“Una obra, dos abordajes, tres experiencias creativas”

Desde el proyecto de investigación presentado en la Universidad Nacional de Villa María, denominado “Reformulación transdisciplinaria del efecto de distanciamiento en la ópera de tres centavos de Bertolt Brecht y Kurt Weill”, se generaron a lo largo de los últimos dos años tres puestas creativas basadas en dicha ópera. La ponencia contempla una descripción de la metodología de trabajo y los criterios artístico/realizativos utilizados, en un abordaje transdisciplinario donde confluyen música, danza, teatro y medios audiovisuales.publishedVersio

Cómo generar una perfomance transdisciplinaria en el marco de un proyecto de investigación, y no morir en el intento

En la presente ponencia nos proponemos problematizar la performance “Pido Gancho: Jugando con Brech” del grupo transdisciplinar Brechtianas de la Universidad Nacional de Villa María, a partir de reflexiones conceptuales que refieren a la transdisciplina, el juego, y los procesos de creación abordados. Después de dos años consecutivos de trabajo, buscamos entender nuestros procesos creativos en un contexto universitario de producción de conocimientos. Es así que el juego se nos vuelve una metodología, y una categoría conceptual, que va asumiendo cada vez más relevancia en nuestras producciones teóricas y prácticas.Gestión, asociación y políticas estéticasFacultad de Humanidades y Ciencias de la Educació

Cómo generar una perfomance transdisciplinaria en el marco de un proyecto de investigación, y no morir en el intento

En la presente ponencia nos proponemos problematizar la performance “Pido Gancho: Jugando con Brech” del grupo transdisciplinar Brechtianas de la Universidad Nacional de Villa María, a partir de reflexiones conceptuales que refieren a la transdisciplina, el juego, y los procesos de creación abordados. Después de dos años consecutivos de trabajo, buscamos entender nuestros procesos creativos en un contexto universitario de producción de conocimientos. Es así que el juego se nos vuelve una metodología, y una categoría conceptual, que va asumiendo cada vez más relevancia en nuestras producciones teóricas y prácticas.Gestión, asociación y políticas estéticasFacultad de Humanidades y Ciencias de la Educació

Cómo generar una perfomance transdisciplinaria en el marco de un proyecto de investigación, y no morir en el intento

En la presente ponencia nos proponemos problematizar la performance “Pido Gancho: Jugando con Brech” del grupo transdisciplinar Brechtianas de la Universidad Nacional de Villa María, a partir de reflexiones conceptuales que refieren a la transdisciplina, el juego, y los procesos de creación abordados. Después de dos años consecutivos de trabajo, buscamos entender nuestros procesos creativos en un contexto universitario de producción de conocimientos. Es así que el juego se nos vuelve una metodología, y una categoría conceptual, que va asumiendo cada vez más relevancia en nuestras producciones teóricas y prácticas.Gestión, asociación y políticas estéticasFacultad de Humanidades y Ciencias de la Educació

Contribution of Rare and Low-Frequency Variants to Multiple Sclerosis Susceptibility in the Italian Continental Population

Genome-wide association studies identified over 200 risk loci for multiple sclerosis (MS) focusing on common variants, which account for about 50% of disease heritability. The goal of this study was to investigate whether low-frequency and rare functional variants, located in MS-established associated loci, may contribute to disease risk in a relatively homogeneous population, testing their cumulative effect (burden) with gene-wise tests. We sequenced 98 genes in 588 Italian patients with MS and 408 matched healthy controls (HCs). Variants were selected using different filtering criteria based on allelic frequency and in silico functional impacts. Genes showing a significant burden (n = 17) were sequenced in an independent cohort of 504 MS and 504 HC. The highest signal in both cohorts was observed for the disruptive variants (stop-gain, stop-loss, or splicing variants) located in EFCAB13, a gene coding for a protein of an unknown function (p < 10(-4)). Among these variants, the minor allele of a stop-gain variant showed a significantly higher frequency in MS versus HC in both sequenced cohorts (p = 0.0093 and p = 0.025), confirmed by a meta-analysis on a third independent cohort of 1298 MS and 1430 HC (p = 0.001) assayed with an SNP array. Real-time PCR on 14 heterozygous individuals for this variant did not evidence the presence of the stop-gain allele, suggesting a transcript degradation by non-sense mediated decay, supported by the evidence that the carriers of the stop-gain variant had a lower expression of this gene (p = 0.0184). In conclusion, we identified a novel low-frequency functional variant associated with MS susceptibility, suggesting the possible role of rare/low-frequency variants in MS as reported for other complex diseases

A multicenter randomized phase 4 trial comparing sodium picosulphate plus magnesium citrate vs. polyethylene glycol plus ascorbic acid for bowel preparation before colonoscopy. The PRECOL trial

Background: Adequate bowel preparation before colonoscopy is crucial. Unfortunately, 25% of colonoscopies have inadequate bowel cleansing. From a patient perspective, bowel preparation is the main obstacle to colonoscopy. Several low-volume bowel preparations have been formulated to provide more tolerable purgative solutions without loss of efficacy. Objectives: Investigate efficacy, safety, and tolerability of Sodium Picosulphate plus Magnesium Citrate (SPMC) vs. Polyethylene Glycol plus Ascorbic Acid (PEG-ASC) solutions in patients undergoing diagnostic colonoscopy. Materials and methods: In this phase 4, randomized, multicenter, twoarm trial, adult outpatients received either SPMC or PEG-ASC for bowel preparation before colonoscopy. The primary aims were quality of bowel cleansing (primary endpoint scored according to Boston Bowel Preparation Scale) and patient acceptance (measured with six visual analogue scales). The study was open for treatment assignment and blinded for primary endpoint assessment. This was done independently with videotaped colonoscopies reviewed by two endoscopists unaware of study arms. A sample size of 525 patients was calculated to recognize a difference of 10% in the proportion of successes between the arms with a two-sided alpha error of 0.05 and 90% statistical power. Results: Overall 550 subjects (279 assigned to PEG-ASC and 271 assigned to SPMC) represented the analysis population. There was no statistically significant difference in success rate according to BBPS: 94.4% with PEG-ASC and 95.7% with SPMC (P = 0.49). Acceptance and willing to repeat colonoscopy were significantly better for SPMC with all the scales. Compliance was less than full in 6.6 and 9.9% of cases with PEG-ASC and SPMC, respectively (P = 0.17). Nausea and meteorism were significantly more bothersome with PEG-ASC than SPMC. There were no serious adverse events in either group. Conclusion: SPMC and PEG-ASC are not different in terms of efficacy, but SPMC is better tolerated than PEG-ASC. SPMC could be an alternative to lowvolume PEG based purgative solutions for bowel preparation

Conversion to secondary progressive multiple sclerosis: patient awareness and needs. results from an online survey in Italy and Germany

Background: Few studies have investigated the experiences of patients around the conversion to secondary progressive multiple sclerosis (SPMS). ManTra is a mixed-method, co-production research project conducted in Italy and Germany to develop an intervention for newly-diagnosed SPMS patients. In previous project actions, we identified the needs and experiences of patients converting to SPMS via literature review and qualitative research which involved key stakeholders.Aims: The online patient survey aimed to assess, on a larger and independent sample of recently-diagnosed SPMS patients: (a) the characteristics associated to patient awareness of SPMS conversion; (b) the experience of conversion; (c) importance and prioritization of the needs previously identified.Methods: Participants were consenting adults with SPMS since <= 5 years. The survey consisted of three sections: on general and clinical characteristics; on experience of SPMS diagnosis disclosure (aware participants only); and on importance and prioritization of 33 pre-specified needs.Results: Of 215 participants, those aware of their SPMS diagnosis were 57% in Italy vs. 77% in Germany (p = 0.004). In both countries, over 80% of aware participants received a SPMS diagnosis from the neurologist; satisfaction with SPMS disclosure was moderate to high. Nevertheless, 28-35% obtained second opinions, and 48-56% reported they did not receive any information on SPMS. Participants actively seeking further information were 63% in Germany vs. 31% in Italy (p < 0.001).Variables independently associated to patient awareness were geographic area (odds ratio, OR 0.32, 95% CI 0.13-0.78 for Central Italy; OR 0.21, 95% CI 0.08-0.58 for Southern Italy [vs. Germany]) and activity limitations (OR 7.80, 95% CI 1.47-41.37 for dependent vs. autonomous patients).All pre-specified needs were scored a lot or extremely important, and two prioritized needs were shared by Italian and German patients: "physiotherapy" and "active patient care involvement." The other two differed across countries: "an individualized health care plan" and "information on social rights and policies" in Italy, and "psychological support" and "cognitive rehabilitation" in Germany.Conclusions: Around 40% of SPMS patients were not aware of their disease form indicating a need to improve patient-physician communication. Physiotherapy and active patient care involvement were prioritized in both countries