Rationale and design of a multicenter, international and collaborative coronary artery aneurysm registry (CAAR)

Coronary artery aneurysm has been classically defined as a coronary dilation that exceeds the diameter of normal adjacent segments or the diameter of the patient’s largest coronary vessel by 1.5×. Termed by Bourgon,1 it is an uncommon disease that has been diagnosed with increasing occurrence since the advent of coronary angiography.2,3 The incidence has been reported to vary from 1.5% to 5%, with suggested male dominance and a predilection for the right coronary artery.2,3 Although several causes have been shown, atherosclerosis accounts for ≥50% of coronary aneurysms in adults. Reported complications include thrombosis and distal embolization, vasospasm, and rupture, producing ischemia, heart failure, or arrhythmias. The natural history and long-term outcomes remain unclear, as definitive data are lacking. In addition, controversies persist regarding the use of medical treatment (antithrombotic therapy) or interventional/surgical procedures.1–

ST-Segment Elevation Myocardial Infarction Following Transcatheter Aortic Valve Replacement

International audienc

Charged-particle production as a function of the relative transverse activity classifier in pp, p−-Pb, and Pb−-Pb collisions at the LHC

International audienceMeasurements of charged-particle production in pp, p$-$Pb, and Pb$-$Pb collisions in the toward, away, and transverse regions with the ALICE detector are discussed. These regions are defined event-by-event relative to the azimuthal direction of the charged trigger particle, which is the reconstructed particle with the largest transverse momentum ($p_{\mathrm{T}}^{\rm trig}$) in the range $8<p_{\mathrm{T}}^{\rm trig}<15$ GeV$/c$. The toward and away regions contain the primary and recoil jets, respectively; both regions are accompanied by the underlying event (UE). In contrast, the transverse region perpendicular to the direction of the trigger particle is dominated by the so-called UE dynamics, and includes also contributions from initial- and final-state radiation. The relative transverse activity classifier, $R_{\mathrm{T}}=N_{\mathrm{ch}}^{\mathrm{T}}/\langle N_{\mathrm{ch}}^{\mathrm{T}}\rangle$, is used to group events according to their UE activity, where $N_{\mathrm{ch}}^{\mathrm{T}}$ is the charged-particle multiplicity per event in the transverse region and $\langle N_{\mathrm{ch}}^{\mathrm{T}}\rangle$ is the mean value over the whole analysed sample. The energy dependence of the $R_{\mathrm{T}}$ distributions in pp collisions at $\sqrt{s}=2.76$, 5.02, 7, and 13 TeV is reported, exploring the Koba-Nielsen-Olesen (KNO) scaling properties of the multiplicity distributions. The first measurements of charged-particle $p_{\rm T}$ spectra as a function of $R_{\mathrm{T}}$ in the three azimuthal regions in pp, p$-$Pb, and Pb$-$Pb collisions at $\sqrt{s_{\rm NN}}=5.02$ TeV are also reported. Data are compared with predictions obtained from the event generators PYTHIA 8 and EPOS LHC. This set of measurements is expected to contribute to the understanding of the origin of collective-like effects in small collision systems (pp and p$-$Pb)

Charm production and fragmentation fractions at midrapidity in pp collisions at s=13\sqrt{s} = 13 TeV

International audienceMeasurements of the production cross sections of prompt ${\rm D^0}$, ${\rm D^+}$, ${\rm D^{\ast +}}$, ${\rm D_s^+}$, ${\rm \Lambda_{c}^{+}}$, and ${\rm \Xi_{c}^{+}}$ charm hadrons at midrapidity in proton$-$proton collisions at $\sqrt{s}=13$ TeV with the ALICE detector are presented. The D-meson cross sections as a function of transverse momentum ($p_{\rm T}$) are provided with improved precision and granularity. The ratios of $p_{\rm T}$-differential meson production cross sections based on this publication and on measurements at different rapidity and collision energy provide a constraint on gluon parton distribution functions at low values of Bjorken-$x$ ($10^{-5}-10^{-4}$). The measurements of ${\rm \Lambda_{c}^{+}}$ (${\rm \Xi_{c}^{+}}$) baryon production extend the measured $p_{\rm T}$ intervals down to $p_{\rm T}=0(3)$~GeV$/c$. These measurements are used to determine the charm-quark fragmentation fractions and the ${\rm c\overline{c}}$ production cross section at midrapidity ($|y|<0.5$) based on the sum of the cross sections of the weakly-decaying ground-state charm hadrons ${\rm D^0}$, ${\rm D^+}$, ${\rm D_s^+}$, ${\rm \Lambda_{c}^{+}}$, ${\rm \Xi_{c}^{0}}$ and, for the first time, ${\rm \Xi_{c}^{+}}$, and of the strongly-decaying J/$psi$ mesons. The first measurements of ${\rm \Xi_{c}^{+}}$ and ${\rm \Sigma_{c}^{0,++}}$ fragmentation fractions at midrapidity are also reported. A significantly larger fraction of charm quarks hadronising to baryons is found compared to e$^+$e$^-$ and ep collisions. The ${\rm c\overline{c}}$ production cross section at midrapidity is found to be at the upper bound of state-of-the-art perturbative QCD calculations

Dielectron production in central Pb−-Pb collisions at sNN\sqrt{s_\mathrm{NN}} = 5.02 TeV

International audienceThe first measurement of the e$^+$e$^-$ pair production at midrapidity and low invariant mass in central Pb$-$Pb collisions at $\sqrt{s_{\mathrm{NN}}}=5.02$ TeV at the LHC is presented. The yield of e$^+$e$^-$ pairs is compared with a cocktail of expected hadronic decay contributions in the invariant mass ($m_{\rm ee}$) and pair transverse momentum ($p_{\rm T,ee}$) ranges $m_{\rm ee} < 3.5$ GeV$/c^2$ and $p_{\rm T,ee} < 8$ GeV$/c$. For $0.18 < m_{\rm ee} < 0.5$ GeV$/c^2$ the ratio of data to the cocktail of hadronic contributions without $\rho$ mesons amounts to $1.42 \pm 0.12 \ ({\rm stat.}) \pm 0.17 \ ({\rm syst.}) \pm 0.12 \ ({\rm cocktail})$ and $1.44 \pm 0.12 \ ({\rm stat.}) \pm 0.17 \ ({\rm syst.}) ^{+0.17}_{-0.21} \ ({\rm cocktail})$, including or not including medium effects in the estimation of the heavy-flavor background, respectively. It is consistent with predictions from two different models for an additional contribution of thermal e$^+$e$^-$ pairs from the hadronic and partonic phases. In the intermediate-mass range ($1.2 < m_{\rm ee} < 2.6$ GeV$/c^2$), the pair transverse impact parameter of the e$^+$e$^-$ pairs (DCA$_{\rm ee}$) is used for the first time in Pb$-$Pb collisions to separate displaced dielectrons from heavy-flavor hadron decays from a possible (thermal) contribution produced at the interaction point. The data are consistent with a suppression of e$^+$e$^-$ pairs from ${\rm c\overline{c}}$ and an additional prompt component. Finally, the first direct-photon measurement in the 10% most central Pb$-$Pb collisions at $\sqrt{s_{\mathrm{NN}}}=5.02$ TeV is reported via the study of virtual direct photons in the transverse momentum range $1 < p_{\rm T} < 5$ GeV$/c$. A model including prompt photons, as well as photons from the pre-equilibrium and fluid-dynamic phases, can reproduce the result, while being at the upper edge of the data uncertainties

Dielectron production in central Pb−-Pb collisions at sNN\sqrt{s_\mathrm{NN}} = 5.02 TeV

International audienceThe first measurement of the e$^+$e$^-$ pair production at midrapidity and low invariant mass in central Pb$-$Pb collisions at $\sqrt{s_{\mathrm{NN}}}=5.02$ TeV at the LHC is presented. The yield of e$^+$e$^-$ pairs is compared with a cocktail of expected hadronic decay contributions in the invariant mass ($m_{\rm ee}$) and pair transverse momentum ($p_{\rm T,ee}$) ranges $m_{\rm ee} < 3.5$ GeV$/c^2$ and $p_{\rm T,ee} < 8$ GeV$/c$. For $0.18 < m_{\rm ee} < 0.5$ GeV$/c^2$ the ratio of data to the cocktail of hadronic contributions without $\rho$ mesons amounts to $1.42 \pm 0.12 \ ({\rm stat.}) \pm 0.17 \ ({\rm syst.}) \pm 0.12 \ ({\rm cocktail})$ and $1.44 \pm 0.12 \ ({\rm stat.}) \pm 0.17 \ ({\rm syst.}) ^{+0.17}_{-0.21} \ ({\rm cocktail})$, including or not including medium effects in the estimation of the heavy-flavor background, respectively. It is consistent with predictions from two different models for an additional contribution of thermal e$^+$e$^-$ pairs from the hadronic and partonic phases. In the intermediate-mass range ($1.2 < m_{\rm ee} < 2.6$ GeV$/c^2$), the pair transverse impact parameter of the e$^+$e$^-$ pairs (DCA$_{\rm ee}$) is used for the first time in Pb$-$Pb collisions to separate displaced dielectrons from heavy-flavor hadron decays from a possible (thermal) contribution produced at the interaction point. The data are consistent with a suppression of e$^+$e$^-$ pairs from ${\rm c\overline{c}}$ and an additional prompt component. Finally, the first direct-photon measurement in the 10% most central Pb$-$Pb collisions at $\sqrt{s_{\mathrm{NN}}}=5.02$ TeV is reported via the study of virtual direct photons in the transverse momentum range $1 < p_{\rm T} < 5$ GeV$/c$. A model including prompt photons, as well as photons from the pre-equilibrium and fluid-dynamic phases, can reproduce the result, while being at the upper edge of the data uncertainties