About the parabolic relation existing between the skewness and the kurtosis in time series of experimental data

In this work we investigate the origin of the parabolic relation between skewness and kurtosis often encountered in the analysis of experimental time-series. We argue that the numerical values of the coefficients of the curve may provide informations about the specific physics of the system studied, whereas the analytical curve per se is a fairly general consequence of a few constraints expected to hold for most systems.Comment: To appear in Physica Script

Does the length of uniportal video-assisted thoracoscopic lobectomy affect postoperative pain? Results of a randomized controlled trial

Background: Uniportal video-assisted thoracoscopic surgery (VATS) lobectomy has become a common approach for the treatment of early stage lung cancer. Here, we aimed to establish whether the length of uniportal incision could affect postoperative pain and surgical outcomes in consecutive patients undergoing uniportal VATS lobectomy for early stage lung cancer. Methods: This was a unicenter Randomized Control Trial (NCT 03218098). Consecutive patients undergoing uniportal VATS lobectomy for Stage I lung cancer were randomly assigned to a Small Incision group or Long Incision group in 1:1 ratio based on whether patients received a 4 cm or 8 cm incision. The endpoints were to compare the intergroup difference regarding (i) postoperative pain measured by brief pain inventory (BPI) questionnaire (first endpoint); (ii) operative time; (iii) length of chest drainage; (iv) length of hospital stay; (v) postoperative complications; and (vi) pulmonary functional status (secondary endpoints). Results: A total of 48 patients were eligible for the study. Four patients were excluded; the study population included 44 patients: 23 within the Small Incision group, and 21 within the Long Incision group. The 11 BPI scores between the two groups showed no significant difference. Small Incision group presented higher operative time than Long Incision group (138.69 vs. 112.14 minutes; P = 0.0001) while no significant differences were found regarding length of hospital stay (P = 0.95); respiratory complications (P = 0.92); FEV1% (P = 0.63), and 6-Minute Walking Test (P = 0.77). Conclusions: A larger incision for uniportal VATS lobectomy significantly reduced the operative time due to better exposure of the anatomical structures without increasing postoperative pain or affecting the surgical outcome. Key points: A larger incision for uniportal VATS lobectomy significantly reduced the operative time due to better exposure of the anatomical structures without increasing postoperative pain or affecting the surgical outcome. To perform a larger incision could be a valuable strategy, particularly in nonexpert hands or when the patient's anatomy or tumor size make exposure of anatomic structures through smaller incisions difficult

Feasibility of a combined mobile-health electrocardiographic and rapid diagnostic test screening for chagas-related cardiac alterations

Background: Chronic Chagas cardiomyopathy (CChC) is the most common cause of death related to Chagas disease (CD). The aim of this study was to assess the feasibility of a combined rapid diagnostic test (RDT) and electrocardiographic (ECG) screening in a remote rural village of the Bolivian Chaco, with a high prevalence of CChC. Methods: Consecutive healthy volunteers > 15 years were enrolled in the community of Palmarito (municipality of Gutierrez, Santa Cruz Department, Bolivia) in February 2019. All patients performed an RDT with Chagas Stat-Pak(®) (CSP, Chembio Diagnostic System, Medford, NY, USA) and an ECG by D-Heart(®) technology, a low-cost, user-friendly smartphone-based 8-lead Bluetooth ECG. RDTs were read locally while ECGs were sent to a cardiology clinic which transmitted reports within 24 h from recording. Results: Among 140 people (54 men, median age 38(interquartile range 23–54) years), 98 (70%) were positive for Trypanosoma cruzi infection, with a linear, age-dependent, increasing trend (p < 0.001). Twenty-five (18%) individuals showed ECG abnormalities compatible with CD. Prevalence of ECG abnormalities was higher in infected individuals and was associated with higher systolic blood pressure and smoking. Following screening, 22 (16%) individuals underwent clinical evaluation and chest X-ray and two were referred for further evaluation. At multivariate analysis, positive CSP results (OR = 4.75, 95%CI 1.08–20.96, p = 0.039) and smoking (OR = 4.20, 95%CI 1.18–14.92, p = 0.027) were independent predictors of ECG abnormalities. Overall cost for screening implementation was <10 $. Conclusions: Combined mobile-Health and RDTs was a reliable and effective low-cost strategy to identify patients at high risk of disease needing cardiologic assessment suggesting potential future applications

Incidence of stroke in patients with hypertrophic cardiomyopathy in stable sinus rhythm during long-term monitoring.

Patients with hypertrophic cardiomyopathy (HCM) are at increased risk of stroke, but the incidence and factors associated with cardioembolic events in HCM patients without atrial fibrillation (AF) remain unresolved. We determined the incidence of stroke in patients in sinus rhythm (SR) monitored with a cardiac implantable electronic device (CIED). All consecutive patients diagnosed with HCM and referred to CIED implantation with &gt;16 years at diagnosis and ≥ 1 year follow-up post CIED implantation were retrospectively reviewed. Severe LA dilatation was defined as ≥48 mm. Patients were stratified by rhythm as: Pre-existing AF (AF present prior to CIED); De novo AF (AF present after CIED implantation); SR: no episodes of AF. Of 1651 patients, 185 (11.2%) implanted with a CIED were included (57% men, age: 54 ± 17 years). Baseline, pre-existing AF was present in 73 (39%) patients. Ischemic stroke was reported in 19 (10.3%, 1.78%/year) patients and was similar across the three groups (2.3%/year vs 1.1%/year vs 0.6%/year in patients in SR vs pre-existing AF vs de novo AF, respectively, p = 0.235). In SR patients, a LAD≥48 mm posed the greatest risk of stroke (Hazard Ratio: 10.03,95% Confidence-Interval 2.79-16.01). At Cox multivariable analysis, after adjustment for oral anticoagulation, LA was independently associated with stroke while rhythm was not. in HCM patients with CIED long-term monitoring and no prior history of AF, stroke rates were similar in those with de novo AF or stable SR. Severe LA dilatation was a powerful risk factor, irrespective of AF

Almost sure-sign convergence of Hardy-type Dirichlet series

[EN] Hartman proved in 1939 that the width of the largest possible strip in the complex plane on which a Dirichlet series is uniformly a.s.- sign convergent (i.e., converges uniformly for almost all sequences of signs epsilon (n) = +/- 1) but does not convergent absolutely, equals 1/2. We study this result from a more modern point of view within the framework of so-called Hardytype Dirichlet series with values in a Banach space.Supported by CONICET-PIP 11220130100329CO, PICT 2015-2299 and UBACyT 20020130100474BA. Supported by MICINN MTM2017-83262-C2-1-P. Supported by MICINN MTM2017-83262-C2-1-P and UPV-SP20120700.Carando, D.; Defant, A.; Sevilla Peris, P. (2018). Almost sure-sign convergence of Hardy-type Dirichlet series. Journal d Analyse Mathématique. 135(1):225-247. https://doi.org/10.1007/s11854-018-0034-yS2252471351A. Aleman, J.-F. Olsen, and E. Saksman, Fourier multipliers for Hardy spaces of Dirichlet series, Int. Math. Res. Not. IMRN 16 (2014), 4368–4378.R. Balasubramanian, B. Calado, and H. Queffélec, The Bohr inequality for ordinary Dirichlet series Studia Math. 175 (2006), 285–304.F. Bayart, Hardy spaces of Dirichlet series and their composition operators, Monatsh. Math. 136 (2002), 203–236.F. Bayart, A. Defant, L. Frerick, M. Maestre, and P. Sevilla-Peris, Monomial series expansion of Hp-functions and multipliers ofHp-Dirichlet series, Math. Ann. 368 (2017), 837–876.F. Bayart, D. Pellegrino, and J. B. Seoane-Sepúlveda, The Bohr radius of the n-dimensional polydisk is equivalent to $$\sqrt {\left( {\log n} \right)/n}$$ ( log n ) / n , Adv. Math. 264 (2014), 726–746.F. Bayart, H. Queffélec, and K. Seip, Approximation numbers of composition operators on Hp spaces of Dirichlet series, Ann. Inst. Fourier (Grenoble) 66 (2016), 551–588.H. F. Bohnenblust and E. Hille. On the absolute convergence of Dirichlet series, Ann. of Math. (2) 32 (1931), 600–622.H. Bohr, Über die Bedeutung der Potenzreihen unendlich vieler Variablen in der Theorie der Dirichlet–schen Reihen $$\sum {\frac{{{a_n}}}{{{n^s}}}}$$ ∑ a n n s , Nachr. Ges.Wiss. Göttingen, Math. Phys. Kl., 1913, pp. 441–488.D. Carando, A. Defant, and P. Sevilla-Peris, Bohr’s absolute convergence problem for Hp- Dirichlet series in Banach spaces, Anal. PDE 7 (2014), 513–527.D. Carando, A. Defant, and P. Sevilla-Peris, Some polynomial versions of cotype and applications, J. Funct. Anal. 270 (2016), 68–87.B. J. Cole and T. W. Gamelin, Representing measures and Hardy spaces for the infinite polydisk algebra, Proc. London Math. Soc. (3) 53 (1986), 112–142.R. de la Bretèche. Sur l’ordre de grandeur des polynômes de Dirichlet, Acta Arith. 134 (2008), 141–148.A. Defant, L. Frerick, J. Ortega-Cerdà, M. Ounäies, and K. Seip, The Bohnenblust-Hille inequality for homogeneous polynomials is hypercontractive, Ann. of Math. (2) 174 (2011), 485–497.A. Defant, D. García, M. Maestre, and D. Pérez-García, Bohr’s strip for vector valued Dirichlet series, Math. Ann. 342 (2008), 533–555.A. Defant, M. Maestre, and U. Schwarting, Bohr radii of vector valued holomorphic functions, Adv. Math. 231 (2012), 2837–2857.A. Defant and A. Pérez, Hardy spaces of vector-valued Dirichlet series, StudiaMath. (to appear), 2018 DOI: 10.4064/sm170303-26-7.A. Defant, U. Schwarting, and P. Sevilla-Peris, Estimates for vector valued Dirichlet polynomials, Monatsh. Math. 175 (2014), 89–116.J. Diestel, H. Jarchow, and A. Tonge, Absolutely Summing Operators, Cambridge University Press, Cambridge, 1995.P. Hartman, On Dirichlet series involving random coefficients, Amer. J. Math. 61 (1939), 955–964.H. Hedenmalm, P. Lindqvist, and K. Seip, A Hilbert space of Dirichlet series and systems of dilated functions in L2(0, 1), Duke Math. J. 86 (1997), 1–37.A. Hildebrand, and G. Tenenbaum, Integers without large prime factors, J. Thor. Nombres Bordeaux 5 (1993), 411–484.S. V. Konyagin and H. Queffélec, The translation 1/2 in the theory of Dirichlet series, Real Anal. Exchange 27 (2001/02) 155–175.J. Lindenstrauss and L. Tzafriri, Classical Banach Spaces. II, Springer-Verlag, Berlin, 1979.B. Maurizi and H. Queffélec, Some remarks on the algebra of bounded Dirichlet series, J. Fourier Anal. Appl. 16 (2010), 676–692.H. Queffélec, H. Bohr’s vision of ordinary Dirichlet series; old and new results, J. Anal. 3 (1995), 43–60.H. Queffélec and M. Queffélec, Diophantine Approximation and Dirichlet Series, Hindustan Book Agency, New Delhi, 2013.G. Tenenbaum, Introduction to Analytic and Probabilistic Number Theory, Cambridge University Press, Cambridge, 1995

Multipliers of Dirichlet series and monomial series expansions of holomorphic functions in infinitely many variables

[EN] Let H-infinity be the set of all ordinary Dirichlet series D = Sigma(n) a(n)(n-1) ann-s representing bounded holomorphic functions on the right half plane. A completely multiplicative sequence (b(n)) of complex numbers is said to be an l(1)-multiplier for H-infinity whenever Sigma(n vertical bar)a(n)b(n vertical bar) < infinity for every D is an element of H-infinity. We study the problem of describing such sequences (b(n)) in terms of the asymptotic decay of the subsequence (b(pj)), where p(j) denotes the j th prime number. Given a completely multiplicative sequence b = (b(n)) we prove (among other results): b is an l(1)-multiplier for H-infinity provided vertical bar b(pj)vertical bar < 1 for all j and (lim(n)) over bar 1/log(n) Sigma(n)(j=1) b(p j)*(2) < 1, and conversely, if b is an l(1)-multiplier for H-infinity, then vertical bar b(pj)vertical bar < 1 for all j and (lim(n)) over bar 1/log(n) Sigma(n)(j=1) b(p j)*(2) <= 1 (here b* stands for the decreasing rearrangement of b). Following an ingenious idea of Harald Bohr it turns out that this problem is intimately related with the question of characterizing those sequences z in the infinite dimensional polydisk D-infinity (the open unit ball of l(infinity)) for which every bounded and holomorphic function f on D-infinity has an absolutely convergent monomial series expansion Sigma(alpha) partial derivative alpha f (0)/alpha! z alpha. Moreover, we study analogous problems in Hardy spaces of Dirichlet series and Hardy spaces of functions on the infinite dimensional polytorus T-infinity.The second, fourth and fifth authors were supported by MINECO and FEDER Project MTM2014-57838-C2-2-P. The fourth author was also supported by PrometeoII/2013/013. The fifth author was also supported by project SP-UPV20120700.Bayart, F.; Defant, A.; Frerick, L.; Maestre, M.; Sevilla Peris, P. (2017). Multipliers of Dirichlet series and monomial series expansions of holomorphic functions in infinitely many variables. Mathematische Annalen. 368(1-2):837-876. https://doi.org/10.1007/s00208-016-1511-1S8378763681-2Aleman, A., Olsen, J.-F., Saksman, E.: Fatou and brother Riesz theorems in the infinite-dimensional polydisc. arXiv:1512.01509Balasubramanian, R., Calado, B., Queffélec, H.: The Bohr inequality for ordinary Dirichlet series. Studia Math. 175(3), 285–304 (2006)Bayart, F.: Hardy spaces of Dirichlet series and their composition operators. Monatsh. Math. 136(3), 203–236 (2002)Bayart, F., Pellegrino, D., Seoane-Sepúlveda, J.B.: The Bohr radius of the $$n$$ n -dimensional polydisk is equivalent to $$\sqrt{(\log n)/n}$$ ( log n ) / n . Adv. Math. 264:726–746 (2014)Bohnenblust, H.F., Hille, E.: On the absolute convergence of Dirichlet series. Ann. Math. 32(3), 600–622 (1931)Bohr, H.: Über die Bedeutung der Potenzreihen unendlich vieler Variablen in der Theorie der Dirichlet–schen Reihen $$\sum \,\frac{a_n}{n^s}$$ ∑ a n n s . Nachr. Ges. Wiss. Göttingen, Math. Phys. Kl. 441–488 (1913)Bohr, H.: Über die gleichmäßige Konvergenz Dirichletscher Reihen. J. Reine Angew. Math. 143, 203–211 (1913)Cole, B.J., Gamelin., T.W.: Representing measures and Hardy spaces for the infinite polydisk algebra. Proc. Lond. Math. Soc. 53(1), 112–142 (1986)Davie, A.M., Gamelin, T.W.: A theorem on polynomial-star approximation. Proc. Am. Math. Soc. 106(2), 351–356 (1989)de la Bretèche, R.: Sur l’ordre de grandeur des polynômes de Dirichlet. Acta Arith. 134(2), 141–148 (2008)Defant, A., Frerick, L., Ortega-Cerdà, J., Ounaïes, M., Seip, K.: The Bohnenblust–Hille inequality for homogeneous polynomials is hypercontractive. Ann. Math. 174(1), 485–497 (2011)Defant, A., García, D., Maestre, M.: New strips of convergence for Dirichlet series. Publ. Mat. 54(2), 369–388 (2010)Defant, A., García, D., Maestre, M., Pérez-García, D.: Bohr’s strip for vector valued Dirichlet series. Math. Ann. 342(3), 533–555 (2008)Defant, A., Maestre, M., Prengel, C.: Domains of convergence for monomial expansions of holomorphic functions in infinitely many variables. J. Reine Angew. Math. 634, 13–49 (2009)Dineen, S.: Complex Analysis on Infinite-dimensional Spaces. Springer Monographs in Mathematics. Springer-Verlag London Ltd, London (1999)Floret, K.: Natural norms on symmetric tensor products of normed spaces. Note Mat. 17(153–188), 1997 (1999)Harris, L. A.: Bounds on the derivatives of holomorphic functions of vectors. In: Analyse fonctionnelle et applications (Comptes Rendus Colloq. Analyse, Inst. Mat., Univ. Federal Rio de Janeiro, Rio de Janeiro, 1972), pp. 145–163. Actualités Aci. Indust., No. 1367. Hermann, Paris (1975)Hedenmalm, H., Lindqvist, P., Seip, K.: A Hilbert space of Dirichlet series and systems of dilated functions in $$L^2(0,1)$$ L 2 ( 0 , 1 ) . Duke Math. J. 86(1), 1–37 (1997)Helson, H., Lowdenslager, D.: Prediction theory and Fourier series in several variables. Acta Math. 99, 165–202 (1958)Hibert, D.: Gesammelte Abhandlungen (Band 3). Verlag von Julius Springer, Berlin (1935)Hilbert, D.: Wesen und Ziele einer Analysis der unendlichvielen unabhängigen Variablen. Rend. del Circolo Mat. di Palermo 27, 59–74 (1909)Kahane, J.-P.: Some Random Series of Functions, Volume 5 of Cambridge Studies in Advanced Mathematics, second edn. 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What Is Italian Antispeciesism? An Overview of Recent Tendencies in Animal Advocacy

This chapter offers an overview of the different agents currently operating in Italy as part of the animal liberation movement. It analyses the impact on this social reality by books and essays published or translated in Italian in the last 20 years in the field of Animal Ethics. From the reception of Peter Singer and Tom Regan\u2019s ideas mediated by the work of Paola Cavalieri, Italian philosophers have shaped the narratives and the rhetoric of animal advocates and liberationists. On the other side, activists\u2019 debates on the best strategies to adopt involved intellectuals and enriched their production on Animal Liberation. Groups with an intersectional approach have paid particular attention to theoretical implications and political consequences of their acts, developing radical, non-anthropocentric forms of antispeciesism

On the statistics of edge fluctuations: comparative study between various fusion devices

In this paper we present a statistical study of edge fluctuations taken with the Gas Puffing Imaging (GPI) diagnostics. We carry out a comparison of GPI signal from an extensive database including four devices (two Tokamaks and two Reversed Field Pinches). The data are analyzed in terms of their statistical moments Skewness and Kurtosis, as done in [B. Labit, et al, Phys. Rev. Lett. \textbf{98}, 255002 (2007)]. The data align along parabolic curves, although different from machine to machine, with some spread around the best-fitting curve. A discussion about the meaning of the parabolic trend as well as the departure of real data from it is provided. A phenomenological model is finally provided, attempting to accomodate experimental evidence.Comment: To appear in Plasma Physics and Controlled Fusio

Keratin 12 missense mutation induces the unfolded protein response and apoptosis in meesmann epithelial corneal dystrophy

Meesmann epithelial corneal dystrophy (MECD) is a rare autosomal dominant disorder caused by dominant-negative mutations within the KRT3 or KRT12 genes, which encode the cytoskeletal protein keratins K3 and K12, respectively. To investigate the pathomechanism of this disease, we generated and phenotypically characterized a novel knock-in humanized mouse model carrying the severe, MECD-associated, K12-Leu132Pro mutation. Although no overt changes in corneal opacity were detected by slit-lamp examination, the corneas of homozygous mutant mice exhibited histological and ultrastructural epithelial cell fragility phenotypes. An altered keratin expression profile was observed in the cornea of mutant mice, confirmed by western blot, RNA-seq and quantitative real-time polymerase chain reaction. Mass spectrometry (MS) and immunohistochemistry demonstrated a similarly altered keratin profile in corneal tissue from a K12-Leu132Pro MECD patient. The K12-Leu132Pro mutation results in cytoplasmic keratin aggregates. RNA-seq analysis revealed increased chaperone gene expression, and apoptotic unfolded protein response (UPR) markers, CHOP and Caspase 12, were also increased in the MECD mice. Corneal epithelial cell apoptosis was increased 17-fold in the mutant cornea, compared with the wild-type (P &lt; 0.001). This elevation of UPR marker expression was also observed in the human MECD cornea. This is the first reporting of a mouse model for MECD that recapitulates the human disease and is a valuable resource in understanding the pathomechanism of the disease. Although the most severe phenotype is observed in the homozygous mice, this model will still provide a test-bed for therapies not only for corneal dystrophies but also for other keratinopathies caused by similar mutations

Diabetes-Related Autoantibodies in Children With Acute Lymphoblastic Leukemia

[No abstract available