976 research outputs found

    Intonation in unaccompanied singing: Accuracy, drift, and a model of reference pitch memory

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    Copyright 2014 Acoustical Society of America. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the Acoustical Society of America. The following article appeared in J. Acoust. Soc. Am. 136, 401 (2014) and may be found at http://dx.doi.org/10.1121/1.4881915

    Association between Antibodies to the MR 67,000 Isoform of Glutamate Decarboxylase (GAD) and Type 1 (Insulin-Dependent) Diabetes Mellitus with Coexisting Autoimmune Polyendocrine Syndrome Type II

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    By using an immunoprecipitation assay, we analysed reactivity of autoantibodies to human recombinant GAD65 and GAD67 in sera from patients with autoimmune polyendocrine syndrome Type II (APS II) with and without Type 1 (insulin-dependent) diabetes mellitus (IDDM) compared to patients with organ-specific autoimmunity. Overall antibodies to GAD65 were correlated with IDDM in all study groups, whereas GAD67 antibodies were associated with IDDM when APS II coexists. Antibodies to GAD65 and GAD67 were detected in 13 (44.8%) and 7 (24.1%) out of 29 APS II patients with IDDM, but in only 4 (13.8%) and 2 (6.9%) out of 29 APS II patients without IDDM, respectively (p < 0.05). In short-standing IDDM (< 1 year), antibodies to GAD67 were significantly more frequent in patients with APS II (5 of 9 [55.6%] subjects) compared to matched diabetic patients without coexisting polyendocrinopathy (1 of 18 [5.6%] subjects) (p < 0.02). The levels of GAD65 (142 ± 90 AU) and GAD67 antibodies (178 ± 95 AU) were significantly higher in patients with polyglandular disease than in patients with isolated IDDM (91 ± 85 AU and 93 ± 57 AU) (p < 0.02). Interestingly, all 11 GAD67 antibody positive subjects also had GAD65 antibodies (p < 0.0001), and in 10 of 11 anti-GAD67 positive sera the GAD67 antibodies could be blocked by either GAD67 or GAD65, suggesting the presence of cross-reactive autoantibodies. No correlation was observed between GAD antibodies and age, sex or any particular associated autoimmune disease, besides IDDM. GAD antibodies were present in only 1 of 6 (16.7%) patients with APS Type I, in 1 of 26 (3.9%) patients with autoimmune thyroid disease but in none of the patients with Addison's disease (n = 16), pernicious anaemia (n = 7) or normal controls (n = 50). Our data suggest distinct antibody specificities reactive to GAD isoforms in APS II and IDDM, which might reflect different mechanisms of autoimmune response in IDDM with coexisting autoimmune polyendocrine autoimmunity

    ATPMN: accurate positions and flux densities at 5 and 8 GHz for 8,385 sources from the PMN survey

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    We present a source catalogue of 9,040 radio sources resulting from high-resolution observations of 8,385 PMN sources with the Australia Telescope Compact Array. The catalogue lists flux density and structural measurements at 4.8 and 8.6 GHz, derived from observations of all PMN sources in the declination range -87 deg < delta < -38.5 deg (exclusive of galactic latitudes |b| 70 mJy (50 mJy south of delta = -73 deg). We assess the quality of the data, which was gathered in 1992-1994, describe the population of catalogued sources, and compare it to samples from complementary catalogues. In particular we find 127 radio sources with probable association with gamma-ray sources observed by the orbiting Fermi Large Area Telescope.Comment: 20 pages, 21 figure

    Editorial: Rising stars in biofilms 2022

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    [Excerpt] The emergence of antibiotic-resistant bacteria, including globally-disseminated multidrug-resistant strains, has become one of the most alarming threats for human health. Fundamentally originated by an inadequate use of antibiotics in clinical and nonclinical settings, infections caused by multidrug-resistant bacteria are currently responsible for around two million deaths each year and are estimated to be the cause of death of as many as 10 million people yearly by 2050 (O'Neill, 2016).info:eu-repo/semantics/publishedVersio

    Accretion and nuclear activity in Virgo early-type galaxies

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    We use Chandra observations to estimate the accretion rate of hot gas onto the central supermassive black hole in four giant (of stellar mass 10E11 - 10E12 solar masses) early-type galaxies located in the Virgo cluster. They are characterized by an extremely low radio luminosity, in the range L < 3E25 - 10E27 erg/s/Hz. We find that, accordingly, accretion in these objects occurs at an extremely low rate, 0.2 - 3.7 10E-3 solar masses per year, and that they smoothly extend the relation accretion - jet power found for more powerful radio-galaxies. This confirms the dominant role of hot gas and of the galactic coronae in powering radio-loud active galactic nuclei across ~ 4 orders of magnitude in luminosity. A suggestive trend between jet power and location within the cluster also emerges.Comment: Accepted for publication in A&

    Mechanosensitive Expression of a Lipoxygenase Gene in Wheat

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    1.4 GHz polarimetric observations of the two fields imaged by the DASI experiment

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    We present results of polarization observations at 1.4 GHz of the two fields imaged by the DASI experiment (α=23h30m\alpha = 23^{\rm h} 30^{\rm m}, δ=55\delta = -55^{\circ} and α=00h30m\alpha = 00^{\rm h} 30^{\rm m}, δ=55\delta = -55^{\circ}, respectively). Data were taken with the Australia Telescope Compact Array with 3.4 arcmin resolution and 0.18\sim 0.18 mJy beam1^{-1} sensitivity. The emission is dominated by point sources and we do not find evidence for diffuse synchrotron radiation even after source subtraction. This allows to estimate an upper limit of the diffuse polarized emission. The extrapolation to 30 GHz suggests that the synchrotron radiation is lower than the polarized signal measured by the DASI experiment by at least 2 orders of magnitude. This further supports the conclusions drawn by the DASI team itself about the negligible Galactic foreground contamination in their data set, improving by a factor 5\sim 5 the upper limit estimated by Leitch et al. (2005). The dominant point source emission allows us to estimate the contamination of the CMB by extragalactic foregrounds. We computed the power spectrum of their contribution and its extrapolation to 30 GHz provides a framework where the CMB signal should dominate. However, our results do not match the conclusions of the DASI team about the negligibility of point source contamination, suggesting to take into account a source subtraction from the DASI data.Comment: 7 pages, six figures, submitted to MNRA
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