Two-micron spectrophotometry of the galaxy NGC 253

A very strong Brackett-gamma hydrogen emission line, and the 2.3 micron CO stellar absorption feature were measured in NGC 253. The presence and strength of the CO feature indicates that late type giant stars produce most of the 2.2 micron continuum emission, while the rate of ionization implied by strength of the Brackett-gamma line indicates that much, perhaps all, of the luminosity detected at far infrared wavelengths originates from a large number of OB stars. As compared to the corresponding region of the Galaxy, the number of massive young stars in the central 200 pc of NGC 253 is thirty times greater, but the total mass of stars is roughly the same

Magnetic Field Structure around Low-Mass Class 0 Protostars: B335, L1527 and IC348-SMM2

We report new 350 micron polarization observations of the thermal dust emission from the cores surrounding the low-mass, Class 0 YSOs L1527, IC348-SMM2 and B335. We have inferred magnetic field directions from these observations, and have used them together with results in the literature to determine whether magnetically regulated core-collapse and star-formation models are consistent with the observations. These models predict a pseudo-disk with its symmetry axis aligned with the core magnetic field. The models also predict a magnetic field pinch structure on a scale less than or comparable to the infall radii for these sources. In addition, if the core magnetic field aligns (or nearly aligns) the core rotation axis with the magnetic field before core collapse, then the models predict the alignment (or near alignment) of the overall pinch field structure with the bipolar outflows in these sources. We show that if one includes the distorting effects of bipolar outflows on magnetic fields, then in general the observational results for L1527 and IC348-SMM2 are consistent with these magnetically regulated models. We can say the same for B335 only if we assume the distorting effects of the bipolar outflow on the magnetic fields within the B335 core are much greater than for L1527 and IC348-SMM2. We show that the energy densities of the outflows in all three sources are large enough to distort the magnetic fields predicted by magnetically regulated models.Comment: Accepted for publication in The Astrophysical Journa

Multiprotein DNA looping

DNA looping plays a fundamental role in a wide variety of biological processes, providing the backbone for long range interactions on DNA. Here we develop the first model for DNA looping by an arbitrarily large number of proteins and solve it analytically in the case of identical binding. We uncover a switch-like transition between looped and unlooped phases and identify the key parameters that control this transition. Our results establish the basis for the quantitative understanding of fundamental cellular processes like DNA recombination, gene silencing, and telomere maintenance.Comment: 11 pages, 4 figure

Capabilities and Limitations of the Shuttle for Future Cargo Programs

This paper presents a view of future Shuttle cargo operations. Planned and potential performance improvements are addressed. On-orbit operations, performance and experience are discussed with a view of anticipated changes. Current and future cargo integration activities are also addressed. The future Shuttle user is provided a projection to assist in planning and payload development

Controlling Link Congestion on Complex Network

We studied the impact of bandwidth utilization factor on converged network of Zain Contact Centre which is a complex network environment in Nigeria. Some congestion control techniques were reviewed. Experiments were carried out on the real network, a legacy network and an integrated converged network considering the same number of users. The corresponding packets were compared. As a result, higher throughput and minimal packet loss were achieved at lower bandwidth utilization and better than what was obtained at higher utilization using the same parameters

Second messenger-activated calcium influx in rat peritoneal mast cells.

To study the regulation of calcium influx in non-excitable cells, membrane currents of rat peritoneal mast cells were recorded using the whole-cell patch-clamp technique. At the same time, intracellular calcium concentration ([Ca2+]i) was monitored via the fluorescent calcium-indicator dye Fura-2, which was loaded into cells by diffusion from the patch pipette. 2. Stimulation of mast cells with secretagogues, such as compound 48/80 or substance P, caused release of Ca2+ from internal stores. In addition, external agonists also induced influx of external calcium in 26% of the cells investigated. The agonist-stimulated Ca2+ influx was increased during membrane hyperpolarization and was associated with small whole-cell currents. 3. Likewise, internal application of inositol 1,4,5-trisphosphate (Ins1,4,5P3:0.5-10 microM) elevated [Ca2+]i due both to release of Ca2+ from internal stores and to influx of external calcium. The Ins1,4,5P3-induced influx was greater at more negative membrane potentials, suggesting that Ins1,4,5P3 opened a pathway through which calcium could enter at a rate governed by its electrochemical driving force. 4. Inositol 1,3,4,5-tetrakisphosphate (Ins1,3,4,5P4) did not induce Ca2+ influx by itself nor did it facilitate or enhance Ins1,4,5P3-induced Ca2+ entry. Calcium influx was also induced by inositol 2,4,5-trisphosphate. Since this inositol phosphate is a poor substrate for Ins1,4,5P3 3-kinase it seems unlikely that Ins1,3,4,5P4 plays a role in the regulation of the Ca2(+)-influx pathway in mast cells. 5. The Ins1,4,5P3-induced Ca2+ influx was associated with whole-cell currents of 1-2 pA or less, with no channel activity detectable in whole-cell recordings. The small size of the whole-cell current suggests either that the Ins1,4,5P3-dependent influx occurs via small-conductance channels that are highly calcium specific or that the influx is not via ion channels. 6. Agonist stimulation also activated large-conductance (ca 50 pS) cation channels, through which divalent cations could permeate; thus, these channels represent a second pathway for Ca2+ influx. The slow speed of activation of the channels by agonists, their activation by internal guanosine 5'-O-(3-thiotriphosphate) (GTP-gamma-S), and the inhibition of agonist activation by internal guanosine 5'-O-(2-thiodiphosphate) (GDP-beta-S) all suggest that the 50 pS channels are regulated by a second messenger and/or a GTP-binding protein. The activity of the 50 pS channel in mast cells is not sensitive to either Ins1,4,5P3 or Ins1,3,4,5P4. Activity of the channel was inhibited by elevated [Ca2+]

Mass and orbit constraints of the gamma-ray binary LS 5039

We present the results of space-based photometric and ground-based spectroscopic observing campaigns on the gamma-ray binary LS 5039. The new orbital and physical parameters of the system are similar to former results, except we found a lower eccentricity. Our MOST-data show that any broad-band optical photometric variability at the orbital period is below the 2 mmag level. Light curve simulations support the lower value of eccentricity and imply that the mass of the compact object is higher than 1.8 solar masses.Comment: 2 pages, 1 figure (with 2 panels); to be published in the Proceedings: From Interacting Binaries to Exoplanets: Essential Modeling Tools, IAU Symposium 282 (18-22 July, 2011, Tatranska Lomnica, Slovakia

APM 08279+5255: Keck Near- and Mid-IR High-Resolution Imaging

We present Keck high-resolution near-IR (2.2 microns; FWHM~0.15") and mid-IR (12.5 microns; FWHM~0.4") images of APM08279+5255, a z=3.91 IR-luminous BALQSO with a prodigious apparent bolometric luminosity of 5x10^{15} Lsun, the largest known in the universe. The K-band image shows that this system consists of three components, all of which are likely to be the gravitationally lensed images of the same background object, and the 12.5 micron image shows a morphology consistent with such an image configuration. Our lens model suggests that the magnification factor is ~100 from the restframe UV to mid-IR, where most of the luminosity is released. The intrinsic bolometric luminosity and IR luminosity of APM08279+5255 are estimated to be 5x10^{13} Lsun and 1x10^{13} Lsun, respectively. This indicates that APM 08279+5255 is intriniscally luminous, but it is not the most luminous object known. As for its dust contents, little can be determined with the currently available data due to the uncertainties associated with the dust emissivity and the possible effects of differential magnification. We also suggest that the lensing galaxy is likely to be a massive galaxy at z~3.Comment: 32 pages, 4 tables, 11 figures; Accepted for publication in Ap