distributed, loosely-controlled and evolvInG Engineering processes of oNTologies (DILIGENT). In: Proceedings of the 2nd European semantic web conference, ESWC, pp 241–256Toulmin SE (1958) The uses of argument. Cambridge University Press, Cambridge, UKTrojahn C, Quaresma P, Vieira R, Isaac A (2009) Comparing argumentation frameworks for composite ontology matching. in: Proceedings of the 6th international workshop on argumentation in multi-agent systems, ArgMASTruthMapping. http://truthmapping.com/Walter FE, Battiston S, Schweitzer F (2007) A model of a trust-based recommendation system on a social network. J Auton Agents Multi-Agent Syst 16(1):57–74Walton D, Krabbe E (1995) Commitment in dialogue: basic concepts of interpersonal reasoning. State University of New York Press, New York, NYWalton D, Reed C, Macagno F (2008) Argumentation schemes. Cambridge University Press, CambridgeWells S, Gourlay C, Reed C (2009) Argument blogging. Computational models of natural argument, CMNAWyner A, Schneider J (2012) Arguing from a point of view. In: Proceedings of the first international conference on agreement technologie
Health-related quality of life after myocardial infarction is associated with level of left ventricular ejection fraction
<p>Abstract</p> <p>Background</p> <p>The objective was to explore the relationship between left ventricular ejection fraction (LVEF) assessed during hospitalization for acute myocardial infarction (MI) and later health-related quality of life (HRQoL).</p> <p>Methods</p> <p>We used multivariable linear regression to assess the relationship between LVEF and HRQoL in 256 MI patients who responded to the Kansas City Cardiomyopathy Questionnaire (KCCQ), the EQ-5D Index, and the EuroQol Visual Analogue Scale (EQ-VAS) 2.5 years after the index MI.</p> <p>Results</p> <p>167 patients had normal LVEF (>50%), 56 intermediate (40%–50%), and 33 reduced (<40%). The mean (SD) KCCQ clinical summary scores were 85 (18), 75 (22), and 68 (21) (<it>p </it><0.001) in the three groups, respectively. The corresponding EQ-5D Index scores were 0.83 (0.18), 0.72 (0.27), and 0.76 (0.14) (<it>p </it>= 0.005) and EQ-VAS scores were 72 (18), 65 (21), and 57 (20) (<it>p </it>= 0.001). In multivariable linear regression analysis age ≥ 70 years, known chronic obstructive pulmonary disease (COPD), subsequent MI, intermediate LVEF, and reduced LVEF were independent determinants for reduced KCCQ clinical summary score. Female sex, medication for angina pectoris at discharge, and intermediate LVEF were independent determinants for reduced EQ-5D Index score. Age ≥ 70 years, COPD, and reduced LVEF were associated with reduced EQ-VAS score.</p> <p>Conclusion</p> <p>LVEF measured during hospitalization for MI was a determinant for HRQoL 2.5 years later.</p
B cells and monocytes from patients with active multiple sclerosis exhibit increased surface expression of both HERV-H Env and HERV-W Env, accompanied by increased seroreactivity
<p>Abstract</p> <p>Background</p> <p>The etiology of the neurogenerative disease multiple sclerosis (MS) is unknown. The leading hypotheses suggest that MS is the result of exposure of genetically susceptible individuals to certain environmental factor(s). Herpesviruses and human endogenous retroviruses (HERVs) represent potentially important factors in MS development. Herpesviruses can activate HERVs, and HERVs are activated in MS patients.</p> <p>Results</p> <p>Using flow cytometry, we have analyzed HERV-H Env and HERV-W Env epitope expression on the surface of PBMCs from MS patients with active and stable disease, and from control individuals. We have also analyzed serum antibody levels to the expressed HERV-H and HERV-W Env epitopes. We found a significantly higher expression of HERV-H and HERV-W Env epitopes on B cells and monocytes from patients with active MS compared with patients with stable MS or control individuals. Furthermore, patients with active disease had relatively higher numbers of B cells in the PBMC population, and higher antibody reactivities towards HERV-H Env and HERV-W Env epitopes. The higher antibody reactivities in sera from patients with active MS correlate with the higher levels of HERV-H Env and HERV-W Env expression on B cells and monocytes. We did not find such correlations for stable MS patients or for controls.</p> <p>Conclusion</p> <p>These findings indicate that both HERV-H Env and HERV-W Env are expressed in higher quantities on the surface of B cells and monocytes in patients with active MS, and that the expression of these proteins may be associated with exacerbation of the disease.</p
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