A Barefoot Running Program For A College Lacrosse Player With Chronic Exertional Compartment Syndrome: A Case Report

Background and Purpose: Although barefoot running has been investigated for anterior and lateral exertional compartment syndrome, a specific barefoot running program aimed at altering running mechanics has not been determined for posterior exertional compartment syndrome for a college lacrosse player. The purpose of this case report was to examine the effects of adopting a forefoot running pattern through a barefoot running program in a 20-year-old college lacrosse player with posterior chronic exertional compartment syndrome (CECS) in conjunction with a comprehensive physical therapy program. Case description: The patient was a 20-year-old female college lacrosse player who presented to physical therapy with a 9-month history of bilateral, posterior lower leg pain, which was brought on by running on pavement, up hills, and longer than 5-10 minutes. The patient reported extreme tightness and throbbing in the posterior lower leg and numbness and tingling into the feet while running on pavement and long distance runs greater than 1 mile. The patient was seen 1-2x/week for twelve weeks. Outcomes: DF ROM improved from lacking 16° to lacking 8° on the right and lacking 12° to lacking 4° on the left. All hip and ankle strength improved from 4-4+/5 to 5/5 throughout. The LEFS improved from 9% disability to 5% disability. The patient’s running tolerance improved from 1 min shod to 12 min barefoot before experiencing tightness in her legs. Discussion: Barefoot running, in conjunction with manual therapy, lower extremity (LE) stretching, strengthening, and stabilization exercises was found to be effective at improving running tolerance for a female college lacrosse player. Future research should investigate the efficacy of barefoot running programs and appropriate timelines for progression in patients with posterior CECS

A Barefoot Running Program For A College Lacrosse Player With Chronic Exertional Compartment Syndrome: A Case Report

Barefoot running protocols have been effective in decreasing anterior and lateral chronic exertional compartment syndrome (CECS), but they have not been studied in patients with posterior CECS. Additionally, there is a lack of research that has investigated a barefoot running protocol in a college lacrosse athlete. The purpose of this case report was to examine the effects of adopting a forefoot strike pattern, through a barefoot running program, in a 20-year-old college lacrosse player with posterior chronic exertional compartment syndrome.https://dune.une.edu/pt_studcrposter/1134/thumbnail.jp

Meccanismi specifici di fibrogenesi ed analisi di possibili predittori istologici/clinici di evoluzione del danno in soggetti affetti da epatite acuta alcolica (AH) ed insufficienza epatica acuta su cronica (ACLF)

Valutare ruolo dei progenitori epatocitari nella fisiopatologia del danno in pazienti con epatite acuta alcolica ed ACLF

Enhancing operational performance of AHUs through an advanced fault detection and diagnosis process based on temporal association and decision rules

The pervasive monitoring of HVAC systems through Building Energy Management Systems (BEMSs) is enabling the full exploitation of data-driven based methodologies for performing advanced energy management strategies. In this context, the implementation of Automated Fault Detection and Diagnosis (AFDD) based on collected operational data of Air Handling Units (AHUs) proved to be particularly effective to prevent anomalous running modes which can lead to significant energy waste over time and discomfort conditions in the built environment. The present work proposes a novel methodology for performing AFDD, based on both unsupervised and supervised data-driven methods tailored according to the operation of an AHU during transient and non-transient periods. The whole process is developed and tested on a sample of real data gathered from monitoring campaigns on two identical AHUs in the framework of the Research Project ASHRAE RP-1312. During the start-up period of operation, the methodology exploits Temporal Association Rules Mining (TARM) algorithm for an early detection of faults, while during non-transient period a number of classification models are developed for the identification of the deviation from the normal operation. The proposed methodology, conceived for quasi real-time implementation, proved to be capable of robustly and promptly identifying the presence of typical faults in AHUs

L'efficienza delle banche: quali determinanti? Teoria ed evidenze empiriche

The work analysis the several determinants of bank efficiency, through a huge literature review and two empirical application

L'efficienza delle banche: quali determinanti? Teoria ed evidenze empiriche

The work analysis the several determinants of bank efficiency, through a huge literature review and two empirical application

CLU "in and out": looking for a link.

Cancer cells need to interact synergistically with their surrounding microenvironment to form a neoplasm and to progress further to colonize distant organs. The microenvironment can exert profound epigenetic effects on cells through cell-derived interactions between cells, or through cell-derived factors deposited into the microenvironment. Tumor progression implies immune-escaping and triggers several processes that synergistically induce a cooperation among transformed and stromal cells, that compete for space and resources such as oxygen and nutrients. Therefore, the extra cellular milieu and tissue microenvironment heterotypic interactions cooperate to promote tumor growth, angiogenesis, and cancer cell motility, through elevated secretion of pleiotropic cytokines and soluble factors. Clusterin (CLU), widely viewed as an enigmatic protein represents one of the numerous cellular factors sharing the intracellular information with the microenvironment and it has also a systemic diffusion, tightly joining the "In and the Out" of the cell with a still debated variety of antagonistic functions. The multiplicity of names for CLU is an indication of the complexity of the problem and could reflect, on one hand its multifunctionality, or alternatively could mask a commonality of function. The posited role for CLU, further supported as a cytoprotective prosurvival chaperone-like molecule, seems compelling, in contrast its tumor suppressor function, as a guide of the guardians of the genome (DNA-repair proteins Ku70/80, Bax cell death inducer), could really reflect the balanced expression of its different forms, most certainly depending on the intra- and extracellular microenvironment cross talk. The complicated balance of cytokines network and the regulation of CLU forms production in cancer and stromal cells undoubtedly represent a potential link among adaptative responses, genomic stability, and bystander effect after oxidative stresses and damage. This review focuses on the tumor-microenvironment interactions strictly involved in controlling local cancer growth, invasion, and distant metastases that play a decisive role in the regulation of CLU different forms expression and release. In addition, we focus on the pleiotropic action of the extracellular form of this protein, sCLU, that may play a crucial role in redirecting stromal changes, altering intercellular communications binding cell surface receptors and contributing to influence the secretion of chemokines in paracrine and autocrine fashion. Further elucidation of CLU functions inside and outside ("in and out") of cancer cell are warranted for a deeper understanding of the interplay between tumor and stroma, suggesting new therapeutic cotargeting strategies

CLU "in and out": looking for a link

Cancer cells need to interact synergistically with their surrounding microenvironment to form a neoplasm and to progress further to colonize distant organs. The microenvironment can exert profound epigenetic effects on cells through cell-derived interactions between cells, or through cell-derived factors deposited into the microenvironment. Tumor progression implies immune-escaping and triggers several processes that synergistically induce a cooperation among transformed and stromal cells, that compete for space and resources such as oxygen and nutrients. Therefore, the extra cellular milieu and tissue microenvironment heterotypic interactions cooperate to promote tumor growth, angiogenesis, and cancer cell motility, through elevated secretion of pleiotropic cytokines and soluble factors. Clusterin (CLU), widely viewed as an enigmatic protein represents one of the numerous cellular factors sharing the intracellular information with the microenvironment and it has also a systemic diffusion, tightly joining the "In and the Out" of the cell with a still debated variety of antagonistic functions. The multiplicity of names for CLU is an indication of the complexity of the problem and could reflect, on one hand its multifunctionality, or alternatively could mask a commonality of function. The posited role for CLU, further supported as a cytoprotective prosurvival chaperone-like molecule, seems compelling, in contrast its tumor suppressor function, as a guide of the guardians of the genome (DNA-repair proteins Ku70/80, Bax cell death inducer), could really reflect the balanced expression of its different forms, most certainly depending on the intra- and extracellular microenvironment cross talk. The complicated balance of cytokines network and the regulation of CLU forms production in cancer and stromal cells undoubtedly represent a potential link among adaptative responses, genomic stability, and bystander effect after oxidative stresses and damage. This review focuses on the tumor-microenvironment interactions strictly involved in controlling local cancer growth, invasion, and distant metastases that play a decisive role in the regulation of CLU different forms expression and release. In addition, we focus on the pleiotropic action of the extracellular form of this protein, sCLU, that may play a crucial role in redirecting stromal changes, altering intercellular communications binding cell surface receptors and contributing to influence the secretion of chemokines in paracrine and autocrine fashion. Further elucidation of CLU functions inside and outside ("in and out") of cancer cell are warranted for a deeper understanding of the interplay between tumor and stroma, suggesting new therapeutic cotargeting strategies

Validation of a 5-Item Tool to Measure Patient Assessment of Clinician Compassion in Hospitals

BACKGROUND: We previously validated a 5-item compassion measure to assess patient experience of clinician compassion in the outpatient setting. However, currently, there is no validated and feasible method for health care systems to measure patient experience of clinician compassion in the inpatient setting across multiple hospitals. OBJECTIVE: To test if the 5-item compassion measure can validly and distinctly measure patient assessment of physician and nurse compassion in the inpatient setting. DESIGN: Cross-sectional study between July 1 and July 31, 2020, in a US health care network of 91 community hospitals across 16 states consisting of approximately 15,000 beds. PATIENTS: Adult patients who had an inpatient hospital stay and completed the Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey. MEASUREMENTS: We adapted the original 5-item compassion measure to be specific for physicians, as well as for nurses. We disseminated both measures with the HCAHPS survey and used confirmatory factor analysis for validity testing. We tested reliability using Cronbach\u27s alpha, as well as convergent validity with patient assessment of physician and nursing communication and overall hospital rating questions from HCAHPS. RESULTS: We analyzed 4756 patient responses. Confirmatory factor analysis found good fit for two distinct constructs (i.e., physician and nurse compassion). Both measures demonstrated good internal consistency (alpha \u3e 0.90) and good convergent validity but reflected a construct (compassionate care) distinct from what is currently captured in HCAHPS. CONCLUSION: We validated two 5-item tools that can distinctly measure patient experience of physician and nurse compassion for use in the inpatient hospital setting in conjunction with HCAHPS