O uso e o potencial da pitanga (Eugenia uniflora L.).

EVINCI. Resumo

APENet: LQCD clusters a la APE

Developed by the APE group, APENet is a new high speed, low latency, 3-dimensional interconnect architecture optimized for PC clusters running LQCD-like numerical applications. The hardware implementation is based on a single PCI-X 133MHz network interface card hosting six indipendent bi-directional channels with a peak bandwidth of 676 MB/s each direction. We discuss preliminary benchmark results showing exciting performances similar or better than those found in high-end commercial network systems.Comment: Lattice2004(machines), 3 pages, 4 figure

A network of sex and competition: The promiscuous mating system of an invasive weevil

Abstract Invasive alien pest insect species represent a major threat for agriculture and biodiversity. Because chemical treatments employed to contrast such pests elicit serious environmental and human health problems, a great effort is currently directed to develop long term and environmentally friendly biological control strategies. However, the successful application of some promising techniques, such as the Sterile Insect Technique (SIT), requires a deep knowledge of the pest basic biology. Here, we argue that understanding pest sexual biology using a social network approach can significantly improve the performance of control strategies. For example, SIT may benefit from understanding how individuals interact and how males accede to reproduction, in order to target the most reproductively active and polygamic males. In this paper we studied the socio-sexual networks of the Asian red palm weevil (RPW) Rhynchophorus ferrugineus, a worldwide invader which is causing heavy economic impacts on several palm species. We found that the RPW has a highly promiscuous mating system, characterized by forced interruptions of pair copulations by additional males. The social network is highly non-random nor regular: few males almost monopolize reproduction, behaving as key-players in the network of matings. Additionally, males have a stable pattern of sexual behaviour over time. We use RPW social network as a case study to direct the development of management techniques such as SIT strategy

An integer programming framework for inferring disease complexes from network data

MOTIVATION: Unraveling the molecular mechanisms that underlie disease calls for methods that go beyond the identification of single causal genes to inferring larger protein assemblies that take part in the disease process. RESULTS: Here, we develop an exact, integer-programming-based method for associating protein complexes with disease. Our approach scores proteins based on their proximity in a protein-protein interaction network to a prior set that is known to be relevant for the studied disease. These scores are combined with interaction information to infer densely interacting protein complexes that are potentially disease-associated. We show that our method outperforms previous ones and leads to predictions that are well supported by current experimental data and literature knowledge. AVAILABILITY AND IMPLEMENTATION: The datasets we used, the executables and the results are available at www.cs.tau.ac.il/roded/disease_complexes.zip. CONTACT: [email protected]

Sickness certification of workers compensation claimants by general practitioners in Victoria, 2003-2010

Objective: To examine patterns of the sickness certification of workers compensation claimants by general practitioners in Victoria, Australia, by nature of injury or illness. Design, setting and patients: Retrospective analysis of Victorian workers compensation data for all injured and ill workers with an accepted workers compensation claim between 2003 and 2010. Main outcome measures: Type (unfit for work, alternative duties, or fit for work) and duration of initial medical certificates relating to workers compensation claims that were issued by GPs, in six categories of injury and illness. Results: Of 124 424 initial medical certificates issued by GPs, 74.1% recommended that workers were unfit for work and 22.8% recommended alternative duties. Unfit-for-work certificates were issued to 94.1% of workers with mental health conditions, 81.3% of those with fractures, 79.1% of those with other traumatic injuries, 77.6% of those with back pain and strains, 68.0% of those with musculoskeletal conditions and 53.0% of those with other diseases. Alternative-duties certificates were significantly longer in duration than unfit-for-work certificates in all injury and illness categories (P<0.001) but certificates for workers with musculoskeletal injuries and diseases, back pain and strains and other traumatic injuries were of lesser duration than those for workers with fractures, mental health conditions and other diseases. Conclusion: The high proportion of medical certificates recommending complete absence from work presents major challenges in terms of return to work, labour force productivity, the viability of the compensation system, and long-term social and economic development. There is substantial variation in the type and duration of medical certificates issued by GPs. People with mental health conditions are unlikely to receive a certificate recommending alternative duties. Further research is required to understand GP certification behaviour

Domain duplication, divergence, and loss events in vertebrate Msx paralogs reveal phylogenomically informed disease markers

<p>Abstract</p> <p>Background</p> <p>Msx originated early in animal evolution and is implicated in human genetic disorders. To reconstruct the functional evolution of Msx and inform the study of human mutations, we analyzed the phylogeny and synteny of 46 metazoan Msx proteins and tracked the duplication, diversification and loss of conserved motifs.</p> <p>Results</p> <p>Vertebrate Msx sequences sort into distinct Msx1, Msx2 and Msx3 clades. The sister-group relationship between <it>MSX1 </it>and <it>MSX2 </it>reflects their derivation from the 4p/5q chromosomal paralogon, a derivative of the original "MetaHox" cluster. We demonstrate physical linkage between Msx and other MetaHox genes (<it>Hmx</it>, <it>NK1</it>, <it>Emx</it>) in a cnidarian. Seven conserved domains, including two Groucho repression domains (N- and C-terminal), were present in the ancestral Msx. In cnidarians, the Groucho domains are highly similar. In vertebrate Msx1, the N-terminal Groucho domain is conserved, while the C-terminal domain diverged substantially, implying a novel function. In vertebrate Msx2 and Msx3, the C-terminal domain was lost. MSX1 mutations associated with ectodermal dysplasia or orofacial clefting disorders map to conserved domains in a non-random fashion.</p> <p>Conclusion</p> <p>Msx originated from a MetaHox ancestor that also gave rise to Tlx, Demox, NK, and possibly EHGbox, Hox and ParaHox genes. Duplication, divergence or loss of domains played a central role in the functional evolution of Msx. Duplicated domains allow pleiotropically expressed proteins to evolve new functions without disrupting existing interaction networks. Human missense sequence variants reside within evolutionarily conserved domains, likely disrupting protein function. This phylogenomic evaluation of candidate disease markers will inform clinical and functional studies.</p

Association of a homozygous GCK missense mutation with mild diabetes

Background: Homozygous inactivating GCK mutations have been repeatedly reported to cause severe hyperglycemia, presenting as permanent neonatal diabetes mellitus (PNDM). Conversely, only two cases of GCK homozygous mutations causing mild hyperglycemia have been so far described. We here report a novel GCK mutation (c.1116G&gt;C, p.E372D), in a family with one homozygous member showing mild hyperglycemia. Methods: GCK mutational screening was carried out by Sanger sequencing. Computational analyses to investigate pathogenicity and molecular dynamics (MD) were performed for GCK-E372D and for previously described homozygous mutations associated with mild (n&nbsp;=&nbsp;2) or severe (n&nbsp;=&nbsp;1) hyperglycemia, used as references. Results: Of four mildly hyperglycemic family-members, three were heterozygous and one, diagnosed in the adulthood, was homozygous for GCK-E372D. Two nondiabetic family members carried no mutations. Fasting glucose (p&nbsp;=&nbsp;0.016) and HbA1c (p&nbsp;=&nbsp;0.035) correlated with the number of mutated alleles (0–2). In-silico predicted pathogenicity was not correlated with the four mutations’ severity. At MD, GCK-E372D conferred protein structure flexibility intermediate between mild and severe GCK mutations. Conclusions: We present the third case of homozygous GCK mutations associated with mild hyperglycemia, rather than PNDM. Our in-silico analyses support previous evidences suggesting that protein stability plays a role in determining clinical severity of GCK mutations

Modeling Stray Capacitances of High-Voltage Capacitive Dividers for Conventional Measurement Setups

Stray capacitances (SCs) are a serious issue in high-voltage (HV) applications. Their presence can alter the circuit or the operation of a device, resulting in wrong or even disastrous consequences. To this purpose, in this work, we describe the modeling of SCs in HV capacitive dividers. Such modeling does not rely on finite element analysis or complicated geometries; instead, it starts from an equivalent circuit of a conventional measurement setup described by the standard IEC 61869-11. Once the equivalent model including the SCs is found, closed expressions of the SCs are derived starting from the ratio error definition. Afterwards, they are validated in a simulation environment by implementing various circuit configurations. The results demonstrate the expressions applicability and effectiveness; hence, thanks to their simplicity, they can be implemented by system operators, researchers, and manufacturers avoiding the use of complicated methods and technologies