SmO thin films: a flexible route to correlated flat bands with nontrivial topology

Using density functional theory based calculations, we show that the correlated mixed-valent compound SmO is a 3D strongly topological semi-metal as a result of a 4$f$-5$d$ band inversion at the X point. The [001] surface Bloch spectral density reveals two weakly interacting Dirac cones that are quasi-degenerate at the M_bar-point and another single Dirac cone at the Gamma_bar-point. We also show that the topological non-triviality in SmO is very robust and prevails for a wide range of lattice parameters, making it an ideal candidate to investigate topological nontrivial correlated flat bands in thin-film form. Moreover, the electron filling is tunable by strain. In addition, we find conditions for which the inversion is of the 4f-6s type, making SmO to be a rather unique system. The similarities of the crystal symmetry and the lattice constant of SmO to the well studied ferromagnetic semiconductor EuO, makes SmO/EuO thin film interfaces an excellent contender towards realizing the quantum anomalous Hall effect in a strongly correlated electron system.Comment: Paper+supplemen

Children over‐imitate adults and peers more than puppets (advance online)

Researchers commonly use puppets in development science. Amongst other things,puppets are employed to reduce social hierarchies between child participants andadult experimenters akin to peer interactions. However, it remains controversialwhether children treat puppets like real-world social partners in these settings.This study investigated children’s imitation of causally irrelevant actions (i.e., over-imitation) performed by puppet, adult, or child models. Seventy-two German children(AgeRange =4.6–6.5 years; 36 girls) from urban, socioeconomically diverse backgroundsobserved a model retrieving stickers from reward containers. The model performedcausally irrelevant actions either in contact with the reward container or not. Childrenwere more likely to over-imitate adults’ and peers’ actions as compared to puppets’actions. Across models, they copied contact actions more than no-contact actions.While children imitate causally irrelevant actions from puppet models to some extent,their social learning from puppets does not necessarily match their social learning fromreal-world social agents, such as children or adults

Effectiveness of Surgery for Lumbar Spinal Stenosis : A Systematic Review and Meta-Analysis

Peer reviewedPublisher PD

Average case analysis of the MST-heuristic for the power assignment problem:Special cases

We present an average case analysis of the minimum spanning tree heuristic for the power assignment problem. The worst-case approximation ratio of this heuristic is 2. We have the following results: (a) In the one-dimensional case, with uniform [0,1]-distributed distances, the expected approximation ratio is bounded above by 2-2=(p+2), where p denotes the distance power gradient. (b) For the complete graph, with uniform [0,1] distributed edge weights, the expected approximation ratio is bounded above by 2-1/2ζ(3), where ζ denotes the Riemann zeta function

Low cancer incidence in naked mole-rats may be related to their inability to express the Warburg effect

Metabolic flexibility in mammals enables stressed tissues to generate additional ATP by converting large amounts of glucose into lactic acid; however, this process can cause transient local or systemic acidosis. Certain mammals are adapted to extreme environments and are capable of enhanced metabolic flexibility as a specialized adaptation to challenging habitat niches. For example, naked mole-rats (NMRs) are a fossorial and hypoxia-tolerant mammal whose metabolic responses to environmental stressors markedly differ from most other mammals. When exposed to hypoxia, NMRs exhibit robust hypometabolism but develop minimal acidosis. Furthermore, and despite a very long lifespan relative to other rodents, NMRs have a remarkably low cancer incidence. Most advanced cancers in mammals display increased production of lactic acid from glucose, irrespective of oxygen availability. This hallmark of cancer is known as the Warburg effect (WE). Most malignancies acquire this metabolic phenotype during their somatic evolution, as the WE benefits tumor growth in several ways. We propose that the peculiar metabolism of the NMR makes development of the WE inherently difficult, which might contribute to the extraordinarily low cancer rate in NMRs. Such an adaptation of NMRs to their subterranean environment may have been facilitated by modified biochemical responses with a stronger inhibition of the production of C

Low Cancer Incidence in Naked Mole-Rats May Be Related to Their Inability to Express the Warburg Effect

Metabolic flexibility in mammals enables stressed tissues to generate additional ATP by converting large amounts of glucose into lactic acid; however, this process can cause transient local or systemic acidosis. Certain mammals are adapted to extreme environments and are capable of enhanced metabolic flexibility as a specialized adaptation to challenging habitat niches. For example, naked mole-rats (NMRs) are a fossorial and hypoxia-tolerant mammal whose metabolic responses to environmental stressors markedly differ from most other mammals. When exposed to hypoxia, NMRs exhibit robust hypometabolism but develop minimal acidosis. Furthermore, and despite a very long lifespan relative to other rodents, NMRs have a remarkably low cancer incidence. Most advanced cancers in mammals display increased production of lactic acid from glucose, irrespective of oxygen availability. This hallmark of cancer is known as the Warburg effect (WE). Most malignancies acquire this metabolic phenotype during their somatic evolution, as the WE benefits tumor growth in several ways. We propose that the peculiar metabolism of the NMR makes development of the WE inherently difficult, which might contribute to the extraordinarily low cancer rate in NMRs. Such an adaptation of NMRs to their subterranean environment may have been facilitated by modified biochemical responses with a stronger inhibition of the production of CO2 and lactic acid by a decreased extracellular pH. Since this pH-inhibition could be deeply hard-wired in their metabolic make-up, it may be difficult for malignant cells in NMRs to acquire the WE-phenotype that facilitates cancer growth in other mammals. In the present commentary, we discuss this idea and propose experimental tests of our hypothesis