Liiketoiminnan transformaation tuottaneet toimijaryhmät : Kemira GrowHow'n synty

The subject of my research is the transformation of the dominant business unit of the Kemira Corporation, a Finnish chemical company. As a result of the transformation, the fertilizer business was ultimately separated from the corporation under the name Kemira GrowHow and listed on the stock exchange. At the core of the transformation was the creation of a networkbased business offering out of a traditional functional organization. Dozens of partners joined in the development of the services and tens of thousands of farmers became the users. A collaborative network that expanded and deepened relationships among the actors was developed between the service developers and service users. To build up this network-based business, the middle management of the business unit founded new companies and initiated co-development with the support of a shared internet-based data and communication system. The establishment of GrowHow was clearly a radical and historically significant example of a transformation of the dominant business of a corporation. The case of GrowHow shows that middle management can transform a business with solution models that it has itself developed, without a support person in corporate management. In devising a mechanism to explain the emergence of Kemira GrowHow, I have approached the phenomenon from the perspective of critical realism by elaborating the situational context at three levels. On the first level, I have identified four actor groups and their arenas of action and four solution models. On the second level, I have elaborated the praxis of the three actor groups that created their distinctive solution models and the chains of events related to the efforts of the fourth group to sell the business concept and mode of operation to corporate management. On the third level, I have further analyzed the process of selling the new business concept to corporate management and identified the means developed by middle management for handling confrontations with corporate management and owners. Hence, the mechanism for explaining the emergence of GrowHow goes back to development of the praxis of the actor groups mobilized by middle management and the competencies used in selling the issue to corporate-level decision-makers. Researchers have seldom discovered what kind of collective learning was required to create solution models for a new business concept. The case of GrowHow provided an opportunity for this. I took part in the development work conducted by management at the corporate, division, and business unit levels for 15 years, during which time I collected material on the history of the event. The principal material for this research consists of the knowledge and experience of 12 key individuals who took part in the development of the network. The case of GrowHow shows that an explanation for a business transformation can be attributed to the level of the unique collaborative learning process of the actor groups that created the solution model

New tricks and emerging applications from contemporary azobenzene research

Azobenzenes have many faces. They are well-known as dyes, but most of all, azobenzenes are versatile photoswitchable molecules with powerful photochemical properties. Azobenzene photochemistry has been extensively studied for decades, but only relatively recently research has taken a steer towards applications, ranging from photonics and robotics to photobiology. In this perspective, after an overview of the recent trends in the molecular design of azobenzenes, we highlight three research areas where the azobenzene photoswitches may bring about promising technological innovations: chemical sensing, organic transistors, and cell signaling. Ingenious molecular designs have enabled versatile control of azobenzene photochemical properties, which has in turn facilitated the development of chemical sensors and photoswitchable organic transistors. Finally, the power of azobenzenes in biology is exemplified by vision restoration and photactivation of neural signaling. Although the selected examples reveal only some of the faces of azobenzenes, we expect the fields presented to develop rapidly in the near future, and that azobenzenes will play a central role in this development.publishedVersionPeer reviewe

Food system by-products upcycled in livestock and aquaculture feeds can increase global food supply

Optimizing biomass use by reducing food-feed competition is paramount to achieving sustainable food systems. This study assesses global food systems in terms of livestock and aquaculture feed use and the availability of food system by-products and residues to quantify the potential for replacing food-grade feeds with food system by-products. Many livestock and aquaculture feeds compete for resources with food production. Increasing the use of food system by-products and residues as feed could reduce this competition. We gathered data on global food system material flows for crop, livestock and aquaculture production, focusing on feed use and the availability of by-products and residues. We then analysed the potential of replacing food-competing feedstuff-here cereals, whole fish, vegetable oils and pulses that account for 15% of total feed use-with food system by-products and residues. Considering the nutritional requirements of food-producing animals, including farmed aquatic species, this replacement could increase the current global food supply by up to 13% (10-16%) in terms of kcal and 15% (12-19%) in terms of protein content. Increasing the use of food system by-products as feed has considerable potential, particularly when combined with other measures, in the much-needed transition towards circular food systems.Peer reviewe

Red-light photoswitching of indigos in polymer thin films

Through simple synthetic derivatisation, the parent indigo dye becomes a red-light E-Z photoswitch exhibiting negative photochromism and tuneable thermal isomerisation kinetics. These attributes make indigo derivatives extremely attractive for applications related to materials and living systems. However, there is a lack of knowledge in translating indigo photoswitching dynamics from solution to solid state - the environment crucial for most applications. Herein, we study the photoswitching performance of six structurally distinct indigo derivatives in five polymers of varying rigidity. Three key strategies are identified to enable efficient photoswitching under red (660 nm) light: (i) choosing a soft polymer matrix to minimise its resistance toward the isomerisation, (ii) creating free volume around the indigo molecules through synthetic modifications, and (iii) applying low dye loading (80% Z form in the photostationary state) is nearly identical to that in solution. These findings thus pave the way for designing new red-light photochromic materials based on indigos.publishedVersionPeer reviewe

Expanding excitation wavelengths for azobenzene photoswitching into the near-infrared range via endothermic triplet energy transfer

Developing azobenzene photoswitches capable of selective and efficient photoisomerization by long-wavelength excitation is an enduring challenge. Herein, rapid isomerization from the Z- to E-state of two ortho-functionalized bistable azobenzenes with near-unity photoconversion efficiency was driven by triplet energy transfer upon red and near-infrared (up to 770 nm) excitation of porphyrin photosensitizers in catalytic micromolar concentrations. We show that the process of triplet-sensitized isomerization is efficient even when the sensitizer triplet energy is substantially lower (>200 meV) than that of the azobenzene used. This makes the approach applicable for a wide variety of sensitizer-azobenzene combinations and enables the expansion of excitation wavelengths into the near-infrared spectral range. Therefore, indirect excitation via endothermic triplet energy transfer provides efficient and precise means for photoswitching upon 770 nm near-infared light illumination with no chemical modification of the azobenzene chromophore, a desirable feature in photocontrollable biomaterials.Peer reviewe

A relational database to identify differentially expressed genes in the endometrium and endometriosis lesions

Endometriosis is a common inflammatory estrogen-dependent gynecological disorder, associated with pelvic pain and reduced fertility in women. Several aspects of this disorder and its cellular and molecular etiology remain unresolved. We have analyzed the global gene expression patterns in the endometrium, peritoneum and in endometriosis lesions of endometriosis patients and in the endometrium and peritoneum of healthy women. In this report, we present the EndometDB, an interactive web-based user interface for browsing the gene expression database of collected samples without the need for computational skills. The EndometDB incorporates the expression data from 115 patients and 53 controls, with over 24000 genes and clinical features, such as their age, disease stages, hormonal medication, menstrual cycle phase, and the different endometriosis lesion types. Using the web-tool, the end-user can easily generate various plot outputs and projections, including boxplots, and heatmaps and the generated outputs can be downloaded in pdf-format.Peer reviewe

Measurement of complement receptor 1 on neutrophils in bacterial and viral pneumonia

BACKGROUND: A reliable prediction of the causative agent of community-acquired pneumonia (CAP) is not possible based on clinical features. Our aim was to test, whether the measurement of the expression of complement receptors or Fcγ receptors on neutrophils and monocytes would be a useful preliminary test to differentiate between bacterial and viral pneumonia. METHODS: Sixty-eight patients with CAP were studied prospectively. Thirteen patients had pneumococcal pneumonia; 13 patients, influenza A pneumonia; 5 patients, atypical pneumonia, and 37 patients, aetiologically undefined pneumonia. Leukocyte receptor expression was measured within 2 days of hospital admission. RESULTS: The mean expression of complement receptor 1 (CR1) on neutrophils was significantly higher in the patients with pneumococcal pneumonia than in those with influenza A pneumonia. The mean expression of CR1 was also significantly higher in aetiologically undefined pneumonia than in influenza A pneumonia, but there was no difference between pneumococcal and undefined pneumonia. CONCLUSION: Our results suggest that the expression of CR1 is higher in classical bacterial pneumonia than in viral pneumonia. Determination of the expression of CR1 may be of value as an additional rapid tool in the aetiological diagnosis, bacterial or viral infection, of CAP. These results are preliminary and more research is needed to assess the utility of this new method in the diagnostics of pneumonia

Notable shifts beyond pre-industrial streamflow and soil moisture conditions transgress the planetary boundary for freshwater change

Human actions compromise the many life-supporting functions provided by the freshwater cycle. Yet, scientific understanding of anthropogenic freshwater change and its long-term evolution is limited. Here, using a multi-model ensemble of global hydrological models, we estimate how, over a 145-year industrial period (1861–2005), streamflow and soil moisture have deviated from pre-industrial baseline conditions (defined by 5th–95th percentiles, at 0.5° grid level and monthly timestep over 1661–1860). Comparing the two periods, we find an increased frequency of local deviations on ~45% of land area, mainly in regions under heavy direct or indirect human pressures. To estimate humanity’s aggregate impact on these two important elements of the freshwater cycle, we present the evolution of deviation occurrence at regional to global scales. Annually, local streamflow and soil moisture deviations now occur on 18.2% and 15.8% of global land area, respectively, which is 8.0 and 4.7 percentage points beyond the ~3 percentage point wide pre-industrial variability envelope. Our results signify a substantial shift from pre-industrial streamflow and soil moisture reference conditions to persistently increasing change. This indicates a transgression of the new planetary boundary for freshwater change, which is defined and quantified using our approach, calling for urgent actions to reduce human disturbance of the freshwater cycle