EUR-ASSESS Project Subgroup Report on Coverage

The issue of health benefits coverage—and its relation to health technology assessment (HTA)—has gained increasing attention in recent years. Economic constraints on health care, as well as the rapid pace of technological change, have forced European countries to face difficult choices in providing such care. The active use of coverage decision making has been proposed as a tool to help rationalize health care, and HTA has been advocated as a necessary activity to improve coverage decision

L’expertise scientifique en médecine

The goal of quality in the health-care system is common to professionals, policy-makers and users. Assessments of medical technologies and formalised expressions of the state of the art of medical knowledge both aim to improve decision-making for the public authorities and for health care professionals and users. Innovation should not be brought into question by the assessment procedure itself or by the various interested connections of working group members, including experts : the quality of expert scientific assessments in medicine must rely on the education of all those involved, including teachers and decision-makers.La recherche de qualité dans le système de santé est un objectif commun des professionnels, des décideurs et des usagers. L’évaluation des technologies médicales et la formalisation de l’état des connaissances scientifiques en médecine sont deux démarches ayant pour objectif l’amélioration de la prise de décision pour les autorités publiques et pour les professionnels de santé et usagers. L’innovation ne devrait pas être mise en cause par les procédures d’évaluation, ni par les divers liens d’intérêts des membres des groupes de travail, y compris des experts. L’éducation des acteurs, dont les enseignants et décideurs, doit améliorer la qualité de l’expertise scientifique en médecine

Pancreatic Allograft Thrombosis: Implementation of the CPAT-Grading System in a Retrospective Series of Simultaneous Pancreas-Kidney Transplantation

Pancreatic graft thrombosis (PAT) is a major surgical complication, potentially leading to graft loss. The recently proposed Cambridge Pancreas Allograft Thrombosis (CPAT) grading system provides diagnostic, prognostic and therapeutic recommendations. The aim of the present study was to retrospectively assess computed tomography angiography (CTA) examinations performed routinely in simultaneous pancreas-kidney (SPK) recipients to implement the CPAT grading system and to study its association with the recipients' outcomes. We retrospectively studied 319 SPK transplant recipients, who underwent a routine CTA within the first 7 postoperative days. Analysis of the CTA scans revealed PAT in 215 patients (106 grade 1, 85 grade 2, 24 grade 3), while 104 showed no signs. Demographic data of the patients with and without PAT (thrombosis and non-thrombosis group) were not significantly different, except for the higher number of male donors in the thrombosis group. Pancreatic graft survival was significantly shorter in the thrombosis group. Graft loss due to PAT was significantly associated with grade 2 and 3 thrombosis, while it did not differ for recipients with grade 0 or grade 1 thrombosis. In conclusion, the CPAT grading system was successfully implemented in a large series of SPK transplant recipients and proved applicable in clinical practice

Prevalence of and Predictive Factors for Burnout Among French Urologists in Training

The burnout rate among young doctors currently seems to be increasing [1]. It is essential to be able to diagnose and prevent this condition to better take care of young caregivers. Burnout is defined as a “feeling of intense exhaustion, loss of control and inability to achieve concrete results at work” according to the World Health Organisation. The assessment questionnaire used most often is the Maslach Burnout Inventory (MBI), which covers (1) emotional exhaustion, (2) depersonalisation, and (3) personal accomplishment [2]

Etude et realisation d'un reflectometre vectoriel millimetrique et automatique

SIGLECNRS T Bordereau / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc

Problèmes de traduction et d'adaptation de Kraljevo de Miroslav Krleža

Matillon-Lasič Janine. Problèmes de traduction et d'adaptation de Kraljevo de Miroslav Krleža. In: Revue des études slaves, tome 51, fascicule 1-2, 1978. Communications de la délégation française au VIIIe Congrès international des slavistes (Zagreb, 3-9 septembre 1978) pp. 181-184

EPIDEMIOLOGIE, QUALITE DE LA PRISE EN CHARGE, ET PRONOSTIC DE L'ENDOCARDITE INFECTIEUSE

LYON1-BU Santé (693882101) / SudocPARIS-BIUM (751062103) / SudocPARIS-BIUP (751062107) / SudocSudocFranceF

Structure modeling of the Poly (A) binding protein C-terminus family

The solution structure of the C-terminal domain of the yeast Poly(A) Binding Protein (yPABC) was determined by NMR spectroscopy. The tridimensional fold is similar to that previously observed for the human isoform, except for a missing N-terminal alpha helix out of the five helices expected in total. A series of putative binding partners was identified in public databases, based on a consensual interaction motif that we formally defined as being S-X-L-[NS]-X-[ND]-A-X-E-F-X-P. However, no putative binding partner could be found that would match this pattern in S. Cerevisiae. Phylogenetic modeling tends to indicate that such an interacting domain might not be a fundamental part, if existing at all, of PABC function.A tridimensional model of each of the remaining twenty PABC orthologs was generated: the overall fold of five consecutive helices seen in human PABC is well conserved, in contradiction with recently published modeling studies based on the crystal structure of the homologous PABC domain from HYD, which predicts only four helices

ETUDE DESCRIPTIVE DES CARACTERISTIQUES DES ETUDIANTS DE LA FACULTE LAENNEC - LYON 1 (ELABORATION DU PROFIL DE L'ETUDIANT EN MEDECINE EN FIN DE CURSUS)

LYON1-BU Santé (693882101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF