Apprentissages collectifs informels en réseau : où, avec qui, comment, pourquoi ? (Table ronde)

International audienc

Apprentissages collectifs informels en réseau : où, avec qui, comment, pourquoi ? (Table ronde)

International audienc

La gestion du sol influence l’export du cuivre dans des parcelles d’un vignoble alsacien

International audienc

Atelier réflexif autour des jeux sérieux : compte-rendu d'atelier

International audienceL'atelier réflexif sur les fresques et jeux sérieux a eu lieu à Archipel le lundi de 14h à 17h30. Il suivait la matinée dans laquelle ces mêmes participant•es ont joué au choix à la Fresque des Risques Systémiques Globaux (RSG), au Radar du rebond, ou à la Fresque du climat. Les objectifs de l’atelier étaient les suivants :- Amener une vision critique des outils sur les thématiques écologiques.- Faire réfléchir aux moyens d’enseignement pour les RSG.- Faire émerger des pistes sur les moyens d’enseigner les RSG.- Rendu : Produire un compte rendu des discussions et réflexions, en aval de l’atelier.Une vingtaine de participant•es étaient présent•es. Le déroulé de l’atelier est en annexe

Atelier réflexif autour des jeux sérieux : compte-rendu d'atelier

International audienceL'atelier réflexif sur les fresques et jeux sérieux a eu lieu à Archipel le lundi de 14h à 17h30. Il suivait la matinée dans laquelle ces mêmes participant•es ont joué au choix à la Fresque des Risques Systémiques Globaux (RSG), au Radar du rebond, ou à la Fresque du climat. Les objectifs de l’atelier étaient les suivants :- Amener une vision critique des outils sur les thématiques écologiques.- Faire réfléchir aux moyens d’enseignement pour les RSG.- Faire émerger des pistes sur les moyens d’enseigner les RSG.- Rendu : Produire un compte rendu des discussions et réflexions, en aval de l’atelier.Une vingtaine de participant•es étaient présent•es. Le déroulé de l’atelier est en annexe

Atelier réflexif autour des jeux sérieux : compte-rendu d'atelier

International audienceL'atelier réflexif sur les fresques et jeux sérieux a eu lieu à Archipel le lundi de 14h à 17h30. Il suivait la matinée dans laquelle ces mêmes participant•es ont joué au choix à la Fresque des Risques Systémiques Globaux (RSG), au Radar du rebond, ou à la Fresque du climat. Les objectifs de l’atelier étaient les suivants :- Amener une vision critique des outils sur les thématiques écologiques.- Faire réfléchir aux moyens d’enseignement pour les RSG.- Faire émerger des pistes sur les moyens d’enseigner les RSG.- Rendu : Produire un compte rendu des discussions et réflexions, en aval de l’atelier.Une vingtaine de participant•es étaient présent•es. Le déroulé de l’atelier est en annexe

Cohort study: “Outcomes of kidney transplantation in patients with prosthetic heart valves”

International audienceThe number of kidney transplant candidates with prosthetic heart valves (PHVs) is increasing. Yet, outcomes of kidney transplantation in these patients are still unclear. This is the first report of post-transplant outcomes in patients with PHVs at time of kidney transplantation. We conducted a matched cohort study among recipients from the multicentric and prospective DIVAT cohort to compare the outcomes in patients with left-sided PHVs at time of transplantation and a group of recipients without PHV matched according to age, dialysis time, initial disease, pretransplant DSA, diabetes, and cardiovascular events. Of 23 018 patients, 92 patients with PHVs were included and compared to 276 patients without PHV. Delayed graft function and postoperative bleeding occurred more frequently in patients with PHVs. Kidney graft survival was similar between groups. 5-year overall survival was 68.5% in patients with PHV vs. 87.9% in patients without PHV [HR, 2.72 (1.57-4.70), P = 0.0004]. Deaths from infection, endocarditis, and bleeding were more frequent in patients with PHV. Mechanical valves, but not bioprosthetic valves, were independent risk factors for mortality [HR, 2.89 (1.68-4.97), P = 0.0001]. Patients with PHV have high mortality rates after kidney transplantation. These data suggest that mechanical valves, but not biological valves, increase risks of post-transplant mortality

Effect of anakinra versus usual care in adults in hospital with COVID-19 and mild-to-moderate pneumonia (CORIMUNO-ANA-1): a randomised controlled trial

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Effect of Tocilizumab vs Usual Care in Adults Hospitalized With COVID-19 and Moderate or Severe Pneumonia

International audienceImportance Severe pneumonia with hyperinflammation and elevated interleukin-6 is a common presentation of coronavirus disease 2019 (COVID-19).Objective To determine whether tocilizumab (TCZ) improves outcomes of patients hospitalized with moderate-to-severe COVID-19 pneumonia.Design, Setting, and Particpants This cohort-embedded, investigator-initiated, multicenter, open-label, bayesian randomized clinical trial investigating patients with COVID-19 and moderate or severe pneumonia requiring at least 3 L/min of oxygen but without ventilation or admission to the intensive care unit was conducted between March 31, 2020, to April 18, 2020, with follow-up through 28 days. Patients were recruited from 9 university hospitals in France. Analyses were performed on an intention-to-treat basis with no correction for multiplicity for secondary outcomes.Interventions Patients were randomly assigned to receive TCZ, 8 mg/kg, intravenously plus usual care on day 1 and on day 3 if clinically indicated (TCZ group) or to receive usual care alone (UC group). Usual care included antibiotic agents, antiviral agents, corticosteroids, vasopressor support, and anticoagulants.Main Outcomes and Measures Primary outcomes were scores higher than 5 on the World Health Organization 10-point Clinical Progression Scale (WHO-CPS) on day 4 and survival without need of ventilation (including noninvasive ventilation) at day 14. Secondary outcomes were clinical status assessed with the WHO-CPS scores at day 7 and day 14, overall survival, time to discharge, time to oxygen supply independency, biological factors such as C-reactive protein level, and adverse events.Results Of 131 patients, 64 patients were randomly assigned to the TCZ group and 67 to UC group; 1 patient in the TCZ group withdrew consent and was not included in the analysis. Of the 130 patients, 42 were women (32%), and median (interquartile range) age was 64 (57.1-74.3) years. In the TCZ group, 12 patients had a WHO-CPS score greater than 5 at day 4 vs 19 in the UC group (median posterior absolute risk difference [ARD] −9.0%; 90% credible interval [CrI], −21.0 to 3.1), with a posterior probability of negative ARD of 89.0% not achieving the 95% predefined efficacy threshold. At day 14, 12% (95% CI −28% to 4%) fewer patients needed noninvasive ventilation (NIV) or mechanical ventilation (MV) or died in the TCZ group than in the UC group (24% vs 36%, median posterior hazard ratio [HR] 0.58; 90% CrI, 0.33-1.00), with a posterior probability of HR less than 1 of 95.0%, achieving the predefined efficacy threshold. The HR for MV or death was 0.58 (90% CrI, 0.30 to 1.09). At day 28, 7 patients had died in the TCZ group and 8 in the UC group (adjusted HR, 0.92; 95% CI 0.33-2.53). Serious adverse events occurred in 20 (32%) patients in the TCZ group and 29 (43%) in the UC group (P = .21).Conclusions and Relevance In this randomized clinical trial of patients with COVID-19 and pneumonia requiring oxygen support but not admitted to the intensive care unit, TCZ did not reduce WHO-CPS scores lower than 5 at day 4 but might have reduced the risk of NIV, MV, or death by day 14. No difference on day 28 mortality was found. Further studies are necessary for confirming these preliminary results.Trial Registration ClinicalTrials.gov Identifier: NCT0433180