Collapse and Fragmentation of Rotating Magnetized Clouds. I. Magnetic Flux - Spin Relation

We discuss evolution of the magnetic flux density and angular velocity in a molecular cloud core, on the basis of three-dimensional numerical simulations, in which a rotating magnetized cloud fragments and collapses to form a very dense optically thick core of > 5 times 10 ^10 cm^-3 . As the density increases towards the formation of the optically thick core, the magnetic flux density and angular velocity converge towards a single relationship between the two quantities. If the core is magnetically dominated its magnetic flux density approaches 1.5 (n/5 times 10^10 cm^-3)^1/2 mG, while if the core is rotationally dominated the angular velocity approaches 2.57 times 10^-3, (n/5 times 10^10 cm^-3)^1/2 yr^-1, where n is the density of the gas. We also find that the ratio of the angular velocity to the magnetic flux density remains nearly constant until the density exceeds 5 times 10^10 cm^-3. Fragmentation of the very dense core and emergence of outflows from fragments are shown in the subsequent paper.Comment: 17 pages, 12 figures, accepted for publication in MNRA

The Circumbinary Outflow: A Protostellar Outflow Driven by a Circumbinary Disk

The protostellar outflows have indispensable role in the formation of single stars, because they carry off the excess angular momentum from the centre of the shrinking gas cloud, and permits further collapse to form a star. On the other hand, a significant fraction of stars is supposed to be born as binaries with circumbinary disk that are frequently observed. Here, we investigate the evolution of a magnetized rotating cloud using three-dimensional resistive MHD nested-grid code, and show that the outflow is driven by the circumbinary disk and has an important role even in the binary formation. After the adiabatic core formation in the collapsing cloud core, the magnetic flux is significantly removed from the centre of the cloud by the Ohmic dissipation. Since this removal makes the magnetic braking ineffective, the adiabatic core continuously acquires the angular momentum to induce fragmentation and subsequent binary formation. The magnetic field accumulates in the circumbinary disk where the removal and accretion of magnetic field are balanced, and finally drives circumbinary outflow. This result explains the spectacular morphology of some specific young stellar objects such as L1551 IRS5. We can infer that most of the bipolar molecular outflows observed by low density tracers (i.e., CO) would correspond to circumbinary or circum-multiple outflows found in this report, since most of the young stellar objects are supposed to be binaries or multiples.Comment: 11 pages, 3 figures, Submitted to ApJL. For high resolution figures see http://www2-tap.scphys.kyoto-u.ac.jp/~machidam/astro-ph/Circumbinary.pd

Magnetic Field in The Isolated Massive Dense Clump IRAS 20126+4104

We measured polarized dust emission at 350µm towards the high-mass star forming massive dense clump IRAS 20126+4104 using the SHARC II Polarimeter, SHARP, at the Caltech Submillimeter Observatory. Most of the observed magnetic field vectors agree well with magnetic field vectors obtained from a numerical simulation for the case when the global magnetic field lines are inclined with respect to the rotation axis of the dense clump. The results of the numerical simulation show that rotation plays an important role on the evolution of the massive dense clump and its magnetic field. The direction of the cold CO 1-0 bipolar outflow is parallel to the observed magnetic field within the dense clump as well as the global magnetic field, as inferred from optical polarimetry data, indicating that the magnetic field also plays a critical role in an early stage of massive star formation. The large-scale Keplerian disk of the massive (proto)star rotates in almost opposite sense to the clump's envelope. The observed magnetic field morphology and the counter-rotating feature of the massive dense clump system provide hints to constrain the role of magnetic fields in the process of high mass star formation

A novel role of interleukin-6 as a regulatory factor of inflammation-associated deterioration in osteoblast arrangement

Inflammatory disorders are associated with bone destruction; that is, deterioration in bone cell activities are under the control of the innate immune system. Macrophages play a central role in innate immunity by switching their polarized phenotype. A disturbed immune system causes aberrance in the ordered bone matrix microarrangement, which is a dominant determinant of bone tissue functionalization. However, the precise relationship between the immune system and bone tissue organization is unknown. In this study, the controlled in vitro co-culture assay results showed that M1-polarized macrophages disrupted the osteoblast alignment, which directly modulate the oriented bone matrix organization, by secreting pro-inflammatory cytokines. Notably, interleukin6 was found to be a key regulator of unidirectional osteoblast alignment. Our results demonstrated that inflammatory diseases triggered bone dysfunction by regulating the molecular interaction between the immune system and bone tissue organization. These findings may contribute to the development of therapeutic targets for inflammatory disorders, including rheumatoid arthritis.Matsugaki A., Matsumoto S., Nakano T.. A novel role of interleukin-6 as a regulatory factor of inflammation-associated deterioration in osteoblast arrangement. International Journal of Molecular Sciences, 21, 18, 1. https://doi.org/10.3390/ijms21186659

Current concepts and future perspectives in computer-assisted navigated total knee replacement.

BACKGROUND: Total knee replacements (TKR) aim to restore stability of the tibiofemoral and patella-femoral joints and provide relief of pain and improved quality of life for the patient. In recent years, computer-assisted navigation systems have been developed with the aim of reducing human error in joint alignment and improving patient outcomes. METHODS: We examined the current body of evidence surrounding the use of navigation systems and discussed their current and future role in TKR. RESULTS: The current body of evidence shows that the use of computer navigation systems for TKR significantly reduces outliers in the mechanical axis and coronal prosthetic position. Also, navigation systems offer an objective assessment of soft tissue balancing that had previously not been available. Although these benefits represent a technical superiority to conventional TKR techniques, there is limited evidence to show long-term clinical benefit with the use of navigation systems, with only a small number of studies showing improvement in outcome scores at short-term follow-up. Because of the increased costs and operative time associated with their use as well as the emergence of more affordable and patient-specific technologies, it is unlikely for navigation systems to become more widely used in the near future. CONCLUSIONS: Whilst this technology helps surgeons to achieve improved component positioning, it is important to consider the clinical and functional implications, as well as the added costs and potential learning curve associated with adopting new technology

Efficacy of FimA antibody and clindamycin in silkworm larvae stimulated with Porphyromonas gulae

Objective: Porphyromonas gulae, a major periodontal pathogen in animals, possesses fimbriae that have been classified into three genotypes (A, B, C) based on the diversity of fimA genes encoding fimbrillin protein (FimA). P. gulae strains with type C fimbriae were previously shown to be more virulent than other types. In this study, we further examined the host toxicity mediated by P. gulae fimbriae by constructing recombinant FimA (rFimA) expression vectors for each genotype and raised antibodies to the purified proteins. Methods and Results: All larvae died within 204 h following infection with P. gulae type C at the low-dose infection, whereas type A and B did not. Among fimA types, the survival rates of the larvae injected with rFimA type C were remarkably decreased, while the survival rates of the larvae injected with rFimA type A and type B were greater than 50%. Clindamycin treatment inhibited the growth of type C strains in a dose-dependent manner, resulting in an increased rate of silkworm survival. Finally, type C rFimA-speci?c antiserum prolonged the survival of silkworm larvae stimulated by infection with P. gulae type C strain or injection of rFimA type C protein. Conclusion: These results suggested that type C fimbriae have high potential for enhancement of bacterial pathogenesis, and that both clindamycin and anti-type C rFimA-specific antibodies are potent inhibitors of type C fimbriae-induced toxicity. This is the first report to establish a silkworm infection model using P. gulae for toxicity assessment

Numerical-Diagonalization Study of Spin Gap Issue of the Kagome Lattice Heisenberg Antiferromagnet

We study the system size dependence of the singlet-triplet excitation gap in the $S=1/2$ kagome-lattice Heisenberg antiferromagnet by numerical diagonalization. We successfully obtain a new result of a cluster of 42 sites. The two sequences of gaps of systems with even-number sites and that with odd-number sites are separately analyzed. Careful examination clarifies that there is no contradiction when we consider the system to be gapless.Comment: 5 pages, 3 figures, 1 table, received by J. Phys. Soc. Jpn. on 20 Jan 2011, to be published in this journa

Recurrent Planet Formation and Intermittent Protostellar Outflows Induced by Episodic Mass Accretion

The formation and evolution of a circumstellar disk in magnetized cloud cores is investigated from prestellar core stage until sim 10^4 yr after protostar formation. In the circumstellar disk, fragmentation first occurs due to gravitational instability in a magnetically inactive region, and substellar-mass objects appear. The substellar-mass objects lose their orbital angular momenta by gravitational interaction with the massive circumstellar disk and finally fall onto the protostar. After this fall, the circumstellar disk increases its mass by mass accretion and again induces fragmentation. The formation and falling of substellar-mass objects are repeated in the circumstellar disk until the end of the main accretion phase. In this process, the mass of fragments remain small, because the circumstellar disk loses its mass by fragmentation and subsequent falling of fragments before it becomes very massive. In addition, when fragments orbit near the protostar, they disturb the inner disk region and promote mass accretion onto the protostar. The orbital motion of substellar-mass objects clearly synchronizes with the time variation of the accretion luminosity of the protostar. Moreover, as the objects fall, the protostar shows a strong brightening for a short duration. The intermittent protostellar outflows are also driven by the circumstellar disk whose magnetic field lines are highly tangled owing to the orbital motion of fragments. The time-variable protostellar luminosity and intermittent outflows may be a clue for detecting planetary-mass objects in the circumstellar disk.Comment: 48 pages, 16 figures, accepted for publication in Ap

Roles of Porphyromonas gulae proteases in bacterial and host cell biology

Porphyromonas gulae, an animal-derived periodontal pathogen, expresses several virulence factors, including fimbria, lipopolysaccharide (LPS) and proteases. We previously reported that its invasive efficiency was dependent on fimbriae types. In addition, P. gulae LPS increased inflammatory responses via toll-like receptors. The present study was conducted to investigate the involvement of P. gulae proteases in bacterial and host cell biology. Porphyromonas gulae strains showed an ability to agglutinate mouse erythrocytes and also demonstrated co-aggregation with Actinomyces viscosus, while the protease inhibitors antipain, PMSF, TLCK and leupeptin diminished P. gulae proteolytic activity, resulting in inhibition of haemagglutination and co-aggregation with A. viscosus. In addition, specific proteinase inhibitors were found to reduce bacterial cell growth. Porphyromonas gulae inhibited Ca9-22 cell proliferation in a multiplicity of infection- and time-dependent manner. Additionally, P. gulae-induced decreases in cell contact and adhesion-related proteins were accompanied by a marked change in cell morphology from well spread to rounded. In contrast, inhibition of protease activity prevented degradation of proteins, such as E-cadherin, beta-catenin and focal adhesion kinase, and also blocked inhibition of cell proliferation. Together, these results indicate suppression of the amount of human proteins, such as gamma-globulin, fibrinogen and fibronectin, by P. gulae proteases, suggesting that a novel protease complex contributes to bacterial virulence