Heat transfer to a gas containing a cloud of particles

Heat transfer to gas containing particle clou

Benchmark stars for Gaia: fundamental properties of the Population II star HD140283 from interferometric, spectroscopic and photometric data

We determined the fundamental properties of HD 140283 by obtaining new interferometric and spectroscopic measurements and combining them with photometry from the literature. The interferometric measurements were obtained using the visible interferometer VEGA on the CHARA array and we determined a 1D limb-darkened angular diameter of 0.353 +/- 0.013 milliarcseconds. Using photometry from the literature we derived the bolometric flux with two solutions: a zero-reddening one of Fbol = 3.890 +/- 0.066 1E-8 erg/s/cm2 and a solution with a maximum of Av = 0.1 mag, Fbol= 4.220 +/- 0.067 1E-8 erg/s/cm2. The interferometric Teff is thus 5534 +/- 103 K or 5647 +/- 105 K and its radius is R = 2.21 +/- 0.08 Rsol. Spectroscopic measurements of HD140283 were obtained using HARPS, NARVAL, and UVES and a 1D LTE analysis of H-alpha line wings yields Teff(Halpha) = 5626 +/- 75 K. Using fine-tuned stellar models including diffusion of elements we then determined the mass M and age t of HD140283. Once the metallicity has been fixed, the age of the star depends on M, initial helium abundance Yi and mixing-length parameter alpha, only two of which are independent. We need to adjust alpha to much lower values than the solar one (~2) in order to fit the observations, and if Av = 0.0 mag then 0.5 < alpha < 1. We give an equation to estimate t from M, Yi (alpha) and Av. Establishing a reference alpha = 1.00 and adopting Yi = 0.245 we derive a mass and age of HD140283: M = 0.780 +/- 0.010 Msol and t = 13.7 +/- 0.7 Gyr (Av = 0.0) or M = 0.805 +/- 0.010 Msol and t = 12.2 +/- 0.6 Gyr (Av=0.1 mag). Our stellar models yield an initial metallicity of [Z/X]i = -1.70 and logg = 3.65 +/- 0.03. Asteroseismic observations are critical for overcoming limitations in our results.Comment: final accepted version paper (2 column format

Fundamental properties of the Population II fiducial stars HD 122563 and Gmb 1830 from CHARA interferometric observations

We have determined the angular diameters of two metal-poor stars, HD 122563 and Gmb 1830, using CHARA and Palomar Testbed Interferometer observations. For the giant star HD 122563, we derive an angular diameter theta_3D = 0.940 +- 0.011 milliarcseconds (mas) using limb-darkening from 3D convection simulations and for the dwarf star Gmb 1830 (HD 103095) we obtain a 1D limb-darkened angular diameter theta_1D = 0.679 +- 0.007 mas. Coupling the angular diameters with photometry yields effective temperatures with precisions better than 55 K (Teff = 4598 +- 41 K and 4818 +- 54 K --- for the giant and the dwarf star, respectively). Including their distances results in very well-determined luminosities and radii (L = 230 +- 6 L_sun, R = 23.9 +- 1.9 R_sun and L = 0.213 +- 0.002 L_sun, R = 0.664 +- 0.015 R_sun, respectively). We used the CESAM2k stellar structure and evolution code in order to produce models that fit the observational data. We found values of the mixing-length parameter alpha (which describes 1D convection) that depend on the mass of the star. The masses were determined from the models with precisions of <3% and with the well-measured radii excellent constraints on the surface gravity are obtained (log g = 1.60 +- 0.04, 4.59 +- 0.02, respectively). The very small errors on both log g and Teff provide stringent constraints for spectroscopic analyses given the sensitivity of abundances to both of these values. The precise determination of Teff for the two stars brings into question the photometric scales for metal-poor stars.Comment: accepted A&A, 8 dbl-column pages, incl. 7 tables and 4 figure

Competitive endothelial adhesion between Plasmodium falciparum isolates under physiological flow conditions

<p>Abstract</p> <p>Background</p> <p>Sequestration of parasitized red blood cells in the microvasculature of major organs involves a sequence of events that is believed to contribute to the pathogenesis of severe falciparum malaria. <it>Plasmodium falciparum </it>infections are commonly composed of multiple subpopulations of parasites with varied adhesive properties. A key question is: do these subpopulations compete for adhesion to endothelium? This study investigated whether, in a laboratory model of cytoadherence, there is competition in binding to endothelium between pRBC infected with <it>P. falciparum </it>of variant adhesive phenotypes, particularly under flow conditions.</p> <p>Methods</p> <p>Four different <it>P. falciparum </it>isolates, of known adherence phenotypes, were matched in pairs, mixed in different proportions and allowed to bind to cultured human endothelium. Using <it>in vitro </it>competitive static and flow-based adhesion assays, that allow simultaneous testing of the adhesive properties of two different parasite lines, adherence levels of paired <it>P. falciparum </it>isolates were quantified and analysed using either non-parametric Wilcoxon's paired signed rank test or Student paired test.</p> <p>Results</p> <p>Study findings show that <it>P. falciparum </it>parasite lines show marked differences in the efficiency of adhesion to endothelium.</p> <p>Conclusion</p> <p><it>Plasmodium falciparum </it>variants will compete for adhesion to endothelia and variants can be ranked by their efficiency of binding. These findings suggest that variants from a mixed infection will not show uniform cytoadherence and so may vary in their ability to cause disease.</p

Recent progress in dilute nitride-antimonide materials for photonic and electronic applications

International audienceThis paper reviews the recent progress in GaNAsSb material for photonic and electronic applications. All the results and data presented in this review article are summarized from our previously published works in refs. 6-12. Photoresponsivity of 12A/W and cut-off frequency of 4.5GHz were achieved in the 1.3µm GaNAsSb based photodetector. A GaNAsSb/GaAs optical waveguide system was also demonstrated at 1.55µm. The GaNAsSb based photoconductive switch exhibits pulsed response with FWHM of 30ps and photoresponse of up to 1.6µm. The turn-on voltage of the device fabricated from GaNAsSb based HBT is ~330mV lower than that of a conventional AlGaAs/GaAs HBT

Identification of phosphorylated proteins in erythrocytes infected by the human malaria parasite Plasmodium falciparum

Background: Previous comparative proteomic analysis on Plasmodium falciparum isolates of different adhesion properties suggested that protein phosphorylation varies between isolates with different cytoadherence properties. But the extent and dynamic changes in phosphorylation have not been systematically studied. As a baseline for these future studies, this paper examined changes in the phosphoproteome of parasitized red blood cells (pRBC). Methods: Metabolic labelling with [S-35] methionine on pRBC and 2D gel electrophoresis (2-DE) has previously been used to show the expression of parasite proteins and changes in protein iso-electric point (PI). 2-DE of different parasite strains was combined with immunoblotting using monoclonal antibodies specifically to phosphorylated serine/threonine and tyrosine, to obtain the phosphorylation profiles throughout the erythrocytic lifecycle. Affinity chromatography was used to purify/enrich phosphorylated proteins and these proteins from mature trophozoite stages which were identified using high-accuracy mass spectrometry and MASCOT search. Results: 2D-immunoblots showed that P. falciparum infection greatly increased phosphorylation of a set of proteins in pRBC, the dominant size classes for phosphorylated tyrosine proteins were 95, 60, 50 and 30 kDa and for phosphorylated serine/threonine were 120, 95, 60, 50, 43, 40 and 30 kDa. The most abundant molecules from 2D-gel mapping of phosphorylated proteins in ItG infected RBCs were identified by MALDI-TOF. A proteomic overview of phosphorylated proteins in pRBC was achieved by using complementary phosphorylated protein enrichment techniques combined with nano-flow LC/MS/MS analysis and MASCOT MS/MS ions search with phosphorylation as variable modifications. The definite phosphoproteins of pRBC are reported and discussed. Conclusion: Protein phosphorylation is a major process in P. falciparum-parasitized erythrocytes. Preliminary screens identified 170 P. falciparum proteins and 77 human proteins as phosphorylated protein in pRBC, while only 48 human proteins were identified in the corresponding fractions from uninfected RBC. Refinement of the search to include significant ion scores indicating a specific phospho-peptide identified 21 P. falciparum proteins and 14 human proteins from pRBC, 13 host proteins were identified from normal RBC. The results achieved by complementary techniques consistently reflect a reliable proteomic overview of pRBC