Subleading Shape Functions in Inclusive B Decays

The contributions of subleading shape functions to inclusive decay distributions of B mesons are derived from a systematic two-step matching of QCD current correlators onto soft-collinear and heavy-quark effective theory. At tree-level, the results can be expressed in terms of forward matrix elements of bi-local light-cone operators. Four-quark operators, which arise at O(g^2), are included. Their effects can be absorbed entirely into a redefinition of other shape functions. Our results are in disagreement with some previous studies of subleading shape-function effects in the literature. A numerical analysis of B->X_u+l+nu decay distributions suggests that power corrections are small, with the possible exception of the endpoint region of the charged-lepton energy spectrum.Comment: 22 pages, 2 figures; several typos corrected; version published in JHE

Gauge Orbit Types for Theories with Classical Compact Gauge Group

We determine the orbit types of the action of the group of local gauge transformations on the space of connections in a principal bundle with structure group O(n), SO(n) or $Sp(n)$ over a closed, simply connected manifold of dimension 4. Complemented with earlier results on U(n) and SU(n) this completes the classification of the orbit types for all classical compact gauge groups over such space-time manifolds. On the way we derive the classification of principal bundles with structure group SO(n) over these manifolds and the Howe subgroups of SO(n).Comment: 57 page

Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis

Pneumonia is a major cause of mortality worldwide and a serious problem in critical care medicine, but the immunophysiological processes that confer either protection or morbidity are not completely understood. We show that in response to lung infection, B1a B cells migrate from the pleural space to the lung parenchyma to secrete polyreactive emergency immunoglobulin M (IgM). The process requires innate response activator (IRA) B cells, a transitional B1a-derived inflammatory subset which controls IgM production via autocrine granulocyte/macrophage colony-stimulating factor (GM-CSF) signaling. The strategic location of these cells, coupled with the capacity to produce GM-CSF–dependent IgM, ensures effective early frontline defense against bacteria invading the lungs. The study describes a previously unrecognized GM-CSF-IgM axis and positions IRA B cells as orchestrators of protective IgM immunity

Towards Higgs boson production in gluon fusion to NNLO in the MSSM

We consider the Higgs boson production in the gluon-fusion channel to next-to-next-to-leading order within the Minimal Supersymmetric Standard Model. In particular, we present analytical results for the matching coefficient of the effective theory and study its influence on the total production cross section in the limit where the masses of all MSSM particles coincide. For supersymmetric masses below 500 GeV it is possible to find parameters leading to a significant enhancement of the Standard Model cross section, the $K$-factors, however, change only marginally.Comment: 20 pages; v2: modification of discussion of numerical effect, version to appear in EPJC; v3: eq.(18) corrected, minor correction

Low-Energy Brane-World Effective Actions and Partial Supersymmetry Breaking

As part of a programme for the general study of the low-energy implications of supersymmetry breaking in brane-world scenarios, we study the nonlinear realization of supersymmetry which occurs when breaking N=2 to N=1 supergravity. We consider three explicit realizations of this supersymmetry breaking pattern, which correspond to breaking by one brane, by one antibrane or by two (or more) parallel branes. We derive the minimal field content, the effective action and supersymmetry transformation rules for the resulting N=1 theory perturbatively in powers of kappa = 1/M_{Planck}. We show that the way the massive gravitino and spin-1 fields assemble into N=1 multiplets implies the existence of direct brane-brane contact interactions at order O(kappa). This result is contrary to the O(kappa^2) predicted by the sequestering scenario but in agreement with recent work of Anisimov et al. Our low-energy approach is model independent and is a first step towards determining the low-energy implications of more realistic brane models which completely break all supersymmetries.Comment: Latex, 29 Page

Schrödinger operators with δ and δ′-potentials supported on hypersurfaces

Self-adjoint Schrödinger operators with δ and δ′-potentials supported on a smooth compact hypersurface are defined explicitly via boundary conditions. The spectral properties of these operators are investigated, regularity results on the functions in their domains are obtained, and analogues of the Birman–Schwinger principle and a variant of Krein’s formula are shown. Furthermore, Schatten–von Neumann type estimates for the differences of the powers of the resolvents of the Schrödinger operators with δ and δ′-potentials, and the Schrödinger operator without a singular interaction are proved. An immediate consequence of these estimates is the existence and completeness of the wave operators of the corresponding scattering systems, as well as the unitary equivalence of the absolutely continuous parts of the singularly perturbed and unperturbed Schrödinger operators. In the proofs of our main theorems we make use of abstract methods from extension theory of symmetric operators, some algebraic considerations and results on elliptic regularity

Local proliferation dominates lesional macrophage accumulation in atherosclerosis

During the inflammatory response that drives atherogenesis, macrophages accumulate progressively in the expanding arterial wall1,2. The observation that circulating monocytes give rise to lesional macrophages3–9 has reinforced the concept that monocyte infiltration dictates macrophage build-up. Recent work indicates, however, that macrophages do not depend on monocytes in some inflammatory contexts10. We therefore revisited the mechanism of macrophage accumulation in atherosclerosis. We show that murine atherosclerotic lesions experience a surprisingly rapid, 4-week, cell turnover. Replenishment of macrophages in these experimental atheromata depends predominantly on local macrophage proliferation rather than monocyte influx. The microenvironment orchestrates macrophage proliferation via the involvement of scavenger receptor (SR)-A. Our study reveals macrophage proliferation as a key event in atherosclerosis and identifies macrophage self-renewal as a therapeutic target for cardiovascular disease

BMP-SMAD Signaling Regulates Lineage Priming, but Is Dispensable for Self-Renewal in Mouse Embryonic Stem Cells

Naive mouse embryonic stem cells (mESCs) are in a metastable state and fluctuate between inner cell mass- and epiblast-like phenotypes. Here, we show transient activation of the BMP-SMAD signaling pathway in mESCs containing a BMP-SMAD responsive reporter transgene. Activation of the BMP-SMAD reporter transgene in naive mESCs correlated with lower levels of genomic DNA methylation, high expression of 5-methylcytosine hydroxylases Tet1/2 and low levels of DNA methyltransferases Dnmt3a/b. Moreover, naive mESCs, in which the BMP-SMAD reporter transgene was activated, showed higher resistance to differentiation. Using double Smad1;Smad5 knockout mESCs, we showed that BMP-SMAD signaling is dispensable for self-renewal in both naive and ground state. These mutant mESCs were still pluripotent, but they exhibited higher levels of DNA methylation than their wild-type counterparts and had a higher propensity to differentiate. We showed that BMP-SMAD signaling modulates lineage priming in mESCs, by transiently regulating the enzymatic machinery responsible for DNA methylation

Search for Higgs Bosons in e+e- Collisions at 183 GeV

The data collected by the OPAL experiment at sqrts=183 GeV were used to search for Higgs bosons which are predicted by the Standard Model and various extensions, such as general models with two Higgs field doublets and the Minimal Supersymmetric Standard Model (MSSM). The data correspond to an integrated luminosity of approximately 54pb-1. None of the searches for neutral and charged Higgs bosons have revealed an excess of events beyond the expected background. This negative outcome, in combination with similar results from searches at lower energies, leads to new limits for the Higgs boson masses and other model parameters. In particular, the 95% confidence level lower limit for the mass of the Standard Model Higgs boson is 88.3 GeV. Charged Higgs bosons can be excluded for masses up to 59.5 GeV. In the MSSM, mh > 70.5 GeV and mA > 72.0 GeV are obtained for tan{beta}>1, no and maximal scalar top mixing and soft SUSY-breaking masses of 1 TeV. The range 0.8 < tanb < 1.9 is excluded for minimal scalar top mixing and m{top} < 175 GeV. More general scans of the MSSM parameter space are also considered.Comment: 49 pages. LaTeX, including 33 eps figures, submitted to European Physical Journal

A Measurement of the Product Branching Ratio f(b->Lambda_b).BR(Lambda_b->Lambda X) in Z0 Decays

The product branching ratio, f(b->Lambda_b).BR(Lambda_b->Lambda X), where Lambda_b denotes any weakly-decaying b-baryon, has been measured using the OPAL detector at LEP. Lambda_b are selected by the presence of energetic Lambda particles in bottom events tagged by the presence of displaced secondary vertices. A fit to the momenta of the Lambda particles separates signal from B meson and fragmentation backgrounds. The measured product branching ratio is f(b->Lambda_b).BR(Lambda_b->Lambda X) = (2.67+-0.38(stat)+0.67-0.60(sys))% Combined with a previous OPAL measurement, one obtains f(b->Lambda_b).BR(Lambda_b->Lambda X) = (3.50+-0.32(stat)+-0.35(sys))%.Comment: 16 pages, LaTeX, 3 eps figs included, submitted to the European Physical Journal