Fluid Delivery System for a Cell Culture on a Microfluidic Chip

This project report provides a description of the progress made in the development of a fluid delivery system for a microfluidic cell culture on a chip. The system is intended to be used in a humidified incubator in a university laboratory and the fluid delivery system is required to exist and operate within that incubator for extended periods of time. Therefore, the system will be gravity-driven and contain no electronic components. The key specification of the system is to provide fluid flow at a constant velocity. After manufacturing and testing the device, all specifications were met except for the fluid velocity remaining constant over extended periods of time. This report will go into detail on the results of the tests that passed and why this specification was not met during testing, as well as future recommendations for this system

Gamma-ray burst spectroscopy capabilities of the BATSE/GRO experiment

A scintillation spectrometer is included in each of the eight BATSE/GRO detector modules, resulting in all-sky coverage for gamma-ray bursts. The scientific motivation, design and capabilities of these spectrometers for performing spectral observations over a wide range of gamma-ray energies and burst intensities are described

Solar response of the BATSE instrument on the gamma-ray observatory

The Burst and Transient Source Experiment (BATSE) on board the gamma ray observatory (GRO) aims at comprehensive observations of time profiles, spectra, and locations of high-energy transient sources. The mysterious cosmic gamma ray bursts provided the main motivation for the observations, but BATSE will make excellent observations of many classes of sources, and in particular solar flares. The solar response of BATSE, as inferred from its design parameters, is analyzed for two purposes: the optimization of the solar observations themselves, and the characterization of the solar effects on ordinary nonsolar observations

BATSE Gamma-Ray Burst Line Search: V. Probability of Detecting a Line in a Burst

The physical importance of the apparent discrepancy between the detections by pre-BATSE missions of absorption lines in gamma-ray burst spectra and the absence of a BATSE line detection necessitates a statistical analysis of this discrepancy. This analysis requires a calculation of the probability that a line, if present, will be detected in a given burst. However, the connection between the detectability of a line in a spectrum and in a burst requires a model for the occurrence of a line within a burst. We have developed the necessary weighting for the line detection probability for each spectrum spanning the burst. The resulting calculations require a description of each spectrum in the BATSE database. With these tools we identify the bursts in which lines are most likely to be detected. Also, by assuming a small frequency with which lines occur, we calculate the approximate number of BATSE bursts in which lines of various types could be detected. Lines similar to the Ginga detections can be detected in relatively few BATSE bursts; for example, in only ~20 bursts are lines similar to the GB 880205 pair of lines detectable. Ginga reported lines at ~20 and ~40 keV whereas the low energy cutoff of the BATSE spectra is typically above 20 keV; hence BATSE's sensitivity to lines is less than that of Ginga below 40 keV, and greater above. Therefore the probability that the GB 880205 lines would be detected in a Ginga burst rather than a BATSE burst is ~0.2. Finally, we adopted a more appropriate test of the significance of a line feature.Comment: 20 pages, AASTeX 4.0, 5 figures, Ap.J. in pres

Spectral Hardness Decay with Respect to Fluence in BATSE Gamma-Ray Bursts

We have analyzed the evolution of the spectral hardness parameter Epk as a function of fluence in gamma-ray bursts. We fit 41 pulses within 26 bursts with the trend reported by Liang & Kargatis (1996) which found that Epk decays exponentially with respect to photon fluence. We also fit these pulses with a slight modification of this trend, where Epk decays linearly with energy fluence. In both cases, we found the set of 41 pulses to be consistent with the trend. For the latter trend, which we believe to be more physical, the distribution of the decay constant is roughly log-normal, with a mean of 1.75 +/- 0.07 and a FWHM of 1.0 +/- 0.1. Regarding an earlier reported invariance in the decay constant among different pulses in a single burst, we found probabilities of 0.49 to 0.84 (depending on the test used) that such invariance would occur by coincidence, most likely due to the narrow distribution of decay constant values among pulses.Comment: 17 pages, 7 figure pages, 2 table pages, submitted to The Astrophysical Journa

Structural Change in (Economic) Time Series

Methods for detecting structural changes, or change points, in time series data are widely used in many fields of science and engineering. This chapter sketches some basic methods for the analysis of structural changes in time series data. The exposition is confined to retrospective methods for univariate time series. Several recent methods for dating structural changes are compared using a time series of oil prices spanning more than 60 years. The methods broadly agree for the first part of the series up to the mid-1980s, for which changes are associated with major historical events, but provide somewhat different solutions thereafter, reflecting a gradual increase in oil prices that is not well described by a step function. As a further illustration, 1990s data on the volatility of the Hang Seng stock market index are reanalyzed.Comment: 12 pages, 6 figure

Evolution of the Low-Energy Photon Spectra in Gamma-Ray Bursts

We report evidence that the asymptotic low-energy power law slope alpha (below the spectral break) of BATSE gamma-ray burst photon spectra evolves with time rather than remaining constant. We find a high degree of positive correlation exists between the time-resolved spectral break energy E_pk and alpha. In samples of 18 "hard-to-soft" and 12 "tracking" pulses, evolution of alpha was found to correlate with that of the spectral break energy E_pk at the 99.7% and 98% confidence levels respectively. We also find that in the flux rise phase of "hard-to-soft" pulses, the mean value of alpha is often positive and in some bursts the maximum value of alpha is consistent with a value > +1. BATSE burst 3B 910927, for example, has a alpha_max equal to 1.6 +/- 0.3. These findings challenge GRB spectral models in which alpha must be negative of remain constant.Comment: 12 pages (including 6 figures), accepted to Ap

BATSE Gamma-Ray Burst Line Search: IV. Line Candidates from the Visual Search

We evaluate the significance of the line candidates identified by a visual search of burst spectra from BATSE's Spectroscopy Detectors. None of the candidates satisfy our detection criteria: an F-test probability less than 10^-4 for a feature in one detector and consistency among the detectors which viewed the burst. Most of the candidates are not very significant, and are likely to be fluctuations. Because of the expectation of finding absorption lines, the search was biased towards absorption features. We do not have a quantitative measure of the completeness of the search which would enable a comparison with previous missions. Therefore a more objective computerized search has begun.Comment: 18 pages AASTEX 4.0; 4 POSTSCRIPT figures on request from [email protected]

The BATSE experiment on the Gamma Ray Observatory: Solar flare hard x ray and gamma-ray capabilities

The Burst and Transient Source Experiment (BATSE) for the Gamma Ray Observatory (GRO) consists of eight detector modules that provide full-sky coverage for gamma-ray bursts and other transient phenomena such as solar flares. Each detector module has a thin, large-area scintillation detector (2025 sq cm) for high time-resolution studies, and a thicker spectroscopy detector (125 sq cm) to extend the energy range and provide better spectral resolution. The total energy range of the system is 15 keV to 100 MeV. These 16 detectors and the associated onboard data system should provide unprecedented capabilities for observing rapid spectral changes and gamma-ray lines from solar flares. The presence of a solar flare can be detected in real-time by BATSE; a trigger signal is sent to two other experiments on the GRO. The launch of the GRO is scheduled for June 1990, so that BATSE can be an important component of the Max '91 campaign